Abstract:
:Of 113 cyclosporine-treated primary renal allograft recipients, 60 were randomized to receive standard therapy without diltiazem (ND) and 53 received standard therapy plus diltiazem (D). There was no difference in CsA blood levels between ND and D at all intervals between 3 and 24 months follow-up, yet the D group required 35% less CsA than the ND group (measured at 12 months). At all intervals to 24 months there was no difference in blood pressure, renal function (as measured by serum creatinine), or in the number of grafts lost between the 2 groups (ND, 4 lost; D, 3 lost). There was no significant difference in the total number of rejection episodes in the 2 groups (ND, 89 episodes; D, 71 episodes). However, the severity of rejection episodes was greater in the ND group as evidenced by a significant difference in the usage of OKT3 (ND, 17 courses; D, 8 courses of OKT3, P < 0.05). Of the biopsy-proven episodes of rejection, there were more episodes of vascular rejection in the ND group (ND, 14 episodes; D, 3 episodes, P = 0.005). The incidence of primary nonfunction was less in the D group (ND, 16 patients; D, 5 patients, P = 0.05). It was concluded that the use of diltiazem was associated with a markedly reduced requirement for CsA without any adverse effect on graft function or graft outcome. Diltiazem with CsA was associated with fewer episodes of primary nonfunction and less-severe rejection episodes and in particular fewer episodes of vascular rejection.
journal_name
Transplantationjournal_title
Transplantationauthors
Chrysostomou A,Walker RG,Russ GR,d'Apice AJ,Kincaid-Smith P,Mathew THdoi
10.1097/00007890-199302000-00014subject
Has Abstractpub_date
1993-02-01 00:00:00pages
300-4issue
2eissn
0041-1337issn
1534-6080journal_volume
55pub_type
临床试验,杂志文章,随机对照试验相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Apoptosis is a well-documented pathway for islet cell death. One potential mechanism is overexpression of death-promoting Bax compared with antiapoptotic Bcl-2 in islets. METHODS:We isolated islets from 10 human pancreata and measured the expression of Bax mRNA and Bcl-2 mRNA by real-time quantitative polym...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200212150-00003
更新日期:2002-12-15 00:00:00
abstract:BACKGROUND:Bone complications after hematopoietic stem-cell transplantation (HSCT) are relatively frequent. Evaluation of biomarkers of bone turnover and dual energy x-ray absorptiometry (DEXA) are not known in this context. METHODS:We prospectively evaluated bone mineral density, biomarkers of bone turnover, and the ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d84c8e
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Early enteral nutrition with solutions containing prebiotics (fiber) and probiotics (Lactobacillus) is suggested to reduce bacterial translocation and minimize the incidence of infections after liver transplantation. METHODS:In a prospective, randomized placebo-controlled trial consisting of 95 patients, we...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-200207150-00021
更新日期:2002-07-15 00:00:00
abstract:BACKGROUND:The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs and the migration of dendritic cells into afferent lymphatic vessels. Antigen presentation, T cell recruitment, and expansion of regulatory cells are crucial events in establish...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181826a97
更新日期:2008-08-27 00:00:00
abstract::Since June 1979, percutaneous transluminal angioplasty (PTA) has been the procedure of choice for renal transplant artery stenosis (RTAS) at the Hospital of the University of Pennsylvania. Of 241 renal allograft recipients, 17 (7%) when studied by arteriogram because of suspected RTAS proved to have significant stenos...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198212000-00005
更新日期:1982-12-01 00:00:00
abstract::Fetal liver cells (FLC) were obtained from beagle fetuses 52 days postconception, and were cryopreserved prior to transplantation into ten sibling recipients that had previously been exposed to total-body irradiation delivered in 3 fractions of 6 Gy each at 4 days, 2 days, and 2 hr before grafting. Donors and hosts we...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::Immunosuppression with sirolimus and low-dose tacrolimus has facilitated successful clinical islet transplantation (CIT). Because the long-term effects on the kidney are unknown and immunosuppressant drugs can be nephrotoxic, CIT is currently restricted to patients with preserved renal function or a functioning renal ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000134971.15093.07
更新日期:2004-09-27 00:00:00
abstract:BACKGROUND:Alterations in microcirculation are considered central to the pathogenesis of hyperacute xenogeneic rejection (HXR) of vascularized xenografts, but currently there exist no data describing these microhemodynamic alterations. METHODS:Rat livers were perfused in situ with either isogeneic rat blood or xenogen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199702150-00022
更新日期:1997-02-15 00:00:00
abstract:BACKGROUND:Infectious complications occur in approximately 50% of cadaveric liver transplant (CDLT) recipients. Living-donor liver transplantation (LDLT) is an established alternative to shorten the waiting time. Currently, the incidence of pulmonary infections after LDLT and the microbiologic causes are unknown. In th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816f61a6
更新日期:2008-06-15 00:00:00
abstract:BACKGROUND:For certain uremic, diabetic patients, a sequential transplant of a kidney (usually from a living donor) followed by a cadaver pancreas has become an attractive option. But how long to wait after the kidney transplant before proceeding with a pancreas transplant is unclear. We studied outcomes in recipients ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200010270-00022
更新日期:2000-10-27 00:00:00
