Induction of delayed hypersensitivity to alloantigens coinjected with Langerhans cells into the anterior chamber of the eye. Abrogation of anterior chamber-associated immune deviation.

Abstract:

:Inoculation of P815 tumor cells (DBA/2 origin) into the anterior chamber of eyes of BALB/c mice normally produces anterior chamber-associated immune deviation (ACAID) whereby delayed hypersensitivity (DH) responses to the minor H alloantigens of the tumor cells are suppressed. Based on our previous work showing an association of Langerhans cell infiltration into central cornea with the abrogation of ACAID, we have hypothesized that the induction of ACAID may depend upon the avoidance of local antigen processing within the anterior chamber. In this study, we have examined whether various putative antigen-presenting cells coinjected with allogeneic P815 cells into the anterior chamber could alter the course of the subsequent systemic alloimmune response. BALB/c recipients of intracameral P815 cells admixed with BALB/c spleen cells, B cells, or A20 B lymphoma cells developed ACAID. However, recipients of tumor cells admixed with cutaneous epidermal cells containing LC, and those receiving intracameral P815 cells admixed with purified LC developed vigorous DBA/2-specific delayed hypersensitivity responses. We conclude that avoidance of antigen processing and presentation by specialized APC such as dendritic LC within the anterior chamber is a condition for the induction of ACAID. Since under normal circumstances the anterior chamber is lined by tissues that are devoid of LC and contain very few class II MHC-expressing cells, this immunologically privileged site appears to be designed physiologically to avoid the unique form of local antigen presentation offered by dendritic LC--a condition that favors induction of selective immunologic incompetence.

journal_name

Transplantation

journal_title

Transplantation

authors

Williamson JS,Streilein JW

doi

10.1097/00007890-198903000-00024

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

519-24

issue

3

eissn

0041-1337

issn

1534-6080

journal_volume

47

pub_type

杂志文章
  • Normalization of circadian blood pressure profiles after renal transplantation.

    abstract::Most patients with secondary hypertension due to renal disease or on maintenance hemodialysis have lost the physiologic fall of blood pressure during sleep. To test the notion that kidney transplantation normalizes the blood pressure profile, we monitored ambulatory blood pressure over 24 hr in 45 patients (29 males a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Gatzka CD,Schobel HP,Klingbeil AU,Neumayer HH,Schmieder RE

    更新日期:1995-05-15 00:00:00

  • Treatment with humanized monoclonal antibodies against CD80 and CD86 combined with sirolimus prolongs renal allograft survival in cynomolgus monkeys.

    abstract:BACKGROUND:Co-stimulatory blockade has been shown to prolong allograft survival in different transplant models. We investigated the effect of combining humanized anti-CD80 and anti-CD86 monoclonal antibodies (mAb) with sirolimus in cynomolgus monkey renal transplant recipients. METHODS:After renal transplantation, gro...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000066806.10029.7A

    authors: Bîrsan T,Hausen B,Higgins JP,Hubble RW,Klupp J,Stalder M,Celniker A,Friedrich S,O'Hara RM,Morris RE

    更新日期:2003-06-27 00:00:00

  • Analysis of T cell subpopulations and cyclosporine levels in the blood of two neonates born to immunosuppressed heart-lung transplant recipients.

    abstract::The influence of continuous immunosuppression on the immune system of 2 neonates born to heart-lung transplant recipients was analyzed. T cells, T cell subpopulations, B cells and cyclosporine levels were measured in maternal and cord blood at the time of delivery. Cyclosporine, both parent compound, and metabolites w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198908000-00008

    authors: Rose ML,Dominguez M,Leaver N,Lachno R,Yacoub MH

    更新日期:1989-08-01 00:00:00

  • Biochemical, pathological, and clinical response to transplantation of normal bone marrow cells into acid sphingomyelinase-deficient mice.

    abstract:BACKGROUND:Acid sphingomyelinase knock-out (ASMKO) mice are a model of types A and B Niemann-Pick disease. In the present study, we evaluated whether bone marrow transplantation (BMT) carried out on newborn ASMKO mice could prevent or alter the Niemann-Pick disease phenotype. METHODS:Previous work from our laboratory ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199804150-00005

    authors: Miranda SR,Erlich S,Friedrich VL Jr,Haskins ME,Gatt S,Schuchman EH

    更新日期:1998-04-15 00:00:00

  • A predictive test for the efficacy of intravenous immunoglobulin in the inhibition of alloantibodies.

    abstract::Preformed recipient HLA-specific antibodies can cause hyperacute rejection of a transplanted kidney if they are directed against mismatched donor HLA antigens. To avoid hyperacute rejection it is essential that recipient antibodies be identified during patient workup for transplantation and HLA antigens to which a pat...

