Cerebrovascular events in renal transplant recipients.


BACKGROUND:The incidence of stroke and risk factors for different subtypes of cerebrovascular (CBV) events in renal transplant recipients have not been examined in any large prospective controlled trial. METHODS:The Assessment of Lescol in Renal Transplantation was a randomized, double-blind, placebo-controlled study of the effect of fluvastatin (40-80 mg) daily on cardiovascular, and renal outcomes in renal transplant recipients. Patients initially randomized to fluvastatin or placebo in the 5 to 6 year trial was offered open-label fluvastatin in a 2-year extension to the original study. We investigated the incidence of stroke and risk factors for ischemic and hemorrhagic CBV events in 2102 renal graft recipients participating in the Assessment of Lescol in Renal Transplantation core and extension trial with a mean follow-up of 6.7 years. RESULTS:The incidence and type of CBV events did not differ between the lipid lowering arm and the placebo arm. A total of 184 (8.8%, 95% confidence interval 4.6-12.9) of 2102 patients experienced a CBV event during follow-up, corresponding to an incidence of 1.3% CBV event per year. The mortality for patients experiencing a hemorrhagic stroke was 48% (13 of 27), whereas the mortality for ischemic strokes was 6.0% (8 of 133). Diabetes mellitus, previous CBV event, age, and serum creatinine were independent risk factors for cerebral ischemic events. The risk of a hemorrhagic cerebral event was increased by diabetes mellitus, polycystic kidney disease, left ventricular hypertrophy, and systolic blood pressure. INTERPRETATION:Risk factors for CBV events in renal transplant recipients differ according to subtype.






Abedini S,Holme I,Fellström B,Jardine A,Cole E,Maes B,Holdaas H,ALERT Study Group.




Has Abstract


2009-01-15 00:00:00














  • Differential immune response to influenza and pneumococcal vaccination in immunosuppressed patients after heart transplantation.

    abstract:INTRODUCTION:Patients after solid organ transplantation are at an increased risk for microbial infections. Due to therapeutic immunosuppression, the response to active immunizations may be reduced. The serological efficacy of pneumococcal and influenza vaccination was studied in heart transplant recipients. PATIENTS A...


    pub_type: 杂志文章


    authors: Dengler TJ,Strnad N,Bühring I,Zimmermann R,Girgsdies O,Kubler WE,Zielen S

    更新日期:1998-11-27 00:00:00

  • Conversion from cyclosporine to azathioprine in renal allograft recipients.

    abstract::Fifty seven recipients of renal allografts initially treated with CsA and low-dose prednisone were switched to azathioprine and low-dose steroids. Ten had prolonged (greater than 28 days) allograft nonfunction after transplantation (group 1), 8 had ongoing, poorly controlled rejection (group 2), and 39 had stable func...


    pub_type: 杂志文章


    authors: Rocher LL,Milford EL,Kirkman RL,Carpenter CB,Strom TB,Tilney NL

    更新日期:1984-12-01 00:00:00

  • Rapid rejection of HLA-A2 transgenic skin graft due to indirect allorecognition.

    abstract:BACKGROUND:At present, it is not clear whether xenogeneic MHC molecules are recognized by T cells directly or indirectly through self-MHC-restricted presentation in a transplantation setting. METHODS:We have transplanted skin from HLA-A2 transgenic (B6.A2) to nontransgenic C57BL/6 (B6) mice and investigated the subseq...


    pub_type: 杂志文章


    authors: Jurcevic S,Chandler P,Sacks SH,Simpson E

    更新日期:2001-09-27 00:00:00

  • Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.

    abstract::The mission of the recently established Immune Tolerance Network includes the development of protocols for the induction of transplant tolerance in organ allograft recipients and the development of assays that correlate with and may be predictive of the tolerant state. The state of clinical organ transplant tolerance ...


    pub_type: 杂志文章,评审


    authors: Thomson AW,Mazariegos GV,Reyes J,Donnenberg VS,Donnenberg AD,Bentlejewski C,Zahorchak AF,O'Connell PJ,Fung JJ,Jankowska-Gan E,Burlingham WJ,Heeger PS,Zeevi A

