mTOR Inhibition Role in Cellular Mechanisms.

abstract：BACKGROUND:Early enteral nutrition with solutions containing prebiotics (fiber) and probiotics (Lactobacillus) is suggested to reduce bacterial translocation and minimize the incidence of infections after liver transplantation. METHODS:In a prospective, randomized placebo-controlled trial consisting of 95 patients, we...

journal_title：Transplantation

authors： Rayes N,Seehofer D,Hansen S,Boucsein K,Müller AR,Serke S,Bengmark S,Neuhaus P

更新日期：2002-07-15 00:00:00

abstract：BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

journal_title：Transplantation

authors： Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

更新日期：2003-05-15 00:00:00

abstract：BACKGROUND:Tacrolimus is a potent immunosuppressive agent that provides higher freedom from acute and chronic rejection than cyclosporine after liver transplantation (LTx). Initially, a steroid-free state was observed in about 70% of patients at 1 year; this did not change over the next 5 years. The present study ident...

journal_title：Transplantation

authors： Jain A,Kashyap R,Marsh W,Rohal S,Khanna A,Fung JJ

更新日期：2001-04-27 00:00:00

abstract：:The individual effects of verapamil and 2 antioxidants on perfused rat liver nucleoside triphosphate (NTP) recovery following cold storage in University of Wisconsin (UW) solution was assessed using 31P nuclear magnetic resonance spectroscopy. The pharmacological agents were added to UW solution and were present only ...

journal_title：Transplantation

authors： Bowers JL,Neymark E,Cook CU,Clouse ME

更新日期：1994-06-15 00:00:00

abstract：BACKGROUND:In this report, we compare the long-term outcome of pediatric liver transplantation (LTx) patients maintained with tacrolimus-based and with cyclosporine (CsA)-based immunosuppressive therapy. We examine long-term patient and graft survival, the incidence of rejection, and immunosuppression-related complicat...

journal_title：Transplantation

authors： Jain A,Mazariegos G,Kashyap R,Green M,Gronsky C,Starzl TE,Fung J,Reyes J

更新日期：2000-08-27 00:00:00

abstract：:Cyclosporine (CsA) administration and nitric oxide (NO) blockade promote similar chronic renal hemodynamic alterations in rats. We evaluated various clinical CsA doses under conditions of NO blockade using L-NAME (N-nitro L-arginine methyl ester). Groups of Sprague-Dawley rats kept on a normal salt (+NaCl) or low-salt...

journal_title：Transplantation

authors： Gardner MP,Houghton DC,Andoh TF,Lindsley J,Bennett WM

更新日期：1996-05-27 00:00:00

abstract：:Acute rejection episodes still occur after kidney transplantation in spite of modern immunosuppressive protocols including combined tacrolimus, mycophenolate mofetil, and prednisolone. The authors present seven cases of biopsy-proven acute rejection after kidney transplantation refractory to conventional rejection the...

journal_title：Transplantation

authors： Kumlien G,Genberg H,Shanwell A,Tydén G

更新日期：2005-01-15 00:00:00

abstract：BACKGROUND:We previously reported that posttransplant lymphoproliferative disorders (PTLD) occurred more frequently in non-African American (AF) kidney transplant recipients. An in-depth analysis of racial differences in the development of PTLD has not been reported. METHODS:We assessed Medicare claims for PTLD in a r...

journal_title：Transplantation

authors： Nee R,Hurst FP,Dharnidharka VR,Jindal RM,Agodoa LY,Abbott KC

更新日期：2011-07-27 00:00:00

abstract：:Sensitized patients awaiting renal transplantation have a markedly reduced probability of receiving a crossmatch (XM)-negative renal allograft, and, even if transplanted with a negative complement-dependent cytotoxicity (CDC)-XM, they are at an increased risk of antibody-mediated humoral rejection with early graft los...

journal_title：Transplantation

authors： Beimler JH,Morath C,Schmidt J,Ovens J,Opelz G,Rahmel A,Zeier M,Süsal C

更新日期：2009-03-15 00:00:00

abstract：:Until recently, islet allotransplantation for type 1 diabetic patients has been largely unsuccessful. Previous pharmacologic studies of single drugs have suggested that one factor contributing to this poor success is toxicity of immunosuppressive drugs on transplanted islets. However, no comprehensive study of agents ...

