Utility of colonoscopy in the evaluation of diarrhea in solid organ transplant recipients.

abstract：BACKGROUND:HLAMatchmaker is a computer algorithm that determines human leukocyte antigen (HLA) compatibility at the level of polymorphic amino acid triplets in antibody-accessible sequence positions. Recent studies have shown that HLA-DR-matched kidney transplant recipients with zero to two triplet mismatches had almos...

journal_title：Transplantation

authors： Duquesnoy RJ,Howe J,Takemoto S

更新日期：2003-03-27 00:00:00

abstract：BACKGROUND:Bone marrow (BM) is an excellent source of mesenchymal stem cells (MSC) which can be expanded in vitro for further use. However, large volumes of BM specimens are not routinely available. We hypothesized that the normally discarded BM collection kits might be a convenient source of large numbers of MSC. MET...

journal_title：Transplantation

authors： Mageed AS,Pietryga DW,DeHeer DH,West RA

更新日期：2007-04-27 00:00:00

abstract：:Our current knowledge of cytotoxic T lymphocytes (CTL) is largely derived from studies of effector populations generated in allogeneic mixed leukocyte cultures (MLC) and assayed for lytic activity to lymphoid cell (LC) targets. We herein report that the CTL response to allogeneic renal epithelial cell lines (REC) is d...

journal_title：Transplantation

authors： Hadley GA,Rostapshova EA,Bartlett ST

更新日期：1996-07-15 00:00:00

abstract：:Seven murine anti-H-2 and three nonimmune mouse sera were tested for cytotoxicity toward B and T lymphocytes from a panel of human donors. One group of sera, including two anti-H-2.33 sera, exhibited cytotoxicity directed exclusively toward human B but not T cells from all donors. Absorption studies on human lymphobla...

journal_title：Transplantation

authors： Verghese MW,Ward FE

更新日期：1979-08-01 00:00:00

abstract：:Cyclosporine treatment of BALB/c mice (at a dose of 20 mg/kg every other day for 3 weeks) caused a remarkable reduction in the PNA-, L3T4+Lyt-2- subset of thymocytes. A significant reduction of the L3T4+Lyt-2-subset was also observed in both the lymph node and spleen cells of CsA-treated mice, though the degree of the...

journal_title：Transplantation

authors： Hiramine C,Hojo K,Matsumoto H,Koseto M,Itoh M

更新日期：1989-03-01 00:00:00

abstract：:The results of OKT3 use for steroid-resistant rejection rescue in adult liver transplantation were analyzed retrospectively from a single transplant center. Comparison was made with concurrent patients who had no rejection (NR) or steroid-responsive rejections (SR). The records of 290 patients who underwent 323 liver ...

journal_title：Transplantation

authors： Solomon H,Gonwa TA,Mor E,Holman MJ,Gibbs J,Watemberg I,Netto G,Goldstein RM,Husberg BS,Klintmalm GB

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Recipients of vascularized composite allografts require aggressive and lifelong immunosuppression, and because the surgery is usually performed in nonlife-threatening situations, the development of strategies to minimize immunosuppression is especially pertinent for this procedure. We investigated how comple...

journal_title：Transplantation

authors： Zhu P,Bailey SR,Lei B,Paulos CM,Atkinson C,Tomlinson S

更新日期：2017-04-01 00:00:00

abstract：:The glycosaminoglycan hyaluronan is not only involved in cellular differentiation and migration but may also play a role in several inflammatory diseases. We have previously demonstrated an increased local production of hyaluronan in chronically rejected kidneys and the correspondingly affected renal vessels. In this ...

journal_title：Transplantation

authors： Wells A,Larsson E,Hanás E,Laurent T,Hällgren R,Tufveson G

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Hepatic artery thrombosis (HAT) is a significant cause of morbidity after liver transplantation. The aims of this study are to identify and compare risk factors that might contribute to HAT. METHODS:A total of 424 liver transplants performed at the University of Virginia were reviewed. HAT was defined as co...

journal_title：Transplantation

authors： Oh CK,Pelletier SJ,Sawyer RG,Dacus AR,McCullough CS,Pruett TL,Sanfey HA

更新日期：2001-03-27 00:00:00

abstract：:Two anti-H-2Ld sera were analyzed, BALB/c-H-2dm2 anti-BALB/cBy and (C3H X BALB/c-H-2dm2)F1 anti-BALB/cHe, the latter also containing anti-Qa antibodies. Their reaction patterns were compared with an anti-Qa serum (C3H X BALB/cBy)F1 anti-BALB/cHe. Four H-2 specificities could be detected by the anti-H-2Ld sera, two alr...

