Efficacy of caspofungin addition to trimethoprim-sulfamethoxazole treatment for severe pneumocystis pneumonia in solid organ transplant recipients.

abstract：:Patients undergoing primary cadaveric kidney transplantation were followed for 1 year as part of a phase II, multicenter, open-label concentration-ranging trial of FK506 and cyclosporine. One hundred twenty patients were randomly assigned to a cyclosporine-based regimen or one of three FK506-based regimens designed to...

journal_title：Transplantation

authors： Vincenti F,Laskow DA,Neylan JF,Mendez R,Matas AJ

更新日期：1996-06-15 00:00:00

abstract：:It was the objective of these experiments to study the time-related changes in the responsiveness of the cellular elements of the immune system following contact with single non-H-2 or multiple H-2 histocompatibility antigens. The reactivity of spleen cells from mice that received injections of spleen cells bearing H-...

journal_title：Transplantation

authors： Graff RJ,Kurtz ME,Russell H,Martin-Morgan D

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Solid organ xenograft rejection is associated with vascular injury resulting at least in part in platelet activation, and rejected xenografts invariably demonstrate intravascular thrombosis and interstitial hemorrhage. Complement activation plays a prominent role in platelet-endothelial interaction. We teste...

journal_title：Transplantation

authors： Brandl U,Jöckle H,Erhardt M,Michel S,Burdorf L,Brenner P,Bittmann I,Rössle M,Mordstein V,Hammer C,Thein E,Reichart B,Schmoeckel M

更新日期：2007-12-27 00:00:00

abstract：:The potential role of donor's mature T lymphocytes on the recovery of various immunological functions and hematopoiesis was investigated in lethally irradiated BALB/c mice by studying reconstitution with normal, as compared with T-cell-depleted, syngeneic marrow grafts. Recovery of total, as well as mononuclear, perip...

journal_title：Transplantation

authors： Shalit M,Ayalon M,Weiss L,Leshem B,Kedar E,Slavin S

更新日期：1986-08-01 00:00:00

abstract：:Potential female donors frequently ask whether unilateral nephrectomy will impair future childbearing capabilities. To address this question, we surveyed 220 women who underwent donor nephrectomy between 1985 and 1992. Of the 144 women who responded, 33 became pregnant after donation for a total of 45 pregnancies. Sev...

journal_title：Transplantation

authors： Wrenshall LE,McHugh L,Felton P,Dunn DL,Matas AJ

更新日期：1996-12-27 00:00:00

abstract：:Distribution of cadaveric donor kidneys, based upon the donor-recipient HLA match grade, remains one of the major controversies in transplantation. To determine whether matching results in fewer rejection episodes and better graft survival, we retrospectively studied our single-center patient population of 683 cyclosp...

journal_title：Transplantation

authors： Kerman RH,Kimball PM,Lindholm A,Van Buren CT,Katz SM,Lewis RM,McClain J,Podbielski J,Williams J,Kahan BD

更新日期：1993-11-01 00:00:00

abstract：:We have noted a decrease in the time to development of posttransplant lymphoproliferative disorder (PTLD) over the last two and one-half years in our multiorgan transplant program. From February 1965 until December 1990, 1622 transplants were performed including 1489 kidneys (KTxp), 87 livers (LTxp), and 46 pancreata....

journal_title：Transplantation

authors： Alfrey EJ,Friedman AL,Grossman RA,Perloff LJ,Naji A,Barker CF,Montone KT,Tomaszewski JE,Chmielewski C,Holland T

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Several single nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) absorption in renal transplant patients. METHODS:An analysis of CsA absorption measured by the dose- and weight-adjusted 4 hr area under the time-co...

journal_title：Transplantation

authors： Foote CJ,Greer W,Kiberd B,Fraser A,Lawen J,Nashan B,Belitsky P

更新日期：2007-05-27 00:00:00

abstract：:Incompatibility for DBA/2 (D2) minor histocompatibility antigens (MiHA) alone leads to a severe lethal graft-versus-host reaction (GVHR) in irradiated (D2 X B10.D2)F1 mice receiving a bone-marrow-plus-spleen-cell graft from B10.D2 donors. This mortality is abrogated when the donors are preimmunized simultaneously agai...

journal_title：Transplantation

authors： Pritchard LL,Halle-Pannenko O

更新日期：1983-09-01 00:00:00

abstract：:We studied the reactivity of cardiac graft-infiltrating cells, cultured from endomyocardial biopsy specimens, toward heart endothelial cells (Hec). In two cases, Hec derived from the specific donor heart or Hec compatible with the donor were lysed, but not the syngeneic B cell line. A vessel-derived endothelial cell l...

