Graft-protective role of high pretransplantation IgA-anti-Fab autoantibodies: confirmatory evidence obtained in more than 4000 kidney transplants. The Collaborative Transplant Study.

abstract：BACKGROUND:Successful islet transplantation can result in insulin independence in many patients with type 1 diabetes mellitus, but it often requires more than one islet infusion. The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited org...

journal_title：Transplantation

authors： Koh A,Senior P,Salam A,Kin T,Imes S,Dinyari P,Malcolm A,Toso C,Nilsson B,Korsgren O,Shapiro AM

更新日期：2010-02-27 00:00:00

abstract：:The immunosuppressive potentials of mAbs to lymphocyte function-associated antigen-1 (LFA-1) and CD2 molecules were examined in murine islet transplantation. Crude digested islets from BALB/c (H-2d) mice were transplanted into the renal subcapsular space of streptozotocin-induced diabetic C57BL/6 (H-2b) mice. The rat ...

journal_title：Transplantation

authors： Gotoh M,Fukuzaki T,Monden M,Dono K,Kanai T,Yagita H,Okumura K,Mori T

更新日期：1994-01-01 00:00:00

abstract：:Over the decade between 2003 and 2012, the UK has seen major changes in how organ donation and transplantation is delivered. The number of deceased organ donors has increased from 709 (12.0 per million population [pmp]) to 1,164 (18.3 pmp); this increase has been predominantly a result of an increase in donors after c...

journal_title：Transplantation

authors： Johnson RJ,Bradbury LL,Martin K,Neuberger J,UK Transplant Registry.

更新日期：2014-01-15 00:00:00

abstract：BACKGROUND:Preemptive kidney transplantation (prior to the institution of dialysis) avoids the morbidity and mortality of dialysis; however, detailed studies of high-risk patients are lacking. The aim of the current study was to compare recent outcomes of preemptive (P) versus nonpreemptive (NP) living donor kidney tra...

journal_title：Transplantation

authors： Innocenti GR,Wadei HM,Prieto M,Dean PG,Ramos EJ,Textor S,Khamash H,Larson TS,Cosio F,Kosberg K,Fix L,Bauer C,Stegall MD

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Increasing use of kidney grafts for simultaneous liver and kidney (SLK) transplants is causing concern about the most effective utilization of scarce kidney graft resources. This study evaluated the impact of implementing the proposed United Network for Organ Sharing SLK transplant policy on outcomes for end...

journal_title：Transplantation

authors： Chang Y,Gallon L,Shetty K,Chang Y,Jay C,Levitsky J,Ho B,Baker T,Ladner D,Friedewald J,Abecassis M,Hazen G,Skaro AI

更新日期：2015-02-01 00:00:00

abstract：:Non-A, non-B hepatitis is a significant cause of liver disease among renal allograft recipients. In order to assess the impact and prevalence of hepatitis C in a series of renal allograft recipients, we retrospectively screened 621 consecutive patients transplanted between 1979 and 1989 and 484 cadaver organ donors re...

journal_title：Transplantation

authors： Roth D,Fernandez JA,Burke GW,Esquenazi V,Miller J

更新日期：1991-02-01 00:00:00

abstract：:Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the pr...

journal_title：Transplantation

authors： Sutton P,Moreland A,Hutchinson IV,Müllbacher A

更新日期：1995-11-15 00:00:00

abstract：:The success of kidney transplants is limited by the lack of robust improvements in long-term survival. It is now recognized that alloimmune responses are responsible for the majority of allograft failures. Development of novel therapies to decrease allosensitization is critical. The lack of new drug development in kid...

journal_title：Transplantation

authors： Jordan SC,Choi J,Kim I,Wu G,Toyoda M,Shin B,Vo A

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to investigate excretion of urinary and pancreatic juice neopterin in patients after combined pancreas-kidney transplantation and to relate it to the clinical course. The study design was a prospective observation study. Thirty consecutive patients with end-stage diabetic disease received a s...

journal_title：Transplantation

authors： Tilg H,Königsrainer A,Krausler R,Aulitzky WE,Margreiter R,Reibnegger G,Wachter H,Huber C

更新日期：1992-04-01 00:00:00

abstract：:Considerable variations in the suppression of graft-versus-host disease with monoclonal anti-Thy-1 antibodies were found to relate to substantial differences noted in the expression of mouse Thy-1 marker on lymph node and spleen cells of Thy-1.1 (AKR/J, C57BL/6.Thy-1.1) and Thy 1.2 (AKR/Cu, C57BL/6) mice. Thy-1.1 mice...