    journal_title:Transplantation

    pub_type: 评论,杂志文章

    doi:10.1097/00007890-200105270-00002

    authors: Martin S

    更新日期:2001-05-27 00:00:00

  • Section 8. Management of portal venous complications in pediatric living donor liver transplantation.

    abstract::Portal vein (PV) complications after living donor liver transplant (LDLT) have been a major concern in pediatric liver transplantation. The incidence of PV complications is more in pediatric (0%-33%) than in adult recipients. Early diagnosis and treatment of PV complications may ensure optimal graft function and good ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000446272.05687.ce

    authors: Cheng YF,Ou HY,Yu CY,Tsang LL,Huang TL,Chen TY,Concejero A,Wang CC,Wang SH,Lin TS,Liu YW,Yang CH,Yong CC,Chiu KW,Jawan B,Eng HL,Chen CL

    更新日期:2014-04-27 00:00:00

  • Segmental pancreatic autotransplantation in the pig.

    abstract::The pig has been considered unsuitable for experimental pancreatic transplantation. In order to develop a model for segmental transplantation, the vascular anatomy was studied in 41 pigs. No variation in venous drainage of the pancrease was found. In contrast, 3 variations of arterial supply were noted. In 29 of the p...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198901000-00010

    authors: Shokouh-Amiri MH,Rahimi-Saber S,Andersen HO

    更新日期:1989-01-01 00:00:00

  • Immunity to Vaccine-preventable Viral Infections in Australians Being Evaluated for Liver Transplantation.

    abstract:BACKGROUND:Vaccine-preventable viral infections are associated with increased risk of morbidity and mortality in immunocompromised patients. Current guidelines recommend routine screening and vaccination of all patients before solid organ transplantation. We studied rates of immunity against vaccine-preventable viruses...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002722

    authors: Gardiner A,Liu K,Bonnichsen M,Joshi V,Davis RJ,Strasser SI

    更新日期:2019-11-01 00:00:00

  • KIR/HLA ligand incompatibility in kidney transplantation.

    abstract:BACKGROUND:The polymorphic family of killer-cell immunoglobulin-like receptors (KIRs) consists of activating and inhibitory receptors expressed by natural killer (NK) cells and effector T cells that recognize human leukocyte antigen (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts benefi...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000290681.41859.41

    authors: Kunert K,Seiler M,Mashreghi MF,Klippert K,Schönemann C,Neumann K,Pratschke J,Reinke P,Volk HD,Kotsch K

    更新日期:2007-12-15 00:00:00

  • Tissue cardiomyoplasty using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient myocardium.

    abstract:BACKGROUND:We hypothesized that tissue-engineered contractile cardiomyocyte sheets without a scaffold would show histological and electrical integration with impaired myocardium, leading to the regeneration of infarcted myocardium. METHODS:Neonatal rat cardiomyocytes were cultured on Poly(N-isopropylacrylamide)-grafte...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000181163.69108.dd

    authors: Miyagawa S,Sawa Y,Sakakida S,Taketani S,Kondoh H,Memon IA,Imanishi Y,Shimizu T,Okano T,Matsuda H

    更新日期:2005-12-15 00:00:00

  • The Ethics of Penile Transplantation: Preliminary Recommendations.

    abstract:BACKGROUND:For men with significant genitourinary injury, penile transplantation is being considered as an option when reconstruction is not feasible or proves unacceptable to the injured patient. METHODS:A review of the literature was conducted to assess the current state of penile reconstruction and transplantation ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000001352

    authors: Caplan AL,Kimberly LL,Parent B,Sosin M,Rodriguez ED

    更新日期:2017-06-01 00:00:00

  • Heterotopic Abdominal Rat Heart Transplantation as a Model to Investigate Volume Dependency of Myocardial Remodeling.

    abstract::Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the ex...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000001585

    authors: Benke K,Sayour AA,Mátyás C,Ágg B,Németh BT,Oláh A,Ruppert M,Hartyánszky I,Szabolcs Z,Radovits T,Merkely B,Szabó G

    更新日期:2017-03-01 00:00:00

  • Thymoglobulin versus ATGAM induction therapy in pediatric kidney transplant recipients: a single-center report.

    abstract:BACKGROUND:Induction immunosuppressive therapy with the anti-T-cell antibody Thymoglobulin decreases the incidence of acute rejection in adult kidney transplant (KTx) recipients, but limited data are available for pediatric KTx recipients. METHODS:We conducted a historical cohort study to compare rates of survival, re...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.tp.0000158325.12837.a2

    authors: Khositseth S,Matas A,Cook ME,Gillingham KJ,Chavers BM

    更新日期:2005-04-27 00:00:00

  • Deoxyspergualin in lethal murine graft-versus-host disease.

