Effect of FK506 treatment on allocytolytic T lymphocyte induction in vivo: differential effects of FK506 on L3T4+ and Ly2+ T cells.

abstract：BACKGROUND:We recently described a new approach that enables the generation of human/mouse chimera by adoptive transfer of human peripheral blood mononuclear cells into lethally irradiated normal strains of mice or rats, radioprotected with bone marrow from donors with severe combined immune deficiency. In such human/m...

journal_title：Transplantation

authors： Burakova T,Marcus H,Canaan A,Dekel B,Shezen E,David M,Lubin I,Segal H,Yair R

更新日期：1997-04-27 00:00:00

abstract：:Although the clinical relevance of endothelial cell-monocyte (E-M) antigens has been demonstrated in organ graft transplantation, very limited data exist describing the nature of these antigens. The current study presents biochemical characterization of three different surface antigens of endothelial cells and monocyt...

journal_title：Transplantation

authors： Wood NL,Schook LB,Studer EJ,Mohanakumar T

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Most transplant centers in the United States, including our own, use creatinine clearance (Ccr) to estimate glomerular filtration rate (GFR) in potential living kidney donors. The purpose of this study was to evaluate our experience with estimation of donor GFR by Ccr and to explore other potential strategie...

journal_title：Transplantation

authors： Bertolatus JA,Goddard L

更新日期：2001-01-27 00:00:00

abstract：BACKGROUND:Urolithiasis occurs in approximately 6% of adult kidney transplant (KTx) recipients. Limited data are available on urolithiasis after pediatric KTx. We report the incidence, management of, and risk factors for stone development in children after KTx. METHODS:We reviewed the medical records of 399 children w...

journal_title：Transplantation

authors： Khositseth S,Gillingham KJ,Cook ME,Chavers BM

更新日期：2004-11-15 00:00:00

abstract：:Nonadherence to immunosuppressants in renal transplant recipients is a major factor affecting graft survival, but it is difficult to detect accurately in clinical practice. Adherence was measured in 153 adult renal transplant recipients using self-report questionnaires and interview, clinician rating, and cyclosporine...

journal_title：Transplantation

authors： Butler JA,Peveler RC,Roderick P,Horne R,Mason JC

更新日期：2004-03-15 00:00:00

abstract：:A 44-year-old man was maintained on prednisone and azathioprine after renal transplantation. One and a half years after transplantation, he developed multiple perianal Escherichia coli abscesses. These became chronic and resisted antibiotic therapy. Histologically, the lesions were typical of malakoplakia. Peripheral ...

journal_title：Transplantation

authors： Biggar WD,Keating A,Bear RA

更新日期：1981-02-01 00:00:00

abstract：:Most patients with secondary hypertension due to renal disease or on maintenance hemodialysis have lost the physiologic fall of blood pressure during sleep. To test the notion that kidney transplantation normalizes the blood pressure profile, we monitored ambulatory blood pressure over 24 hr in 45 patients (29 males a...

journal_title：Transplantation

authors： Gatzka CD,Schobel HP,Klingbeil AU,Neumayer HH,Schmieder RE

更新日期：1995-05-15 00:00:00

abstract：BACKGROUND:Calcineurin inhibitor-induced renal dysfunction is a major problem in liver transplantation. Interleukin-2 receptor antagonist induction followed by delayed tacrolimus (Tac) administration may minimize the renal insult without compromising immunoprotection. METHODS:This open, randomized, multicenter trial e...

journal_title：Transplantation

authors： Calmus Y,Kamar N,Gugenheim J,Duvoux C,Ducerf C,Wolf P,Samuel D,Vanlemmens C,Neau-Cransac M,Salamé E,Chazouillères O,Declerck N,Pageaux GP,Dubel L,Rostaing L

更新日期：2010-06-27 00:00:00

abstract：:Living donor renal allograft survival is superior to that achieved from deceased donors, although graft outcome is suboptimal in some of these patients. In an effort to identify the subset of patients at high risk for poor outcomes we studied donor risk factors in 248 living kidney donor-recipient pairs. Unadjusted do...

journal_title：Transplantation

authors： Issa N,Stephany B,Fatica R,Nurko S,Krishnamurthi V,Goldfarb DA,Braun WE,Dennis VW,Heeger PS,Poggio ED

更新日期：2007-03-15 00:00:00

abstract：:We describe four patients who suffered asystole, myocardial infarction (in two cases) and supraventricular tachycardia at the time of high-dose methylprednisolone infusion. One patient died during infusion. We measured the effects of methylprednisolone and placebo infusion on heart rate, blood pressure, and cardiac ou...

