A potential immunosuppressive effect of anti-lymphocyte function-associated antigen-1 monoclonal antibody on islet transplantation.

abstract：BACKGROUND:Deceased donor kidneys with acute kidney injury (AKI) and deceased after circulatory death kidneys are viable sources of organs. The outcomes of renal transplantation from deceased after circulatory death (DCD) donors with AKI are not known. METHODS:A retrospective review of deceased donor renal transplants...

journal_title：Transplantation

authors： Lia D,Singer P,Nair V,Yang J,Teperman L,Grodstein E

更新日期：2020-05-15 00:00:00

abstract：:Although FK506 has been widely investigated as a potent suppressor of organ allograft rejection in animals, little is known about the effect of FK506 on T cell responses to allografts in vivo. In the present study, we have studied the effect of FK506 on the induction of allocytolytic T lymphocyte using mice primed wit...

journal_title：Transplantation

authors： Maruyama M,Suzuki H,Yamashita N,Yano S

更新日期：1990-08-01 00:00:00

abstract：:In the literature, varying terminology for living organ donation can be found. However, there seems to be a need for a new classification to avoid confusion. Therefore, we assessed existing terminology in the light of current living organ donation practices and suggest a more straightforward classification. We propose...

journal_title：Transplantation

authors： Dor FJ,Massey EK,Frunza M,Johnson R,Lennerling A,Lovén C,Mamode N,Pascalev A,Sterckx S,Van Assche K,Zuidema WC,Weimar W

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:In 2000, the United Network for Organ Sharing/Organ Procurement and Transplantation Network Registry reported 540 recovered kidneys were discarded because of biopsy results, and 210 were discarded because of poor organ function. We compared the percentage of glomerulosclerosis (GS) and creatinine clearance (...

journal_title：Transplantation

authors： Edwards EB,Posner MP,Maluf DG,Kauffman HM

更新日期：2004-05-15 00:00:00

abstract：:Organ shortage in liver transplantation has led the transplant community to expand the donor organ pool and reduce waiting list mortality by using so-called marginal donor or extended criteria donor (ECD) livers. The exact impact of these criteria on graft function and recipient survival are still under investigation....

journal_title：Transplantation

authors： Mittler J,Pascher A,Neuhaus P,Pratschke J

更新日期：2008-10-15 00:00:00

abstract：:Comparative experiments were performed on 41 allogenic rat kidney transplants to determine the mitotic behaviour and proliferative metabolism (application of 3H-thymidine) in the first 6 days after recirculation. Three days after transplantation, DNA synthesis in the tubular epithelial cells of the cortex and the medu...

journal_title：Transplantation

authors： Lauschke H

更新日期：1978-07-01 00:00:00

abstract：BACKGROUND/AIM:It remains uncertain whether autoimmune hepatitis (AIH), as an original indication for orthotopic liver transplantation (OLTX), predisposes to the development of chronic rejection (CR) after surgery and published reports on heterogeneous groups of patients provided conflicting data. In this work we analy...

journal_title：Transplantation

authors： Milkiewicz P,Gunson B,Saksena S,Hathaway M,Hubscher SG,Elias E

更新日期：2000-08-15 00:00:00

abstract：:To determine the degree of graft versus host disease (GVHD) prophylaxis that might be necessary if cord blood (CB) transplantation is more widely applied, we compared human cord blood mononuclear cell (CBMC) and adult peripheral blood mononuclear cell (PBMC) proliferative responses and stimulatory capabilities; to exa...

journal_title：Transplantation

authors： Greenfeld JI,Noizat-Pirenne F,Hardy MA,Oluwole SF,Hesdorffer CA,Preti RA,De Groote D,Franchimont P

更新日期：1994-08-27 00:00:00

abstract：:The individual effects of verapamil and 2 antioxidants on perfused rat liver nucleoside triphosphate (NTP) recovery following cold storage in University of Wisconsin (UW) solution was assessed using 31P nuclear magnetic resonance spectroscopy. The pharmacological agents were added to UW solution and were present only ...

journal_title：Transplantation

authors： Bowers JL,Neymark E,Cook CU,Clouse ME

更新日期：1994-06-15 00:00:00

abstract：BACKGROUND:We assess whether remote ischemic preconditioning (rIPC) of the recipient can modify ischemia-reperfusion (IR) injury in the donor heart following orthotopic heart transplantation from brain dead donors and to examine potential mechanisms of protection. METHODS:Sixteen pigs weighing from 26 to 34.2 (mean 29...

journal_title：Transplantation

authors： Konstantinov IE,Li J,Cheung MM,Shimizu M,Stokoe J,Kharbanda RK,Redington AN

