Bcl-2 protection of islet allografts is unmasked by costimulation blockade.

abstract：:Low-affinity, cold-reactive antibodies easily removed by washing were not detected by the antiglobulin technique but killed T lymphocytes when washing was omitted, incubation was prolonged, and cytotoxic tests were incubated at room temperature or at 4 degrees C. These antibodies were present in approximately 25% of s...

journal_title：Transplantation

authors： Pettaway CA,Freeman C,Helderman JH,Stastny P

更新日期：1987-10-01 00:00:00

abstract：:Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of these important antigen-presenting cells may be suppressed by continual exposure to microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is emerging for a role of specific intracellular...

journal_title：Transplantation

authors： Sumpter TL,Lunz JG 3rd,Demetris AJ,Thomson AW

更新日期：2009-08-15 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion (I/R) injury is the major cause of delayed renal graft function in kidney transplantation. To date, there are no effective therapeutic approaches for preventing I/R injury. We previously reported that treatment of animals with small interference RNA (siRNA) would prevent warm I/R injury ...

journal_title：Transplantation

authors： Zheng X,Zang G,Jiang J,He W,Johnston NJ,Ling H,Chen R,Zhang X,Liu Y,Haig A,Luke P,Jevnikar AM,Min WP

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:We evaluated liver transplantation waitlist and posttransplantation outcomes in those aged 18 to 24 years compared with both younger (0-17 years) and older (25-34 years) registrants and recipients. METHODS:Using national data from the United Network for Organ Sharing, competing risk, Cox regression and Kapl...

journal_title：Transplantation

authors： Ebel NH,Hsu EK,Berry K,Horslen SP,Ioannou GN

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:We recently demonstrated that inhibition of inducible nitric oxide synthase (iNOS) ameliorated severe acute lung allograft rejection. This study used a rat lung transplant model to determine (1) the time course and cellular localization of iNOS expression during the histological progression of unmodified acu...

journal_title：Transplantation

authors： Worrall NK,Boasquevisque CH,Botney MD,Misko TP,Sullivan PM,Ritter JH,Ferguson TB Jr,Patterson GA

更新日期：1997-04-27 00:00:00

abstract：INTRODUCTION:This study examines the efficacy and toxicity of sirolimus used as primary immunosuppression in combination with reduced dose tacrolimus (calcineurin inhibitor [CI]-sparing regimen) or mycophenolate mofetil (CI-free regimen) in high-risk cadaveric renal transplantation. METHODS:Seventy subjects were treat...

journal_title：Transplantation

authors： Lo A,Egidi MF,Gaber LW,Amiri HS,Vera S,Nezakatgoo N,Gaber AO

更新日期：2004-04-27 00:00:00

abstract：:If ABO antigens/antibodies play any role in the pathogenesis of acute graft-versus-host disease (GVHD), one would expect the highest incidence of GVHD in recipients of minor ABO-mismatched grafts, followed by ABO-matched grafts, and the lowest incidence in major ABO-mismatched transplants. To test this hypothesis 174 ...

journal_title：Transplantation

authors： Bacigalupo A,Van Lint MT,Occhini D,Margiocco M,Ferrari G,Pittaluga PA,Frassoni F,Peralvo J,Lercari G,Carubia F

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:The literature indicates few studies on kidney patients' perception of the donor kidney. In light of this fact, we decided to explore this issue with adult patients. METHODS:We carried out a phenomenological study with 40 adult kidney patients. RESULTS:In this study, three main themes became apparent: the ...

journal_title：Transplantation

authors： Buldukoglu K,Kulakac O,Kececioglu N,Alkan S,Yilmaz M,Yucetin L

更新日期：2005-08-27 00:00:00

abstract：:Cyclosporine extends kidney allograft survival in the chacma baboon, and this study explores various administration protocols to generate optimal serum concentrations of the drug, assessed by radioimmunoassay and by inhibition of lymphocyte transformation by phytohemagglutinin and allogeneic lymphocytes in culture. Se...

journal_title：Transplantation

authors： Smit JA,Drielsma RF,Myburgh JA,Laupacis A,Stiller CR

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:There are anti-idiotypes in the sera of highly sensitized (HS) patients that stimulate B cells to produce antibody to HLA class I antigens. The purpose of this study is to determine if there is an abnormality in B cell responses to these anti-idiotypes. METHODS:Supernatants from normal and HS B cells expose...