journal_title：Transplantation

authors： Oudshoorn-Snoek M,Iványi D,Démant P

更新日期：1981-08-01 00:00:00

abstract：:In a prospective randomized double-blind placebo-controlled trial, the effect of rh-SOD, given in a dose of 200 mg intravenously during surgery to cyclosporine-treated recipients of cadaveric renal allografts, on both acute and chronic rejection events as well as patient and graft survival was investigated by analyzin...

journal_title：Transplantation

authors： Land W,Schneeberger H,Schleibner S,Illner WD,Abendroth D,Rutili G,Arfors KE,Messmer K

更新日期：1994-01-01 00:00:00

abstract：:Controversy exists as to the type of cells present in the urine during renal allograft rejection. In order to resolve this controversy as well as to evaluate the value of urine sediment examination as a means of detecting AR, we quantitated the different cells present in urine during AR using an immunoperoxidase techn...

journal_title：Transplantation

authors： Segasothy M,Birch DF,Fairley KF,Kincaid-Smith P

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:There is a debate about the relative contribution of immunologic (rejection) and nonimmunologic (limited nephron mass) factors in long-term graft survival. METHODS:Using multivariate analysis, we studied the association of the following variables with outcome: delayed graft function (DGF), acute rejection, ...

journal_title：Transplantation

authors： Matas AJ,Gillingham KJ,Humar A,Dunn DL,Sutherland DE,Najarian JS

更新日期：2000-01-15 00:00:00

abstract：:Histoincompatibility was analyzed to describe as precisely as possible the sequence of gross morphological events taking place during allograft rejection among closely related conspecifics from a natural population of the bisexual lizard Cnemidophorus tigris. Two types of rejection were noted, depending on whether the...

journal_title：Transplantation

authors： Cuellar O,Smart C

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:Liver transplantation using ABO-incompatible grafts is rarely performed because the reported outcome is poorer than with compatible grafts. We report our positive experience with adult-to-adult living-donor liver transplant (LDLT) using ABO-incompatible grafts. METHODS:The immunosuppressive protocol consist...

journal_title：Transplantation

authors： Testa G,Vidanovic V,Chejfec G,Gangemi A,Iqpal R,Porubsky M,Pham T,Benedetti E

更新日期：2008-03-15 00:00:00

abstract：BACKGROUND:A recent proposal supports the elimination of allocation points for human leukocyte antigen (HLA) mismatches (MM) in cadaveric kidney transplantation. The intent is to increase access for some racial groups that might be disadvantaged by the representation of race-specific HLA in a largely white donor pool. ...

journal_title：Transplantation

authors： Rebellato LM,Arnold AN,Bozik KM,Haisch CE

更新日期：2002-12-15 00:00:00

abstract：BACKGROUND:Mycophenolic acid (MPA) is an inhibitor of lymphocyte proliferation and is well established as an immunosuppressive agent in solid organ transplantation. The initial formulation of the drug was a prodrug formulation, mycophenolate mofetil (MMF, Cellcept), which is well absorbed and rapidly converted to mycop...

journal_title：Transplantation

authors： Johnston A,He X,Holt DW

更新日期：2006-12-15 00:00:00

abstract：BACKGROUND:Chronic renal allograft failure remains a major challenge to overcome. Factors such as donor quality, delayed graft function (DGF), acute rejection, and immunosuppression are known to affect long-term outcome, but their relationship to histological damage to graft outcome is unclear. METHODS:Protocol kidney...

journal_title：Transplantation

authors： Nankivell BJ,Fenton-Lee CA,Kuypers DR,Cheung E,Allen RD,O'Connell PJ,Chapman JR

更新日期：2001-02-27 00:00:00

abstract：:Diarrhea is a frequent but overlooked complication of kidney transplantation. Diarrhea is repeatedly neglected, often considered by patients and clinicians an unavoidable side effect of immunosuppressive regimens. It is, however, associated with a significant impairment in life quality. Severe and chronic posttranspla...

journal_title：Transplantation

authors： Aulagnon F,Scemla A,DeWolf S,Legendre C,Zuber J

更新日期：2014-10-27 00:00:00

abstract：BACKGROUND:Everolimus reduces the progression of cardiac allograft vasculopathy (CAV) in de novo heart transplant (HTx) recipients, but the influence on established CAV is unknown. METHODS:In this Nordic Certican Trial in Heart and lung Transplantation substudy, 111 maintenance HTx recipients (time post-HTx 5.8 ± 4.3 ...

journal_title：Transplantation

authors： Arora S,Ueland T,Wennerblom B,Sigurdadottir V,Eiskjær H,Bøtker HE,Ekmehag B,Jansson K,Mortensen SA,Saunamaki K,Simonsen S,Gude E,Bendz B,Solbu D,Aukrust P,Gullestad L