    abstract::The beneficial effect of deoxyspergualin (DSG, NKT-01) on lethal graft-versus-host disease in mice has been studied in a major histoincompatible donor-recipient combination. Suppression of the effector mechanisms responsible for the lethal outcome in this GVHD model is also noted. This study reveals: (1) DSG has a mar...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199103000-00032

    authors: Nemoto K,Hayashi M,Ito J,Sugawara Y,Mae T,Fujii H,Abe F,Fujii A,Takeuchi T

    更新日期:1991-03-01 00:00:00

  • Impact of parathyroid hormone on bone density in long-term renal transplant patients with good graft function.

    abstract:BACKGROUND:It remains unknown whether low-grade hyperparathyroidism persisting beyond the first year postrenal transplantation has any impact on bone density. METHODS:Parathyroid hormone (PTH), glomerular filtration rate (GFR), and bone density (by dual-energy x-ray absorptiometry [DXA]) were monitored in the follow-u...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000230130.50451.78

    authors: Akaberi S,Lindergård B,Simonsen O,Nyberg G

    更新日期:2006-09-27 00:00:00

  • The results of reduced-size liver transplantation, including split livers, in patients with end-stage liver disease.

    abstract::We initiated a policy of using RSLT in critically ill patients in June of 1988. Since that time we have performed 30 RSLTs in 29 patients, including 28 children and 1 adult. The mean age of the children was 27 months (range 1 month to 10 years) with 14 (52%) being 1 year of age or less. The mean weight was 11.3 kg (ra...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199202010-00023

    authors: Langnas AN,Marujo WC,Inagaki M,Stratta RJ,Wood RP,Shaw BW Jr

    更新日期:1992-02-01 00:00:00

  • HLA-G is a crucial immunosuppressive molecule secreted by adult human mesenchymal stem cells.

    abstract::Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotential cells capable of regenerating injured tissues. In addition to their multipotency, MSCs inhibit natural killer cell cytotoxicity and T-lymphocyte alloproliferation. Several immunosuppressive mechanisms have been described, including indoleamine ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181a2a4b3

    authors: Selmani Z,Naji A,Gaiffe E,Obert L,Tiberghien P,Rouas-Freiss N,Carosella ED,Deschaseaux F

    更新日期:2009-05-15 00:00:00

  • Comparison of pulsatile perfusion and cold storage for paired kidney allografts.

    abstract::Use of pulsatile perfusion to optimize outcomes in deceased donor kidney transplantation remains controversial. This study is a retrospective analysis of all cadaveric renal allografts procured locally by our center over a 3-year period. Kidney pairs were identified in which one kidney underwent pulsatile perfusion an...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318187b978

    authors: Shah AP,Milgrom DP,Mangus RS,Powelson JA,Goggins WC,Milgrom ML

    更新日期:2008-10-15 00:00:00

  • The role of PCR in the diagnosis and management of CMV in solid organ recipients: what is the predictive value for the development of disease and should PCR be used to guide antiviral therapy?

    abstract::Cytomegalovirus remains a significant source of morbidity and mortality in immunocompromised hosts. The increased sensitivity of molecular diagnostic techniques (PCR, antigenemia) has resulted in our ability to detect viral replication earlier in the posttransplant period, before the onset of symptoms. With the advent...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199701270-00017

    authors: Abecassis MM,Koffron AJ,Kaplan B,Buckingham M,Muldoon JP,Cribbins AJ,Kaufman DB,Fryer JP,Stuart J,Stuart FP

    更新日期:1997-01-27 00:00:00

  • Endotelin ETA and ETB receptor antagonism during cold preservation in renal transplantation.

    abstract:BACKGROUND:In this study, we investigated the effects of selective endothelin (ET) receptor antagonism during different periods of cold ischemia on glomerular and tubular function and long-term survival in renal transplantation. METHODS:Left renal transplantation was performed in Lewis rats after 2 hr of cold ischemia...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200103150-00007

    authors: Hammad FT,Davis G,Zhang XY,Wheatley AM

    更新日期:2001-03-15 00:00:00

  • Anti-CD3 F(ab')2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb.

    abstract::The use of anti-CD3 monoclonal antibodies to treat organ allograft rejection has been complicated by (1) the morbidity associated with the initial dose, (2) the humoral response of the patients against the mAbs, and (3) the generalized immunosuppression induced by the mAbs. We investigated the potential of F(ab')2 fra...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199006000-00018

    authors: Hirsch R,Bluestone JA,DeNenno L,Gress RE

    更新日期:1990-06-01 00:00:00

  • Factors with an impact on chimerism development and long-term survival after umbilical cord blood transplantation.

