Abstract:
BACKGROUND:Co-stimulatory blockade has been shown to prolong allograft survival in different transplant models. We investigated the effect of combining humanized anti-CD80 and anti-CD86 monoclonal antibodies (mAb) with sirolimus in cynomolgus monkey renal transplant recipients. METHODS:After renal transplantation, groups of four animals were treated daily with sirolimus, sirolimus and nine weekly doses of mAb, two weekly doses of mAb, or sirolimus and two weekly doses of mAb. RESULTS:Survival was significantly better in monkeys treated with the combination of sirolimus and mAb when compared with treatment with either agent alone (P=0.0067 by log-rank analysis). When combined with sirolimus, nine weekly doses of mAb did not result in an additional survival benefit compared with only two mAb doses (P=0.74). None of the treatment regimens used in this study resulted in development of transplantation tolerance. CONCLUSIONS:Sirolimus can be successfully combined with humanized mAb against CD80 and CD86. Induction with a short course of mAb is effective in prolonging allograft survival in combination with sirolimus.
journal_name
Transplantationjournal_title
Transplantationauthors
Bîrsan T,Hausen B,Higgins JP,Hubble RW,Klupp J,Stalder M,Celniker A,Friedrich S,O'Hara RM,Morris REdoi
10.1097/01.TP.0000066806.10029.7Asubject
Has Abstractpub_date
2003-06-27 00:00:00pages
2106-13issue
12eissn
0041-1337issn
1534-6080journal_volume
75pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Although it has long been appreciated that establishment of chimerism is important in the acquisition and maintenance of allograft tolerance, the importance of this relationship has been reemphasized recently. Using the exquisite sensitivity of the polymerase chain reaction we have studied qualitatively and quantitati...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199511270-00012
更新日期:1995-11-27 00:00:00
abstract::Intestinal transplantation has become the treatment of choice for patients who are experiencing life-threatening complications of intestinal failure. Early attempts with intestinal transplantation were unsuccessful as a consequence of both technical and immunologic failures. The introduction of tacrolimus provided the...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000126931.23349.15
更新日期:2004-05-15 00:00:00
abstract::A 44-year-old man was maintained on prednisone and azathioprine after renal transplantation. One and a half years after transplantation, he developed multiple perianal Escherichia coli abscesses. These became chronic and resisted antibiotic therapy. Histologically, the lesions were typical of malakoplakia. Peripheral ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract::Single amino acid disparities in MHC class I molecules can elicit transplantation responses. Since beta 2 microglobulin (beta 2m) is noncovalently associated with class I antigens on the cell membrane we investigated whether the single amino acid polymorphism at position 85 (Asp-->Ala) in the mouse beta 2m molecule ca...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601270-00023
更新日期:1996-01-27 00:00:00
abstract::The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198401000-00004
更新日期:1984-01-01 00:00:00
abstract::Frozen sections of lymph nodes from normal mice were examined by immunofluorescence with anti-T lymphocyte and anti-Ig reagents and by autoradiography following [3H]TdR administration. The scattered T lymphocytes present among B lymphocytes of primary follicles were found to be mostly nonproliferating; the few prolife...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198111000-00018
更新日期:1981-11-01 00:00:00
abstract:BACKGROUND:The influence of the preservation solution used for in situ perfusion of the donor and pancreas storage on islet isolation has received little attention. METHODS:In this prospective controlled trial, we compared the outcome of human islet isolation from pancreata perfused with University of Wisconsin (UW) s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000251723.97483.16
更新日期:2007-02-15 00:00:00
abstract:BACKGROUND:We report long-term outcomes and side effects after transplantation for hepatocellular carcinoma (HCC) using de novo, sirolimus-based immunosuppression (IS). METHODS:A total of 70 patients with HCC (mean age: 54.4+/-7 years, female/male: 12/58) were transplanted and included in the study. Immunosuppression ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000262607.95372.e0
更新日期:2007-05-15 00:00:00
abstract::The nephrotoxic effects of cyclosporine (CsA) seem to be augmented by co-existing renal injury. A high rate of prolonged delayed function (acute tubular necrosis [ATN]) and non-function (NF) has been associated with the use of CsA prior to and following renal transplantation. Cyclosporine has also been associated with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198701000-00019
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Monocarboxylate transporter (MCT)-1, a member of a family of molecules, transports monocarboxylates such as lactate. Inhibiting MCT-1 leads to long-term graft survival in rodent heart transplantation and induces tolerance. We evaluated an MCT-1 inhibitor, AS2495674, in a rat heart transplant model and analyz...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ff8818
更新日期:2010-12-27 00:00:00
abstract::The purpose of this study was to describe the clinical presentation, treatment, and outcome of Mycobacterium haemophilum infection in patients undergoing bone marrow transplantation at a cancer center. Bone marrow transplant recipients with M haemophilum infection were identified upon culture of the organism by implem...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-11-15 00:00:00
abstract::During acute rejection of rat renal allografts, numerous activated monocytes accumulate in the vasculature of the graft. These monocytes seem to be involved in allograft destruction. Proinflammatory and effector functions of monocytes and macrophages can be down-regulated by peroxisome proliferators, which are probabl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000052591.91653.52
更新日期:2003-03-15 00:00:00
abstract:BACKGROUND:Knowledge on the reinnervation of transplanted organs is scarce, and the aim of the study was therefore to evaluate to what degree syngeneic pancreas grafts were reinnervated in rats. METHODS:Syngeneic pancreatico-duodenal transplantations were performed in normoglycemic Wistar-Furth rats. Native and transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101150-00002
