Evidence that the fate of class II-disparate corneal grafts is determined by the timing of class II expression.

Abstract:

:While the immune privilege nature of the eye affords significant protection to corneal grafts, immunologic rejection is the leading cause of graft failure. Class II antigens are normally absent or expressed at very low levels in normal cornea. The role that class II antigens play in causing graft rejection is particularly interesting. Class II molecules are present on many cells of the immune system, and therefore are important in modulating and mediating immune reactions. The absence of class II bearing cells in the cornea leads to the interesting issue of whether or not those antigens can induce immune rejection of a corneal graft. In the current study we have made use of a pair of congenic rat strains that differ only at class II loci to determine the impact of these antigens on corneal graft survival. Central corneal grafts were not rejected. Recipients preimmunized with skin grafts rejected 100% of the class II disparate corneas with a median survival time (MST) of 15.5 days. When class II disparate Langerhans-cell-containing (LC+) corneas were grafted, the corneas were not rejected, but they immunized the recipients as evidenced by the rejection of a second corneal graft on the contralateral eye. Immunofluorescent stains demonstrated transient expression of class II antigens on graft epithelium after transplantation. This temporary appearance of class II provides a target for rejection in the preimmunized animals but is of insufficient duration to both prime naive animals and provide a target for antigraft effectors.

journal_name

Transplantation

journal_title

Transplantation

authors

Ross J,Callanan D,Kunz H,Niederkorn J

doi

10.1097/00007890-199102000-00049

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

532-6

issue

2

eissn

0041-1337

issn

1534-6080

journal_volume

51

pub_type

杂志文章
  • Postoperative oral glucose tolerance and stimulated insulin secretion: a predictor of endocrine graft function more than 10 years after pancreas-kidney transplantation.

    abstract:BACKGROUND:After pancreas transplantation, endocrine function is determined by the insulin secretory capacity of the transplanted pancreas. The authors evaluated the predictive value of postoperative oral glucose tolerance test (OGTT) and stimulated insulin secretion on long-term endocrine function. METHODS:Forty-one ...

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    pub_type: 杂志文章

    doi:10.1097/01.TP.0000098821.26466.DE

    authors: Pfeffer F,Nauck MA,Drognitz O,Benz S,von Dobschuetz E,Hopt UT

    更新日期:2003-11-27 00:00:00

  • Multiple Cladosporium brain abscesses in a renal transplant patient: aggressive management improves outcome.

    abstract::Infection remains one of the major complications of nonspecific immunosuppression in renal transplant patients and accounts for significant morbidity and mortality. The incidence of infectious complications has been shown to be related to the degree of immunosuppression and correlated with the total steroid dosage, us...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199701150-00030

    authors: Salama AD,Rogers T,Lord GM,Lechler RI,Mason PD

    更新日期:1997-01-15 00:00:00

  • Corneal Stromal Transplantation With Human-derived Acellular Dermal Matrix for Pellucid Marginal Corneal Degeneration: A Nonrandomized Clinical Trial.

    abstract:BACKGROUND:To investigate the transparency, biocompatibility, and safety of human-derived acellular dermal matrix for application in corneal stromal transplantation. METHODS:Twenty-four patients (24 eyes) with pellucid marginal corneal degeneration were enrolled, and intrastromal keratoplasty was performed with human-...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/TP.0000000000002681

    authors: Jiang X,Wang Y,Qiu W,Huang C,Liu Z,Ding T,Shi D,Li X

    更新日期:2019-06-01 00:00:00

  • Endoscopic evaluation of small intestine transplant grafts.

    abstract:BACKGROUND:The management of small bowel transplantation is unique because signs of rejection can be obtained visually by endoscopy. The aim of this study was to evaluate the accuracy of endoscopic appearance in assessing histologic evidence of acute cellular rejection (ACR). METHODS:Endoscopies were performed in 66 a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31825f4410

    authors: O'Keefe SJ,El Hajj II,Wu T,Martin D,Mohammed K,Abu-Elmagd K

    更新日期:2012-10-15 00:00:00

  • Posttransplant bone disease: a case illustrating dramatic improvements in bone density with vitamin D replacement therapy.

    abstract::Although bisphosponates are proposed as first-line treatment for posttransplant bone disease they are not optimal in all situations. A kidney transplant recipient developed hypercalcemia from mobilization of extraskeletal calcium. He had low serum parathyroid hormone and vitamin D; high calcium excretion; and normal c...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200106270-00025

    authors: Dhingra RK,Sprague SM,Ojo AO,Leavey SF

    更新日期:2001-06-27 00:00:00

  • High prevalence of GB virus-C/hepatitis G virus infection in liver transplant recipients.