journal_title：Transplantation

authors： Jutte NH,Knoop CJ,Heijse P,Balk AH,Mochtar B,Claas FH,Weimar W

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Knowledge on the reinnervation of transplanted organs is scarce, and the aim of the study was therefore to evaluate to what degree syngeneic pancreas grafts were reinnervated in rats. METHODS:Syngeneic pancreatico-duodenal transplantations were performed in normoglycemic Wistar-Furth rats. Native and transp...

journal_title：Transplantation

authors： Korsgren O,Jansson L,Ekblad E,Sundler F

更新日期：2001-01-15 00:00:00

abstract：BACKGROUND:In the experiment described here, we investigated the effects of the immunosuppressants FK506 and leflunomide (Lef) on the survival of hamster hearts and liver xenografts in Lewis rats. METHODS:Lewis rats were used as recipients of hamster heart or liver grafts using different regimens of FK506 and Lef. Don...

journal_title：Transplantation

authors： Sankary HN,Yin DP,Chong AS,Ma LL,Blinder L,Shen JK,Foster P,Williams JW

更新日期：1998-10-15 00:00:00

abstract：BACKGROUND:The results of the transplantation of marginal donor kidneys remain controversial. This study aimed to investigate the impact of donor risk factors as predictors of kidney-graft outcome. METHODS:Allograft failure risk factors were studied in 7,209 cadaveric kidney-transplant recipients reporting to the Etab...

journal_title：Transplantation

authors： Pessione F,Cohen S,Durand D,Hourmant M,Kessler M,Legendre C,Mourad G,Noël C,Peraldi MN,Pouteil-Noble C,Tuppin P,Hiesse C

更新日期：2003-02-15 00:00:00

abstract：:Liver transplantation (LT) is the most effective treatment for small and unresectable hepatocellular carcinomas (HCCs). With scarcity of deceased donor livers, living donor LT (LDLT) is the alternative to deceased donor LT (DDLT). Animal studies have suggested that regeneration of the partial liver graft encourages HC...

journal_title：Transplantation

authors： Chan SC

更新日期：2014-04-27 00:00:00

abstract：:Cyclosporine CsA nephrotoxicity was examined in male Sprague-Dawley rats with or without prior uninephrectomy, injected daily with 12.5 mg/kg CsA, and fed a salt-depleted or normal diet for 3-10 weeks. Control rats received the CsA vehicle. CsA induced a fall in creatinine clearance in salt-depleted rats, from 1.3 +/-...

journal_title：Transplantation

authors： Rosen S,Greenfeld Z,Brezis M

更新日期：1990-02-01 00:00:00

abstract：:Clinical transplantation of fetal porcine islet-like cell clusters (ICC) to kidney transplanted diabetic patients has shown both morphological and biochemical evidence of prolonged xenograft survival, but no effect was seen on the insulin requirement of the transplanted patients. One possible explanation for this rela...

journal_title：Transplantation

authors： Sandberg JO,Andersson A

更新日期：1996-04-27 00:00:00

abstract：:We have used a polymerase chain reaction-based assay measuring polymorphic (CA)n repeats, a class of simple sequence repeats, to assess the success of allogeneic canine marrow transplants. Results were compared with those obtained with karyotype analysis of dividing cells in recipients that were sex mismatched with th...

journal_title：Transplantation

authors： Yu C,Ostrander E,Bryant E,Burnett R,Storb R

更新日期：1994-09-27 00:00:00

abstract：:The success of kidney transplants is limited by the lack of robust improvements in long-term survival. It is now recognized that alloimmune responses are responsible for the majority of allograft failures. Development of novel therapies to decrease allosensitization is critical. The lack of new drug development in kid...

journal_title：Transplantation

authors： Jordan SC,Choi J,Kim I,Wu G,Toyoda M,Shin B,Vo A

更新日期：2017-01-01 00:00:00

abstract：:Living-donor liver transplantation has provided a solution to the severe lack of cadaveric grafts for the replacement of livers afflicted with end-stage cirrhosis, fulminant disease, or inborn errors of metabolism. The pioneering experience in Japan in the early 1990s helped open wide the avenues of a new branch of sc...

journal_title：Transplantation

authors： Chen CL,Fan ST,Lee SG,Makuuchi M,Tanaka K

更新日期：2003-02-15 00:00:00

abstract：:In a canine model of acute ischemic lung injury, a hypertonic citrate solution (HTC) widely used for renal preservation in the United Kingdom, was compared with modified Euro-Collins' solution (ECS) currently the most widely clinically used pulmonary perfusate. Ten beagle dogs underwent left thoracotomy and exclusion ...

journal_title：Transplantation

authors： Hooper TL,Jones MT,Thomson DS,Cook L,Owen S,Wilkes S,Woodcock A,Webster AH,Hasleton P,McGregor CG

