Hepatitis C genotype influences post-liver transplant outcomes.

abstract：:Cyclosporine (CsA) is an immunosuppressive drug requiring dose individualization and regular control due to its highly variable pharmacokinetics. Since gastroparesis may influence the absorption of CsA, a randomized cross-over study was performed to assess the pharmacokinetics and tolerability of a novel microemulsion...

journal_title：Transplantation

authors： van der Pijl JW,Srivastava N,Denouël J,Burggraaf J,Schoemaker RC,van der Woude FJ,Cohen AF

更新日期：1996-08-27 00:00:00

abstract：:Islets were isolated from the pancreata of Sprague-Dawley rats and transplanted into streptozotocin-induced diabetic outbred Wistar rats. The effect of transplantation of islets into the cisterna magna on the diabetic state of the recipients was compared with that of the conventional transplantation of islets into liv...

journal_title：Transplantation

authors： Lee HC,Ahn KJ,Lim SK,Kim KR,Ahn YS,Lee KE,Huh KB

更新日期：1992-03-01 00:00:00

abstract：:A cadaveric renal transplant was performed on a 63-year-old woman. The donor renal artery and vein were anastomosed to the recipient external iliac vessels using the vascular clipping system. These vascular anastomoses were performed with four stay sutures and several clips for each anastomosis, without a continuous v...

journal_title：Transplantation

authors： Mital D,Foster PF,Jensik SC,del Rio JV,Sankary HN,McChesney LP,Williams JW

更新日期：1996-10-27 00:00:00

abstract：BACKGROUND:Pancreatic islets are avascular immediately after transplantation and depend on revascularization. Recently, the authors found decreased vascular density in mouse islets 1 month after implantation into nondiabetic recipients. This study investigated possible differences in revascularization between islets im...

journal_title：Transplantation

authors： Mattsson G,Jansson L,Nordin A,Carlsson PO

更新日期：2003-03-15 00:00:00

abstract：:Hepatitis C viral recurrence after orthotopic liver transplantation is almost universal. Hepatitis C induced graft failure may occur, but the clinical and histologic profiles are not well defined. The aim of this study was to describe the pattern of early graft failure in patients with recurrent hepatitis C after live...

journal_title：Transplantation

authors： Dickson RC,Caldwell SH,Ishitani MB,Lau JY,Driscoll CJ,Stevenson WC,McCullough CS,Pruett TL

更新日期：1996-03-15 00:00:00

abstract：BACKGROUND:Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance. METHODS:We assessed 64 re...

journal_title：Transplantation

authors： Segundo DS,Ruiz JC,Izquierdo M,Fernández-Fresnedo G,Gómez-Alamillo C,Merino R,Benito MJ,Cacho E,Rodrigo E,Palomar R,López-Hoyos M,Arias M

更新日期：2006-08-27 00:00:00

abstract：:Seven murine anti-H-2 and three nonimmune mouse sera were tested for cytotoxicity toward B and T lymphocytes from a panel of human donors. One group of sera, including two anti-H-2.33 sera, exhibited cytotoxicity directed exclusively toward human B but not T cells from all donors. Absorption studies on human lymphobla...

journal_title：Transplantation

authors： Verghese MW,Ward FE

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Current insulin therapies for control of glucose metabolism in patients with type I diabetes mellitus prevent major metabolic consequences of insulin deficiency, but none prevents or arrests long-term complications. In experimental models of canine diabetes, retinopathy, neuropathy, and nephropathy have been...

journal_title：Transplantation

authors： Hawthorne WJ,Wilson TG,Williamson P,Stewart GJ,Allen RD,Little JM,Deane SA,Ekberg H

更新日期：1997-10-15 00:00:00

abstract：BACKGROUND:Uterus transplantation is a treatment for absolute uterine infertility and can be performed with living and deceased donors. Given the safety and increased utilization of robotic assistance with other gynecologic and transplant donor operations, we adopted a robot-assisted approach to donor hysterectomy. Thi...

journal_title：Transplantation

authors： Johannesson L,Koon EC,Bayer J,McKenna GJ,Wall A,Fernandez H,Martinez EJ,Gupta A,Ruiz R,Onaca N,Testa G

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Renal interstitial fibrosis (IF) is the main histopathological feature of chronic allograft injury. IF is currently assessed by semiquantitative analysis, but automatic color image analysis may be more reliable and reproducible. We performed a retrospective analysis to calculate IF on routine renal biopsies ...

journal_title：Transplantation

authors： Servais A,Meas-Yedid V,Buchler M,Morelon E,Olivo-Marin JC,Lebranchu Y,Legendre C,Thervet E