更新日期：2011-07-27 00:00:00

abstract：BACKGROUND:The organ donor shortage has led to a reconsideration of the use of non-heart-beating donors (NHBDs). However, graft injury due to warm ischemia in NHBD livers strongly affects posttransplant outcome. The present study was aimed at investigating the role of the cellular cyclic (c)AMP second messenger signal ...

journal_title：Transplantation

authors： Minor T,Akbar S

更新日期：1998-10-27 00:00:00

abstract：:The question has not been previously investigated as to whether host lymphocytes infiltrate vascularized organ allografts in indiscriminate fashion, or whether they are retained selectively because of specific antigenic recognition sites on their surfaces. By using a dual cardiac allograft model in LEW rats, we have e...

journal_title：Transplantation

authors： Tilney NL,Notis-McConarty J,Strom TB

更新日期：1978-09-01 00:00:00

abstract：:The effect of the graft-versus-host reaction in response to minor histocompatibility antigens on the antibody response to a T-dependent antigen was studied in four strains of mice. Lethally irradiated mice were transplanted with bone marrow plus graded numbers of spleen cells from H-2-compatible donors. Recipients of ...

journal_title：Transplantation

authors： Hamilton BL,Ochs HD

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Preemptive kidney transplantation (prior to the institution of dialysis) avoids the morbidity and mortality of dialysis; however, detailed studies of high-risk patients are lacking. The aim of the current study was to compare recent outcomes of preemptive (P) versus nonpreemptive (NP) living donor kidney tra...

journal_title：Transplantation

authors： Innocenti GR,Wadei HM,Prieto M,Dean PG,Ramos EJ,Textor S,Khamash H,Larson TS,Cosio F,Kosberg K,Fix L,Bauer C,Stegall MD

更新日期：2007-01-27 00:00:00

abstract：:We examined graft and patient survival rates of 47,146 patients in the United Network for Organ Sharing registry following transplants between donors and recipients who were cytomegalovirus (CMV) antibody negative and positive. CMV positivity increased with age to about 80% in patients over 60. Seropositivity was seen...

journal_title：Transplantation

authors： Hirata M,Terasaki PI,Cho YW

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:In a pilot trial we evaluated the toxicity and efficacy of sirolimus (rapamycin) as second-line therapy for the treatment of acute graft-versus-host disease (GVHD) in 21 patients (1-46 years of age) after allogeneic hematopoietic stem cell transplantation (HSCT). METHODS:All patients were treated with methy...

journal_title：Transplantation

authors： Benito AI,Furlong T,Martin PJ,Anasetti C,Appelbaum FR,Doney K,Nash RA,Papayannopoulou T,Storb R,Sullivan KM,Witherspoon R,Deeg HJ

更新日期：2001-12-27 00:00:00

abstract：:The aim of this study was to analyze the possible protective effects of a glutamine and arginine precursor (ornithine-alpha-ketoglutarate [OKG]) on the mucosa of a transplanted intestine when administered with either a defined formula oral diet (DFD) or a standard chow. Isogenic male Lewis rats (250 g) were submitted ...

journal_title：Transplantation

authors： de Oca J,Bettonica C,Cuadrado S,Vallet J,Martín E,Garcia A,Montañés T,Jaurrieta E

更新日期：1997-03-15 00:00:00

abstract：BACKGROUND:Arterial hypertension (HT) is common in renal transplant recipients (RTRs). Control of HT is not optimal in this high-risk population despite recommendations for target blood pressure levels under 130/80 mm Hg. METHODS:We performed a cross-sectional analysis of the prevalence of uncontrolled HT, and using a...

journal_title：Transplantation

authors： Vetromile F,Pernin V,Szwarc I,Garrigue V,Delmas S,Mourad G,Fesler P

更新日期：2015-05-01 00:00:00

abstract：:Indium 111-labeled monoclonal antibody to cardiac myosin was examined for efficacy in the detection of cardiac graft rejection and rejection-related myocyte necrosis. Heterotopic heart transplants were performed in isogenic and allogenic groups of rats (n = 56). At selected intervals posttransplant, uptake of injected...

journal_title：Transplantation

authors： Allen MD,Tsuboi H,Togo T,Eary JF,Gordon D,Thomas R,Reichenbach DD

更新日期：1989-12-01 00:00:00

abstract：:In the DA-to-Lewis renal allograft model, donor whole blood enhanced renal allograft survival (14.5 +/- 7.6 days versus 6.9 +/- 0.6 days in controls [P less than 0.01]). The effect of individual cell components given in numbers equivalent to those present in the enhancing volumes of donor whole blood was studied. Immu...

journal_title：Transplantation

authors： El-Malik F,Malik ST,Varghese Z,Sweny P,Moorhead JF

更新日期：1984-09-01 00:00:00