journal_title：Transplantation

authors： Paty BW,Harmon JS,Marsh CL,Robertson RP

更新日期：2002-02-15 00:00:00

abstract：:As a consequence of its large volume, a microencapsulated islet graft can be implanted only into the peritoneal cavity. The graft volume can be reduced by using small capsules. However, reduction of the diameter of the capsules holds a certain risk, because with smaller capsules, more islets may be found to protrude f...

journal_title：Transplantation

authors： De Vos P,De Haan B,Pater J,Van Schilfgaarde R

更新日期：1996-10-15 00:00:00

abstract：:We initiated a policy of using RSLT in critically ill patients in June of 1988. Since that time we have performed 30 RSLTs in 29 patients, including 28 children and 1 adult. The mean age of the children was 27 months (range 1 month to 10 years) with 14 (52%) being 1 year of age or less. The mean weight was 11.3 kg (ra...

journal_title：Transplantation

authors： Langnas AN,Marujo WC,Inagaki M,Stratta RJ,Wood RP,Shaw BW Jr

更新日期：1992-02-01 00:00:00

abstract：:The requirement for effective, minimally toxic immunosuppression remains a major obstacle to performing human composite tissue allotransplantation. The skin component of composite tissue (e.g., limb) allografts is especially antigenic, necessitating toxic immunosuppressant doses to prevent or reverse acute rejection. ...

journal_title：Transplantation

authors： van den Helder TB,Benhaim P,Anthony JP,McCalmont TH,Mathes SJ

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:During the isolation process, pancreatic islets are exposed to an environment of sterile inflammation resulting in an upregulated inflammatory state before transplantation. Toll-like receptor 4 (TLR4) has been identified as a major mediator of sterile inflammation. Therefore, we sought to determine whether e...

journal_title：Transplantation

authors： Chang CA,Murphy K,Kane RR,Lawrence MC,Naziruddin B

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Exercise training is effective in improving the cardiovascular risk profiles of nontransplanted patients, but the health benefits and potential harms of routine exercise training after solid organ transplantation are unclear. This study aims to assess the health benefits and harms of supervised exercise trai...

journal_title：Transplantation

authors： Didsbury M,McGee RG,Tong A,Craig JC,Chapman JR,Chadban S,Wong G

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:Combined liver and kidney transplantation (CLKT) is a surgical challenge in small children because of technical aspects, lack of pediatric donors, and restrictions related to the size of the abdominal cavity. We report outcomes after CLKT in this challenging group of smaller children. METHOD:A review of pro...

journal_title：Transplantation

authors： Perera MT,Silva MA,Sharif K,McKiernan PJ,Kelly DA,Lloyd C,Milford DV,Mayer DA,Mirza DF

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:In patients with acute liver failure (ALF) of unknown cause, viral infections are believed to be involved. This study investigates the involvement of human herpesvirus-6 (HHV-6). METHODS:Thirty-two patients with ALF who underwent transplantations during a 6-year period were studied for viruses in biopsies f...

journal_title：Transplantation

authors： Härmä M,Höckerstedt K,Lautenschlager I

更新日期：2003-08-15 00:00:00

abstract：BACKGROUND:Previous studies have identified more morbidity in simultaneous pancreas-kidney (SPK) transplant recipients compared with kidney alone (KA) recipients. With the development of novel immunosuppressive drugs, studies are needed to determine optimal treatment regimens in specific patient populations. METHODS:W...

journal_title：Transplantation

authors： Lee CM,Scandling JD,Krieger NR,Dafoe DC,Alfrey EJ

更新日期：1997-11-15 00:00:00

abstract：:Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...

journal_title：Transplantation

authors： Singh N,Gayowski T,Wagener MM,Marino IR

更新日期：1996-02-15 00:00:00

abstract：:The combination of pharmacokinetic and pharmacodynamic (measurement of the biological effect) monitoring of immunosuppressive drugs provides a method for the optimization of drug dosing. We chose to investigate this using mycophenolic acid (MPA), an immunosuppressive drug that mediates its effect by the inhibition of ...

journal_title：Transplantation

authors： Langman LJ,Shapiro AM,Lakey JR,LeGatt DF,Kneteman NM,Yatscoff RW

更新日期：1996-01-15 00:00:00

abstract：:Disseminated varicella-zoster (VZV) infection is a rare complication after renal allotransplantation in adults. We report four patients, among them one with combined VZV and cytomegalovirus infection. The main complications were hepatitis, pneumonitis, and disseminated intravascular coagulation. A review of the litera...

