Abstract:
:Controversy exists as to the type of cells present in the urine during renal allograft rejection. In order to resolve this controversy as well as to evaluate the value of urine sediment examination as a means of detecting AR, we quantitated the different cells present in urine during AR using an immunoperoxidase technique and monoclonal antibodies reactive with lymphocytes, monocytes, granulocytes, glomerular epithelial, tubular, and urothelial cells. Urine sediment (n = 176) was examined serially over 3 months in 15 transplant recipients. There were 12 episodes of early posttransplant acute tubular necrosis and 21 episodes of AR. It was possible to detect AR as well as to distinguish AR from ATN. Lymphocyte and tubular cell excretions were increased significantly during AR. Excretion of urothelial cells was also significantly increased during most episodes of AR suggesting that rejection of ureters occurs concomitantly with rejection of the kidneys.
journal_name
Transplantationjournal_title
Transplantationauthors
Segasothy M,Birch DF,Fairley KF,Kincaid-Smith Pdoi
10.1097/00007890-198903000-00017subject
Has Abstractpub_date
1989-03-01 00:00:00pages
482-7issue
3eissn
0041-1337issn
1534-6080journal_volume
47pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::The pig has been considered unsuitable for experimental pancreatic transplantation. In order to develop a model for segmental transplantation, the vascular anatomy was studied in 41 pigs. No variation in venous drainage of the pancrease was found. In contrast, 3 variations of arterial supply were noted. In 29 of the p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00010
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Posttransplantation measurement of soluble CD30 (sCD30) may be useful for identifying kidney graft recipients at risk of impending graft rejection in the early posttransplantation period. METHODS:We measured plasma sCD30 levels and evaluated the levels in relation to the diagnosis of rejection. RESULTS:Rec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000044702.18327.66
更新日期:2003-02-15 00:00:00
abstract:BACKGROUND:Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial. METHODS:We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of dd-cfDNA. Relevant literature was ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003443
更新日期:2020-09-02 00:00:00
abstract:BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral dens...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000164353.86447.db
更新日期:2005-06-27 00:00:00
abstract:BACKGROUND:Injection of neonatal BALB/c mice with semi-allogeneic splenocytes leads to antigen-specific tolerance lasting into adulthood. Tolerant mice accept A/J skin grafts and fail to generate CD8 cytotoxic T lymphocyte (CTL) activity against A/J targets. Anergic CD8 T cells are present in tolerant mice, and CD4 reg...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199912270-00013
更新日期:1999-12-27 00:00:00
abstract::We have investigated retrospectively sera from 70 renal allograft recipients for the presence of antibodies binding to a preanastomosis biopsy of the donor kidney by an indirect immunoperoxidase technique. All recipients had a negative T cell lymphocytotoxic crossmatch. A positive immunoperoxidase crossmatch for kidne...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198812000-00011
更新日期:1988-12-01 00:00:00
abstract::Endothelial cells serve an important role in augmenting immune responses through enhanced expression of MHC class II antigens. Immune-mediated vascular injury associated with rejection requires reendothelialization to restore vascular integrity. The origin of the reparative endothelial cells can be determined when ABO...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199102000-00033
更新日期:1991-02-01 00:00:00
abstract::Cell-mediated cytotoxicity directed toward pancreatic islets plays a significant role in the pathogenesis of type 1 diabetes mellitus. Histologically, autoimmune insulitis appears as mononuclear infiltrates that precede actual beta cell loss. Experimental studies by Bartlett et al. on the BB rat model suggest that who...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00014
更新日期:1996-12-27 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the population pharmacokinetics of tacrolimus in pediatric liver transplant recipients and to identify factors that may explain pharmacokinetic variability. METHODS:Data were collected retrospectively from 35 children who received oral immunosuppressant therapy with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200109270-00013
更新日期:2001-09-27 00:00:00
abstract:BACKGROUND:Insults to the airway epithelium play a key role in constrictive bronchiolitis after lung transplantation, the typical hallmark of chronic rejection. Our hypothesis is that immunosuppressives might affect airway integrity. METHODS:A biculture of human bronchial epithelial cells and lung microvascular endoth...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001809
更新日期:2017-12-01 00:00:00
abstract::A monoclonal anti-Lyt-1.1 serum has been characterized in terms of its effect on various cell populations involved in cell-mediated immune responses. The monoclonal serum was compared to a conventionally prepared anti-Lyt-1.1 serum. Cytotoxic T cell precursors and effectors were found to be Lyt-1.1+. Helper T cells wh...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198101000-00013
更新日期:1981-01-01 00:00:00
abstract::Distribution of cadaveric donor kidneys, based upon the donor-recipient HLA match grade, remains one of the major controversies in transplantation. To determine whether matching results in fewer rejection episodes and better graft survival, we retrospectively studied our single-center patient population of 683 cyclosp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199311000-00037
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:We evaluated the importance and mechanism of graft and host accommodation in hamster-to-rat cardiac xenotransplantation models. METHODS:To evaluate graft accommodation, accommodated hamster grafts (Group 2) were transplanted to naïve host rats treated with FK506, and compared with naïve hamster grafts (Grou...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000296030.88283.92
更新日期:2008-01-15 00:00:00
