Living-donor liver transplantation: 12 years of experience in Asia.

abstract：BACKGROUND:Chronic allograft nephropathy (CAN) is the most common cause of long-term renal-allograft dysfunction and the second most common cause of transplant loss. There are concerns that prolonged patient exposure to calcineurin inhibitors (CNIs) exacerbates or promotes the process of CAN. METHODS:In our unit, we c...

journal_title：Transplantation

authors： Afzali B,Shah S,Chowdhury P,O'sullivan H,Taylor J,Goldsmith D

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:Intrahepatic bile duct strictures are a serious complication after non-heart-beating (NHB) liver transplantation. Bile salt toxicity has been identified as an important factor in the pathogenesis of bile duct injury and cholangiopathies. The role of bile salt toxicity in the development of biliary strictures...

journal_title：Transplantation

authors： Yska MJ,Buis CI,Monbaliu D,Schuurs TA,Gouw AS,Kahmann ON,Visser DS,Pirenne J,Porte RJ

更新日期：2008-06-15 00:00:00

abstract：:The safety of the use of kidneys procured from a hepatitis C virus (HCV)-positive cadaver donors in transplantation has recently been the subject of controversy. One factor that is important in determining the transmission of the virus and/or viral liver disease is the total viral inoculum to which the renal allograft...

journal_title：Transplantation

authors： Zucker K,Cirocco R,Roth D,Olson L,Burke GW,Nery J,Esquenazi V,Miller J

更新日期：1994-03-27 00:00:00

abstract：:The mechanism (or mechanisms) underlying the indefinite survival of DBA/2 islet allografts in strongly histoincompatible (C57BL/6xA)F1 (B6AF1) mice, induced either by the combined use of Ficoll-prepared crude islets and treatment of recipients with antilymphocyte serum (ALS), or by the use of handpicked, purified isle...

journal_title：Transplantation

authors： Gotoh M,Porter J,Monaco AP,Maki T

更新日期：1988-02-01 00:00:00

abstract：:Hepatocyte transplantation (HT) has been performed in patients with liver-based metabolic disease and acute liver failure as a potential alternative to liver transplantation. The results are encouraging in genetic liver conditions where HT can replace the missing enzyme or protein. However, there are limitations to th...

journal_title：Transplantation

authors： Hughes RD,Mitry RR,Dhawan A

更新日期：2012-02-27 00:00:00

abstract：:Ninety-eight renal transplant recipients who had been followed for 1-6.5 years (median 3.2 years) were reviewed to determine the effect of donor and recipient hepatitis B surface antigen status on the incidence of hepatitis and on patient survival. The cumulative risk of developing hepatitis posttransplant was signifi...

journal_title：Transplantation

authors： Chan PC,Lok AS,Cheng IK,Chan MK

更新日期：1992-01-01 00:00:00

abstract：:Of 213 renal allgraft recipients suspected to have had pulmonary tuberculosis, 132 had sputum examinations and 14 showed acid-fast bacilli. Of the remaining 118 patients, 25 had gastric aspirations, 18 had bronchoalveolar lavage, and 75 did not require further investigation because of spontaneous improvement or confir...

journal_title：Transplantation

authors： John GT,Juneja R,Mukundan U,Date A,Vincent L,Jacob CK,Shastry JC

更新日期：1996-03-27 00:00:00

abstract：BACKGROUND:The urinary CXC chemokine ligand (CXCL)10 detects renal transplant inflammation noninvasively, but has limited sensitivity and specificity. In this study, we performed urinary proteomic analysis to identify novel biomarkers that may improve the diagnostic performance of urinary CXCL10 for detecting alloimmun...

journal_title：Transplantation

authors： Ho J,Rush DN,Krokhin O,Antonovici M,Gao A,Bestland J,Wiebe C,Hiebert B,Rigatto C,Gibson IW,Wilkins JA,Nickerson PW

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Islet transplantation studies with diabetic rodents frequently use treatment with diabetogens such as alloxan or streptozotocin to render hosts hyperglycemic. These chemicals produce unwanted toxic side effects, which complicate interpretations of damage produced by hyperglycemia versus direct toxin-induced ...

journal_title：Transplantation

authors： Mathews CE,Langley SH,Leiter EH

更新日期：2002-04-27 00:00:00

abstract：:The mixed leukocyte culture (MLC) of peripheral blood lymphocytes (PBLs) from two prospective kidney transplant recipients and their respective donors, produced a primed cell population that functioned as suppressors. The primed cells suppressed the primary and secondary MLC when added as third components, without dem...

