Abstract:
:Chronic kidney disease is common in patients with multiple myeloma. Historically, individuals with end-stage renal disease and multiple myeloma did poorly with renal transplantation due to higher mortality rates from the malignancy itself or associated comorbidities. However, over the past 2 decades, there have been significant advances in the treatment of multiple myeloma with the advent of new therapeutic agents resulting in an improvement of long-term survival. As a result, more individuals with multiple myeloma are being referred for kidney transplantation, especially those with good functional capacity and minimal comorbidities. Recent literature has suggested that certain patients with multiple myeloma can successfully undergo renal transplantation after stem transplantation with consideration for maintenance therapy, although caution should be used with immunomodulating drugs due to the anecdotally reported risk of acute rejection. Therefore, having a multidisciplinary approach with the transplant team and hematology both before and after transplant is crucial in maximizing the chance of success for these individuals. This review summarizes the literature on renal transplantation in patients with multiple myeloma as well as the therapeutic advancements that have occurred which may allow certain patients to undergo successful transplantation.
journal_name
Transplantationjournal_title
Transplantationauthors
Huskey JL,Heilman RL,Khamash H,Fonseca Rdoi
10.1097/TP.0000000000002449subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1994-2001issue
12eissn
0041-1337issn
1534-6080journal_volume
102pub_type
杂志文章,评审相关文献
TRANSPLANTATION文献大全abstract::In an attempt to investigate the nonspecificity of the effect of administration of donor splenocytes treated with mitomycin C (MMC) 7 days before transplantation in inducing immunological unresponsiveness, the survival rates of liver, heart, small bowel, and skin allografts were compared in the RT1-incompatible ACI(RT...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198902000-00036
更新日期:1989-02-01 00:00:00
abstract::Agarose is known to inhibit nonspecifically the cytotoxic effects of normal sera on xenogeneic lymphoid cells. To find an explanation for this agarose effect we have studied its requirements using guinea pig and human sera as the source of activity and rat thymocytes as target cells. Control assays were performed usin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00007
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Hemostatic complications are not uncommon after bone marrow transplantation (BMT). However, little is known about the frequency, localization, determinants, and outcome of hemostatic events in autologous and allogeneic BMT. METHODS:Four hundred forty-seven patients (364 allogeneic, 83 autologous transplants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200211150-00018
更新日期:2002-11-15 00:00:00
abstract::For many individuals suffering from end-stage liver disease (ESLD), the only treatment option is liver transplantation. However, liver transplant rejection is observed in 24-80% of transplant patients and lifelong drug regimens that follow the transplant procedure lead to serious side effects. Furthermore, the pool of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003598
更新日期:2021-01-06 00:00:00
abstract::This study evaluated the utility of duplex Doppler sonograms (DS) and the resistive index (RI) in the identification and differential diagnosis of various causes of renal allograft dysfunction. The efficacy of DS and RI was studied either during acute episodes of allograft dysfunction or during periodic posttransplant...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199012000-00015
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Several technical modifications in portal vein (PV) reconstruction have shown excellent outcomes in pediatric liver transplantation (LT); however, which procedure is the best for PV reconstruction of the hypoplastic PV in pediatric LT remains unclear. METHODS:One hundred sixteen pediatric patients aged 1 or...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002793
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:To identify factors related with successful pregnancy in renal transplant recipients and the effect of pregnancy on long-term graft outcome. METHODS:The study group consisted of 48 women who conceived after undergoing renal transplantation (total pregnancies 74). The control group consisted of 187 nonpregna...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318170f8ed
更新日期:2008-05-27 00:00:00
abstract::The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199004000-00010
更新日期:1990-04-01 00:00:00
abstract::A technique of orthotopic renal transplantation in rabbits is described. The technique has been evolved in an experience of over 400 grafts, and difficulties encountered in producing satisfactory anaesthesia and techniques of anastomosis and in obtaining reliable graft function postoperatively have been defined and ov...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197611000-00003
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:Calcineurin inhibitor (CI)-based immunosuppression has prolonged the survival of heart transplant recipients. However, CI-induced renal injury remains as a major problem in these patients. Sirolimus is an immunosuppressant with no significant impact on renal function. A limited number of recent papers have s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000177644.45192.a3
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000057245.59998.95
更新日期:2003-05-15 00:00:00
abstract::Chronic graft-versus-host disease often results in a combined deficiency of humoral and cell-mediated immunity. Clinical and experimental studies have suggested that the decrease in B cell responsiveness is due to a failure of B cell production in the bone marrow, intrinsic B cell defects, excessive suppressor T cell ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199303000-00025
更新日期:1993-03-01 00:00:00
abstract::Preoperative portal venous injection of donor lymphocytes has been shown to extend allograft survival in inbred animals. However, the effect of perioperative injection in a large animal model has not been carefully studied. We examined the effect of perioperative (day 0) donor spleen cell administration in a canine ki...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199410270-00004
更新日期:1994-10-27 00:00:00
