Detection of donor-derived cells by polymerase chain reaction in neonatally tolerant mice. Microchimerism fails to predict tolerance.

abstract：BACKGROUND:Human cytomegalovirus (HCMV) infection is associated with allograft vasculopathy and rejection. One potential mechanism is vascular injury from immunologically mediated processes. HCMV infection has been shown to increase the constitutive expression of intercellular adhesion molecule-1 (ICAM-1). The objectiv...

journal_title：Transplantation

authors： Burns LJ,Pooley JC,Walsh DJ,Vercellotti GM,Weber ML,Kovacs A

更新日期：1999-01-15 00:00:00

abstract：BACKGROUND:Apoptosis has been identified after ischemia-reperfusion (IR) injury to the brain, heart, kidney, retina, and the adrenals. Intestinal IR injury causes villous and crypt damage, which has so far been attributed to cellular necrosis. This study was undertaken to investigate the possible role of apoptosis afte...

journal_title：Transplantation

authors： Shah KA,Shurey S,Green CJ

更新日期：1997-11-27 00:00:00

abstract：:Since 1981, when the liver transplantation program was initiated at the University of Pittsburgh, we have been impressed with the prevalence of pancreatitis occurring following liver transplantation in patients transplanted for hepatitis B-related liver disease. To either confirm this clinical impression or refute it,...

journal_title：Transplantation

authors： Alexander JA,Demetrius AJ,Gavaler JS,Makowka L,Starzl TE,Van Thiel DH

更新日期：1988-06-01 00:00:00

abstract：:Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...

journal_title：Transplantation

authors： Woodle ES,Kulkarni S

更新日期：1998-09-27 00:00:00

abstract：:The effect of prophylactic i.v. administration of high doses of human gamma-immunoglobulin (IgG) on kidney graft survival was investigated in rhesus monkeys treated with azathioprine and prednisolone. In nontransfused recipients not treated with IgG (controls), graft survival ranged from 9 to 22 days; if nontreated an...

journal_title：Transplantation

authors： Borleffs JC,Marquet RL,de By-Aghai Z,Dolkart RE,Persijn GG,Balner H

更新日期：1982-01-01 00:00:00

abstract：:Tacrolimus (FK) and cyclosporine (Cs) are potent immunosuppressants that effectively prevent the rejection of transplanted organs including liver and small intestine. Our study examined the effects of these immunosuppressants on Peyer's patches, which play an important role in mucosal immune response through uptake an...

journal_title：Transplantation

authors： Fujimura Y,Owen RL

更新日期：2002-04-15 00:00:00

abstract：:To gain insight into the contribution of immunologic and hemodynamic factors in the progressive demise of structure and function in chronic renal allograft dysfunction, we studied the histological changes, the immunostainable glomerular anionic sites, and glomerular capillary hydrostatic pressures of rat renal allogra...

journal_title：Transplantation

authors： Benediktsson H,Chea R,Davidoff A,Paul LC

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:It has been proposed that hyperacute rejection (HAR) of pig-to-primate vascularized xenografts is due in large part to ineffective regulation of recipient complement by pig complement regulatory proteins (CRPs), and indeed transgenic expression of human CRPs in pigs can prevent hyperacute rejection. However,...

journal_title：Transplantation

authors： Fisicaro N,Aminian A,Hinchliffe SJ,Morgan BP,Pearse MJ,D'Apice AJ,Cowan PJ

更新日期：2000-09-27 00:00:00

abstract：:Our current knowledge of cytotoxic T lymphocytes (CTL) is largely derived from studies of effector populations generated in allogeneic mixed leukocyte cultures (MLC) and assayed for lytic activity to lymphoid cell (LC) targets. We herein report that the CTL response to allogeneic renal epithelial cell lines (REC) is d...

journal_title：Transplantation

authors： Hadley GA,Rostapshova EA,Bartlett ST

更新日期：1996-07-15 00:00:00

abstract：:The immunological events mediated by, and antigen specificity of, allograft-bound lymphocytes (ABLs) are poorly understood. To further define the role of antibody-mediated rejection, a rejected allograft from a patient with primary anti-TBM disease was sterilely minced and pressed through a microscreen. The ABLs were ...

journal_title：Transplantation

authors： Jordan SC,Barkley SC,Lemire JM,Sakai RS,Cohen A,Fine RN

更新日期：1986-02-01 00:00:00

abstract：:The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...