journal_title：Transplantation

authors： Smith RS,Warren DJ

更新日期：1983-04-01 00:00:00

abstract：:In vitro pretreatment of islets of Langerhans with deoxyguanosine (dGuo) has been shown to be effective for the prolongation of islet allograft survival in rats. [This study evaluates the effect of pretreatment of islets with dGuo transplanted into CsA-treated recipients.] Transplantation of dGuo-treated islets from W...

journal_title：Transplantation

authors： al-Abdullah IH,Kumar AM,al-Adnani MS,Abouna GM

更新日期：1991-05-01 00:00:00

abstract：:We have demonstrated that DA hearts grafted into PVG rats were completely protected from rejection by simultaneous liver transplantation from the same donor. In subsequent experiments PVG animals were given DA hearts followed 5 or 6 days later by livers from the same donor strain. Instead of the expected rapid rejecti...

journal_title：Transplantation

authors： Kamada N,Wight DG

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Progressively better therapies have largely prevented or at least effectively treated acute allograft rejection. Consequently, the long-term survival of solid organ transplants has increasingly become limited primarily by the development of chronic allograft rejection. The mechanisms of chronic rejection rem...

journal_title：Transplantation

authors： Heslan JM,Renaudin K,Thebault P,Josien R,Cuturi MC,Chiffoleau E

更新日期：2006-11-15 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF) based immunosuppression after renal transplantation has proven to be safe and beneficial for children and adolescents. However, long-term analysis, in particular of pediatric patients, is scarce. PATIENTS:Data of 140 patients receiving MMF versus azathioprine (AZA) in combination...

journal_title：Transplantation

authors： Jungraithmayr TC,Wiesmayr S,Staskewitz A,Kirste G,Bulla M,Fehrenbach H,Dippell J,Greiner C,Griebel M,Helmchen U,Klaus G,Leichter HE,Mihatsch MJ,Michalk DV,Misselwitz J,Plank C,Tönshoff B,Weber LT,Zimmerhackl LB,Germ

更新日期：2007-04-15 00:00:00

abstract：BACKGROUND:The leflunomide analog, FK778, is a selective pyrimidine synthesis inhibitor. In rodent models, FK778 is efficacious in the prevention of allograft and xenograft rejection, and a combination of FK778 and cyclosporine has synergistic immunosuppressive efficacy. METHODS:Heterotopic renal transplantation was p...

journal_title：Transplantation

authors： Kyles AE,Gregory CR,Griffey SM,Bernsteen L,Pierce J,Lilja HS,Morris RE

更新日期：2003-04-27 00:00:00

abstract：:T cells play an important role in protective immunity against tuberculosis. As patients are not reimmunized with BCG after BMT, the question arises as to whether PPD-specific memory T cells are transferred from the marrow donor to the recipient and persist in the long-term. We studied long-term survivors of non-T cell...

journal_title：Transplantation

authors： Rouleau M,Senik A,Leroy E,Vernant JP

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The polymorphic family of killer-cell immunoglobulin-like receptors (KIRs) consists of activating and inhibitory receptors expressed by natural killer (NK) cells and effector T cells that recognize human leukocyte antigen (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts benefi...

journal_title：Transplantation

authors： Kunert K,Seiler M,Mashreghi MF,Klippert K,Schönemann C,Neumann K,Pratschke J,Reinke P,Volk HD,Kotsch K

更新日期：2007-12-15 00:00:00

abstract：:The ability of concanavalin-A (Con-A) to activate lymphocytes to secrete human lymphotoxin (LT) was tested in the presence of agents known to modify the intracellular levels of cyclic nucleotides (cAMP and cGMP). Lymphocytes were treated with these agents at different stages of activation: (1) during the first encount...

journal_title：Transplantation

authors： Prieur AM,Granger GA

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:Live kidney donation is safe for healthy donors and an effective treatment for patients with end-stage renal disease. Many potential donors are referred for live kidney donation, but only a small percentage donate. This study aims to determine reasons for nondonation and establish if racial differences exist...

journal_title：Transplantation

authors： Lunsford SL,Simpson KS,Chavin KD,Menching KJ,Miles LG,Shilling LM,Smalls GR,Baliga PK

更新日期：2006-10-15 00:00:00

abstract：:By using the lysostrip and the blocking of cytotoxicity by Fab2 fragments, HLA-A and B antibodies were detected in sera from rabbits and goats immunized with human high-density lipoprotein (HDL)-associated HLA antigens isolated from sera and from cultured lymphoid cells. After appropriate absorptions, the xenoantisera...

