Abstract:
:Two anti-H-2Ld sera were analyzed, BALB/c-H-2dm2 anti-BALB/cBy and (C3H X BALB/c-H-2dm2)F1 anti-BALB/cHe, the latter also containing anti-Qa antibodies. Their reaction patterns were compared with an anti-Qa serum (C3H X BALB/cBy)F1 anti-BALB/cHe. Four H-2 specificities could be detected by the anti-H-2Ld sera, two already known (H-2.64, H-2.65) and two new specificities (H-2.81, H-2.82). According to their reaction pattern H-2.64, H-2.81, and H-2.82 can be regarded as members of the H-2.28 family of specificities. A quantitative difference in the expression of these H-2 specificities exists in different haplotypes. The cells of the strain against which the sera were made (BALB/cHe and BALB/cBy, respectively) did not give the highest titers with the antisera and had a relatively low absorbing capacity. The H-2dx haplotype carries two new specificities of the H-2.28 family, namely, H-2.81 and H-2.82. Lysostrip tests showed that the antibodies against those specificities cap the H-2.1-positive H-2Ddx molecules, suggesting that these molecules may react with both anti-H-2.1-like and anti-H-2.28-like antibodies. The H-2 specificities detected by the BALB/c-H-2dm2 anti-BALB/cBy serum were detected also in liver, kidney, spleen, heart, and lung tissue. New information on the strain distribution of Qa-2 was obtained from the experiments and a quantitative difference in Qa-2 antigens between H-2 congenic strains was observed as well. The H-2b strains react with these antibodies with higher titers than the strains carrying the H-2d haplotype.
journal_name
Transplantationjournal_title
Transplantationauthors
Oudshoorn-Snoek M,Iványi D,Démant Pdoi
10.1097/00007890-198108000-00009subject
Has Abstractpub_date
1981-08-01 00:00:00pages
128-36issue
2eissn
0041-1337issn
1534-6080journal_volume
32pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::For maximum use of left liver plus caudate lobe grafts, the short hepatic vein draining the caudate lobe should be reconstructed. We devised a new venoplasty technique. On the graft side, a wide venous orifice with a long cuff was formed by gathering the left, middle, and short hepatic veins using a conduit vein graft...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000244729.39485.7c
更新日期:2007-01-27 00:00:00
abstract:BACKGROUND:New-onset diabetes is common after kidney transplantation, but the benefit of lifestyle intervention to improve glucose metabolism posttransplantation is unproven. METHODS:We conducted a single-center, randomized controlled trial involving 130 nondiabetic kidney transplant recipients with stable function be...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000002969
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been l...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001396
更新日期:2016-12-01 00:00:00
abstract::Organ shortage in liver transplantation has led the transplant community to expand the donor organ pool and reduce waiting list mortality by using so-called marginal donor or extended criteria donor (ECD) livers. The exact impact of these criteria on graft function and recipient survival are still under investigation....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318186ad7a
更新日期:2008-10-15 00:00:00
abstract:BACKGROUND:Post-lung transplant infection is one of the leading causes of morbidity and mortality. The cause and incidence are similar in many series; however, infections such as Mycobacterium tuberculosis are influenced by the epidemiologic situation. The authors present a prospective and observational study to define...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000147784.53188.dc
更新日期:2005-01-15 00:00:00
abstract:BACKGROUND:Alterations in microcirculation are considered central to the pathogenesis of hyperacute xenogeneic rejection (HXR) of vascularized xenografts, but currently there exist no data describing these microhemodynamic alterations. METHODS:Rat livers were perfused in situ with either isogeneic rat blood or xenogen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199702150-00022
更新日期:1997-02-15 00:00:00
abstract:BACKGROUND:Geographic variation in kidney transplantation rates in the United States has been described previously but remains unexplained by age, race, sex, or socioeconomic status differences. Geographic variations in the concentration of poverty appear to impact end-stage renal disease care and potentially access to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000125
更新日期:2014-09-27 00:00:00
abstract:BACKGROUND:Extracorporeal membrane oxygenation (ECMO) and mechanical ventilation (MV) can be used as a bridge to heart-lung transplantation (HLT). The goal of this study was to determine if pretransplantation ECMO or MV affects survival in HLT. METHODS:The United Network for Organ Sharing database was reviewed for all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a860b8
更新日期:2014-01-15 00:00:00
abstract::A group of 170 patients having functional renal allografts were evaluated at least six months after renal transplantation. They were assessed for symptoms and signs of tendinitis in the Achilles and Supraspinatus tendons. Of the 170 patients, 34 had tendinitis. Four patients (11.8%) had spontaneous rupture of the Achi...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:The role of combined liver-kidney transplantation (CLKT) for cirrhotic patients with renal failure (RF) is controversial. Since the model for end-stage liver disease era, there has been a rise in the number of CLKT. Using the Organ Procurement Transplant Network/United Network for Organ Sharing database, thi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182590d6b
更新日期:2012-08-27 00:00:00
abstract::Graft and patient survival rates after transplantation of ABO-incompatible liver allografts have been poor. We used plasmapheresis and a potent immunosuppressive regimen to control hemagglutinin levels and prevent early rejection. Ten patients who had a United Network for Organ Sharing status of 4 received ABO-incompa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199504150-00011
更新日期:1995-04-15 00:00:00
abstract::Cytomegalovirus (CMV) is a major pathogen in transplant recipients and AIDS patients, and the virus may also play a role in allograft rejection. Previous work from this laboratory demonstrated increased cell surface expression of the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) following CMV infection in vitro. W...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199610270-00014
更新日期:1996-10-27 00:00:00
