In vivo alloreactive potential of ex vivo-expanded primary T lymphocytes.

abstract：:In the USA approximately 10% of candidates for renal transplantation have serum antibodies to hepatitis C (HCV). To assess the possible impact of HCV infection on early posttransplant events we assessed allograft complications during the first 6 months following renal transplantation in three groups of adult renal all...

journal_title：Transplantation

authors： Cosio FG,Sedmak DD,Henry ML,Al Haddad C,Falkenhain ME,Elkhammas EA,Davies EA,Bumgardner GL,Ferguson RM

更新日期：1996-10-27 00:00:00

abstract：BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...

journal_title：Transplantation

authors： Simeoni E,Vassalli G,Seydoux C,Ramsay D,Noll G,von Segesser LK,Fleury S

更新日期：2005-11-15 00:00:00

abstract：:We have previously shown that trophic factor supplementation (TFS) of University of Wisconsin (UW) solution enhanced kidney viability after cold storage. Here, we use an in vitro model to study the effect of TFS on early apoptotic changes after cold ischemic storage. Mitochondrial membrane potential was determined by ...

journal_title：Transplantation

authors： Kwon YS,Foley JD,Murphy CJ,McAnulty JF

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) antibodies were normally not found in subjects who have not been immunized by pregnancies, transfusions, or transplants. But with new methodology, we now see that HLA antibodies are often found in nonalloimmunized males. METHODS:The sera of 424 healthy male donors were tested w...

journal_title：Transplantation

authors： Morales-Buenrostro LE,Terasaki PI,Marino-Vázquez LA,Lee JH,El-Awar N,Alberú J

更新日期：2008-10-27 00:00:00

abstract：:One major limitation in pancreatic islet transplantation is availability of donor tissue. Donor shortage is exacerbated by islet apoptosis from the stresses of islet isolation and transplantation. Furthermore, the side effects of immunosuppressive drugs preclude transplants into patients whose diabetes is controlled b...

journal_title：Transplantation

authors： Sutherland RM,Allison J,Thomas HE,Brady JL,Kay TW,Lew AM

更新日期：2004-05-27 00:00:00

abstract：:A technique for orthotopic bone transplantation in mice has been developed. A section of recipient tibia was removed and replaced by a similar section from the donor animal. The graft was held in place by internal fixation. Bone healing was assessed clinically, histologically, radiologically, and by torsion testing. T...

journal_title：Transplantation

authors： Halloran PF,Ziv I,Lee EH,Langer F,Pritzker KP,Gross AE

更新日期：1979-06-01 00:00:00

abstract：:Seasonal variation in blood pressure (BP) has been described in the general and dialysis populations, with higher recordings noted in the winter than in the summer. This difference has been attributed to changes in weight, ambient temperature, and length of daylight. In this study, we sought to determine whether such ...

journal_title：Transplantation

authors： Prasad GV,Nash MM,Zaltzman JS

更新日期：2001-12-15 00:00:00

abstract：:Two anti-H-2Ld sera were analyzed, BALB/c-H-2dm2 anti-BALB/cBy and (C3H X BALB/c-H-2dm2)F1 anti-BALB/cHe, the latter also containing anti-Qa antibodies. Their reaction patterns were compared with an anti-Qa serum (C3H X BALB/cBy)F1 anti-BALB/cHe. Four H-2 specificities could be detected by the anti-H-2Ld sera, two alr...

journal_title：Transplantation

authors： Oudshoorn-Snoek M,Iványi D,Démant P

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Liver transplant (LT) for nonalcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC) is not well characterized in the literature. The aim of the study was to examine characteristics and outcomes of patients who had LT for NASH-HCC (NASH) versus HCC from other liver diseases (non-NASH). METHO...

journal_title：Transplantation

authors： Sadler EM,Mehta N,Bhat M,Ghanekar A,Greig PD,Grant DR,Yao F,Sapisochin G

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR)...

journal_title：Transplantation

authors： Camós M,Esteve J,Rimola A,Grande L,Rozman M,Colomer D,Villamor N,Costa D,Montserrat E

更新日期：2004-01-27 00:00:00

abstract：BACKGROUND:Recently published pediatric trial of Rituximab for the treatment of CD20+ acute renal allograft rejection (AR) demonstrated transient depletion of circulating/intragraft B cells (Zarkhin et al., Am J Transplant 2008; 8: 2607). In this study, we have evaluated phenotypic definition of circulating B-cell subs...

