Abstract:
:Since 1981, when the liver transplantation program was initiated at the University of Pittsburgh, we have been impressed with the prevalence of pancreatitis occurring following liver transplantation in patients transplanted for hepatitis B-related liver disease. To either confirm this clinical impression or refute it, the records of the 27 HbsAg+ patients and those of an additional 24 HbsAg- but HbcAb and/or HbsAb+ patients who underwent orthotopic liver transplantation were reviewed to determine the prevalence of clinical pancreatitis and hyperamylasemia (biochemical pancreatitis) following liver transplantation (OLTx). Post-OLTx hyperamylasemia occurred significantly more frequently in HbsAg+ patients (6/27) than it did in the HbsAg- patients (0/24) (P less than 0.05). More importantly, clinical pancreatitis occurred in 14% (4/27) of the HbsAg+ patients and 0% (0/24) of the HbsAg- patients. Interestingly, in each case, the pancreatitis was associated with the occurrence of acute hepatitis B infection of the allograft. Based upon these data, we conclude that pancreatitis occurring after liver transplantation is more common in patients transplanted for active viral liver disease caused by hepatitis B than in those with inactive viral liver disease. These observations suggest that pancreatitis occurring in, at least some cases following liver transplantation for viral liver disease, may result from hepatitis B virus infection of the pancreas.
journal_name
Transplantationjournal_title
Transplantationauthors
Alexander JA,Demetrius AJ,Gavaler JS,Makowka L,Starzl TE,Van Thiel DHdoi
10.1097/00007890-198806000-00012subject
Has Abstractpub_date
1988-06-01 00:00:00pages
1062-5issue
6eissn
0041-1337issn
1534-6080journal_volume
45pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Between December 1983 and August 1985, 110 cadaver transplants were performed at our institution. All were started on cyclosporine (CsA) and prednisone (P) for immunosuppressive therapy. Of the 110 patients, 46 were converted from CsA to azathioprine (AZA) for a variety of reasons (cost, toxicity, patient preference, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198702000-00012
更新日期:1987-02-01 00:00:00
abstract::Cold-storage preservation of the canine pancreas prior to islet isolation has previously been noted to reduce the intrasplenic islet autograft success rate; but the mechanism of this deleterious effect has not been determined. We undertook a study in both outbred dogs and Lewis (RT1-1) rats to determine the influence ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00007
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000576
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199807150-00007
更新日期:1998-07-15 00:00:00
abstract:BACKGROUND:We previously reported that no cytotoxic T-lymphocyte precursor frequencies (CTLpf) were found in 60% of patients on azathioprine or mycophenolate mofetil+Pred long after kidney transplantation. We questioned whether the absence of donor-specific CTLpf was associated with low levels of stimulatory Th1 (tumor...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a36c85
更新日期:2009-05-27 00:00:00
abstract::A total of 151 potential recipients of kidney grafts from one-HLA-haplotype-mismatched MLC-positive (RR greater than 20%) donors treated during 1980-1984 was investigated. The recipients were divided retrospectively into four groups: (A) 42 patients who received pretransplant donor-specific transfusions (DST) and post...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:The role of asymptomatic bacteriuria in kidney transplant recipients is unknown. There is no clear evidence of its effect on transplanted kidney. METHODS:We studied urine cytokines profile among kidney transplant recipients with bacteriuria found in screening examination. Urine cultures were collected in 26...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000226072.20185.f8
更新日期:2006-06-27 00:00:00
abstract::Seventy-two dog kidneys were stored under hypothermia as described by Collins and Sacks between 24 and 72 hr and then transplanted. The immediate function of the kidneys was measured by p-aminohippuric acid and inulin clearances. Twenty-four hr proved to be the maximum safe preservation time with both methods. The imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197705000-00009
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Recently, TT virus (TTV) was discovered as a potential causative agent for non-A-E hepatitis. Little is known about the prevalence of TTV infection in renal transplant recipients. METHODS:One hundred and seventeen Brazilian renal transplant recipients and 100 normal subjects were examined to determine the p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200010270-00012
更新日期:2000-10-27 00:00:00
abstract:BACKGROUND:Successful islet transplantation can result in insulin independence in many patients with type 1 diabetes mellitus, but it often requires more than one islet infusion. The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited org...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c478fd
更新日期:2010-02-27 00:00:00
abstract:BACKGROUND:Murine umbilical cord blood cells (UCBCs) were studied for their ability to reconstitute the hematopoietic system. METHODS:On average, 150 microL of cord blood per fetus containing 1.2 to 2 x 10(4) nucleated cells were collected from day 18.5 fetal umbilical cord, and 3 to 6 x 10(3) cells per fetus were obt...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000065295.99190.03
更新日期:2003-06-15 00:00:00
abstract:BACKGROUND:Whether cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. METHODS:We prospectively assessed CMV-specific CMI predicting late-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002421
更新日期:2018-11-01 00:00:00
abstract::Graft-versus-host disease is a potential problem following small bowel transplantation. We have previously shown that a two-day intraperitoneal course of polyclonal antilymphocyte serum completely prevents GVHD without impairing allograft function in a unidirectional rat small bowel transplant model. In the present st...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199112000-00002
更新日期:1991-12-01 00:00:00
abstract::Because of the inherent difficulties in allele assignment with HLA-DR serological typing, in 1993 our organ procurement organization-based HLA laboratory replaced serology with the molecular method of polymerase chain reaction using sequence-specific primer mixes (PCR-SSP) to type for DR and DQ at a resolution level e...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00024