    abstract:BACKGROUND:To determine the prevalence of GB virus-C/hepatitis G virus (GBV-C/HGV) infection in liver transplant recipients transplanted for non-hepatitis C virus indications, 44 patients transplanted for cryptogenic, autoimmune, hepatitis B, or cholestatic liver disease and 91 non-liver transplantation (LT) patients w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199706150-00028

    authors: Dickson RC,Qian KP,Lau JY

    更新日期:1997-06-15 00:00:00

  • Peripheral monitoring of direct and indirect alloantigen presentation pathways in clinical heart transplant recipients.

    abstract::It has been reported that the response to alloantigens presented by the direct and indirect pathway may be of differential relevance after human kidney transplantation. Accordingly, we monitored these routes in peripheral blood mononuclear cells (PBMC) of heart transplant patients from before transplantation and up to...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199601150-00033

    authors: van Besouw NM,Vaessen LM,Daane CR,Jutte NH,Balk AH,Claas FH,Weimar W

    更新日期:1996-01-15 00:00:00

  • Evaluation of Low- Versus High-dose Valganciclovir for Prevention of Cytomegalovirus Disease in High-risk Renal Transplant Recipients.

    abstract:BACKGROUND:Despite proven efficacy of prolonged cytomegalovirus (CMV) prophylaxis using valganciclovir 900 mg/day, some centers use 450 mg/day due to reported success and cost savings. This multicenter, retrospective study compared the efficacy and safety of 6 months of low-dose versus high-dose valganciclovir prophyla...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/TP.0000000000000570

    authors: Gabardi S,Asipenko N,Fleming J,Lor K,McDevitt-Potter L,Mohammed A,Rogers C,Tichy EM,Weng R,Lee RA

    更新日期:2015-07-01 00:00:00

  • Early induction of immune resistance against leukemia in mice after lethal irradiation followed by syngeneic bone marrow transplantation and injection of syngeneic leukocytes.

    abstract::BALB/cxDBA/2Wf F1 (CD2F1) mice were lethally irradiated and reconstituted with syngeneic bone marrow cells untreated or treated with 75 micrograms/ml of mafosfamide. One day after bone marrow transplantation some groups of mice were injected with syngeneic splenocytes, peripheral blood leukocytes, or thymocytes. Seven...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199104000-00020

    authors: Skórski T,Kawalec M,Kawiak J

    更新日期:1991-04-01 00:00:00

  • Psychiatric care of patients undergoing organ transplantation.

    abstract::Transplantation provides life-saving therapy to critically ill patients with end-stage organ failure. We found that the specialized knowledge of mental health clinicians and physicians, committed to the evaluation and management of transplant recipients, is essential for the optimal care of these patients who require ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0b013e3181a754d4

    authors: Surman OS,Cosimi AB,DiMartini A

    更新日期:2009-06-27 00:00:00

  • Outcomes of African American kidney transplant recipients treated with sirolimus, tacrolimus, and corticosteroids.

    abstract:BACKGROUND:African American kidney transplant recipients generally exhibit poor long-term graft survival compared with other ethnic groups. The combination of sirolimus, tacrolimus, and corticosteroids has proven to be effective in reducing rejection episodes in high-risk organ and islet cell transplant recipients but ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200207270-00008

    authors: Hricik DE,Anton HA,Knauss TC,Rodriguez V,Seaman D,Siegel C,Valente J,Schulak JA

    更新日期:2002-07-27 00:00:00

  • Live donor liver transplantation for acute liver failure.

    abstract:BACKGROUND:Acute liver failure (ALF) carries a high mortality unless urgent orthotopic liver transplantation (OLT) is performed on time. Live donors are utilized to treat this irreversible condition first in pediatric cases and then in adults. Herein, we aimed to report our experience with live donors for ALF in a coun...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000276987.55382.e2

    authors: Kilic M,Aydin U,Noyan A,Arikan C,Aydogdu S,Akyildiz M,Karasu Z,Zeytunlu M,Alper M,Batur Y

    更新日期:2007-08-27 00:00:00

  • Mycophenolate mofetil and C-reactive protein in renal transplant recipients.

    abstract:BACKGROUND:C-reactive protein (CRP) is a strong predictor of cardiovascular disease, all-cause mortality, and renal allograft loss. Little is known about the effects of immunosuppressive and cardiovascular risk-modifying drugs on CRP in renal transplant recipients. METHODS:We retrospectively identified stable patients...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000248864.21574.92

    authors: Wong BM,Huang M,Zaltzman JS,Prasad GV

    更新日期:2007-01-15 00:00:00

  • Right lobe living donor liver transplantation.