journal_title：Transplantation

authors： Mowat AM,Ferguson A

更新日期：1981-09-01 00:00:00

abstract：:Increasing numbers of sensitized patients are either precluded from receiving an allograft or experience accelerated rejection which may be refractory to conventional therapy. Using a rat model, we have shown that accelerated (24 hr) rejection of LBN cardiac Tx in LEW rats sensitized with BN skin grafts 7 days earlier...

journal_title：Transplantation

authors： Hancock WW,DiStefano R,Braun P,Schweizer RT,Tilney NL,Kupiec-Weglinski JW

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:CD200 delivers immunoregulatory signals following engagement of its receptor, CD200R. A family of CD200Rs (CD200R1-4) has been described. Spleen expresses cell surface CD200R1, while bone marrow shows predominantly expression of cell surface CD200R2/R3. We showed that dendritic cell precursors (DCp) cultured...

journal_title：Transplantation

authors： Gorczynski RM

更新日期：2006-04-15 00:00:00

abstract：INTRODUCTION:Patients after solid organ transplantation are at an increased risk for microbial infections. Due to therapeutic immunosuppression, the response to active immunizations may be reduced. The serological efficacy of pneumococcal and influenza vaccination was studied in heart transplant recipients. PATIENTS A...

journal_title：Transplantation

authors： Dengler TJ,Strnad N,Bühring I,Zimmermann R,Girgsdies O,Kubler WE,Zielen S

更新日期：1998-11-27 00:00:00

abstract：:Natural xenoantibodies are believed to be IgM in nature and are known to play a critical role in the hyperacute rejection of distantly related xenografts. The purpose of this study was to determine whether the reducing agent DL-penicillamine could inactivate baboon natural xenoantibodies to pig splenocytes. Pooled bab...

journal_title：Transplantation

authors： Xu H,Kwiatkowski P,Chen JM,Kaplon RJ,Edwards NM,Dong X,Berger C,Michler RE

更新日期：1994-12-27 00:00:00

abstract：:Islet transplantation is currently being explored as a treatment for patients with type 1 diabetes. At present, the number of patients becoming insulin-independent is rapidly increasing world-wide applying the transplantation protocol originally described by the group in Edmonton. A hallmark in this procedure is repea...

journal_title：Transplantation

authors： Korsgren O,Nilsson B,Berne C,Felldin M,Foss A,Kallen R,Lundgren T,Salmela K,Tibell A,Tufveson G

更新日期：2005-05-27 00:00:00

abstract：BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...

journal_title：Transplantation

authors： Nyberg SL,Baskin-Bey ES,Kremers W,Prieto M,Henry ML,Stegall MD

更新日期：2005-10-15 00:00:00

abstract：:Antithymocyte globulin (ATG) has been used successfully for induction therapy as well as for treatment of established allograft rejection. However, this therapy has often been associated with problems of overimmunosuppression and increased costs. In a randomized clinical trial, we compared the immunosuppressive benefi...

journal_title：Transplantation

authors： Abouna GM,al-Abdullah IH,Kelly-Sullivan D,Kumar MS,Loose J,Phillips K,Yost S,Seirka D

更新日期：1995-06-15 00:00:00

abstract：:The CD154-CD40 pathway is one of the critical costimulatory pathways that are required for full activation of T cells during alloimmune responses. Blockade of this pathway with anti-CD154 antibodies has been reported to prolong allograft survival in experimental transplantation models and to induce tolerance in some i...

journal_title：Transplantation

authors： Yamada And A,Sayegh MH

更新日期：2002-01-15 00:00:00

abstract：INTRODUCTION:Statins are an established therapy after cardiac transplantation. Sirolimus (Srl) has been used successfully in cardiac transplant patients. However, potential side effects are hyperlipidemia and interactions with statins. The aim of the study was to evaluate the safety and efficacy of statin therapy after...

journal_title：Transplantation

authors： Aliabadi AZ,Mahr S,Dunkler D,Grömmer M,Zimpfer D,Wolner E,Grimm M,Zuckermann AO

更新日期：2008-12-27 00:00:00

abstract：BACKGROUND:Reactivation of cytomegalovirus (CMV) is frequently observed in recipients of solid organs and bone marrow transplants and is associated with increased risk of acute and chronic allograft rejection, opportunistic infection, graft failure, and patient mortality. The molecular mechanisms by which reactivation ...