    更新日期:2001-10-27 00:00:00

  • Minimal blood loss living donor hepatectomy.

    abstract:BACKGROUND:Donor hepatectomy with maximal safety while preserving graft viability is of principal concern in living donor liver transplantation. There are compelling reasons for avoiding blood transfusion, even with autologous blood, to avoid the potential risks it imposes on healthy donors. This study aims to describe...


    pub_type: 杂志文章


    authors: Chen CL,Chen YS,de Villa VH,Wang CC,Lin CL,Goto S,Wang SH,Cheng YF,Huang TL,Jawan B,Cheung HK

    更新日期:2000-06-27 00:00:00

  • The response to interferon of NK and K cells from conventionally immunosuppressed and cyclosporine-treated renal allograft recipients.

    abstract::Interferon is a potent stimulator of natural killer (NK) and killer (K) cell activity in human beings, both these cytotoxic functions representing host defense mechanisms against viral infections and lymphoid malignancy. Both NK and K cell functions are markedly impaired in conventionally immunosuppressed allograft re...


    pub_type: 杂志文章


    authors: Guillou PJ,Hegarty JH,Ramsden CW,Giles GR

    更新日期:1984-08-01 00:00:00

  • Financial incentives for cadaver organ donation: an ethical reappraisal.

    abstract::A panel of ethicists, organ procurement organization executives, physicians, and surgeons was convened by the sponsorship of the American Society of Transplant Surgeons to determine whether an ethically acceptable pilot trial could be proposed to provide a financial incentive for a family to consent to the donation of...


    pub_type: 杂志文章


    authors: Arnold R,Bartlett S,Bernat J,Colonna J,Dafoe D,Dubler N,Gruber S,Kahn J,Luskin R,Nathan H,Orloff S,Prottas J,Shapiro R,Ricordi C,Youngner S,Delmonico FL

    更新日期:2002-04-27 00:00:00

  • Role of ischemic preconditioning and the portosystemic shunt in the prevention of liver and lung damage after rat liver transplantation.

    abstract:BACKGROUND:This study evaluates whether surgical strategies such as the portosystemic shunt and ischemic preconditioning can protect against hepatic and pulmonary injury associated with liver transplantation. METHODS:The effect of the portosystemic shunt, ischemic preconditioning, and both surgical procedures together...


    pub_type: 杂志文章


    authors: Fernández L,Heredia N,Peralta C,Xaus C,Roselló-Catafau J,Rimola A,Marco A,Serafín A,Deulofeu R,Gelpí E,Grande L

    更新日期:2003-07-27 00:00:00

  • Long-term Safety of Living Kidney Donation in an Emerging Economy.

    abstract:BACKGROUND:Long-term follow-up and management of donors was undertaken in a specialist kidney transplant unit in Pakistan to identify risk and prevent adverse outcomes in living related kidney donors. METHODS:In an observation cohort study between 1985 and 2012, 3748 donors were offered free medical follow-up and trea...


    pub_type: 杂志文章


    authors: Rizvi SA,Zafar MN,Jawad F,Aziz T,Hussain Z,Hashmi A,Hussain M,Akhtar F,Ahmed E,Naqvi R,Naqvi SA

    更新日期:2016-06-01 00:00:00

  • Combined nephrotoxic effects of cyclosporine and endotoxin.

    abstract::This study presents experimental evidence that cyclosporine (CsA) potentiates the nephrotoxicity of endotoxin. This study was motivated by clinical observations in 4 cyclosporine (CsA)-treated renal allograft recipients who developed severe, and sometimes irreversible, nephrotoxicity after infections. CsA or vehicle w...


    pub_type: 杂志文章


    authors: Cosio FG,Innes JT,Nahman NS Jr,Mahan JD,Ferguson RM

    更新日期:1987-09-01 00:00:00

  • An effective immune-monitoring protocol based on gene expression profiles in the peripheral T-cell fraction reactive to graft antigens.