更新日期：1991-05-01 00:00:00

abstract：:Recipients of solid organ allografts require lifelong immunosuppression in order to prevent graft rejection and to maintain graft function. In general, such immunosuppression greatly impairs the cellular immune system, as this level of the immune system is principally responsible for self and non-self recognition. The...

journal_title：Transplantation

authors： Van Thiel DH,Finkel R,Friedlander L,Gavaler JS,Wright HI,Gordon R

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the population pharmacokinetics of tacrolimus in pediatric liver transplant recipients and to identify factors that may explain pharmacokinetic variability. METHODS:Data were collected retrospectively from 35 children who received oral immunosuppressant therapy with ...

journal_title：Transplantation

authors： Staatz CE,Taylor PJ,Lynch SV,Willis C,Charles BG,Tett SE

更新日期：2001-09-27 00:00:00

abstract：:The mixed leukocyte culture (MLC) of peripheral blood lymphocytes (PBLs) from two prospective kidney transplant recipients and their respective donors, produced a primed cell population that functioned as suppressors. The primed cells suppressed the primary and secondary MLC when added as third components, without dem...

journal_title：Transplantation

authors： Fuller L,Kyriakides G,Flaa C,Esquenazi V,Miller J

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:We have previously demonstrated that in a concordant hamster-to-nude rat cardiac transplant model, T-independent specific B-lymphocyte and natural killer (NK)-cell tolerance could be induced, leading to long-term xenograft (Xg) survival. Here, we investigated whether the same could be achieved in a clinicall...

journal_title：Transplantation

authors： Ji P,Xia G,Sefrioui H,Rutgeerts O,Segers C,Waer M

更新日期：1999-07-15 00:00:00

abstract：BACKGROUND:The authors have investigated the effectiveness of virus detection from bronchoalveolar lavage (BAL) samples for the identification of symptomatic cytomegalovirus (CMV) infection in lung transplant recipients. METHODS:Thus, 275 BAL samples taken from 105 lung transplant recipients during follow-up were anal...

journal_title：Transplantation

authors： Zedtwitz-Liebenstein K,Jaksch P,Bauer C,Popow T,Klepetko W,Hofmann H,Puchhammer-Stöckl E

更新日期：2004-06-27 00:00:00

abstract：BACKGROUND:It is controversial whether coronary endothelial function is impaired after cold exposure to University of Wisconsin (UW) or St. Thomas' Hospital (ST) solution during heart transplantation. We therefore examined the effects of cold storage of coronary micro-arteries with UW or ST solution on endothelium-deri...

journal_title：Transplantation

authors： Ge ZD,He GW

更新日期：2000-07-15 00:00:00

abstract：:Polyclonal rabbit antirat thymocyte serum (ATS) has been shown to form in situ glomerular immune aggregates following perfusion into normal rat kidney ex vivo. This may be due to the presence of T-cell-like epitopes in the rat kidney, or it may be a result of contaminating anti-connective-tissue antibodies in ATS. To ...

journal_title：Transplantation

authors： Bagchus WM,Donga J,Rozing J,Hoedemaeker PJ,Bakker WW

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:The long-term metabolic function of microencapsulated xenogeneic adult porcine islets (API) was assessed in a murine model of type 1 diabetes mellitus. METHODS:API were encapsulated in barium-gelled alginate and transplanted intraperitoneally in diabetic nonobese diabetic (NOD) mice given no immunosuppressi...

journal_title：Transplantation

authors： Cui H,Tucker-Burden C,Cauffiel SM,Barry AK,Iwakoshi NN,Weber CJ,Safley SA

更新日期：2009-07-27 00:00:00

abstract：BACKGROUND:NKp46 expression in natural killer (NK) cells has recently been shown to affect the responsiveness to antiviral treatment in hepatitis C virus (HCV)-infected patients. However, the density of NKp46 on intrahepatic NK cells is remarkably higher than that on peripherally circulating NK cells, whereas the bioph...

journal_title：Transplantation

authors： Tanimine N,Tanaka Y,Abe T,Piao J,Chayama K,Ohdan H

更新日期：2016-02-01 00:00:00

abstract：:Hemorrhagic cystitis (HC) is a major cause of morbidity after BMT; we have analyzed its incidence, risk factors, and complications in 977 patients undergoing BMT between 1974 and 1988. Despite vigorous hydration and frequent voiding in all patients receiving cyclophosphamide, 135/977 (15% by Kaplan-Meier projection) d...

journal_title：Transplantation

authors： Sencer SF,Haake RJ,Weisdorf DJ

更新日期：1993-10-01 00:00:00