Influence of prophylactic treatment with gamma-immunoglobulins on renal function after kidney transplantation in rhesus monkeys.

abstract：BACKGROUND:Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a distinct form of glomerulonephritis that often recurs after kidney transplantation causing severe graft injury and often failure. METHODS:We describe post transplant outcomes and response to therapy in 20 recipients with ...

journal_title：Transplantation

authors： Buxeda A,Said SM,Nasr SH,Leung N,El Ters M,Cosio FG

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Renal transplant recipients have an increased incidence of cardiovascular disease, but less data exist about cerebrovascular atherosclerosis. In this study, we assessed the prevalence of carotid lesions as evaluated by B-mode ultrasonography in a group of renal transplant recipients, and we evaluated univari...

journal_title：Transplantation

authors： Barbagallo CM,Pinto A,Gallo S,Parrinello G,Caputo F,Sparacino V,Cefalù AB,Novo S,Licata G,Notarbartolo A,Averna MR

更新日期：1999-02-15 00:00:00

abstract：BACKGROUND:Our aim was to evaluate the effect of FTY720 in discordant islet xenotransplantation. METHODS:Fetal porcine islet-like cell clusters (ICCs) were transplanted into normoglycemic rats that were either left untreated or treated with FTY720 only, with FTY720 plus cyclosporine A (CsA) or with CsA only. Twelve or...

journal_title：Transplantation

authors： Maeda A,Goto M,Zhang J,Bennet W,Groth CG,Korsgren O,Wennberg L

更新日期：2003-04-27 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) replication has been associated with more risk for solid organ graft rejection. We wondered whether this association still holds when patients at risk receive prophylactic treatment for CMV. METHODS:We correlated CMV infection, biopsy-proven graft rejection, and graft loss in 1,414 pat...

journal_title：Transplantation

authors： Stern M,Hirsch H,Cusini A,van Delden C,Manuel O,Meylan P,Boggian K,Mueller NJ,Dickenmann M,Members of Swiss Transplant Cohort Study.

更新日期：2014-11-15 00:00:00

abstract：:A non-complement-binding monoclonal antibody, TA-1, recognizing determinants on human T lymphocytes, was linked to the plant seed toxin ricin, either the intact molecule or purified ricin A chain. Peripheral blood lymphocytes were pretreated with conjugate for 2 hr, washed, and then measured in vitro for T cell prolif...

journal_title：Transplantation

authors： Vallera DA,Quinones RR,Azemove SM,Soderling CC

更新日期：1984-04-01 00:00:00

abstract：:We developed a new and simplified donor-specific blood transfusion (DSBT) protocol for prospective kidney transplant recipients from one-haplotype-mismatched related donors. Prospective kidney donors gave 450 ml of blood in a quad-pack unit, and the blood was stored in a blood bank. Twenty-five patients were transfuse...

journal_title：Transplantation

authors： Cheigh JS,Suthanthiran M,Kaplan M,Evelyn M,Riggio RR,Fotino M,Schechter N,Wolf CF,Stubenbord WT,Stenzel KH

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Treatment with a donor-specific transfusion (DST) and a brief course of anti-mouse CD154 (anti-CD40-ligand) monoclonal antibody (mAb) prolongs the survival of both allografts and rat xenografts in mice. The mechanism by which allograft survival is prolonged is incompletely understood, but depends in part on ...

journal_title：Transplantation

authors： Gordon EJ,Woda BA,Shultz LD,Rossini AA,Greiner DL,Mordes JP

更新日期：2001-01-27 00:00:00

abstract：:A patient with short gut syndrome presented with end-stage liver disease. She underwent an isolated liver transplantation at the age of 3.5 years. Parenteral nutrition was discontinued 1.5 years after surgery. At 7 years of age, the patient has maintained normal nutritional indices and growth while on a normal oral di...

journal_title：Transplantation

authors： Gottrand F,Michaud L,Bonnevalle M,Dubar G,Pruvot FR,Turck D

更新日期：1999-02-27 00:00:00

abstract：:Since June 1979, percutaneous transluminal angioplasty (PTA) has been the procedure of choice for renal transplant artery stenosis (RTAS) at the Hospital of the University of Pennsylvania. Of 241 renal allograft recipients, 17 (7%) when studied by arteriogram because of suspected RTAS proved to have significant stenos...

journal_title：Transplantation

authors： Grossman RA,Dafoe DC,Shoenfeld RB,Ring EJ,McLean GK,Oleaga JA,Freiman DB,Naji A,Perloff LJ,Barker CF

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:A combined liver and kidney transplantation (CLKT) is advocated for selected individuals with chronic kidney disease undergoing liver transplantation (LT). The aim was to develop a risk score to identify the patients whose estimated glomerular filtration rate (eGFR) would decline during the year post-LT to a...