abstract:BACKGROUND:We are presently investigating the therapeutic potential of herpes simplex-thymidine kinase-expressing donor T cells in the setting of a T cell-depleted allogeneic bone marrow transplantation. The generation, expansion, and selection of the gene-modified T cells require a 12-day ex vivo culture period in hig...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199805270-00014
更新日期:1998-05-27 00:00:00
abstract::The development of organ preservation solutions has been primarily accomplished in whole organ animal models. This study examines the toxicity of commonly used organ preservation solutions on endothelial cells in vitro. Primary human umbilical-vein endothelial cell cultures were incubated at 4 degrees C in solutions o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199205000-00002
更新日期:1992-05-01 00:00:00
abstract::In a DBA/2 (H-2d) pancreatic islet-to-B6AF1 (H-2b/k.d) recipient combination, the graft survival of hand-picked islets was compared with that of "crude digested" islets that were prepared simply by collagenase digestion and Ficoll gradient separation and were contaminated with lymph nodes and vascular and ductal tissu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198610000-00011
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Urologic complications cause substantial morbidity in the pediatric population after renal transplantation, but their impact on graft survival and transplant costs is poorly understood. In this retrospective review, we evaluated the records of all pediatric renal transplant recipients at our center from 1995...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818b63da
更新日期:2008-12-15 00:00:00
abstract::Eight patients with chronic myeloid leukemia relapse after allogeneic BMT were treated with IFN-alpha and buffy coat transfusions (BC) of the bone marrow donor. The antileukemic effect of this treatment was directly demonstrated in 4 patients by the disappearance of Philadelphia chromosome-positive metaphases or the l...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199311000-00013
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Posttransplant lymphoproliferative disease (PTLD) is a major complication after bone marrow and solid organ transplantation. The disease encompasses a spectrum of abnormal, Epstein-Barr virus (EBV)-associated B-cell proliferations. We have previously shown that EBV-infected, spontaneous lymphoblastoid cell l...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208150-00017
更新日期:2002-08-15 00:00:00
abstract:BACKGROUND:Systemic inflammation markers, such as neutrophil-to-lymphocyte ratio (NLR), have recently emerged as the prognostic factors for recurrence of liver tumors. METHODS:We assessed the ability of NLR and of other variables to predict the outcomes of orthotopic liver transplantation (OLT) for hepatocellular carc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182187cf0
更新日期:2011-06-15 00:00:00
abstract::Cyclosporine CsA nephrotoxicity was examined in male Sprague-Dawley rats with or without prior uninephrectomy, injected daily with 12.5 mg/kg CsA, and fed a salt-depleted or normal diet for 3-10 weeks. Control rats received the CsA vehicle. CsA induced a fall in creatinine clearance in salt-depleted rats, from 1.3 +/-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199002000-00041
更新日期:1990-02-01 00:00:00
abstract::The mission of the recently established Immune Tolerance Network includes the development of protocols for the induction of transplant tolerance in organ allograft recipients and the development of assays that correlate with and may be predictive of the tolerant state. The state of clinical organ transplant tolerance ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2001-10-27 00:00:00
abstract:BACKGROUND:Ischemia/reperfusion (I/R) injury is a limiting factor in liver transplantation. We have recently shown that pyruvate (PY) inhibits intestinal and renal I/R injury. This study aims to evaluate the protective effect of PY on hepatic I/R injury. METHODS:ACI rats were treated with PY, whereas control animals r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200107150-00008
更新日期:2001-07-15 00:00:00
abstract:BACKGROUND:According to a pooled analysis of three randomized clinical studies concerning the prevention of acute rejection in cadaveric renal transplantation, mycophenolate mofetil (MMF) proved superior to azathioprine or placebo in conjunction with cyclosporine (CsA) and steroids. MMF-treated patients showed reduced ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199908270-00023
更新日期:1999-08-27 00:00:00
abstract::Polyclonal rabbit antirat thymocyte serum (ATS) has been shown to form in situ glomerular immune aggregates following perfusion into normal rat kidney ex vivo. This may be due to the presence of T-cell-like epitopes in the rat kidney, or it may be a result of contaminating anti-connective-tissue antibodies in ATS. To ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198606000-00015
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000002890
更新日期:2019-11-01 00:00:00
abstract::Based on a log-linear model for analyzing multiple effects, center variation in the UCLA Transplant Registry is the most influential factor in early renal graft survival. Among 68 active centers accounting for 70% of all transplants between 1985 and 1989, the 1-year graft survival (adjusted for 15 covariates) varied f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199202010-00018
更新日期:1992-02-01 00:00:00
abstract:METHODS:Two hundred twenty-three recipients of first cadaveric kidney allografts were randomized to receive tacrolimus (TAC) + mycophenolate mofetil (MMF), TAC + azathioprine (AZA), or cyclosporine (Neoral; CsA) + MMF. All regimens contained corticosteroids, and antibody induction was used only in patients who experien...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.TP.0000069831.76067.22
更新日期:2003-06-27 00:00:00
abstract:BACKGROUND:This study evaluated zoom endoscopic findings according to four components in comparison with the histologic findings of acute cellular rejection (ACR) in a living-related small bowel transplantation (SBTx) patient. METHODS:A 16-year-old boy with microvillus inclusion disease underwent SBTx with a 150-cm-lo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200202270-00013
更新日期:2002-02-27 00:00:00
abstract:BACKGROUND:Dendritic cells (DC) can exert powerful immune stimulatory as well as regulatory functions and are therefore important tools for therapeutic strategies. Dexamethasone (Dex) was previously shown to inhibit DC maturation and to induce regulatory properties both in vitro and in vivo. Here, we investigated the i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818a6682
更新日期:2008-11-15 00:00:00
abstract:BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000071846.35825.B1
更新日期:2003-07-15 00:00:00