    abstract:BACKGROUND:The ability to induce tolerance, or at least minimize the need for immunosuppressive therapy, is a high priority in organ transplantation. Accomplishing this goal requires a novel method for determining when a patient has become tolerant to or is rejecting their graft. Here, we sought to develop an efficient...


    pub_type: 杂志文章


    authors: Lim DG,Park YH,Kim SE,Jung EJ,Jeong SH,Lee H,Shin SJ,Park CS,Han DJ,Kim SC

    更新日期:2012-10-27 00:00:00

  • IgA class antibodies and flow cytometric cross-matching in renal transplantation.

    abstract:BACKGROUND:The established method of pretransplant cross-matching does not detect IgA antibodies, and IgA antibodies have thus been ignored when assessing patients for transplantation. The aim of this study was to detect IgA allo- and autoreactive antibodies using flow cytometry and to correlate the results with transp...


    pub_type: 杂志文章


    authors: Doran TJ,Süsal C,Opelz G,Geczy AF

    更新日期:1999-01-27 00:00:00

  • The regulatory/cytotoxic graft-infiltrating T cells differentiate renal allograft borderline change from acute rejection.

    abstract::The interpretation of cellular infiltrate from renal transplant recipients with borderline (BL) changes is still a challenging problem. To analyze the immune phenotype of such infiltrate, we quantified the mRNA expression of Foxp3 and interleukinL-10 and granzyme B (GB) in 15 kidney biopsies with BL changes. Controls ...


    pub_type: 杂志文章


    authors: Grimbert P,Mansour H,Desvaux D,Roudot-Thoraval F,Audard V,Dahan K,Berrehar F,Dehoulle-Poillet C,Farcet JP,Lang P,Le Gouvello S

    更新日期:2007-02-15 00:00:00

  • B cells in cluster or in a scattered pattern do not correlate with clinical outcome of renal allograft rejection.

    abstract:BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...


    pub_type: 杂志文章


    authors: Scheepstra C,Bemelman FJ,van der Loos C,Rowshani AT,van Donselaar-Van der Pant KA,Idu MM,ten Berge IJ,Florquin S

    更新日期:2008-09-27 00:00:00

  • The role of graft and host accommodation in a hamster-to-rat cardiac transplantation model.

    abstract:BACKGROUND:We evaluated the importance and mechanism of graft and host accommodation in hamster-to-rat cardiac xenotransplantation models. METHODS:To evaluate graft accommodation, accommodated hamster grafts (Group 2) were transplanted to naïve host rats treated with FK506, and compared with naïve hamster grafts (Grou...


    pub_type: 杂志文章


    authors: Komori K,Fuchimoto Y,Morikawa Y,Obara H,Kawachi S,Tanabe M,Hoshino K,Shimazu M,Matsuzaki Y,Kitajima M

    更新日期:2008-01-15 00:00:00

  • mTOR Inhibition Role in Cellular Mechanisms.

    abstract::The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a pivotal role in cellular metabolism and in a wide range of eukaryotic biological/cellular functions and signaling networks. Additionally, as ...


    pub_type: 杂志文章,评审


    authors: Zaza G,Granata S,Caletti C,Signorini L,Stallone G,Lupo A

    更新日期:2018-02-01 00:00:00

  • Monocyte-derived dendritic cell precursors facilitate tolerance to heart allografts after total lymphoid irradiation.

    abstract:BACKGROUND:Previous studies have shown that posttransplant total lymphoid irradiation, anti-thymocyte globulin, and an intravenous donor blood cell infusion induce tolerance to ACI heart allografts in Lewis rat hosts. METHODS:In the current study, fresh ACI monocytes and dendritic cell precursors, derived from short-t...


    pub_type: 杂志文章


    authors: Hayamizu K,Huie P,Sibley RK,Strober S

    更新日期:1998-11-27 00:00:00

  • Mucosal plasma cell barrier disruption during intestine transplant rejection.