journal_title：Transplantation

authors： O'Riordan A,Donaldson N,Cairns H,Wendon J,O'Grady JG,Heaton N,Hendry BM

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:Scarring can greatly impact quality of life for individuals (ie, causing depression posttraumatic stress disorder, body image issues). Those who wish to be anonymous live liver donors are warned of the potential negative psychological impacts associated with the large scar left from liver donation surgery. G...

journal_title：Transplantation

authors： Krause S,Pritlove C,Abbey S,Jung J

更新日期：2020-05-25 00:00:00

abstract：:The presence of anti-GOR was determined in paired pre-orthotopic liver transplantation (pre-OLT) and post-OLT sera from 87 OLT patients with hepatitis C virus infection. Before OLT, 48/87 patients were seropositive for anti-GOR, but this marker had no relationship with the clinical and biochemical parameters, or virem...

journal_title：Transplantation

authors： Reiser M,Terrault N,Nelson DR,Mizokami M,Ferrell L,Lake JR,Roberts JP,Ascher NL,Wright TL,Lau JY

更新日期：1997-02-27 00:00:00

abstract：:The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a pivotal role in cellular metabolism and in a wide range of eukaryotic biological/cellular functions and signaling networks. Additionally, as ...

journal_title：Transplantation

authors： Zaza G,Granata S,Caletti C,Signorini L,Stallone G,Lupo A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Cell-based insulin therapies can potentially improve glycemic regulation in insulin-dependent diabetic patients. Enteroendocrine cells engineered to secrete recombinant insulin have exhibited glycemic efficacy, but have been primarily studied as uncontrollable growth systems in immune incompetent mice. Furth...

journal_title：Transplantation

authors： Tiernan AR,Thulé PM,Sambanis A

更新日期：2014-09-15 00:00:00

abstract：OBJECTIVES:To retrospectively compare the accuracy of pretransplant panel of reactivity antibodies (PRA) and serum level of soluble CD30 (sCD30) in predicting early (< 6 months) acute rejection (AR) in living-donor and deceased-donor kidney-transplant (KT) patients. METHODS:Pretransplant sera of 24 KT recipients were ...

journal_title：Transplantation

authors： Cinti P,Pretagostini R,Arpino A,Tamburro ML,Mengasini S,Lattanzi R,De Simone P,Berloco P,Molajoni ER

更新日期：2005-03-15 00:00:00

abstract：:Of 113 cyclosporine-treated primary renal allograft recipients, 60 were randomized to receive standard therapy without diltiazem (ND) and 53 received standard therapy plus diltiazem (D). There was no difference in CsA blood levels between ND and D at all intervals between 3 and 24 months follow-up, yet the D group req...

journal_title：Transplantation

authors： Chrysostomou A,Walker RG,Russ GR,d'Apice AJ,Kincaid-Smith P,Mathew TH

更新日期：1993-02-01 00:00:00

abstract：:Despite improvements in immunosuppression, rejection occurs in 50% of liver transplant patients and may cause significant morbidity. The most frequent cause of death after liver transplantation is severe infection. Determination of the cytokine network may lead to earlier detection of patients at risk for severe rejec...

journal_title：Transplantation

authors： Platz KP,Mueller AR,Rossaint R,Steinmüller T,Lemmens HP,Lobeck H,Neuhaus P

更新日期：1996-11-27 00:00:00

abstract：BACKGROUND:We assess whether remote ischemic preconditioning (rIPC) of the recipient can modify ischemia-reperfusion (IR) injury in the donor heart following orthotopic heart transplantation from brain dead donors and to examine potential mechanisms of protection. METHODS:Sixteen pigs weighing from 26 to 34.2 (mean 29...

journal_title：Transplantation

authors： Konstantinov IE,Li J,Cheung MM,Shimizu M,Stokoe J,Kharbanda RK,Redington AN

更新日期：2005-06-27 00:00:00

abstract：BACKGROUND:Although antibody mechanisms play a pathogenetic role in liver allograft rejection, no data exist on B lymphocytes, plasma cells, complement, and chemokines in rejected liver tissue. METHODS:Liver biopsy specimens from 25 patients with acute allograft rejection (AR) (rejection activity index, RAI score: 1-9...

journal_title：Transplantation

authors： Krukemeyer MG,Moeller J,Morawietz L,Rudolph B,Neumann U,Theruvath T,Neuhaus P,Krenn V

更新日期：2004-07-15 00:00:00

abstract：:Mucosal injury is an immediate event following revascularization of small intestinal grafts in the context of transplantation (SBTx). The generation of oxygen free radicals (OFR) and tissue infiltration by activated neutrophils are consequences of ischemia and reperfusion and known causative factors of tissue injury; ...

