The Immunology of Posttransplant CMV Infection: Potential Effect of CMV Immunoglobulins on Distinct Components of the Immune Response to CMV.

abstract：BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

journal_title：Transplantation

authors： Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

更新日期：2003-05-15 00:00:00

abstract：BACKGROUND:Many models of transplant tolerance have been found to depend on the induction of regulatory T cells (Tregs). Innate immune signals are known to suppress Tregs thereby augmenting immunity by abrogating Treg function. Such signals may also provide a barrier to transplantation tolerance mediated by Tregs. A nu...

journal_title：Transplantation

authors： Sonawane SB,Kim JI,Lee MK,Lee SH,Duff PE,Moore DJ,Lian MM,Deng S,Choi Y,Yeh H,Caton AJ,Markmann JF

更新日期：2009-11-27 00:00:00

abstract：:If ABO antigens/antibodies play any role in the pathogenesis of acute graft-versus-host disease (GVHD), one would expect the highest incidence of GVHD in recipients of minor ABO-mismatched grafts, followed by ABO-matched grafts, and the lowest incidence in major ABO-mismatched transplants. To test this hypothesis 174 ...

journal_title：Transplantation

authors： Bacigalupo A,Van Lint MT,Occhini D,Margiocco M,Ferrari G,Pittaluga PA,Frassoni F,Peralvo J,Lercari G,Carubia F

更新日期：1988-06-01 00:00:00

abstract：:We present a case report of a pediatric orthotopic liver transplant recipient who developed lymphoma with hypercalcemia on cyclosporine and prednisone immunosuppression. This is the first reported posttransplant lymphoproliferative disorder complicated by hypercalcemia, with a finding of an elevated 1,25 dihydroxyl vi...

journal_title：Transplantation

authors： Nakazato P,Esquivel CO,Urbach AH,Makowka L,Scantlebury V,Jaffe R,Starzl TE

更新日期：1989-12-01 00:00:00

abstract：:Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that c...

journal_title：Transplantation

authors： Hebert MF,Zheng S,Hays K,Shen DD,Davis CL,Umans JG,Miodovnik M,Thummel KE,Easterling TR

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:The effect of cyclosporine A (CsA) on polyomavirus BK virus (BKV) replication remains unclear. The aim of this in vitro study was to investigate the effect of CsA on BKV replication in human uroepithelial cells. METHODS:After infection of a human renal proximal tubular cell line, HK-2 with BKV, BKV viral lo...

journal_title：Transplantation

authors： Li YJ,Weng CH,Lai WC,Wu HH,Chen YC,Hung CC,Yang CW,Tian YC

更新日期：2010-02-15 00:00:00

abstract：BACKGROUND:Acute rejection (AR) of the transplanted kidney has been identified as the major risk factor for the development of chronic rejection and immunological graft loss. However, the clinical presentation and response to AR therapy can vary considerably between recipients. METHODS:We studied the first AR episode ...

journal_title：Transplantation

authors： Ishikawa A,Flechner SM,Goldfarb DA,Myles JL,Modlin CS,Boparai N,Papajcik D,Mastroianni B,Novick AC

更新日期：1999-11-15 00:00:00

abstract：:Loss of bile ducts is a characteristic feature of chronic rejection in the liver allograft (also known as irreversible rejection and vanishing bile-duct syndrome). Typically, this occurs as a progressive lesion resulting in irreversible damage and graft failure requiring retransplantation. In this study, we describe 6...

journal_title：Transplantation

authors： Hubscher SG,Buckels JA,Elias E,McMaster P,Neuberger J

更新日期：1991-05-01 00:00:00

abstract：:ICAM-1 is an inducible glycoprotein important in the adhesion, activation, and transmigration of circulating leukocytes across the vascular endothelial monolayer, and it likely plays a key role in the allogeneic response. To determine the reproducibility and significance of variations in resting levels of cell surface...

journal_title：Transplantation

authors： Everett JP,Shipley GD,Mauck KA,Wagner CR,Morris TE,Hosenpud JD

更新日期：1994-10-27 00:00:00

abstract：BACKGROUND:Allogeneic bone marrow transplantation (BMT) and donor lymphocyte infusion (DLI) provide valuable treatments for a range of diseases. However, the therapeutic utility of BMT and DLI is reduced by the high incidence of graft-versus-host disease (GvHD) mediated by activated donor T lymphocytes directed against...