更新日期:1996-12-27 00:00:00
abstract:BACKGROUND:Normothermic perfusion is an alternative but little studied method of organ preservation. Herein, we report the first case of ex vivo normothermic renal transplant perfusion in man. METHODS:The 62-year-old extended criteria donor died of an intracranial hemorrhage and had undergone cardiopulmonary resuscita...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822d4e04
更新日期:2011-10-15 00:00:00
abstract::Graft and patient survival rates were analyzed in 239 consecutive first cadaver renal transplants as a function of time of administration of blood transfusion and the number of units given. There was no statistically significant difference in patient survival in comparing patients who were never transfused, patients n...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198012000-00008
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:Insults to the airway epithelium play a key role in constrictive bronchiolitis after lung transplantation, the typical hallmark of chronic rejection. Our hypothesis is that immunosuppressives might affect airway integrity. METHODS:A biculture of human bronchial epithelial cells and lung microvascular endoth...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001809
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. METHODS:At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1c) or LEW (RT1(1)) rats. Rats having undergon...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003150-00062
更新日期:2000-03-15 00:00:00
abstract:BACKGROUND:Inasmuch as cryopreservation can facilitate clinical islet transplantation by providing a means of storing supplemental islets in order to augment marginally adequate grafts, protocols are needed to allow for a minimal loss in viable beta cells. By replacing the cryoprotectant dimethyl sulfoxide (DMSO) with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199710150-00020
更新日期:1997-10-15 00:00:00
abstract::In a prospective longitudinal study, detection of cytomegalovirus (CMV) DNA in plasma (plasma polymerase chain reaction [PCR]) was compared with PCR of CMV DNA in peripheral blood leukocytes (PBL PCR), the CMV pp65 antigenemia assay, and viral cultures from blood, urine, and throat of 29 patients, 14 of whom received ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199707150-00020
更新日期:1997-07-15 00:00:00
abstract:BACKGROUND:Airway complications continue to be an important source of morbidity and mortality after lung transplantation (LTx). Different approaches have been used for their nonsurgical management. We describe our experience using self-expandable metallic stents (SEMSs) in patients with airway complications post-LTx. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000061229.83500.A0
更新日期:2003-05-15 00:00:00
abstract::Progressive microvascular endothelial damage is a characteristic feature of fulminant acute cardiac allograft rejection in the rat. Serial ultrastructural tracer studies using i.v. administered colloidal carbon and horseradish peroxidase have been performed in an adoptive transfer model to determine the role of cellul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198402000-00013
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the pharmacokinetic profile, tolerability, and safety of a novel once-daily extended-release formulation of tacrolimus (LCPT) with that of once-daily prolonged-release tacrolimus (ODT) in stable adult lung transplant (LT) recipients. METHODS:Phase II, open-label, single-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002348
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:In chronic graft-versus-host disease (cGvHD), skin fibrosis, contractures, and an increase in collagen content form the hallmark. We report a successful treatment of a cGvHD patient by topical application of halofuginone, an inhibitor of collagen alpha1(I) gene expression. METHODS:Halofuginone-containing oi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199912150-00027
更新日期:1999-12-15 00:00:00
abstract:BACKGROUND:In response to recent studies, a better understanding of the risks of renal complications among African American and biologically related living kidney donors is needed. METHODS:We examined a database linking U.S. registry identifiers for living kidney donors (1987-2007) to billing claims from a private hea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000733
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) still limits survival after heart transplantation. Currently available noninvasive tests are of inferior value to detect CAV, and thus invasive coronary angiography (ICA) is frequently performed. Cardiac dual-source computed tomography calcium scoring (DSCTCS) offers the ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318225281d
更新日期:2011-08-27 00:00:00
abstract::Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognosti...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199307000-00019
更新日期:1993-07-01 00:00:00
abstract::Glutathione and glyoxalase II levels were evaluated in cytosolic and mitochondrial compartments of rat liver after 7 and 24 hr of cold storage in University of Wisconsin (UW) and Euro-Collins solutions. 1-4 A similar time-dependent depletion of cytosolic glutathione up to about 60% of control values was observed in bo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199605150-00026
更新日期:1996-05-15 00:00:00
abstract::Increased QT dispersion (QTd), predicting patients with risk of malignant arrhythmia, have recently been reported in hemodialysis patients (HDp). In this prospective study, we aimed to investigate changes in QTd and signal averaged-ECG (SAECG) in HDp after transplantation. Twenty-seven HDp (M/F:18/9, mean age 30+/-8 y...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200111150-00009
更新日期:2001-11-15 00:00:00
abstract::CD4+ cells from CsA-treated DA rats with long-surviving PVG heart allografts specifically suppress the capacity of naive CD4+ cells to restore allograft rejection in irradiated DA rats, but have normal donor-specific alloreactivity in MLC. CD4+ suppressor cells from CsA-treated DA rats cultured for 3 days against eith...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199302000-00027
更新日期:1993-02-01 00:00:00