更新日期：2007-12-27 00:00:00

abstract：BACKGROUND:Heart transplantation (HTx) remains the most effective long-term treatment for advanced heart failure. Primary graft dysfunction (PGD) continues to be a potentially life-threatening early complication. In 2014, a consensus statement released by International Society for Heart and Lung Transplantation (ISHLT)...

journal_title：Transplantation

authors： Avtaar Singh SS,Banner NR,Rushton S,Simon AR,Berry C,Al-Attar N

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:There is growing interest in new therapeutic options for the treatment of end-stage liver diseases. In addition to mechanical devices supporting liver function, such as bioreactors, the transplantation of hepatocyte-like cells derived from (adult) stem cells offer great perspectives. We have generated hepato...

journal_title：Transplantation

authors： Ruhnke M,Nussler AK,Ungefroren H,Hengstler JG,Kremer B,Hoeckh W,Gottwald T,Heeckt P,Fandrich F

更新日期：2005-05-15 00:00:00

abstract：BACKGROUND:We sought to compare the immunoreactive potential of human cord blood (CB) versus normal adult bone marrow (BM) versus mobilized blood (peripheral blood stem cells; PBSC) from cancer patients. METHODS:Forty mice were randomized to receive a range of doses of T cell-replete cell preparations from one of the ...

journal_title：Transplantation

authors： Leung W,Ramírez M,Mukherjee G,Perlman EJ,Civin CI

更新日期：1999-09-15 00:00:00

abstract：:Allograft rejection results from a complex process involving both the innate and acquired immune systems. The innate immune system predominates in the early phase of the allogeneic response, during which chemokines and cell adhesion play essential roles, not only for leukocyte migration into the graft but also for fac...

journal_title：Transplantation

authors： Le Moine A,Goldman M,Abramowicz D

更新日期：2002-05-15 00:00:00

abstract：:Seasonal variation in blood pressure (BP) has been described in the general and dialysis populations, with higher recordings noted in the winter than in the summer. This difference has been attributed to changes in weight, ambient temperature, and length of daylight. In this study, we sought to determine whether such ...

journal_title：Transplantation

authors： Prasad GV,Nash MM,Zaltzman JS

更新日期：2001-12-15 00:00:00

abstract：:An isolated vascularized bone marrow transplant (iVBMT) model was previously developed in the rat to specifically study the role of bone marrow and its environment in a composite tissue allotransplant. An extraperitoneal model was successfully created to avoid laparotomy and cross-clamping of the great vessels. The ex...

journal_title：Transplantation

authors： Tai CY,France MA,Strande LF,Eydelman R,Sheng X,Matthews MS,Dalsey R,Hewitt CW

更新日期：2003-05-15 00:00:00

abstract：:Cyclosporine extends kidney allograft survival in the chacma baboon, and this study explores various administration protocols to generate optimal serum concentrations of the drug, assessed by radioimmunoassay and by inhibition of lymphocyte transformation by phytohemagglutinin and allogeneic lymphocytes in culture. Se...

journal_title：Transplantation

authors： Smit JA,Drielsma RF,Myburgh JA,Laupacis A,Stiller CR

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Thymoglobulin given before allo-hematopoietic stem-cell transplantation (HSCT) from unrelated donors reduces acute graft-versus-host disease (GvHD), but the optimal dose is unknown. METHOD:Four different doses of Thymoglobulin were given to 162 patients with hematologic malignancies undergoing unrelated don...

journal_title：Transplantation

authors： Remberger M,Svahn BM,Mattsson J,Ringdén O

更新日期：2004-07-15 00:00:00

abstract：INTRODUCTION:We carried out an analysis of the United States Renal Data System to determine the incidence, risk factors, prognosis, and costs associated with the diagnosis of renal cell carcinoma (RCC) after kidney transplantation. METHODS:This is a retrospective cohort of 40,821 Medicare primary renal transplant reci...

journal_title：Transplantation

authors： Hurst FP,Jindal RM,Graham LJ,Falta EM,Elster EA,Stackhouse GB,Agodoa LY,Lentine KL,Salifu MO,Abbott KC

更新日期：2010-10-27 00:00:00

abstract：:The frequencies of circulating donor-reactive cytotoxic lymphocyte precursors (CLP) and Il-2-producing helper lymphocyte precursors (HLP) were determined by limiting dilution analysis in 19 kidney allograft recipients before and at various intervals (up to 2 years) after transplantation. A significant, selective, and ...

journal_title：Transplantation

authors： Zanker B,Jooss-Rüdiger J,Franz HE,Wagner H,Kabelitz D

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Sirolimus (rapamycin) is a potent immunosuppressant with a mechanism of action different from cyclosporine (CsA) or tacrolimus. METHODS:In 11 European centers, first cadaveric renal allograft recipients were randomized to CsA (n=42) or sirolimus (n=41). Dosing of these agents was concentration-controlled an...