    abstract:BACKGROUND:The shortage of livers for transplantation has prompted transplant centers to seek alternatives to conventional cadaveric liver transplantation. Left lateral segmentectomy from living donors has proven to be a safe operation for the donor with excellent results in the pediatric population. Left lobectomy, co...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199909270-00012

    authors: Marcos A,Fisher RA,Ham JM,Shiffman ML,Sanyal AJ,Luketic VA,Sterling RK,Posner MP

    更新日期:1999-09-27 00:00:00

  • Human herpesvirus-6 infection after lung and heart-lung transplantation: a prospective longitudinal study.

    abstract:BACKGROUND:Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. METHODS:During 27 months, 30 consecutive heart-lung- and lung-transplant recipients were included on the day of transpl...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000058809.42027.66

    authors: Jacobs F,Knoop C,Brancart F,Gilot P,Mélot C,Byl B,Delforge ML,Estenne M,Liesnard C,Brussels Heart and Lung Transplantation Group.

    更新日期:2003-06-27 00:00:00

  • Effect of granulocyte-macrophage colony-stimulating factor on the induction of unresponsiveness by lymphoid cells.

    abstract::Skin grafts can be significantly prolonged in ALS-treated mice by the injection of 25 x 10(6) donor bone marrow cells or 50 x 10(6) spleen cells. Lymph node cells and thymocytes are only minimally effective in prolonging grafts. The effect of a hematopoietic growth factor, granulocyte-macrophage colony stimulating fac...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199101000-00035

    authors: Monaco AP,Wood ML,Gottschalk R,Seiler FR

    更新日期:1991-01-01 00:00:00

  • Treatment with humanized monoclonal antibodies against CD80 and CD86 combined with sirolimus prolongs renal allograft survival in cynomolgus monkeys.

    abstract:BACKGROUND:Co-stimulatory blockade has been shown to prolong allograft survival in different transplant models. We investigated the effect of combining humanized anti-CD80 and anti-CD86 monoclonal antibodies (mAb) with sirolimus in cynomolgus monkey renal transplant recipients. METHODS:After renal transplantation, gro...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000066806.10029.7A

    authors: Bîrsan T,Hausen B,Higgins JP,Hubble RW,Klupp J,Stalder M,Celniker A,Friedrich S,O'Hara RM,Morris RE

    更新日期:2003-06-27 00:00:00

  • Utility of colonoscopy in the evaluation of diarrhea in solid organ transplant recipients.

    abstract:BACKGROUND:Diarrhea is common in solid organ transplant recipients. Colonoscopy with random biopsies is performed frequently in the diagnostic evaluation of the posttransplant population with diarrhea. The purpose of this study was to determine the sensitivity of colonoscopy with random biopsy in determining a specific...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181ae98ab

    authors: Rice JP,Spier BJ,Cornett DD,Walker AJ,Richie K,Pfau PR

    更新日期:2009-08-15 00:00:00

  • Paclitaxel prevents loss of pulmonary endothelial barrier integrity during cold preservation.

    abstract:BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000131951.72851.57

    authors: Suzuki S,Bing H,Sugawara T,Matsuda Y,Tabata T,Hoshikawa Y,Saijo Y,Kondo T

    更新日期:2004-08-27 00:00:00

  • Evidence that graft coronary arteriosclerosis begins in the early phase after transplantation and progresses without chronic immunoreaction. Histopathological analysis using a retransplantation model.

    abstract::The histopathological features of chronic rejection and its initiation were assessed using rat heterotopic heart transplantation and retransplantation models. Fully allogeneic or minor, non-MHC antigen-mismatch heart grafts transplanted into recipient rats treated with a short course of FK506 showed long-term survival...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199511270-00002

    authors: Izutani H,Miyagawa S,Shirakura R,Matsumiya G,Nakata S,Shimazaki Y,Matsuda H

    更新日期:1995-11-27 00:00:00

  • The effect of cyclosporine and liver autotransplantation on bile flow and composition in dogs.

    abstract::Following liver transplantation bile formation may be influenced by hepatic denervation and cyclosporine therapy. To better establish any effect of liver transplantation on bile secretion, 6 mongrel dogs were studied: 3 underwent liver denervation by a modified autotransplantation procedure and insertion of a Thomas c...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199302000-00001

    authors: Sutherland FR,Preshaw RM,Shaffer EA

    更新日期:1993-02-01 00:00:00

  • Manufacture of antithymocyte globulin (ATGAM) for clinical trials.