journal_title：Transplantation

authors： Hack N,Angra S,McKnight TL,den Hollander N,Cardella CJ

更新日期：2005-11-15 00:00:00

abstract：:Transcription factors of the nuclear factor of activated T cells (NFAT) family regulate both immune activation and insulin production. Calcineurin inhibitors (CNIs) target NFAT activation. Hence, CNIs not only prevent organ transplant rejection but also contribute to the development of new-onset diabetes after transpl...

journal_title：Transplantation

authors： Chen Y,Sampaio MS,Yang JW,Min D,Hutchinson IV

更新日期：2012-02-15 00:00:00

abstract：:By means of double diffusion in gel reactions, "heterophile" antibodies were demonstrated in human renal transplantation sera. Of thirty-two recipients of renal allografts, 12 (37 per cent) had antibodies to extract of bovine erythrocyte stromata, and 5 (19 per cent) of 26 recipients produced antibodies to extract of ...

journal_title：Transplantation

authors： Kano K,Loza U,Gerbasi JR,Milgrom F

更新日期：1975-01-01 00:00:00

abstract：:We have previously demonstrated that liver sinusoidal endothelial cells (LSECs) that endocytose portally injected allogeneic cells exert immunosuppressive effects on T cells with indirect allospecificity. In this study, we have demonstrated that invariant natural killer T cells plays a significant role in such immunos...

journal_title：Transplantation

authors： Shishida M,Ohdan H,Onoe T,Tanaka Y,Igarashi Y,Banshodani M,Asahara T

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:The beneficial effects of glycemic control on both survival and function of transplanted kidneys in patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) have been recognized. METHODS:Herein, we present the clinical outcome of a single-center pilot trial of islet after kidney (IAK...

journal_title：Transplantation

authors： Cure P,Pileggi A,Froud T,Messinger S,Faradji RN,Baidal DA,Cardani R,Curry A,Poggioli R,Pugliese A,Betancourt A,Esquenazi V,Ciancio G,Selvaggi G,Burke GW 3rd,Ricordi C,Alejandro R

更新日期：2008-03-27 00:00:00

abstract：BACKGROUND:We have reported the protective role of heme oxygenase-1 (HO-1) in the mechanism of hypoxic preconditioning. We wish to investigate the role of HO-1 in remote preconditioning (RP) against hepatic ischemia/reperfusion (I/R) injury in rats. METHODS:The remote preconditioning was produced by four cycles of 10-...

journal_title：Transplantation

authors： Lai IR,Chang KJ,Chen CF,Tsai HW

更新日期：2006-05-15 00:00:00

abstract：BACKGROUND:Neonatal primates have been reported to receive pig hearts without hyperacute rejection (HAR). We examined the ontogeny of the anti-pig xenoantibody (XenoAb) and HAR in the neonatal and infant monkeys. METHODS:Twenty-six serum samples from 15 monkeys ages 14-192 days were subjected to hemagglutination titra...

journal_title：Transplantation

authors： Kawauchi M,Nakajima J,Endoh M,Oka T,Takamoto S

更新日期：2000-08-27 00:00:00

abstract：BACKGROUND:Although the value of duodenal histology as a means to diagnose acute rejection in pancreaticoduodenal allografts has been validated, it is not known how the duodenum responds to antirejection treatment in comparison with the pancreas. METHODS:Diabetic Lewis rats received a pancreaticoduodenal allograft. Cy...

journal_title：Transplantation

authors： Mark W,Hechenleitner P,Dietze O,Klima G,Schneeberger S,Steurer W,Candinas D,Margreiter R,Königsrainer A

更新日期：2002-01-27 00:00:00

abstract：:Multiple pretransplant sera obtained from alloimmunized renal transplant recipients were tested for the presence of antiidiotypic-like antibodies (AB2) that inhibit donor-specific HLA antibodies in the microlymphocytotoxicity assay. Fourteen patients received repetitive single-donor blood transfusions (SDT). In this p...

journal_title：Transplantation

authors： Phelan DL,Rodey GE,Anderson CB

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:It is imperative for healthcare providers to examine Western Muslim attitudes on organ donation, because they are reluctant donors. We explored such opinion with the aid of a quantitative survey. METHODS:Voluntary completion of an anonymous survey was promoted (online and paper sampling). For a population t...

journal_title：Transplantation

authors： Sharif A,Jawad H,Nightingale P,Hodson J,Lipkin G,Cockwell P,Ball S,Borrows R

更新日期：2011-11-27 00:00:00

abstract：BACKGROUND:Abrupt temperature shift from hypothermia to normothermia incurred on reperfusion of organ grafts has been delineated as a genuine factor contributing to reperfusion injury and graft dysfunction after transplantation. METHODS:In a first clinical series of 6 patients, cold-stored livers, all allocated by the...