journal_title：Transplantation

authors： Groth CG,Bäckman L,Morales JM,Calne R,Kreis H,Lang P,Touraine JL,Claesson K,Campistol JM,Durand D,Wramner L,Brattström C,Charpentier B

更新日期：1999-04-15 00:00:00

abstract：BACKGROUND:FK506-binding proteins (FKBP) are immunophilins that interact with the immunosuppressive drugs FK506 and rapamycin. Several FKBP family members such as FKBP12, FKBP12.6, and FKBP51 are expressed in T cells. It has been speculated that these FKBPs are possibly redundant in the immunosuppressant-induced T-cell...

journal_title：Transplantation

authors： Xu X,Su B,Barndt RJ,Chen H,Xin H,Yan G,Chen L,Cheng D,Heitman J,Zhuang Y,Fleischer S,Shou W

更新日期：2002-06-15 00:00:00

abstract：:Four skin graft models are created which vary in the rates of lymphatic and vascular reconstitution. Rat allografts (Brown Norway or (L times BN)F1 hybrid) transplanted to Lewis recipients by conventional (immediate lymphatic, delayed vascular), surgical anastomosis (immediate lymphatic, immediate vascular) or isolate...

journal_title：Transplantation

authors： Wustrack KO,Gruber RP,Lucas ZJ

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Intestinal allograft mucosa undergoes repopulation with host immunocytes. However, critical changes within key immunocyte subsets are not known. METHODS:To explain acute cellular rejection after intestine transplantation (ITx) on the basis of altered mucosal immunocytes, rejecting and rejection-free ITx all...

journal_title：Transplantation

authors： Ningappa M,Ashokkumar C,Ranganathan S,Schmitt L,Higgs BW,Sun Q,Branca M,Mazariegos G,Zeevi A,Abu-Elmagd K,Squires R,Rudolph J,Alissa F,Hakonarson H,Sindhi R

更新日期：2012-12-27 00:00:00

abstract：BACKGROUND:Lipid peroxidation by free radicals is a key step in the development of atherosclerosis. Chronic graft nephropathy (CGN) is a common cause of allograft failure and shares many histologic features with atherosclerosis. Although hyperlipidemia is a common finding in renal transplant recipients, not all patient...

journal_title：Transplantation

authors： Morris-Stiff GJ,Oleesky D,Jurewicz WA

更新日期：2003-10-15 00:00:00

abstract：BACKGROUND:Pneumocystis jiroveci pneumonia may be a life-threatening opportunistic infection in immunosuppressed solid organ transplant recipients. Despite effective treatment with high-dose trimethoprim-sulfamethoxazole and steroids, morbidity is often severe and lethality remains high. New therapeutic approaches are ...

journal_title：Transplantation

authors： Utili R,Durante-Mangoni E,Basilico C,Mattei A,Ragone E,Grossi P

更新日期：2007-09-27 00:00:00

abstract：:A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes in vitro is described. Responding lymphocytes are cultured with mitomycin-C treated allogeneic stimulating cells in wells of replicate microtrays for both one-way mixed leukocyte culture (MLC) and cell-mediated lymph...

journal_title：Transplantation

authors： Zarling JM,McKeough M,Bach FH

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Mycophenolic acid, the active metabolite of mycophenolate mofetil, inhibits the glycosylation of cell membrane glycoproteins. We hypothesized that impaired glycosylation of cell adhesion molecules on endothelial cells in vivo results in decreased susceptibility to inflammation or immunogenicity after allogen...

journal_title：Transplantation

authors： Valentin JF,Bruijn JA,Paul LC

更新日期：2000-02-15 00:00:00

abstract：BACKGROUND:Cytotoxic IgG against class I antigens can contribute to renal dysfunction or failure after transplantation. However, the clinical relevance of IgG measured by flow cytometric cross-matching is controversial. This study correlated pre- and postoperative flow reactivity with clinical outcome among renal trans...

journal_title：Transplantation

authors： Kimball P,Rhodes C,King A,Fisher R,Ham J,Posner M

更新日期：1998-02-15 00:00:00

abstract：BACKGROUND:There are few prospective studies of prednisone-free immunosuppression (IS) in pediatric kidney transplant (KTx) recipients. We studied the outcomes of a protocol using rapid discontinuation of prednisone (RDP, <1 week) and thymoglobulin induction. METHODS:Twenty-one RDP recipients (mean age 14+/-3 years) r...

journal_title：Transplantation

authors： Chavers BM,Chang YC,Gillingham KJ,Matas A

更新日期：2009-07-27 00:00:00