journal_title：Transplantation

authors： Cicalese L,Caraceni P,Nalesnik MA,Borle AB,Schraut WH

更新日期：1996-07-27 00:00:00

abstract：:Pancreatic transplantation is intended to normalize carbohydrate metabolism in insulin-dependent diabetics by restoring endogenous insulin release, and it is usually performed together with kidney transplantation in patients with end-stage renal failure. A major problem in these patients is the daily control of the gr...

journal_title：Transplantation

authors： Secchi A,Pontiroli AE,Traeger J,Dubernard JM,Touraine JL,Ruitton A,Blanc N,Pozza G

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:In a pilot trial we evaluated the toxicity and efficacy of sirolimus (rapamycin) as second-line therapy for the treatment of acute graft-versus-host disease (GVHD) in 21 patients (1-46 years of age) after allogeneic hematopoietic stem cell transplantation (HSCT). METHODS:All patients were treated with methy...

journal_title：Transplantation

authors： Benito AI,Furlong T,Martin PJ,Anasetti C,Appelbaum FR,Doney K,Nash RA,Papayannopoulou T,Storb R,Sullivan KM,Witherspoon R,Deeg HJ

更新日期：2001-12-27 00:00:00

abstract：:Recipient dogs were conditioned with 9.2 Gy of total-body irradiation followed by the infusion of bone marrow and peripheral blood leukocytes from a DLA-haploidentical littermate (N = 10) or a completely allogeneic unrelated donor (n = 9). Graft-vs.-host disease (GVHD) prophylaxis consisted of methotrexate (MTX) and c...

journal_title：Transplantation

authors： Deeg HJ,Severns E,Raff RF,Sale GE,Storb R

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Recent data show the efficacy of embryonic stem cells (ESC) to engraft in allogeneic recipients without host pretreatment. This property is due to their low expression of major histocompatibility complex (MHC) class I antigens and lack of MHC class II expression. Here, we tested the hypothesis that the const...

journal_title：Transplantation

authors： Fabricius D,Bonde S,Zavazava N

更新日期：2005-05-15 00:00:00

abstract：BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...

journal_title：Transplantation

authors： Scheepstra C,Bemelman FJ,van der Loos C,Rowshani AT,van Donselaar-Van der Pant KA,Idu MM,ten Berge IJ,Florquin S

更新日期：2008-09-27 00:00:00

abstract：:Nippostrongylus infection strongly stimulates TH2 activity in vivo. Given the evidence of cross regulation between TH2 and TH1 cells, and the link between TH1 activity and graft rejection, we examined the effects of Nippostrongylus infection on the fate of kidney allografts in rats. Both prior Nippostrongylus infectio...

journal_title：Transplantation

authors： Ledingham DL,McAlister VC,Ehigiator HN,Giacomantonio C,Theal M,Lee TD

更新日期：1996-01-27 00:00:00

abstract：:Focal segmental glomerulosclerosis (FSGS) is the primary renal disease in approximately one-tenth of pediatric patients receiving a renal allograft. Recurrence of proteinuria after renal transplantation is observed in approximately 30% of patients and negatively impacts graft survival. Risk factors for recurrence are ...

journal_title：Transplantation

authors： Weber S,Tönshoff B

更新日期：2005-09-27 00:00:00

abstract：BACKGROUND:Insults to the airway epithelium play a key role in constrictive bronchiolitis after lung transplantation, the typical hallmark of chronic rejection. Our hypothesis is that immunosuppressives might affect airway integrity. METHODS:A biculture of human bronchial epithelial cells and lung microvascular endoth...

journal_title：Transplantation

authors： Bellon H,Vandermeulen E,Verleden SE,Heigl T,Vriens H,Lammertyn E,Verlinden L,Vanhove T,Verstuyf M,Hoet P,Vos R,Verleden GM,Vanaudenaerde BM

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:A quantitative model of immunosuppression was previously developed based on the rejection of the allogeneic A/J murine tumor sarcoma 1 (Sa1) in immunocompetent mice. Here, the model is used to evaluate the immunologic mechanisms of graft rejection and to determine the potential of this model to detect synerg...

journal_title：Transplantation

authors： Hammond-McKibben D,Saulnier M,Zhang J,Risher N,Lake P,Weetall M

更新日期：2005-04-27 00:00:00

abstract：:Graft-versus-host disease (GvHD), a life-threatening complication of bone marrow transplantation, is initiated by donor T cells reacting to recipient dendritic cells (DC). GvHD can be controlled by attenuating donor T cells, but few strategies exist to target DC, particularly resident tissue DC, despite recent evidenc...

journal_title：Transplantation

authors： Collin MP,Munster D,Clark G,Wang XN,Dickinson AM,Hart DN

更新日期：2005-03-27 00:00:00