journal_title：Transplantation

authors： Zhang Z,Li Z,Yan S,Wang X,Abecassis M

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:Deciphering the mechanisms of tolerance and chronic rejection (CR) remains a major goal in transplantation. Data in rodents suggest that Toll-like receptors (TLR), regulators of innate immune responses, play a role in determining graft outcome. However, few studies have focused on TLR expression in human kid...

journal_title：Transplantation

authors： Braudeau C,Ashton-Chess J,Giral M,Dugast E,Louis S,Pallier A,Braud C,Moreau A,Renaudin K,Soulillou JP,Brouard S

更新日期：2008-07-15 00:00:00

abstract：:Monocytes from human peripheral blood, when incubated in vitro, spread onto the surface of the glass. Horse antihuman lymphocyte globulin (ALG) added to the incubation chamber inhibits the spreading, while normal horse globulin (NHG) does not. The inhibition depends on the concentration of ALG admixed to the mononucle...

journal_title：Transplantation

authors： Silobrcić V,Mazuran R,Dekaris D,Balner H

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Metabolic syndrome (MS) is a known cardiovascular risk factor in the general population. We explored the influence of MS on the occurrence of atherosclerotic events (AEs) after renal transplantation. METHODS:Three hundred thirty-seven renal transplant recipients were included in the study. Various parameter...

journal_title：Transplantation

authors： Courivaud C,Kazory A,Simula-Faivre D,Chalopin JM,Ducloux D

更新日期：2007-06-27 00:00:00

abstract：BACKGROUND:Ventricular assist devices (VADs) are increasingly being used in pediatric patients to provide long-term cardiac support. One potential complication of VAD therapy is the development of antibodies directed against human leukocyte antigens (HLA). This phenomenon has not been well described with the Berlin Hea...

journal_title：Transplantation

authors： O'Connor MJ,Harville TO,Rhodes-Clark B,Pye SE,Knecht KR,Imamura M,Frazier EA,Morrow WR

更新日期：2013-06-27 00:00:00

abstract：:The effect of the graft-versus-host reaction in response to minor histocompatibility antigens on the antibody response to a T-dependent antigen was studied in four strains of mice. Lethally irradiated mice were transplanted with bone marrow plus graded numbers of spleen cells from H-2-compatible donors. Recipients of ...

journal_title：Transplantation

authors： Hamilton BL,Ochs HD

更新日期：1989-06-01 00:00:00

abstract：:Over the decade between 2003 and 2012, the UK has seen major changes in how organ donation and transplantation is delivered. The number of deceased organ donors has increased from 709 (12.0 per million population [pmp]) to 1,164 (18.3 pmp); this increase has been predominantly a result of an increase in donors after c...

journal_title：Transplantation

authors： Johnson RJ,Bradbury LL,Martin K,Neuberger J,UK Transplant Registry.

更新日期：2014-01-15 00:00:00

abstract：BACKGROUND:Post-lung transplant infection is one of the leading causes of morbidity and mortality. The cause and incidence are similar in many series; however, infections such as Mycobacterium tuberculosis are influenced by the epidemiologic situation. The authors present a prospective and observational study to define...

journal_title：Transplantation

authors： Bravo C,Roldán J,Roman A,Degracia J,Majo J,Guerra J,Monforte V,Vidal R,Morell F

更新日期：2005-01-15 00:00:00

abstract：:In keeping with the in vitro mitogenic properties of anti-CD3 MoAbs, the first injections of anti-CD3 are invariably responsible for an in vivo cellular activation. This activation induces a massive cytokine release in the circulation (TNF, IFN gamma, IL-2, IL-6, and IL-3). Paralleling this release, a severe clinical ...

journal_title：Transplantation

authors： Ferran C,Dy M,Merite S,Sheehan K,Schreiber R,Leboulenger F,Landais P,Bluestone J,Bach JF,Chatenoud L

更新日期：1990-10-01 00:00:00

abstract：INTRODUCTION:We carried out an analysis of the United States Renal Data System to determine the incidence, risk factors, prognosis, and costs associated with the diagnosis of renal cell carcinoma (RCC) after kidney transplantation. METHODS:This is a retrospective cohort of 40,821 Medicare primary renal transplant reci...

journal_title：Transplantation

authors： Hurst FP,Jindal RM,Graham LJ,Falta EM,Elster EA,Stackhouse GB,Agodoa LY,Lentine KL,Salifu MO,Abbott KC

更新日期：2010-10-27 00:00:00