journal_title：Transplantation

authors： Georgantas RW 3rd,Bohana-Kashtan O,Civin CI

更新日期：2006-08-27 00:00:00

abstract：:A patient with end-stage renal disease and known benign monoclonal gammopathy underwent kidney transplantation at Westchester County Medical Center, Valhalla, NY. After surgery, during routine follow-up, the patient had laboratory evidence of frank multiple myeloma. However, she did not show any clinical signs or symp...

journal_title：Transplantation

authors： Dagher F,Sammett D,Abbi R,Tomasula JR,Delaney V,Butt KM

更新日期：1996-12-15 00:00:00

abstract：:OKT3 is considered to be effective in the prophylaxis and treatment of rejection. However, anti-OKT3 immunization is still a major side-effect. Only the IgG antiidiotypic component of the response is responsible for neutralization of OKT3 therapeutic activity by inhibiting OKT3's binding to T cells (i.e., blocking ant...

journal_title：Transplantation

authors： Legendre C,Kreis H,Bach JF,Chatenoud L

更新日期：1992-01-01 00:00:00

abstract：:Immunosuppressive therapy increases the risk of recurrence of initial cancers in organ transplant patients, and compelling therapeutic protocols are needed to suppress the malignancy and protect the allograft. We examined the potential use of 15-deoxyspergualin (DSG) in relation to organ transplantation and cancer. Th...

journal_title：Transplantation

authors： Ohsawa I,Uemoto S,Kobayashi E,Murakami T

更新日期：2007-08-15 00:00:00

abstract：BACKGROUND:Administration of donor bone marrow (BM)-derived dendritic cell (DC) progenitors (DCp) that are major histocompatibility complex (MHC) class II+ but costimulatory molecule (CD40, CD80, CD86)-deficient can prolong mouse heart allograft survival This is associated with microchimerism and inhibition of antidono...

journal_title：Transplantation

authors： Lee WC,Zhong C,Qian S,Wan Y,Gauldie J,Mi Z,Robbins PD,Thomson AW,Lu L

更新日期：1998-12-27 00:00:00

abstract：BACKGROUND:The beneficial effects of glycemic control on both survival and function of transplanted kidneys in patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) have been recognized. METHODS:Herein, we present the clinical outcome of a single-center pilot trial of islet after kidney (IAK...

journal_title：Transplantation

authors： Cure P,Pileggi A,Froud T,Messinger S,Faradji RN,Baidal DA,Cardani R,Curry A,Poggioli R,Pugliese A,Betancourt A,Esquenazi V,Ciancio G,Selvaggi G,Burke GW 3rd,Ricordi C,Alejandro R

更新日期：2008-03-27 00:00:00

abstract：BACKGROUND:Goal tacrolimus concentrations for the prevention of rejection in sensitized renal transplant recipients are not well established. METHODS:We evaluated the association between discharge tacrolimus trough concentration and the incidence of biopsy-proven acute rejection (BPAR) in 216 moderately sensitized ren...

journal_title：Transplantation

authors： Richards KR,Hager D,Muth B,Astor BC,Kaufman D,Djamali A

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Previous reports have established the feasibility of using livers from controlled, non-heart-beating donors (CNHBD) with good immediate graft function. This has been largely borne out of necessity because of the donor shortage. METHODS:Retrospective database review for the last 7 years (1995-2002), encompas...

journal_title：Transplantation

authors： Manzarbeitia CY,Ortiz JA,Jeon H,Rothstein KD,Martinez O,Araya VR,Munoz SJ,Reich DJ

更新日期：2004-07-27 00:00:00

abstract：BACKGROUND:Primary hyperoxaluria type-1 (PH1) is an autosomal recessive disease characterized by excessive oxalate production by hepatocytes caused by the deficiency of peroxisomal alanine-glyoxylate aminotransferase (AGT) activity. Persistent hyperoxaluria causes nephrocalcinosis and urolithiasis, leading to renal fai...

journal_title：Transplantation

authors： Jiang J,Salido EC,Guha C,Wang X,Moitra R,Liu L,Roy-Chowdhury J,Roy-Chowdhury N

更新日期：2008-05-15 00:00:00

abstract：BACKGROUND:Apoptosis has been identified after ischemia-reperfusion (IR) injury to the brain, heart, kidney, retina, and the adrenals. Intestinal IR injury causes villous and crypt damage, which has so far been attributed to cellular necrosis. This study was undertaken to investigate the possible role of apoptosis afte...