journal_title：Transplantation

authors： Fuller L,Kyriakides G,Flaa C,Esquenazi V,Miller J

更新日期：1980-01-01 00:00:00

abstract：:The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--...

journal_title：Transplantation

authors： Barber WH,Hutchinson IV,Morris PJ

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Socioeconomic variables including low income and noncompliance impact negatively upon long-term renal allograft survival, especially in African Americans. We sought to determine whether other socioeconomic variables contributed to noncompliance and allograft survival. METHODS:A detailed history of socioecon...

journal_title：Transplantation

authors： Butkus DE,Dottes AL,Meydrech EF,Barber WH

更新日期：2001-07-27 00:00:00

abstract：BACKGROUND:Leflunomide is a novel immunosuppressive agent with promising activity for xenotransplantation. It is not clear yet which mechanisms of action of leflunomide are responsible for that. METHODS:In a hamster-to-C57BL/6 nude mouse heart transplantation model, a 2-week course of leflunomide was used after transp...

journal_title：Transplantation

authors： Yan Y,Verbeken E,Yu L,Rutgeerts O,Goebels J,Segers C,Lin Y,Waer M

更新日期：2005-01-27 00:00:00

abstract：:A novel, water-soluble metabolite of cyclosporine, a sulphate conjugate, present in high concentrations in human bile and plasma was evaluated for its immunosuppressive properties. The direct binding of the conjugate to surface molecules on lymphocytes was studied. The effect of the metabolite was tested in several in...

journal_title：Transplantation

authors： Johansson A,Henricsson S,Möller E

更新日期：1990-03-01 00:00:00

abstract：:We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD). Two cohorts of patients, 44 simultaneous pancreas and kidney transplant patients (SPK) and 30 kidney transplant-alone patients (KTA), were inclu...

journal_title：Transplantation

authors： Luan FL,Miles CD,Cibrik DM,Ojo AO

更新日期：2007-08-27 00:00:00

abstract：BACKGROUND:Adult orthotopic liver transplantation is associated with significant use of allogenic blood products, which places considerable demands on finite resources. This could be reduced by autologous red cell salvage use, and we evaluated its cost effectiveness in this prospective study. METHODS:Intraoperative au...

journal_title：Transplantation

authors： Phillips SD,Maguire D,Deshpande R,Muiesan P,Bowles MJ,Rela M,Heaton ND

更新日期：2006-02-27 00:00:00

abstract：BACKGROUND:Posttransplantation measurement of soluble CD30 (sCD30) may be useful for identifying kidney graft recipients at risk of impending graft rejection in the early posttransplantation period. METHODS:We measured plasma sCD30 levels and evaluated the levels in relation to the diagnosis of rejection. RESULTS:Rec...

journal_title：Transplantation

authors： Pelzl S,Opelz G,Daniel V,Wiesel M,Süsal C

更新日期：2003-02-15 00:00:00

abstract：:The interaction of T cell costimulatory molecules with their ligands is required for optimal T cell activation. Interference with such interactions can induce antigen unresponsiveness and delay xeno- and allograft rejection. We have previously shown that LFA3TIP, a soluble human lymphocyte function-associated antigen ...

journal_title：Transplantation

authors： Kaplon RJ,Hochman PS,Michler RE,Kwiatkowski PA,Edwards NM,Berger CL,Xu H,Meier W,Wallner BP,Chisholm P,Marboe CC

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:The need for renal replacement therapy (RRT) either before or after orthotopic liver transplant (OLTX) has been reported to be a poor prognostic indicator for survival. Use of continuous veno-venous hemodialysis (CVVHD) for RRT has been reported in three series of OLTX patients with high 90-day mortality rat...

journal_title：Transplantation

authors： Gonwa TA,Mai ML,Melton LB,Hays SR,Goldstein RM,Levy MF,Klintmalm GB

更新日期：2001-05-27 00:00:00

abstract：:Transplant coronary artery disease and malignancy are the major limitations to survival after heart transplantation. In a randomized trial, mycophenolate mofetil (MMF) significantly improved 3-year survival over azathioprine, but the expected reduction in intracoronary ultrasound evidence of vasculopathy was not found...

journal_title：Transplantation

authors： Keogh A

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:Previous studies have identified more morbidity in simultaneous pancreas-kidney (SPK) transplant recipients compared with kidney alone (KA) recipients. With the development of novel immunosuppressive drugs, studies are needed to determine optimal treatment regimens in specific patient populations. METHODS:W...