journal_title：Transplantation

authors： Zarkhin V,Lovelace PA,Li L,Hsieh SC,Sarwal MM

更新日期：2011-05-15 00:00:00

abstract：:The following findings were noted among 45 bone marrow transplant recipients. The patients without cytomegalovirus (CMV) infection or chronic graft-versus-host disease (GVHD) showed normal lymphocyte stimulation in vitro by concanavalin A (Con A) more than 3 months after transplantation, and normal stimulation by phyt...

journal_title：Transplantation

authors： Paulin T,Ringdén O,Lönnqvist B

更新日期：1985-04-01 00:00:00

abstract：:The interpretation of cellular infiltrate from renal transplant recipients with borderline (BL) changes is still a challenging problem. To analyze the immune phenotype of such infiltrate, we quantified the mRNA expression of Foxp3 and interleukinL-10 and granzyme B (GB) in 15 kidney biopsies with BL changes. Controls ...

journal_title：Transplantation

authors： Grimbert P,Mansour H,Desvaux D,Roudot-Thoraval F,Audard V,Dahan K,Berrehar F,Dehoulle-Poillet C,Farcet JP,Lang P,Le Gouvello S

更新日期：2007-02-15 00:00:00

abstract：:The class II region of major histocompatibility complex of the rat. Rattus norvegicus (RT1) consists of RT1.B, RT1.D, and RT1.H subregions. The gene order around the H subregion was determined as RT1.A--H beta-H alpha--B by RFLP analysis of naturally occurring intra-RT1 recombinant rats with HLA DP probes. A unique re...

journal_title：Transplantation

authors： Fujii H,Kakinuma M,Yoshiki T,Natori T

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Few studies have directly compared preemptive therapy (PET) and antiviral prophylaxis (AP) for prevention of cytomegalovirus (CMV) disease in CMV seropositive (R+) orthotopic liver transplant (OLT) recipients. METHODS:We prospectively assessed CMV disease and clinical outcomes among 160 consecutive R+ OLT r...

journal_title：Transplantation

authors： Liu AW,Jutivorakool K,Fisher CE,Rakita RM,Reyes JD,Bhattacharya RB,Jerome KR,Limaye AP

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Human intravenous immunoglobulin G delayed xenogeneic hyperacute rejection (HAR) in the guinea pig-to-rat combination. We investigated the respective roles of the Fc and Fab fragments of the IgG molecule in this inhibitory effect. METHODS:By using a guinea pig-to-rat heart transplantation model, the efficie...

journal_title：Transplantation

authors： Urbani L,Fabre M,Cardoso J,Lambin P,Devillier P,Soubrane O,Houssin D,Gautreau C

更新日期：1998-08-15 00:00:00

abstract：:We performed a multicenter study to investigate the problem of cadaver kidney transplants that never achieve function, or that recover after a period of delayed function, and we used multivariate techniques to model the results. Sixty-nine patients who received cadaver kidney transplants that never functioned (NF) wer...

journal_title：Transplantation

authors： Halloran P,Aprile M

更新日期：1988-01-01 00:00:00

abstract：:Solid organ and allogeneic hematopoietic cell transplantation have become standard therapeutic interventions that save patient lives and improve quality of life. Our enhanced understanding of transplantation immunobiology has refined clinical management and improved outcomes. However, organ rejection and graft-versus-...

journal_title：Transplantation

authors： Radojcic V,Maillard I

更新日期：2016-12-01 00:00:00

abstract：:Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...

journal_title：Transplantation

authors： Nisbet NW,Menage J,Loutit JF

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:The long-term outcome of lung transplantation is impeded by the development of obliterative bronchiolitis (OB). We sought to investigate the relationship between the apoptosis of tracheal epithelial cells and bone marrow-derived myofibroblasts in the process of OB. METHODS:The mouse orthotopic tracheal tran...

journal_title：Transplantation

authors： Wang C,Xia T,Jiang K,Qiao X,Zhang X,Li J,Wang J,Nie J

更新日期：2016-09-01 00:00:00

abstract：:Pregraft transfusion combined with immunosuppression at the time of grafting improves the survival of clinical and experimental allografts. The mechanisms responsible for this effect were investigated in the murine model of cardiac transplantation, combining transfusions 7 to 30 days prior to transplantation with cycl...