journal_title：Transplantation

authors： Mysliwietz J,Thierfelder S,Hoffmann-Fezer G,Kummer U

更新日期：1990-04-01 00:00:00

abstract：:We have recently shown that a single intrathymic injection of synthetic 25mer peptides, representing full sequences of the hypervariable domain of RT1.BuB (4 peptides) and RT1.Du beta (4 peptides) WF class II MHC molecules, 48 hr before transplantation induces donor-specific unresponsiveness to WF rat renal allografts...

journal_title：Transplantation

authors： Sayegh MH,Perico N,Gallon L,Imberti O,Hancock WW,Remuzzi G,Carpenter CB

更新日期：1994-07-27 00:00:00

abstract：:Using C1q binding, Kg binding, and Raji cell radioimmunoassays, the relationship between renal allograft rejection and the circulating immune complexes was examined in 90 patients with renal transplants. The data showed that there was a significant quantitative correlation between C1q-binding and Raji-cell-binding act...

journal_title：Transplantation

authors： Fukuda M

更新日期：1983-08-01 00:00:00

abstract：:Retrospective mixed leukocyte culture studies were performed in eight patients who had either rejected their marrow grafts or experienced graft-versus-host disease and in seven patients with successful marrow engraftment. In tests of pre-and post-transplant lymphocytes we found no evidence that rejection or graft-vers...

journal_title：Transplantation

authors： Opelz G,Gale RP

更新日期：1976-11-01 00:00:00

abstract：:Currently trials of immunosuppression in transplantation are in decline because their objectives remain focused on improving acute rejection rates and graft survival in the first 12 months. With 1 year renal graft survival rates of greater than 90% the best that can be hoped for is noninferiority trial outcomes compar...

journal_title：Transplantation

authors： OʼConnell PJ,Kuypers DR,Mannon RB,Abecassis M,Chadban SJ,Gill JS,Murphy B,Nickerson PW,Schold JD,Stock PG,Seron D,Alloway RR,Bromberg JS,Budde K,Jordan SC,Legendre C,Lefaucheur C,Sarwall M,Segev DL,Stegall MD,Tull

更新日期：2017-07-01 00:00:00

abstract：:A model for immediate vascularization of skin was devised to examine one of the possible explanations for the differential survival rates of transplants of freely grafted skin and organs, i.e., the increased vulnerability of skin to early ischemic necrosis prior to revascularization. Female Fischer (F) rat skin was tr...

journal_title：Transplantation

authors： Perloff LJ,Barker CF

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Nonspecific inflammatory damages occurring prior to organ transplantation reduce long-term graft survival. Here, we tested the beneficial effects of carbon monoxide (CO) induction by methylene chloride (MC). METHODS:Fischer-344 (F-344 Rat) or Dark Agouti (DA Rat) donor animals were either treated with MC fo...

journal_title：Transplantation

authors： Martins PN,Reutzel-Selke A,Jurisch A,Denecke C,Attrot K,Pascher A,Kotsch K,Pratschke J,Neuhaus P,Volk HD,Tullius SG

更新日期：2006-10-15 00:00:00

abstract：BACKGROUND:Auxiliary partial orthotopic liver transplantation (APOLT) has been an effective alternative in acute liver failure (ALF), but clinically several problems remain to be resolved. Thus, we attempt to establish an APOLT model for ALF using a large animal and demonstrate the validity of our model. METHODS:In ex...

journal_title：Transplantation

authors： Fukueda M,Ishizaki N,Hamada N,Kadono J,Kaieda M,Nakamura N,Komokata T,Sakata R

更新日期：2006-11-27 00:00:00

abstract：:Modification of pathogenic antibodies for autoimmune diseases illuminated the biologic relevance of B cells, plasma cells, and pathogenic antibodies in autoimmunity. They have also rejuvenated interest in how B cells mediate multiple effector functions that include antibody production, antigen presentation to T cells,...

journal_title：Transplantation

authors： Jordan SC,Ammerman N,Choi J,Huang E,Peng A,Sethi S,Najjar R,Toyoda M,Lim K,Louie S,Vo A

更新日期：2019-02-01 00:00:00

abstract：:Three strains of miniature swine, each homozygous for a different allele of the major histocompatibility locus (MHC), have been developed by a selective breeding scheme based on tissue typing of the offspring of each generation. Prior to breeding, the original parents were reciprocally immunized by skin grafts and lym...