    abstract:BACKGROUND:Intestinal allograft mucosa undergoes repopulation with host immunocytes. However, critical changes within key immunocyte subsets are not known. METHODS:To explain acute cellular rejection after intestine transplantation (ITx) on the basis of altered mucosal immunocytes, rejecting and rejection-free ITx all...


    pub_type: 杂志文章


    authors: Ningappa M,Ashokkumar C,Ranganathan S,Schmitt L,Higgs BW,Sun Q,Branca M,Mazariegos G,Zeevi A,Abu-Elmagd K,Squires R,Rudolph J,Alissa F,Hakonarson H,Sindhi R

    更新日期:2012-12-27 00:00:00

  • Prevention of complement-mediated activation of xenogeneic endothelial cells in an in vitro model of xenograft hyperacute rejection by C1 inhibitor.

    abstract::The complement system plays a major role in hyperacute rejection of discordant xenografts. In an immediately vascularized xenograft of a porcine organ to a primate, natural antibodies bind to the vascular endothelium of the graft, triggering activation of complement via the classical pathway. One consequence of antibo...


    pub_type: 杂志文章


    authors: Dalmasso AP,Platt JL

    更新日期:1993-11-01 00:00:00

  • Induction of delayed hypersensitivity to alloantigens coinjected with Langerhans cells into the anterior chamber of the eye. Abrogation of anterior chamber-associated immune deviation.

    abstract::Inoculation of P815 tumor cells (DBA/2 origin) into the anterior chamber of eyes of BALB/c mice normally produces anterior chamber-associated immune deviation (ACAID) whereby delayed hypersensitivity (DH) responses to the minor H alloantigens of the tumor cells are suppressed. Based on our previous work showing an ass...


    pub_type: 杂志文章


    authors: Williamson JS,Streilein JW

    更新日期:1989-03-01 00:00:00

  • Antilymphocytic antibodies and bone marrow transplantation. XI. Evidence that reduced Thy-1 expression in Thy-1.1 mice prevents suppression of graft-versus-host disease with anti-Thy-1 monoclonal antibodies.

    abstract::Considerable variations in the suppression of graft-versus-host disease with monoclonal anti-Thy-1 antibodies were found to relate to substantial differences noted in the expression of mouse Thy-1 marker on lymph node and spleen cells of Thy-1.1 (AKR/J, C57BL/6.Thy-1.1) and Thy 1.2 (AKR/Cu, C57BL/6) mice. Thy-1.1 mice...


    pub_type: 杂志文章


    authors: Mysliwietz J,Thierfelder S,Hoffmann-Fezer G,Kummer U

    更新日期:1990-04-01 00:00:00

  • Race, Risk, and Willingness of End-Stage Renal Disease Patients Without Hepatitis C Virus to Accept an HCV-Infected Kidney Transplant.

    abstract:BACKGROUND:Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants of willingness to accept HCV-infected kidneys among HCV-negative patients. METHODS:At 2 centers, 189 patients undergoing initial or reev...


    pub_type: 杂志文章


    authors: McCauley M,Mussell A,Goldberg D,Sawinski D,Molina RN,Tomlin R,Doshi SD,Abt P,Bloom R,Blumberg E,Kulkarni S,Esnaola G,Shults J,Thiessen C,Reese PP

    更新日期:2018-04-01 00:00:00

  • Treatment and prevention of acute graft-versus-host disease with thalidomide in a rat model.

    abstract::We have investigated the immunosuppressive effects of thalidomide (Thal) in a bone marrow transplant (BMT) model for graft-versus-host disease (GVHD). Lewis rats received RT1-incompatible marrow transplants from ACI rats after total-body irradiation. Twenty-two of twenty-three rats with established severe acute GVHD w...


    pub_type: 杂志文章


    authors: Vogelsang GB,Hess AD,Gordon G,Santos GW

    更新日期:1986-05-01 00:00:00

  • Hemorrhagic cystitis after bone marrow transplantation. Risk factors and complications.