journal_title：Transplantation

authors： Fehr T,Bossart W,Wahl C,Binswanger U

更新日期：2002-02-27 00:00:00

abstract：:Forty-three human liver allograft biopsies and normal liver were directly analyzed for inflammatory and immunoregulatory cytokine gene expression by polymerase chain reaction (PCR). IL-5 gene expression was predominantly present in biopsies from liver allografts with histopathological evidence of acute rejection. IL-2...

journal_title：Transplantation

authors： Martinez OM,Krams SM,Sterneck M,Villanueva JC,Falco DA,Ferrell LD,Lake J,Roberts JP,Ascher NL

更新日期：1992-02-01 00:00:00

abstract：:Transcription factors of the nuclear factor of activated T cells (NFAT) family regulate both immune activation and insulin production. Calcineurin inhibitors (CNIs) target NFAT activation. Hence, CNIs not only prevent organ transplant rejection but also contribute to the development of new-onset diabetes after transpl...

journal_title：Transplantation

authors： Chen Y,Sampaio MS,Yang JW,Min D,Hutchinson IV

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:The relationship between institutional case volume and clinical outcomes after living donor liver transplantation is not clarified. METHODS:We conducted a nationwide retrospective cohort study using the database of Korean National Healthcare Insurance Service. Between January 2007 and December 2016, 7073 ad...

journal_title：Transplantation

authors： Yoo S,Jang EJ,Yi NJ,Kim GH,Kim DH,Lee H,Jung CW,Ryu HG

更新日期：2019-05-01 00:00:00

abstract：:High levels of tumor necrosis factor-alpha, interleukin-2, and gamma-interferon appeared in the circulation of kidney transplant recipients after the first injection of the monoclonal antibody OKT3. This initial injection was systematically followed by fever. The three cytokines were released in all patients (n = 9), ...

journal_title：Transplantation

authors： Abramowicz D,Schandene L,Goldman M,Crusiaux A,Vereerstraeten P,De Pauw L,Wybran J,Kinnaert P,Dupont E,Toussaint C

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Immunogenicity of a graft depends on its expression of major histocompatability complex (MHC) antigens and adhesion molecules and on the amount of intragraft leukocytes, the so-called passenger leukocytes. Although long-term culture reduces passenger leukocytes, permanent acceptance is not necessarily observ...

journal_title：Transplantation

authors： Kuttler B,Hartmann A,Wanka H

更新日期：2002-08-27 00:00:00

abstract：:Cyclosporine, but not its nonimmunosuppressive analog cyclosporine H (CsH), caused in a variety of hematopoietic cell types a growth arrest in the G0/G1 phase of the cell cycle. This arrest was associated with a significant reduction in the c-myc mRNA levels, which could be observed already 1 hr following CsA treatmen...

journal_title：Transplantation

authors： Yonish-Rouach E,Kimchi A,Rubinstein M

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Lower liver transplant success is observed when the donor is female. Intracellular acidosis during ischemia is proposed to contribute to the injury sustained by the transplanted organ and its role in livers obtained from nonheartbeating donors is unclear. Research has shown that livers of female rats develop...

journal_title：Transplantation

authors： Soric S,Belanger MP,Askin N,Wittnich C

更新日期：2007-09-27 00:00:00

abstract：BACKGROUND:Previously, we identified an antimitogenic IgG antibody separated from sera of patients with known kidney transplant chronic rejection. This antibody inhibits individual patients' own unprimed T helper cell responses to alloantigens as well as a third-party mixed lymphocyte response, but does not inhibit aut...

journal_title：Transplantation

authors： Shoker AS,Okasha K,Sheridan DP,Kappel JE,Baltzan MA

更新日期：1997-09-27 00:00:00

abstract：BACKGROUND:Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (I...

journal_title：Transplantation

authors： Rayar M,Tron C,Jézéquel C,Beaurepaire JM,Petitcollin A,Houssel-Debry P,Camus C,Verdier MC,Dehlawi A,Lakéhal M,Desfourneaux V,Meunier B,Sulpice L,Bellissant E,Boudjema K,Lemaitre F

更新日期：2018-03-01 00:00:00