Abstract:
BACKGROUND:The incidence of stroke and risk factors for different subtypes of cerebrovascular (CBV) events in renal transplant recipients have not been examined in any large prospective controlled trial. METHODS:The Assessment of Lescol in Renal Transplantation was a randomized, double-blind, placebo-controlled study of the effect of fluvastatin (40-80 mg) daily on cardiovascular, and renal outcomes in renal transplant recipients. Patients initially randomized to fluvastatin or placebo in the 5 to 6 year trial was offered open-label fluvastatin in a 2-year extension to the original study. We investigated the incidence of stroke and risk factors for ischemic and hemorrhagic CBV events in 2102 renal graft recipients participating in the Assessment of Lescol in Renal Transplantation core and extension trial with a mean follow-up of 6.7 years. RESULTS:The incidence and type of CBV events did not differ between the lipid lowering arm and the placebo arm. A total of 184 (8.8%, 95% confidence interval 4.6-12.9) of 2102 patients experienced a CBV event during follow-up, corresponding to an incidence of 1.3% CBV event per year. The mortality for patients experiencing a hemorrhagic stroke was 48% (13 of 27), whereas the mortality for ischemic strokes was 6.0% (8 of 133). Diabetes mellitus, previous CBV event, age, and serum creatinine were independent risk factors for cerebral ischemic events. The risk of a hemorrhagic cerebral event was increased by diabetes mellitus, polycystic kidney disease, left ventricular hypertrophy, and systolic blood pressure. INTERPRETATION:Risk factors for CBV events in renal transplant recipients differ according to subtype.
journal_name
Transplantationjournal_title
Transplantationauthors
Abedini S,Holme I,Fellström B,Jardine A,Cole E,Maes B,Holdaas H,ALERT Study Group.doi
10.1097/TP.0b013e31818bfce8subject
Has Abstractpub_date
2009-01-15 00:00:00pages
112-7issue
1eissn
0041-1337issn
1534-6080pii
00007890-200901150-00018journal_volume
87pub_type
杂志文章,随机对照试验相关文献
TRANSPLANTATION文献大全abstract::In 33 renal allograft recipient-donor pairs, B and T lymphocyte complement-dependent cytotoxicity crossmatches and mixed lymphocyte culture (MLC) blocking experiments were performed and the results were correlated with graft outcome. MLC blocking particularly in the unidirectional culture against donor-stimulating cel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197804000-00002
更新日期:1978-04-01 00:00:00
abstract::In a prospective longitudinal study, detection of cytomegalovirus (CMV) DNA in plasma (plasma polymerase chain reaction [PCR]) was compared with PCR of CMV DNA in peripheral blood leukocytes (PBL PCR), the CMV pp65 antigenemia assay, and viral cultures from blood, urine, and throat of 29 patients, 14 of whom received ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199707150-00020
更新日期:1997-07-15 00:00:00
abstract:BACKGROUND:Kidneys from infectious risk donors (IRD) confer substantial survival benefit in adults, yet the benefit of IRD kidneys to pediatric candidates remains unclear in the context of high waitlist prioritization. METHODS:Using 2010-2016 Scientific Registry of Transplant Recipients data, we studied 2417 pediatric...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000002674
更新日期:2019-12-01 00:00:00
abstract::Renal allograft recipients treated with cyclosporine (CsA) have increased renal vascular resistance that falls when CsA is stopped. With the aim of identifying whether CsA-treated patients with excellent renal function also have an alteration in renal vascular tone and to investigate which vessels are affected, we hav...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198807000-00014
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:In clinical transplantation, "passenger" dendritic cells (DCs) in the allograft have been thought to induce allograft rejection. However, the presence of DCs in the normal human kidney is controversial. Most reports have relied on the examination of MHC class I and II antigen expression in combination with D...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199804150-00025
更新日期:1998-04-15 00:00:00
abstract::Indium 111-labeled monoclonal antibody to cardiac myosin was examined for efficacy in the detection of cardiac graft rejection and rejection-related myocyte necrosis. Heterotopic heart transplants were performed in isogenic and allogenic groups of rats (n = 56). At selected intervals posttransplant, uptake of injected...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198912000-00006
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:The use of liver allografts from an older donor (OD) (age>50 years) is a widespread strategy to manage the disparity between supply and demand of organs for liver transplantation. This study determines the effect of OD allografts on fibrosis progression and graft survival after liver transplantation in patie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000095896.07048.BB
更新日期:2004-01-15 00:00:00
abstract:BACKGROUND:We previously reported the novel activity of alloprimed CD8 T cells that suppress posttransplant alloantibody production. The purpose of the study is to investigate the expression and role of CXCR5 on antibody-suppressor CD8 T-cell function. METHODS:C57BL/6 mice were transplanted with FVB/N hepatocytes. All...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002683
更新日期:2019-09-01 00:00:00
abstract::Inoculation of P815 tumor cells (DBA/2 origin) into the anterior chamber of eyes of BALB/c mice normally produces anterior chamber-associated immune deviation (ACAID) whereby delayed hypersensitivity (DH) responses to the minor H alloantigens of the tumor cells are suppressed. Based on our previous work showing an ass...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00024
更新日期:1989-03-01 00:00:00
abstract::Disturbances of the immune response of the lung induced by the action of immunosuppressive agents on the functional abilities of rat pulmonary alveolar macrophages (PAM) were analyzed following in vitro incubation or in vivo administration (for 30 days) of cyclosporinea, (CsA) azathioprine (Az) or prednisolone (Pr). T...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198306000-00014
更新日期:1983-06-01 00:00:00
abstract::Controversy exists as to the type of cells present in the urine during renal allograft rejection. In order to resolve this controversy as well as to evaluate the value of urine sediment examination as a means of detecting AR, we quantitated the different cells present in urine during AR using an immunoperoxidase techn...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00017
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:There are limited experimental data on the nature of the humoral response elicited in humans against pig antigens. In this study, we have examined the xenoantibody (XAb) response in eight patients with acute liver failure exposed to pig hepatocytes after treatment with the bioartificial liver (BAL). METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901150-00003