    abstract::Hemorrhagic cystitis (HC) is a major cause of morbidity after BMT; we have analyzed its incidence, risk factors, and complications in 977 patients undergoing BMT between 1974 and 1988. Despite vigorous hydration and frequent voiding in all patients receiving cyclophosphamide, 135/977 (15% by Kaplan-Meier projection) d...


    pub_type: 杂志文章


    authors: Sencer SF,Haake RJ,Weisdorf DJ

    更新日期:1993-10-01 00:00:00

  • Long-term prognosis of renal transplantation after preemptive treatment of cytomegalovirus infection.

    abstract::A role for cytomegalovirus (CMV) infection in the etiologies of acute and chronic rejection in renal allograft recipients has been suggested. We previously reported that preemptive treatment of CMV infection with ganciclovir in kidney transplant patients was safe and effective. We now present a retrospective analysis ...


    pub_type: 杂志文章


    authors: Akposso K,Rondeau E,Haymann JP,Peraldi MN,Marlin C,Sraer JD

    更新日期:1997-04-15 00:00:00

  • Guillain-Barre syndrome in organ and bone marrow transplant patients.

    abstract:BACKGROUND:Guillain-Barre Syndrome (GBS) is believed to be caused by autoimmune mechanisms that are predominantly T-cell mediated. We report GBS in organ transplant patients and bone marrow transplant patients, both of whom have iatrogenically suppressed T-cell function. METHODS:We reviewed the Duke University Medical...


    pub_type: 杂志文章


    authors: Bulsara KR,Baron PW,Tuttle-Newhall JE,Clavien PA,Morgenlander J

    更新日期:2001-04-27 00:00:00

  • Inhibition of human monocyte spreading. An in vitro test for immunosuppressive potency of antihum lymphocyte globulin.

    abstract::Monocytes from human peripheral blood, when incubated in vitro, spread onto the surface of the glass. Horse antihuman lymphocyte globulin (ALG) added to the incubation chamber inhibits the spreading, while normal horse globulin (NHG) does not. The inhibition depends on the concentration of ALG admixed to the mononucle...


    pub_type: 杂志文章


    authors: Silobrcić V,Mazuran R,Dekaris D,Balner H

    更新日期:1976-01-01 00:00:00

  • The effect of organ-specific CD26/DPP IV enzymatic activity inhibitor-preconditioning on acute pulmonary allograft rejection.

    abstract:BACKGROUND:Systemic inhibition of serum CD26/dipeptidylpeptidase (DPP IV) enzymatic activity abrogated acute rejection of pulmonary allografts, whereas organ-specific inhibition ameliorated ischemia/reperfusion injury in syngeneic transplants. Here, we analyze the effect of allograft-specific inhibitor preconditioning ...


    pub_type: 杂志文章


    authors: Jungraithmayr W,Oberreiter B,De Meester I,Wiedl T,Inci I,Bain M,Augustyns K,Hillinger S,Scharpé S,Weder W,Korom S

    更新日期:2009-08-27 00:00:00

  • Using biomarkers of tolerance and rejection to identify high- and low-risk patients following kidney transplantation.

    abstract::Despite great improvements in renal allograft survival over the last 3 decades, long-term graft loss, particularly through antibody-mediated rejection, remains the bane of kidney transplantation. Interindividual patient variation means that a given immunosuppressive regimen may be inadequate in certain patients and ex...


    pub_type: 杂志文章,评审


    authors: Ashton-Chess J,Giral M,Soulillou JP,Brouard S

    更新日期:2009-05-15 00:00:00

  • Comparative analysis of live liver donation risk using a comprehensive grading system for severity.

    abstract::We investigated whether right lobe (RL) liver donation is associated with a higher incidence or severity of donor complications than left lobe (LL) liver and left lateral segment (LLS) liver donations. We studied 80 living donors: 35 RL liver donors and 45 LL/LLS liver donors. A modification of the Clavien classificat...


    pub_type: 杂志文章


    authors: Salvalaggio PR,Baker TB,Koffron AJ,Fryer JP,Clark L,Superina RA,Blei AT,Abecassis MM

    更新日期:2004-06-15 00:00:00