journal_title：Transplantation

authors： Hoyer DP,Mathé Z,Gallinat A,Canbay AC,Treckmann JW,Rauen U,Paul A,Minor T

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:It remains unknown whether low-grade hyperparathyroidism persisting beyond the first year postrenal transplantation has any impact on bone density. METHODS:Parathyroid hormone (PTH), glomerular filtration rate (GFR), and bone density (by dual-energy x-ray absorptiometry [DXA]) were monitored in the follow-u...

journal_title：Transplantation

authors： Akaberi S,Lindergård B,Simonsen O,Nyberg G

更新日期：2006-09-27 00:00:00

abstract：BACKGROUND:Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised. METHODS:Forty-three hepatitis B virus car...

journal_title：Transplantation

authors： Chen PM,Chiou TJ,Fan FS,Liu JM,Hsieh RK,Yen CC,Wang WS,Liu JH

更新日期：1999-06-15 00:00:00

abstract：:The incidence of interstitial pneumonitis (IP) was reviewed in 70 consecutive patients who received autologous marrow transplants for hematologic malignancies. All patients were treated with total-body irradiation (TBI), with or without other chemotherapeutic agents. Seven patients (10%) developed IP, 3 were due to cy...

journal_title：Transplantation

authors： Pecego R,Hill R,Appelbaum FR,Amos D,Buckner CD,Fefer A,Thomas ED

更新日期：1986-11-01 00:00:00

abstract：:The influence of ultraviolet (UVB) irradiation on the survival of H-2 class II-disparate skin grafts was studied in congenic mouse strains. Isolated skin was UVB irradiated in vitro at a dose of 40 mJ/cm2 from both sides to remove Ia immunogenicity. Immediately after irradiation the skin was transplanted onto the flan...

journal_title：Transplantation

authors： Vermeer BJ,Santerse B,Van De Kerckhove BA,Schothorst AA,Claas FH

更新日期：1988-03-01 00:00:00

abstract：:We developed and applied a quantitative competitive polymerase chain reaction method to study the expression of various cytokine genes in Con A-stimulated murine splenocytes. This method relies on the use of competitive templates that differ from the target cytokine cDNA templates only by the introduction of a unique ...

journal_title：Transplantation

authors： Zheng XX,Strom TB,Steele AW

更新日期：1994-07-15 00:00:00

abstract：BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...

journal_title：Transplantation

authors： Zaitsu M,Yamashita K,Shibasaki S,Tsunetoshi Y,Fukai M,Ogura M,Yoshida T,Igarashi R,Kobayashi N,Umezawa K,Todo S

更新日期：2015-05-01 00:00:00

abstract：:Since major histocompatibility (MHC) antigen matching was introduced in the early 1970s as the key factor determining kidney transplant allocation, several studies, mainly arising from organ-sharing organizations in the United States and Europe, have debated this complex issue. The first fundamental concern is the int...

journal_title：Transplantation

authors： Hiesse C,Pessione F,Houssin D

更新日期：2004-02-27 00:00:00

abstract：BACKGROUND:In an attempt to reduce chronic calcineurin inhibitor induced allograft nephropathy in first cadaver and human leukocyte antigen non-identical living-donor renal transplantation, sirolimus (Siro) or mycophenolate mofetil (MMF) was tested as adjunctive therapy, with planned dose reductions of tacrolimus (Tacr...

journal_title：Transplantation

authors： Ciancio G,Burke GW,Gaynor JJ,Mattiazzi A,Roth D,Kupin W,Nicolas M,Ruiz P,Rosen A,Miller J

更新日期：2004-01-27 00:00:00

abstract：:BACKGROUND.: Reduced levels of serum adiponectin, an adipokine, are associated with cardiovascular and obesity-related diseases; however, relations between adiponectin and hypertension are unclear. METHODS.: This cross-sectional study examined adiponectin and ambulatory blood pressure monitoring (ABPM) in 33 pediatric...

journal_title：Transplantation

authors： Sethna CB,Leonard MB,Gallagher PR,Meyers KE

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks per day) are scanty. METHODS:Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with non-HD (ND) donors. RESULTS:Of 56 182 firs...

journal_title：Transplantation

authors： Arora SS,Chahal KS,Axley P,Eckhoff DE,Kuo YF,Satapathy SK,Wiesner R,Singal AK

更新日期：2018-11-01 00:00:00