abstract:BACKGROUND:Altered expression of murine MD-1, a molecule controlling expression of members of the interleukin (IL)-1 receptor family of signaling proteins, regulates antigen-presenting cell-induced alloreactions. We investigated the effect of treatment with antisense deoxyoligonucleotides or antibodies to MD-1 in vivo ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200206150-00013
更新日期:2002-06-15 00:00:00
abstract:OBJECTIVES:To determine whether humoral autoimmune responses associated with dilated cardiomyopathy (DCM) influence the postoperative clinical course following cardiac transplantation. METHODS:ELISA levels of preformed cardiac myosin (CM) autoantibodies (Abs) in patients with a pretransplant diagnosis of dilated cardi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200004270-00015
更新日期:2000-04-27 00:00:00
abstract::Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-199809270-00001
更新日期:1998-09-27 00:00:00
abstract:BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000023
更新日期:2014-07-15 00:00:00
abstract::The histopathological features of chronic rejection and its initiation were assessed using rat heterotopic heart transplantation and retransplantation models. Fully allogeneic or minor, non-MHC antigen-mismatch heart grafts transplanted into recipient rats treated with a short course of FK506 showed long-term survival...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199511270-00002
更新日期:1995-11-27 00:00:00
abstract:BACKGROUND:The influence of the preservation solution used for in situ perfusion of the donor and pancreas storage on islet isolation has received little attention. METHODS:In this prospective controlled trial, we compared the outcome of human islet isolation from pancreata perfused with University of Wisconsin (UW) s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000251723.97483.16
更新日期:2007-02-15 00:00:00
abstract::Transcription factors of the nuclear factor of activated T cells (NFAT) family regulate both immune activation and insulin production. Calcineurin inhibitors (CNIs) target NFAT activation. Hence, CNIs not only prevent organ transplant rejection but also contribute to the development of new-onset diabetes after transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823f7f26
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:Toxicity of current immunosuppressive agents to islet grafts is one of the major obstacles to clinical islet transplantation (Tx). This study was designed to assess the efficacy of FTY720, a novel immunomodulator with a unique mechanism of action, on islet graft survival and function in streptozotocin (STZ)-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200205150-00011
更新日期:2002-05-15 00:00:00
abstract:BACKGROUND:The use of liver allografts from an older donor (OD) (age>50 years) is a widespread strategy to manage the disparity between supply and demand of organs for liver transplantation. This study determines the effect of OD allografts on fibrosis progression and graft survival after liver transplantation in patie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000095896.07048.BB
更新日期:2004-01-15 00:00:00
abstract:BACKGROUND:CTLA4IgG that binds to B7 effectively inhibits the signaling of CD28/B7 pathway and induces antigen-specific T-cell unresponsiveness in vitro and in vivo. We examined whether the development of obliterative bronchiolitis in a murine heterotopic airway transplantation model is T cell dependent and whether CTL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003150-00012
更新日期:2000-03-15 00:00:00
abstract:BACKGROUND:Liver transplant recipients suffer many postoperative complications. Few studies evaluated the effects of fluid management on these complications. We conducted an observational cohort study to evaluate the association between intraoperative fluid balance and postoperative acute kidney injury (AKI) and other ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002998
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Chronically elevated vasopressin (VP) plasma levels have been shown to induce accelerated renal function decline in rats with chronic renal failure. Whether endogenous VP is a renal risk factor in humans has not been investigated yet. We aimed to investigate whether, in renal transplant recipients, VP concen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b11ae4
更新日期:2009-08-27 00:00:00
abstract::We have previously demonstrated that the placental spongiotrophoblast and yolk sac venous plexus express paternally derived H-2K and D (class I) antigens in a manner accessible to maternal circulation, and that the placenta serves to prevent antipaternal antibodies from reaching the fetus. Kinetic studies indicated th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198403000-00016
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Hemorrhagic cystitis (HC) is an important cause of morbidity in patients undergoing allogeneic stem-cell transplantation (SCT). Various causes have been identified, such as the use of high-dose cyclophosphamide or busulfan and the occurrence of acute graft-versus-host disease or viral infections (cytomegalov...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200210270-00024
更新日期:2002-10-27 00:00:00
abstract:BACKGROUND:Encapsulated cell therapy might be a promising approach to enable cell transplantation without immunosuppression. This study investigates the viability and hepatic function of hepatocytes encapsulated with alginate/poly-L-lysine in vitro and the effect of the intrasplenic transplantation of cultured encapsul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000156319.47645.3b
更新日期:2005-04-15 00:00:00
abstract:BACKGROUND:Gene targeting in large animals has the potential to be useful in medicine as well as in agriculture. Previously, we reported the first successful targeting of the bovine alpha1,3-galactosyltransferase (alpha1,3GT) gene and establishment of a heterozygous knockout cell line. In this report, we generated both...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000190422.66657.f1
更新日期:2006-03-15 00:00:00
abstract::Allotransplantation into immunosuppressed individuals results in long-term survival of grafts. However, the grafts are damaged, probably at many stages before, during and after implantation. The hypothesis to be presented is that release of antigens and autoantigens from the chronically damaged graft results in breaki...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000153294.38939.5f
更新日期:2005-02-15 00:00:00