journal_title：Transplantation

authors： Mottram PL,Mirisklavos A,Dumble LJ,Clunie GJ

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:In the acute rejection of allografts, the interaction between Fas (CD95) and its ligand (FasL; CD95L) has been shown to be involved in mediating apoptotic cell death. The role, however, of these molecules in the pathogenesis of transplant vascular sclerosis is as yet undetermined. The present study was there...

journal_title：Transplantation

authors： Subbotin V,Sun H,Aitouche A,Salam A,Valdivia LA,Fung JJ,Starzl TE,Rao AS

更新日期：1999-05-27 00:00:00

abstract：:Hepatic grafts from non-heartbeating donors may alleviate the organ shortage, but they inherently suffer from warm ischemia. In the present study, we tested our hypothesis that augmentation of endogenous adenosine by inhibition of nucleoside transport with R75231 attenuates ischemic liver injury. Adult female beagle d...

journal_title：Transplantation

authors： Todo S,Zhu Y,Zhang S,Jin MB,Ishizaki N,Tanaka H,Subbotin V,Starzl TE

更新日期：1997-01-27 00:00:00

abstract：:Islet transplantation is currently being explored as a treatment for patients with type 1 diabetes. At present, the number of patients becoming insulin-independent is rapidly increasing world-wide applying the transplantation protocol originally described by the group in Edmonton. A hallmark in this procedure is repea...

journal_title：Transplantation

authors： Korsgren O,Nilsson B,Berne C,Felldin M,Foss A,Kallen R,Lundgren T,Salmela K,Tibell A,Tufveson G

更新日期：2005-05-27 00:00:00

abstract：BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...

journal_title：Transplantation

authors： Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez D

更新日期：2010-03-27 00:00:00

abstract：INTRODUCTION:HMG-CoA reductase inhibitors play several roles in the maintenance of organ transplants. We investigated the role of pitavastatin, a potent and newly developed HMG-CoA reductase inhibitor, in cardiac allograft rejection and mechanism of graft arterial disease (GAD) suppression. METHODS:Balb/c mice hearts ...

journal_title：Transplantation

authors： Suzuki J,Koga N,Kosuge H,Ogawa M,Haraguchi G,Maejima Y,Saiki H,Isobe M

更新日期：2007-04-27 00:00:00

abstract：:The aim of this study was to analyze the possible protective effects of a glutamine and arginine precursor (ornithine-alpha-ketoglutarate [OKG]) on the mucosa of a transplanted intestine when administered with either a defined formula oral diet (DFD) or a standard chow. Isogenic male Lewis rats (250 g) were submitted ...

journal_title：Transplantation

authors： de Oca J,Bettonica C,Cuadrado S,Vallet J,Martín E,Garcia A,Montañés T,Jaurrieta E

更新日期：1997-03-15 00:00:00

abstract：BACKGROUND:The delayed allograft rejection in C6-deficient PVG C6- rats compared with normal PVG rats has been attributed to the lack of alloantibody activation of the membrane attack complex of complement. As T cells alone have been shown to effect graft rejection, we examined T-cell responses in PVG C6- rats. METHOD...

journal_title：Transplantation

authors： Merten S,Chen JC,Ha H,Plain K,Boyd RA,Penny MJ,Leenaerts P,Hall BM

更新日期：1998-05-15 00:00:00

abstract：BACKGROUND:Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks per day) are scanty. METHODS:Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with non-HD (ND) donors. RESULTS:Of 56 182 firs...

journal_title：Transplantation

authors： Arora SS,Chahal KS,Axley P,Eckhoff DE,Kuo YF,Satapathy SK,Wiesner R,Singal AK

更新日期：2018-11-01 00:00:00

abstract：:Nonmajor histocompatibility complex (non-MHC) antigens are important targets of graft rejection and graft-versus-host disease in clinical transplantation. Little is known regarding immunity to non-MHC antigens. To study this problem we evaluated the effect of antihuman thymocyte globulin (ATG) on reactivity in autolog...

journal_title：Transplantation

authors： Harada M,Gale RP

更新日期：1981-02-01 00:00:00