journal_title：Transplantation

authors： Sachs DH,Leight G,Cone J,Schwarz S,Stuart L,Rosenberg S

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:The aging of liver transplant (LT) recipients, the weighting of the model for end-stage liver disease score, and the increased prevalence of nonalcoholic steatohepatitis has led to an increased number of older LT recipients with pre-LT chronic kidney disease (CKD). There are limited data on the impact of inc...

journal_title：Transplantation

authors： Goldberg DS,Vianna RM,Martin EF,Martin P,Arosemena Benitez LR,O'Brien CB,Bhamidimarri KR

更新日期：2020-12-01 00:00:00

abstract：:We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD). Two cohorts of patients, 44 simultaneous pancreas and kidney transplant patients (SPK) and 30 kidney transplant-alone patients (KTA), were inclu...

journal_title：Transplantation

authors： Luan FL,Miles CD,Cibrik DM,Ojo AO

更新日期：2007-08-27 00:00:00

abstract：:Antibodies against B lymphocytes were found in the serum of the majority of 59 kidney transplant recipients and of 22 eluates obtained from kidney allografts undergoing rejection. To characterize these B cell lymphocytotoxins we have used a mouse monoclonal anti-DR antibody (L227) that inhibits cytotoxicity of antibod...

journal_title：Transplantation

authors： Nunez G,McPhaul JJ Jr,Stastny P

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Both discordant and concordant xenogeneic responses are dominated by humoral immunity. Recent advances in molecular engineering approaches may largely prevent rejection by means of this pathway, leaving the cellular arm of the immune response as the principal remaining barrier to successful engraftment. MET...

journal_title：Transplantation

authors： Trani JL,Song HK,Lerner SM,Markmann JW,Barker CF,Naji A,Markmann JF

更新日期：2001-08-15 00:00:00

abstract：:Numerous studies have reported successful allotransplantation of hepatocytes. However, none have shown long-term correction of a liver-related metabolic defect. In this study, we used a method of regional hepatocyte transplantation and subsequent induction of transplanted cell proliferation by regeneration response in...

journal_title：Transplantation

authors： Eguchi S,Rozga J,Lebow LT,Chen SC,Wang CC,Rosenthal R,Fogli L,Hewitt WR,Middleton Y,Demetriou AA

更新日期：1996-09-15 00:00:00

abstract：:Teratoma 402 AX is an embryo-like tumor cell line originally derived from the testicles of strain 129/J mice. This teratocarcinoma grows well in males and pregnant females but poorly in virgin females when given in small doses. Induction of growth of this tumor is syngeneic and allogeneic virgin females was achieved b...

journal_title：Transplantation

authors： Isa AM,Sanders BR

更新日期：1975-10-01 00:00:00

abstract：:To examine whether cyclosporine (CsA) has mutagenic potential against human cells, we analyzed sister chromatid exchange (SCE) induction by CsA using human lymphocytes in vitro. SCE frequencies increased significantly in the lymphocytes treated with 1 microgram/ml and 5 micrograms/ml CsA, though the frequencies seemed...

journal_title：Transplantation

authors： Yuzawa K,Kondo I,Fukao K,Iwasaki Y,Hamaguchi H

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...

journal_title：Transplantation

authors： De Haan A,Van Der Gun I,Van Der Bij W,De Leij LF,Prop J

更新日期：2002-08-27 00:00:00

abstract：BACKGROUND:Patients with high tacrolimus clearance eliminate more drug within a dose interval compared with those with low clearance. Delays in dosing time will result in transient periods of lower concentrations in high versus low clearance patients. Transient subtherapeutic tacrolimus concentrations may induce acute ...

journal_title：Transplantation

authors： Egeland EJ,Robertsen I,Hermann M,Midtvedt K,Størset E,Gustavsen MT,Reisæter AV,Klaasen R,Bergan S,Holdaas H,Hartmann A,Åsberg A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). METHODS:We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We com...

journal_title：Transplantation

authors： Heilman RL,Cortese C,Geiger XJ,Younan K,Wadei HM,Mai ML,Reddy KS,Gonwa TA

更新日期：2012-01-15 00:00:00

abstract：:Corneal grafts are more likely to be rejected when placed in a vascularized rather than in a normal host cornea. Using immunohistochemical techniques, normal rabbit cornea was found to contain measurable numbers of cells of hemopoietic origin, probably of either macrophage or dendritic lineage. After the deliberate in...

journal_title：Transplantation

authors： Williams KA,Mann TS,Lewis M,Coster DJ

更新日期：1986-12-01 00:00:00