abstract::Controversy exists as to the type of cells present in the urine during renal allograft rejection. In order to resolve this controversy as well as to evaluate the value of urine sediment examination as a means of detecting AR, we quantitated the different cells present in urine during AR using an immunoperoxidase techn...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00017
更新日期:1989-03-01 00:00:00
abstract::Islets were isolated from the pancreata of Sprague-Dawley rats and transplanted into streptozotocin-induced diabetic outbred Wistar rats. The effect of transplantation of islets into the cisterna magna on the diabetic state of the recipients was compared with that of the conventional transplantation of islets into liv...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199203000-00003
更新日期:1992-03-01 00:00:00
abstract:INTRODUCTION:We carried out an analysis of the United States Renal Data System to determine the incidence, risk factors, prognosis, and costs associated with the diagnosis of renal cell carcinoma (RCC) after kidney transplantation. METHODS:This is a retrospective cohort of 40,821 Medicare primary renal transplant reci...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181f30479
更新日期:2010-10-27 00:00:00
abstract:BACKGROUND:In the hamster to rat xenogeneic combination, antibodies, T cells, and natural killer (NK) cells have all been implicated in the process of rejection. 3.2.3 is a mouse IgG1kappa monoclonal antibody (mAb) directed against NKR-P1A on rat NK cells. The purpose of this study was to evaluate the effect of this mA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199803150-00021
更新日期:1998-03-15 00:00:00
abstract::We have demonstrated that DA hearts grafted into PVG rats were completely protected from rejection by simultaneous liver transplantation from the same donor. In subsequent experiments PVG animals were given DA hearts followed 5 or 6 days later by livers from the same donor strain. Instead of the expected rapid rejecti...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198409000-00004
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:Sequential pancreatic islet transplantation via the portal vein has led to insulin independence in patients with type 1 diabetes. Complications associated with the injection of islets into the portal vein have been reported; therefore, in this study we sought to further characterize changes in portal venous ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200210150-00002
更新日期:2002-10-15 00:00:00
abstract:BACKGROUND:Preliminary studies showed an excellent success rate of kidney grafts in patients with high pretransplantation serum levels of IgA autoantibodies directed against the Fab region of the human IgG molecule. METHODS:With the collaboration of 30 centers from around the world, we attempted to verify the role of ...
journal_title:Transplantation
pub_type: 评论,杂志文章,多中心研究
doi:10.1097/00007890-200004150-00021
更新日期:2000-04-15 00:00:00
abstract::A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199210000-00006
更新日期:1992-10-01 00:00:00
abstract::Cadaveric kidney transplants with delayed graft function have poorer graft survival by an unknown mechanism. Nitric oxide, produced by nitric oxide synthase (NOS), has a proven role in both recovery of ischemia and promotion of rejection. We therefore wished to study the patterns of NOS activity in a model of renal is...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199702270-00002
更新日期:1997-02-27 00:00:00
abstract:BACKGROUND:FTY720 prevents allograft rejection with remarkable potency without inducing generalized immunosuppression. We determined the effect of FTY720 on development of autoimmune diabetes in nonobese diabetic (NOD) mice. METHODS:NOD mice were given FTY720 (0.5 mg/kg, orally) five times per week starting from 4 wee...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200212270-00006
更新日期:2002-12-27 00:00:00
abstract:BACKGROUND:We have previously shown that an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts generates a tryptophan-deficient environment that selectively inhibits proliferation and induces apoptosis of bystander CD4+ and CD8+ T cells, but not pancreatic islets. Because these immune cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000661
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:CD4+ T cells play an essential role in allograft rejection. The monoclonal anti-rat CD4 antibody, RIB 5/2, has been shown to modulate the CD4 glycoprotein without eliminating the recipient T cells. We have successfully induced tolerance to rat heart allografts by recipient pretreatment with a single dose of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001270-00015
更新日期:2000-01-27 00:00:00
abstract::In a DBA/2 (H-2d) pancreatic islet-to-B6AF1 (H-2b/k.d) recipient combination, the graft survival of hand-picked islets was compared with that of "crude digested" islets that were prepared simply by collagenase digestion and Ficoll gradient separation and were contaminated with lymph nodes and vascular and ductal tissu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198610000-00011
更新日期:1986-10-01 00:00:00
abstract::Posttransplant lymphoproliferative disorders (PTLD) are EBV-associated lymphoid neoplasms that are caused by the uncontrolled growth of EBV-infected B lymphocytes. The clinical presentation of PTLD can range from benign polygonal lymphoproliferative disorders to aggressive monoclonal immunoblastic lymphomas. In this r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199606270-00010
更新日期:1996-06-27 00:00:00
abstract:BACKGROUND:Administration of donor bone marrow (BM)-derived dendritic cell (DC) progenitors (DCp) that are major histocompatibility complex (MHC) class II+ but costimulatory molecule (CD40, CD80, CD86)-deficient can prolong mouse heart allograft survival This is associated with microchimerism and inhibition of antidono...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199812270-00040
更新日期:1998-12-27 00:00:00
abstract::Cell-mediated cytotoxicity directed toward pancreatic islets plays a significant role in the pathogenesis of type 1 diabetes mellitus. Histologically, autoimmune insulitis appears as mononuclear infiltrates that precede actual beta cell loss. Experimental studies by Bartlett et al. on the BB rat model suggest that who...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00014
更新日期:1996-12-27 00:00:00
abstract::Antibody-mediated injury is a major cause of allograft dysfunction and loss. Antibodies to ABH(O) blood group antigens are classic mediators of ABO-incompatible graft rejection, whereas donor-specific anti-HLA antibodies and, more recently, autoantibodies are appreciated as important contributors to allograft inflamma...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001872
更新日期:2018-02-01 00:00:00