更新日期：2005-06-27 00:00:00

abstract：BACKGROUND:It is unclear whether ischemic preconditioning (IPC) of solid organs induces remote IPC (RIPC) in donors after brain death (DBD). METHODS:Outcomes in kidney recipients from 163 DBD in two randomized trials of liver IPC (5 min=62 and 10 min=101) were obtained retrospectively from the Scientific Registry of T...

journal_title：Transplantation

authors： Desai KK,Mora-Esteves C,Holland BK,Dikdan G,Fisher A,Wilson DJ,Koneru B

更新日期：2014-02-15 00:00:00

abstract：:Natural xenoantibodies are believed to be IgM in nature and are known to play a critical role in the hyperacute rejection of distantly related xenografts. The purpose of this study was to determine whether the reducing agent DL-penicillamine could inactivate baboon natural xenoantibodies to pig splenocytes. Pooled bab...

journal_title：Transplantation

authors： Xu H,Kwiatkowski P,Chen JM,Kaplon RJ,Edwards NM,Dong X,Berger C,Michler RE

更新日期：1994-12-27 00:00:00

abstract：:We have studied organ allograft survival in rhesus monkeys conditioned with myeloablative total-body irradiation and T cell-depleted autologous bone marrow transplantation then given a heterotopic MHC-mismatched cardiac allograft in the immediate postmyeloablative period. This model has enabled us to investigate the r...

journal_title：Transplantation

authors： Moses RD,Sundeen JT,Orr KS,Roberts RR,Gress RE

更新日期：1989-11-01 00:00:00

abstract：:A rapid microcytotoxicity assay for the detection of HL-A antigens on tissue culture cells derived from human solid tumors is described. Tumor cells were prelabeled with 125Iododeoxyuridine. Isotopically labeled tumor cells were reacted with up to 37 highly selected HL-A antisera and diluted rabbit complement. Results...

journal_title：Transplantation

authors： Fritze D,Kern DH,Drogemuller CR,Pilch YH

更新日期：1975-09-01 00:00:00

abstract：:Polymerase chain reaction (PCR) amplification of CMV DNA recovered from bronchial alveolar lavage (BAL) and peripheral blood samples was compared with tissue culture, cytology, and/or histology for the earlier detection of CMV pneumonitis in 12 recipients of single-lung or heart/lung transplants. In patients with conf...

journal_title：Transplantation

authors： Buffone GJ,Frost A,Samo T,Demmler GJ,Cagle PT,Lawrence EC

更新日期：1993-08-01 00:00:00

abstract：:Monocytes play a crucial role in the response of lymphocytes to phytomitogens. This role is evident during the very early events after exposure to the mitogen. Thus, significant lymphocyte transformation does occur when monocytes are removed from the culture within a few hours after exposure to mitogen, and the presen...

journal_title：Transplantation

authors： Mookerjee BK,Ballard J

更新日期：1979-01-01 00:00:00

abstract：:During acute rejection of rat renal allografts, numerous activated monocytes accumulate in the vasculature of the graft. These monocytes seem to be involved in allograft destruction. Proinflammatory and effector functions of monocytes and macrophages can be down-regulated by peroxisome proliferators, which are probabl...

journal_title：Transplantation

authors： Grau V,Garn H,Bette M,Spener F,Steiniger B,Gemsa D,Stehling O

更新日期：2003-03-15 00:00:00

abstract：BACKGROUND:Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant and nonmalignant hematologic diseases. However, acute graft-versus-host disease (aGVHD) is a lethal complication of hematopoietic stem cell transplantation, which limits its application. Cytokines such as ...

journal_title：Transplantation

authors： Qian L,Mei K,Shen J,Cai J

更新日期：2013-03-15 00:00:00

abstract：:Consecutive patients transplanted between January 1984 and December 1988 were followed until August 1992 to detect fatal and nonfatal thromboembolic complications, including sudden death, acute and chronic myocardial infarction, pulmonary and peripheral embolisms, stroke, and thrombophlebitis. The probability of devel...

journal_title：Transplantation

authors： Forrat R,Ferrera R,Boissonnat P,Adeleine P,Dureau G,Ninet J,De Lorgeril M

更新日期：1996-03-15 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) antibodies were normally not found in subjects who have not been immunized by pregnancies, transfusions, or transplants. But with new methodology, we now see that HLA antibodies are often found in nonalloimmunized males. METHODS:The sera of 424 healthy male donors were tested w...

journal_title：Transplantation

authors： Morales-Buenrostro LE,Terasaki PI,Marino-Vázquez LA,Lee JH,El-Awar N,Alberú J