journal_title：Transplantation

authors： Shah KA,Shurey S,Green CJ

更新日期：1997-11-27 00:00:00

abstract：:Israel's rates of organ donation have been one of the lowest among developed countries. An attempt to change this has led to the introduction of a pioneering new law, the Organ Transplant Act 2008, which came into effect in January 2010 and sets out principles underlying a new policy in relation to the allocation of o...

journal_title：Transplantation

authors： Quigley M,Wright L,Ravitsky V

更新日期：2012-05-27 00:00:00

abstract：BACKGROUND:Altered expression of murine MD-1, a molecule controlling expression of members of the interleukin (IL)-1 receptor family of signaling proteins, regulates antigen-presenting cell-induced alloreactions. We investigated the effect of treatment with antisense deoxyoligonucleotides or antibodies to MD-1 in vivo ...

journal_title：Transplantation

authors： Hadidi S,Chen Z,Phillips J,Yu K,Gorczynski RM

更新日期：2002-06-15 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the population pharmacokinetics of tacrolimus in pediatric liver transplant recipients and to identify factors that may explain pharmacokinetic variability. METHODS:Data were collected retrospectively from 35 children who received oral immunosuppressant therapy with ...

journal_title：Transplantation

authors： Staatz CE,Taylor PJ,Lynch SV,Willis C,Charles BG,Tett SE

更新日期：2001-09-27 00:00:00

abstract：BACKGROUND:Although inactivated vaccines are recommended for immunocompromized patients, efficacy and safety of diphtheria and tetanus immunization in renal transplant recipients have received little attention so far. The aim of the study was to investigate the response to a standard diphtheria and tetanus booster vacc...

journal_title：Transplantation

authors： Enke BU,Bökenkamp A,Offner G,Bartmann P,Brodehl J

更新日期：1997-07-27 00:00:00

abstract：:The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...

journal_title：Transplantation

authors： Shelton JA,Goldberg EH

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The need to find a safe, effective liver support system for patients with fulminant hepatic failure (FHF) continues to be unmet. A system using immortalized human hepatocytes was originally developed in the early 1990s. A modified version of the initial extracorporeal liver-assist device (ELAD) was recently ...

journal_title：Transplantation

authors： Millis JM,Cronin DC,Johnson R,Conjeevaram H,Conlin C,Trevino S,Maguire P

更新日期：2002-12-27 00:00:00

abstract：:P-31 nuclear magnetic resonance (NMR) spectroscopy was used to evaluate heterotropic cardiac allograft rejection in the rat. To enable optimal application of NMR spectroscopy for the in vivo study of myocardial metabolism in the transplanted organ, an accessory heart transplantation to groin in the rat was used. The a...

journal_title：Transplantation

authors： Haug CE,Shapiro JI,Chan L,Weil R 3rd

更新日期：1987-08-01 00:00:00

abstract：:While the immune privilege nature of the eye affords significant protection to corneal grafts, immunologic rejection is the leading cause of graft failure. Class II antigens are normally absent or expressed at very low levels in normal cornea. The role that class II antigens play in causing graft rejection is particul...

journal_title：Transplantation

authors： Ross J,Callanan D,Kunz H,Niederkorn J

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Localization of inflammatory stimuli may direct lung allografts to different phenotypes of chronic dysfunction, such as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). We hypothesized that airway stimulation with lipopolysaccharide (LPS) in rats leads to airway-centered infla...

journal_title：Transplantation

authors： Takahagi A,Sato M,Chen-Yoshikawa TF,Miyamoto E,Saito M,Gochi F,Hamaji M,Yoshizawa A,Terasaki Y,Urushiyama H,Aoyama A,Sonobe M,Date H

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:It is imperative for healthcare providers to examine Western Muslim attitudes on organ donation, because they are reluctant donors. We explored such opinion with the aid of a quantitative survey. METHODS:Voluntary completion of an anonymous survey was promoted (online and paper sampling). For a population t...

journal_title：Transplantation

authors： Sharif A,Jawad H,Nightingale P,Hodson J,Lipkin G,Cockwell P,Ball S,Borrows R

更新日期：2011-11-27 00:00:00

abstract：BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...

journal_title：Transplantation

authors： Molnar MZ,Ravel V,Streja E,Kovesdy CP,Mehrotra R,Kalantar-Zadeh K

更新日期：2016-10-01 00:00:00