更新日期:2001-01-15 00:00:00
abstract::The effect of prophylactic i.v. administration of high doses of human gamma-immunoglobulin (IgG) on kidney graft survival was investigated in rhesus monkeys treated with azathioprine and prednisolone. In nontransfused recipients not treated with IgG (controls), graft survival ranged from 9 to 22 days; if nontreated an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198201000-00006
更新日期:1982-01-01 00:00:00
abstract::Increasing numbers of sensitized patients are either precluded from receiving an allograft or experience accelerated rejection which may be refractory to conventional therapy. Using a rat model, we have shown that accelerated (24 hr) rejection of LBN cardiac Tx in LEW rats sensitized with BN skin grafts 7 days earlier...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199002000-00037
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen species. We evaluate...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000305
更新日期:2014-09-27 00:00:00
abstract:BACKGROUND:The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed. METHODS:We performed adult living donor ABO-I-LT on six patients. We used anti-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31815e9672
更新日期:2008-01-27 00:00:00
abstract:BACKGROUND:One of the main concerns after living donor liver transplantation is the risk of morbidity and/or mortality that it imposes on the donors. Respiratory postoperative complications in living liver donors have already been reported but their frequency seems to be underestimated. We designed a prospective study ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000191624.70135.35
更新日期:2006-01-27 00:00:00
abstract::Precision medicine is an emerging integrative approach for disease prevention, early detection, and treatment which takes into account individual variability in genetic and other molecular measurements, medical history, environmental exposures, and lifestyle. The development and availability of genomic and other molec...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001664
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Rat lung allograft rejection is mediated by collagen type V (col(V)) specific T-helper-cell 17 (Th17) cells. Adoptive transfer of these cells is sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allograft rejection. Therefore, we tested whether regulatory T cells f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bcde7b
更新日期:2009-12-27 00:00:00
abstract:BACKGROUND:The incidence of stroke and risk factors for different subtypes of cerebrovascular (CBV) events in renal transplant recipients have not been examined in any large prospective controlled trial. METHODS:The Assessment of Lescol in Renal Transplantation was a randomized, double-blind, placebo-controlled study ...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e31818bfce8
更新日期:2009-01-15 00:00:00
abstract:BACKGROUND:New-onset diabetes after transplantation (NODAT) increases infectious and cardiovascular complications and reduces patient and graft survival. We assessed the incidence and the risk factors for glucose metabolism abnormalities before and after kidney transplantation using an oral glucose tolerance test (OGTT...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31820f0877
更新日期:2011-04-15 00:00:00
abstract:BACKGROUND:In patients with acute liver failure (ALF) of unknown cause, viral infections are believed to be involved. This study investigates the involvement of human herpesvirus-6 (HHV-6). METHODS:Thirty-two patients with ALF who underwent transplantations during a 6-year period were studied for viruses in biopsies f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000069233.13409.DF
更新日期:2003-08-15 00:00:00
abstract:BACKGROUND:Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. METHODS:During 27 months, 30 consecutive heart-lung- and lung-transplant recipients were included on the day of transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000058809.42027.66
更新日期:2003-06-27 00:00:00
abstract::The formation of free radicals after orthotopic liver transplantation in the rat correlates with graft failure. Fatty livers from alcoholics transplant poorly, so these studies were designed to examine the effect of alcohol on free radical formation in a rearterialized rat liver transplantation model. Treatment of rat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199503150-00005
更新日期:1995-03-15 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent endothelial cell growth and permeability factor, expressed in the lung. Overexpression of VEGF is associated with increased vascular permeability in the early stage of acute lung injury in mice. The role of various forms of VEGF in transplantation-induced...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200206150-00003
更新日期:2002-06-15 00:00:00
abstract::Idarubicin was conjugated to anti-Ly-2.1 and anti-L3T4 monoclonal antibodies. These conjugates were used to investigate their effects on skin graft survival in mice. Several donor and recipient combinations were used so that the effect of individual or mixtures of conjugates on class I and class II antigenic differenc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00018
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVES:To determine whether humoral autoimmune responses associated with dilated cardiomyopathy (DCM) influence the postoperative clinical course following cardiac transplantation. METHODS:ELISA levels of preformed cardiac myosin (CM) autoantibodies (Abs) in patients with a pretransplant diagnosis of dilated cardi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200004270-00015
更新日期:2000-04-27 00:00:00
abstract:BACKGROUND:Although the clinical features of early hepatic artery thrombosis (HAT) are well defined, the features of delayed (more than 4 weeks after transplantation) hepatic artery thrombosis are less clearly defined. The aim of our study was to identify risk factors, clinical presentation, and outcome of management o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200106150-00018
更新日期:2001-06-15 00:00:00
abstract:BACKGROUND:In an attempt to reduce chronic calcineurin inhibitor induced allograft nephropathy in first cadaver and human leukocyte antigen non-identical living-donor renal transplantation, sirolimus (Siro) or mycophenolate mofetil (MMF) was tested as adjunctive therapy, with planned dose reductions of tacrolimus (Tacr...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.TP.0000101495.22734.07
更新日期:2004-01-27 00:00:00