更新日期：2008-10-27 00:00:00

abstract：:Discordant xenogeneic organ transplantation is a potential solution to the critical shortage of suitable donor organs. However, clinical application of xenotransplantation with physiologically suitable organs such as those from the pig, is currently limited by the lack of agents to prevent antibody and complement-medi...

journal_title：Transplantation

authors： Kennedy SP,Rollins SA,Burton WV,Sims PJ,Bothwell AL,Squinto SP,Zavoico GB

更新日期：1994-05-27 00:00:00

abstract：BACKGROUND:The authors have previously demonstrated that inhibition of CD28 and CD40 ligand (CD40L) co-stimulatory signals by adenovirus-mediated cytotoxic T-lymphocyte-associated (CTL) antigen 4 (A4) immunoglobulin (Ig) and CD40Ig gene therapies induces tolerance or long-term acceptance in rat liver and heart allograf...

journal_title：Transplantation

authors： Hua N,Yamashita K,Hashimoto T,Masunaga T,Fujita M,Furukawa H,Uede T,Todo S

更新日期：2004-11-27 00:00:00

abstract：BACKGROUND:The pig is currently considered to be the most likely candidate for a xenogenic-organ source. Anti-pig human T-cell response via co-stimulatory molecules has been studied with great interest. The soluble form of porcine CD80 has recently been cloned and characterized, but the sequence of the transmembrane fo...

journal_title：Transplantation

authors： Wada M,Amae S,Sasaki H,Ishii T,Sano N,Nio M,Hayashi Y,Ohi R

更新日期：2003-06-15 00:00:00

abstract：:We report the management of a patient with the late onset of chronic graft-versus-host disease (GVHD) after orthotopic liver transplantation. GVHD is a rare complication of solid organ transplants that usually presents early after transplantation and is fatal in the majority of cases. Our patient differs from the typi...

journal_title：Transplantation

authors： Dunn SP,Krueger LJ,Butani L,Punnett H

更新日期：2001-05-27 00:00:00

abstract：:We investigated the preventive effect of the immunosuppressive agent FK506 on autoimmune insulitis in nonobese diabetic mice. The mice were given FK506 in a dose of 1.0 mg/kg, every other day, from age 2 to 12, 2 to 6, and 4 to 12 weeks, respectively; after which, the incidence of insulitis and overt diabetes was moni...

journal_title：Transplantation

authors： Kai N,Motojima K,Tsunoda T,Kanematsu T

更新日期：1993-04-01 00:00:00

abstract：:Rat recipients of renal allografts and unilaterally nephrectomized control rats were studied to evaluate the response in blood pressure to prednisolone in diverse doses, and to determine the dosage required to achieve adequate immunosuppression without undue complication of hypertension. While a continuous infusion of...

journal_title：Transplantation

authors： de Keijzer MH,Provoost AP,Van Aken M,Wolff ED,Molenaar JC

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:One of the main concerns after living donor liver transplantation is the risk of morbidity and/or mortality that it imposes on the donors. Respiratory postoperative complications in living liver donors have already been reported but their frequency seems to be underestimated. We designed a prospective study ...

journal_title：Transplantation

authors： Dondero F,Taillé C,Mal H,Sommacale D,Sauvanet A,Farges O,Francoz C,Durand F,Delefosse D,Denninger MH,Vilgrain V,Marrash-Chahla R,Fournier M,Belghiti J

更新日期：2006-01-27 00:00:00

abstract：BACKGROUND:Urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged an early marker protein, predicative of acute kidney injury (AKI) in various clinical settings. Here, we demonstrate urinary NGAL to allow for differential diagnosis of AKI, accurately discriminating acute allograft rejection from other ca...

journal_title：Transplantation

authors： Heyne N,Kemmner S,Schneider C,Nadalin S,Königsrainer A,Häring HU

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Organ scarcity continues in solid organ transplantation, such that the availability of organs limits the number of people able to benefit from transplantation. Medical advancements in managing end-stage organ disease have led to an increasing demand for multiorgan transplant, wherein a patient with multiorga...

journal_title：Transplantation

authors： Cheng XS,Goldhaber-Fiebert J,Tan JC,Chertow GM,Kim WR,Wall AE

更新日期：2020-02-01 00:00:00

abstract：:Leflunomide is a compound recently shown to reduce T and B cell-mediated responses in a number of experimental rat, mouse, and human systems. To explore its potential as an immunosuppressant, we studied leflunomide in 128 Brown-Norway/Lewis cardiac transplants and in 48 unoperated Lewis rats. At doses ranging from 0.6...

journal_title：Transplantation

authors： Williams JW,Xiao F,Foster P,Clardy C,McChesney L,Sankary H,Chong AS

更新日期：1994-04-27 00:00:00