    abstract:BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31826c39b2

    authors: Berglund S,Le Blanc K,Remberger M,Gertow J,Uzunel M,Svenberg P,Winiarski J,Ljungman P,Ringdén O,Uhlin M,Mattsson J

    更新日期:2012-11-27 00:00:00

  • The effect of perioperative portal venous injection of donor spleen cells on renal allograft survival in dogs.

    abstract::Preoperative portal venous injection of donor lymphocytes has been shown to extend allograft survival in inbred animals. However, the effect of perioperative injection in a large animal model has not been carefully studied. We examined the effect of perioperative (day 0) donor spleen cell administration in a canine ki...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199410270-00004

    authors: Tsuji T,Tashiro S,Tanabe D,Sawada T,Inoue K,Kawamoto S,Kamimoto Y,Miyauchi Y

    更新日期:1994-10-27 00:00:00

  • Immunological characteristics of purified pancreatic islet grafts.

    abstract::In a DBA/2 (H-2d) pancreatic islet-to-B6AF1 (H-2b/k.d) recipient combination, the graft survival of hand-picked islets was compared with that of "crude digested" islets that were prepared simply by collagenase digestion and Ficoll gradient separation and were contaminated with lymph nodes and vascular and ductal tissu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198610000-00011

    authors: Gotoh M,Maki T,Satomi S,Porter J,Monaco AP

    更新日期:1986-10-01 00:00:00

  • Immunoregulatory abnormalities in patients with Epstein-Barr virus-associated B cell lymphoproliferative disorders.

    abstract::EBVirus-associated B cell lymphoproliferative disorder (BLPD) is a recognized complication of primary immunodeficiency and organ as well as bone marrow transplantation. Although the nature of the immune defects that predispose to the development of BLPD are unknown, it is postulated that aberrant T cell responses are ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Mathur A,Kamat DM,Filipovich AH,Steinbuch M,Shapiro RS

    更新日期:1994-04-15 00:00:00

  • Accept or Decline? An Analytics-Based Decision Tool for Kidney Offer Evaluation.

    abstract:BACKGROUND:When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for futu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001824

    authors: Bertsimas D,Kung J,Trichakis N,Wojciechowski D,Vagefi PA

    更新日期:2017-12-01 00:00:00

  • Cyclosporine absorption in intestinal transplantation.

    abstract::The absorption of oral cyclosporine (CsA) was studied in a canine small intestinal transplantation model. Absorption of CsA was almost absent in bowel-resected dogs. Autotransplanted dogs showed a persisting malabsorption of CsA (mean peak of 687 +/- 348 ng/ml vs. 1683 +/- 154 ng/ml in control dogs). Allotransplanted ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198505000-00007

    authors: Wassef R,Cohen Z,Nordgren S,Langer B

    更新日期:1985-05-01 00:00:00

  • Outcomes of laparoscopic donor nephrectomy in obese patients.

    abstract::The applicability of laparoscopic donor nephrectomy (LDN) has not been assessed in the obese donor. We hypothesized that obesity is not a technical contraindication to LDN. From May 1998 to February 1999, 40 patients underwent LDN at the Georgetown Transplant Institute with the transperitoneal technique. Prophylaxis a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200001150-00031

    authors: Kuo PC,Plotkin JS,Stevens S,Cribbs A,Johnson LB

    更新日期:2000-01-15 00:00:00

  • "Natural" human leukocyte antigen antibodies found in nonalloimmunized healthy males.

    abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies were normally not found in subjects who have not been immunized by pregnancies, transfusions, or transplants. But with new methodology, we now see that HLA antibodies are often found in nonalloimmunized males. METHODS:The sera of 424 healthy male donors were tested w...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/TP.0b013e318186d87b

    authors: Morales-Buenrostro LE,Terasaki PI,Marino-Vázquez LA,Lee JH,El-Awar N,Alberú J

    更新日期:2008-10-27 00:00:00

  • Liver disease after bone marrow transplantation--the Taiwan experience.

    abstract::To investigate the causes of impaired liver function (LF)* after BMT, 88 patients were included for analysis of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, transplant methods, preconditioning regimens, and graft-versus-host disease (GVHD). Fifty of them (56.8%) developed abnormal LF after BMT and a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Chen PM,Liu JH,Fan FS,Hsieh RK,Wei CH,Liu RS,Tzeng CH

    更新日期:1995-04-27 00:00:00