    abstract::Methods are described for preparing large amounts of horse anti-human thymocyte globulin (ATG, ATGAM; The Upjohn Company) for clinical use. These methods have been used since 1968 to provide material for clinical trials. Characteristics of 40 lots of ATG are summarized. ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197910000-00007

    authors: Wechter WJ,Nelson JW,Perper RJ,Parcells AJ,Riebe KW,Evans JS,Satoh PS,Ko H

    更新日期:1979-10-01 00:00:00

  • The Immunology of Posttransplant CMV Infection: Potential Effect of CMV Immunoglobulins on Distinct Components of the Immune Response to CMV.

    abstract::The immune response to cytomegalovirus (CMV) infection is highly complex, including humoral, cellular, innate, and adaptive immune responses. Detection of CMV by the innate immune system triggers production of type I IFNs and inflammatory cytokines which initiate cellular and humoral responses that are critical during...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000001095

    authors: Carbone J

    更新日期:2016-03-01 00:00:00

  • Outcome, incidence, and timing of infectious complications in small bowel and multivisceral organ transplantation patients.

    abstract:BACKGROUND:Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis. METHODS:Th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000185622.91708.57

    authors: Guaraldi G,Cocchi S,Codeluppi M,Di Benedetto F,De Ruvo N,Masetti M,Venturelli C,Pecorari M,Pinna AD,Esposito R

    更新日期:2005-12-27 00:00:00

  • Deceased Organ Donors and PHS Risk Identification: Impact on Organ Usage and Outcomes.

    abstract:BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001716

    authors: Pruett TL,Clark MA,Taranto SE

    更新日期:2017-07-01 00:00:00

  • Improvement of donor myocardial function after treatment of autonomic storm during brain death.

    abstract:BACKGROUND:In experimental brain death models, autonomic storm (AS) triggers severe myocardial dysfunction, which can be attenuated by pharmacologic treatment. The aim of this study was to determine the incidence of AS in a cohort of human organ donors and to evaluate the potential interest of AS treatment on myocardia...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000235825.97538.d5

    authors: Audibert G,Charpentier C,Seguin-Devaux C,Charretier PA,Grégoire H,Devaux Y,Perrier JF,Longrois D,Mertes PM

    更新日期:2006-10-27 00:00:00

  • Fractionation of feline bone marrow with the soybean agglutinin lectin yields populations enriched for erythroid and myeloid elements: transplantation of soybean agglutinin-negative cells into lethally irradiated recipients.

    abstract::Feline bone marrow cells treated with the soybean agglutinin (SBA) lectin are separated into two populations, the agglutinated SBA(+) fraction containing predominantly cells of myeloid origin and the nonagglutinated SBA(-) fraction consisting of cells primarily of the erythroid lineage. FACScan analyses revealed a cle...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199708150-00022

    authors: Gengozian N,Reyes L,Pu R,Homer BL,Bova FJ,Yamamoto JK

    更新日期:1997-08-15 00:00:00

  • One orifice vein reconstruction in left liver plus caudate lobe grafts.

    abstract::For maximum use of left liver plus caudate lobe grafts, the short hepatic vein draining the caudate lobe should be reconstructed. We devised a new venoplasty technique. On the graft side, a wide venous orifice with a long cuff was formed by gathering the left, middle, and short hepatic veins using a conduit vein graft...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.tp.0000244729.39485.7c

    authors: Hashimoto T,Sugawara Y,Tamura S,Kaneko J,Motomura N,Takamoto S,Makuuchi M

    更新日期:2007-01-27 00:00:00

  • Update on C1 Esterase Inhibitor in Human Solid Organ Transplantation.

    abstract::Complement plays important roles in both ischemia-reperfusion injury (IRI) and antibody-mediated rejection (AMR) of solid organ allografts. One approach to possibly improve outcomes after transplantation is the use of C1 inhibitor (C1-INH), which blocks the first step in both the classical and lectin pathways of compl...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000002717

    authors: Berger M,Lefaucheur C,Jordan SC

    更新日期:2019-09-01 00:00:00

  • Malakoplakia: evidence for an acquired disease secondary to immunosuppression.

    abstract::A 44-year-old man was maintained on prednisone and azathioprine after renal transplantation. One and a half years after transplantation, he developed multiple perianal Escherichia coli abscesses. These became chronic and resisted antibiotic therapy. Histologically, the lesions were typical of malakoplakia. Peripheral ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Biggar WD,Keating A,Bear RA

    更新日期:1981-02-01 00:00:00