journal_title：Transplantation

authors： Richiardi P,Pellegrino MA,Ferrone S

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:Community respiratory viruses such as respiratory syncytial virus (RSV), adenovirus, influenza A, influenza B, and the parainfluenza group are frequent causes of respiratory disease in bone marrow transplant (BMT) patients. MATERIAL AND METHODS:During the period from March 1993 to August 1999, 810 samples o...

journal_title：Transplantation

authors： Raboni SM,Nogueira MB,Tsuchiya LR,Takahashi GA,Pereira LA,Pasquini R,Siqueira MM

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Both laboratory and clinical studies have shown that dietary lipids may affect immunologic responses. This study was conducted to compare different classes of long-chain unsaturated fatty acids for their effect on allograft survival in animals receiving a donor-specific transfusion and a short course of low-...

journal_title：Transplantation

authors： Alexander JW,Valente JF,Greenberg NA,Custer DA,Ogle CK,Gibson SW,Babcock GF

更新日期：1998-05-27 00:00:00

abstract：BACKGROUND:T-cell activation through T-cell receptor engagement requires co-stimulatory molecules and also adhesion molecules such as ICAM-1. Moreover ICAM-1 mediates leukocyte invasion from the blood into tissue during inflammatory processes. In animal studies using mouse monoclonal antibodies against ICAM-1 (enlimoma...

journal_title：Transplantation

authors： Salmela K,Wramner L,Ekberg H,Hauser I,Bentdal O,Lins LE,Isoniemi H,Bäckman L,Persson N,Neumayer HH,Jørgensen PF,Spieker C,Hendry B,Nicholls A,Kirste G,Hasche G

更新日期：1999-03-15 00:00:00

abstract：BACKGROUND:Induction therapy is associated with excellent short-term kidney graft outcome. The aim of this study was to evaluate differences in the intragraft transcriptome after successful induction therapy using two rabbit antithymocyte globulins. METHODS:The expression of 376 target genes involved in tolerance, inf...

journal_title：Transplantation

authors： Urbanova M,Brabcova I,Girmanova E,Zelezny F,Viklicky O

更新日期：2012-03-27 00:00:00

abstract：:Cyclosporine (CsA) is an immunosuppressive drug requiring dose individualization and regular control due to its highly variable pharmacokinetics. Since gastroparesis may influence the absorption of CsA, a randomized cross-over study was performed to assess the pharmacokinetics and tolerability of a novel microemulsion...

journal_title：Transplantation

authors： van der Pijl JW,Srivastava N,Denouël J,Burggraaf J,Schoemaker RC,van der Woude FJ,Cohen AF

更新日期：1996-08-27 00:00:00

abstract：:While the immune privilege nature of the eye affords significant protection to corneal grafts, immunologic rejection is the leading cause of graft failure. Class II antigens are normally absent or expressed at very low levels in normal cornea. The role that class II antigens play in causing graft rejection is particul...

journal_title：Transplantation

authors： Ross J,Callanan D,Kunz H,Niederkorn J

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Hyperparathyroidism is reported in 10% to 66% of renal transplant recipients (RTR). The influence of persisting hyperparathyroidism on long-term clinical outcomes in RTR has not been examined in a large prospective study. METHODS:We investigated the association between baseline parathyroid hormone (PTH) lev...

journal_title：Transplantation

authors： Pihlstrøm H,Dahle DO,Mjøen G,Pilz S,März W,Abedini S,Holme I,Fellström B,Jardine AG,Holdaas H

更新日期：2015-02-01 00:00:00

abstract：:The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...

journal_title：Transplantation

authors： Mowat AM,Ferguson A

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively the merits of an allocation of cadaveric kidneys based on broader classes of HLA antigens, called cross-reactive groups (CREG). The objectives of the pilot study consider patient outcomes, but not the potential...

journal_title：Transplantation

authors： Hollenbeak CS,Woodward RS,Cohen DS,Lowell JA,Singer GG,Tesi RJ,Howard TK,Mohanakumar T,Brennan DC,Schnitzler MA

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:Mycophenolic acid, the active metabolite of mycophenolate mofetil, inhibits the glycosylation of cell membrane glycoproteins. We hypothesized that impaired glycosylation of cell adhesion molecules on endothelial cells in vivo results in decreased susceptibility to inflammation or immunogenicity after allogen...

journal_title：Transplantation

authors： Valentin JF,Bruijn JA,Paul LC

更新日期：2000-02-15 00:00:00