更新日期:1999-01-15 00:00:00
abstract::Although cyclosporine has high specificity for the immune system, immunosuppressive therapy with CsA is often complicated by nephrotoxicity. The main morphologic targets of CsA nephrotoxicity include the tubular epithelial and endothelial cells. These cells were investigated in vitro. CsA caused a dose- and time-depen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198808001-00017
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). METHODS:We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We com...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e3182394cb3
更新日期:2012-01-15 00:00:00
abstract::The ability of concanavalin-A (Con-A) to activate lymphocytes to secrete human lymphotoxin (LT) was tested in the presence of agents known to modify the intracellular levels of cyclic nucleotides (cAMP and cGMP). Lymphocytes were treated with these agents at different stages of activation: (1) during the first encount...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197510000-00010
更新日期:1975-10-01 00:00:00
abstract::We reviewed the results of all percutaneous fine needle aspirations (FNA) and open lung biopsies (OLB) after bone marrow transplantation at our center (1984-1987) for the evaluation of focal lung lesions that developed or persisted despite antibiotic administration. We sought to determine the prevalence and types of i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198908000-00017
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:Lung transplant recipients are among those with the highest risk of influenza infection and complications each year. A few studies show adequate responses after influenza immunization; no studies examined the season-long protection. METHODS:Influenza antibody concentrations were measured using hemagglutinat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000391
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion syndrome has been recognized as an important pathogenic factor in renal transplantation, not only in the development of delayed graft function but also in the development of acute and chronic rejection. Hypoxia-inducible factor (HIF)-1 activates transcription of several genes implicated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000063128.86981.B2
更新日期:2003-05-27 00:00:00
abstract:BACKGROUND/AIM:It remains uncertain whether autoimmune hepatitis (AIH), as an original indication for orthotopic liver transplantation (OLTX), predisposes to the development of chronic rejection (CR) after surgery and published reports on heterogeneous groups of patients provided conflicting data. In this work we analy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200008150-00014
更新日期:2000-08-15 00:00:00
abstract::Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for bleeding complications after reperfusion of the liver graft. In 10 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199109000-00018
更新日期:1991-09-01 00:00:00
abstract::BACKGROUND.: Reduced levels of serum adiponectin, an adipokine, are associated with cardiovascular and obesity-related diseases; however, relations between adiponectin and hypertension are unclear. METHODS.: This cross-sectional study examined adiponectin and ambulatory blood pressure monitoring (ABPM) in 33 pediatric...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b9e1ec
更新日期:2009-10-27 00:00:00
abstract:BACKGROUND:Normothermic perfusion is an alternative but little studied method of organ preservation. Herein, we report the first case of ex vivo normothermic renal transplant perfusion in man. METHODS:The 62-year-old extended criteria donor died of an intracranial hemorrhage and had undergone cardiopulmonary resuscita...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822d4e04
更新日期:2011-10-15 00:00:00
abstract::The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198401000-00004
更新日期:1984-01-01 00:00:00
abstract::T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene segments were used preferentially. We have demonstrated previously that a DR1-specific, human renal allograft-derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), estab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199604150-00017
更新日期:1996-04-15 00:00:00
abstract:BACKGROUND:Patients with pretransplantation strong donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) are at higher risk for rejection. We aimed to study the safety of kidney transplantation in patients with lower strength DSAs in a prospective cohort study. METHODS:Three hundred and seventy-three cons...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000191
更新日期:2014-11-27 00:00:00
abstract:BACKGROUND:We report long-term outcomes and side effects after transplantation for hepatocellular carcinoma (HCC) using de novo, sirolimus-based immunosuppression (IS). METHODS:A total of 70 patients with HCC (mean age: 54.4+/-7 years, female/male: 12/58) were transplanted and included in the study. Immunosuppression ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000262607.95372.e0
更新日期:2007-05-15 00:00:00
abstract:BACKGROUND:Acid sphingomyelinase knock-out (ASMKO) mice are a model of types A and B Niemann-Pick disease. In the present study, we evaluated whether bone marrow transplantation (BMT) carried out on newborn ASMKO mice could prevent or alter the Niemann-Pick disease phenotype. METHODS:Previous work from our laboratory ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199804150-00005
更新日期:1998-04-15 00:00:00
abstract:BACKGROUND:Subclinical T cell-mediated rejection (subTCMR) is commonly found after liver transplantation and has a good short-term prognosis, even when it is left untreated. Donor-specific antibodies (DSA) are putatively associated with a worse prognosis for recipient and graft after liver transplantation. METHODS:To ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003034
更新日期:2020-03-01 00:00:00
abstract::Preventing hyperacute rejection (HAR) is a difficult and unsolved problem in xenotransplantation. This may be due, in part, to a lack of therapies that can suppress production of natural antibodies (NA), which are thought to be critical mediators of HAR. This study examined the effect of 15-deoxyspergualin (DSPG) and ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199207000-00004
更新日期:1992-07-01 00:00:00
abstract::A monoclonal anti-Lyt-1.1 serum has been characterized in terms of its effect on various cell populations involved in cell-mediated immune responses. The monoclonal serum was compared to a conventionally prepared anti-Lyt-1.1 serum. Cytotoxic T cell precursors and effectors were found to be Lyt-1.1+. Helper T cells wh...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198101000-00013
更新日期:1981-01-01 00:00:00