journal_title：Transplantation

authors： Lee CM,Scandling JD,Krieger NR,Dafoe DC,Alfrey EJ

更新日期：1997-11-15 00:00:00

abstract：INTRODUCTION:Patients after solid organ transplantation are at an increased risk for microbial infections. Due to therapeutic immunosuppression, the response to active immunizations may be reduced. The serological efficacy of pneumococcal and influenza vaccination was studied in heart transplant recipients. PATIENTS A...

journal_title：Transplantation

authors： Dengler TJ,Strnad N,Bühring I,Zimmermann R,Girgsdies O,Kubler WE,Zielen S

更新日期：1998-11-27 00:00:00

abstract：BACKGROUND:The pathogenesis of acute pulmonary xenograft injury has not yet been determined. The present study evaluates the role of complement in mediating pulmonary xenograft dysfunction by using cobra venom factor (CVF) to deplete recipient complement and transgenic swine, which express human regulators of complemen...

journal_title：Transplantation

authors： Yeatman M,Daggett CW,Parker W,Byrne GW,Logan JS,Platt JL,Davis RD

更新日期：1998-04-27 00:00:00

abstract：:In keeping with the in vitro mitogenic properties of anti-CD3 MoAbs, the first injections of anti-CD3 are invariably responsible for an in vivo cellular activation. This activation induces a massive cytokine release in the circulation (TNF, IFN gamma, IL-2, IL-6, and IL-3). Paralleling this release, a severe clinical ...

journal_title：Transplantation

authors： Ferran C,Dy M,Merite S,Sheehan K,Schreiber R,Leboulenger F,Landais P,Bluestone J,Bach JF,Chatenoud L

更新日期：1990-10-01 00:00:00

abstract：:Chronic kidney disease is common in patients with multiple myeloma. Historically, individuals with end-stage renal disease and multiple myeloma did poorly with renal transplantation due to higher mortality rates from the malignancy itself or associated comorbidities. However, over the past 2 decades, there have been s...

journal_title：Transplantation

authors： Huskey JL,Heilman RL,Khamash H,Fonseca R

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...

journal_title：Transplantation

authors： Uchida H,Kobayashi E,Matsuda K,Mizuta K,Sugimoto K,Kawarasaki H,Hashizume K,Fujimura A

更新日期：1999-05-15 00:00:00

abstract：BACKGROUND:Cyclosporine A (CsA)-associated oxidative stress has been proposed as an important mechanism of renal injury. This study was designed to examine whether N-acetylcysteine (NAC), a well-known antioxidant, affects Klotho, antiaging gene, expression and its signaling pathway in an experimental model of chronic C...

journal_title：Transplantation

authors： Piao SG,Kang SH,Lim SW,Chung BH,Doh KC,Heo SB,Jin L,Li C,Yang CW

更新日期：2013-07-27 00:00:00

abstract：:We initiated a policy of using RSLT in critically ill patients in June of 1988. Since that time we have performed 30 RSLTs in 29 patients, including 28 children and 1 adult. The mean age of the children was 27 months (range 1 month to 10 years) with 14 (52%) being 1 year of age or less. The mean weight was 11.3 kg (ra...

journal_title：Transplantation

authors： Langnas AN,Marujo WC,Inagaki M,Stratta RJ,Wood RP,Shaw BW Jr

更新日期：1992-02-01 00:00:00

abstract：:Islet transplantation may be optimized by islet immunoisolation to prevent direct contact between the islet graft and the host tissue. In this study, we examined the glycemia and insulin secretion in streptozotocin-diabetic rats transplanted with islets subjected to immunoisolation with Algire diffusion chamber or wit...

journal_title：Transplantation

authors： Ar'Rajab A,Bengmark S,Ahrén B

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Natural antibodies (NAbs) against a terminal alpha1-3 galactosyl (alphaGal) epitope have been identified as the major human anti-pig NAbs. METHODS AND RESULTS:We used two synthetic alphaGal trisaccharides--type 6 (alphaGal6) and type 2(alphaGal2)--linked to an inert matrix to remove NAbs from human plasma i...

journal_title：Transplantation

authors： Xu Y,Lorf T,Sablinski T,Gianello P,Bailin M,Monroy R,Kozlowski T,Awwad M,Cooper DK,Sachs DH

更新日期：1998-01-27 00:00:00