abstract:BACKGROUND:Islet transplantation studies with diabetic rodents frequently use treatment with diabetogens such as alloxan or streptozotocin to render hosts hyperglycemic. These chemicals produce unwanted toxic side effects, which complicate interpretations of damage produced by hyperglycemia versus direct toxin-induced ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200204270-00024
更新日期:2002-04-27 00:00:00
abstract:BACKGROUND:New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The ability to transfer immunoregulatory or cytoprotective genes into pancreatic islets may enhance survival. Adenoviral vectors (Ad5) have been used w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000066361.02042.CA
更新日期:2003-07-15 00:00:00
abstract:BACKGROUND:Translational research in a relevant preclinical model is recommended before Treg-inducing protocols can be implemented in humans. We have characterized rhesus monkey CD25 cells phenotypically and functionally. METHODS:The phenotype of CD4(+)CD25(high) cells was determined by FACS, focusing on established m...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816b15b9
更新日期:2008-04-27 00:00:00
abstract::Among the first 52 recipients of primary liver allografts with follow-up of 2 weeks or greater, 6 patients had biopsy-confirmed vanishing bile duct syndrome (VBDS) and required retransplantation. Five of these six patients had positive lymphocyte crossmatches. Of the 46 remaining liver transplant recipients, 11 had po...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198802000-00026
更新日期:1988-02-01 00:00:00
abstract::Cyclosporine A administration produces an increase in renal vascular resistance and a decrease in glomerular filtration rate in both human and animal models. CsA usage in humans has also been shown to alter the ability of the kidney to adapt to alterations in renal hemodynamics. CsA alters the production of prostaglan...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199110000-00025
更新日期:1991-10-01 00:00:00
abstract::ICAM-1 is an inducible glycoprotein important in the adhesion, activation, and transmigration of circulating leukocytes across the vascular endothelial monolayer, and it likely plays a key role in the allogeneic response. To determine the reproducibility and significance of variations in resting levels of cell surface...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199410270-00015
更新日期:1994-10-27 00:00:00
abstract::Human herpesvirus type 6 (HHV-6) causes roseola infantum (exanthema subitum) upon primary infection in young children. Thereafter it persists lifelong in the organism. Like other herpesviruses, HHV-6 can be reactivated in periods of immunosuppression - e.g., after organ transplantation. In order to study the incidence...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602270-00027
更新日期:1996-02-27 00:00:00
abstract:BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001005
更新日期:2016-10-01 00:00:00
abstract::Monocytes from human peripheral blood, when incubated in vitro, spread onto the surface of the glass. Horse antihuman lymphocyte globulin (ALG) added to the incubation chamber inhibits the spreading, while normal horse globulin (NHG) does not. The inhibition depends on the concentration of ALG admixed to the mononucle...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Limited recovery of contractile function and loss of coronary reactivity have been observed following prolonged hypothermic storage and transplantation of the heart. Since lipid peroxidation has a significant role in these deficits, we investigated the cardioprotective effects of a 21-aminosteroid. U74389G, 3 mg/kg i....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199604150-00007
更新日期:1996-04-15 00:00:00
abstract::Phenotype, donor-specific cytolytic activity, and helper activity to release cytokines of cells infiltrating within renal allografts of hosts rendered unresponsive by perioperative administration of donor lymphocytes via the portal vein (p.v.) were investigated in order to analyze the mechanism of prolongation of allo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199001000-00038
更新日期:1990-01-01 00:00:00
abstract::We have previously demonstrated that the placental spongiotrophoblast and yolk sac venous plexus express paternally derived H-2K and D (class I) antigens in a manner accessible to maternal circulation, and that the placenta serves to prevent antipaternal antibodies from reaching the fetus. Kinetic studies indicated th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198403000-00016
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptimal donor livers before implantation. Our aim was to assess the diagnostic accuracy of bile biochemistry for the assessment of bile duct injury (BDI). METHODS:In a preclinical study, 23 human donor livers underwent 6 hour...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002500
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR)...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000102549.40531.13
更新日期:2004-01-27 00:00:00
abstract::To test the importance of B lymphocytes in immunity to major histocompatibility complex class I alloantigens, B cell-deficient mice were generated by reconstituting severe combined immunodeficiency mice, which lack functional B and T lymphocytes, with T cells or with both T and B cells. The reconstituted mice were cha...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:HLAMatchmaker is a computer algorithm that determines human leukocyte antigen (HLA) compatibility at the level of polymorphic amino acid triplets in antibody-accessible sequence positions. Recent studies have shown that HLA-DR-matched kidney transplant recipients with zero to two triplet mismatches had almos...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000055097.58209.83
更新日期:2003-03-27 00:00:00
abstract:BACKGROUND:Both laboratory and clinical studies have shown that dietary lipids may affect immunologic responses. This study was conducted to compare different classes of long-chain unsaturated fatty acids for their effect on allograft survival in animals receiving a donor-specific transfusion and a short course of low-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199805270-00004
更新日期:1998-05-27 00:00:00
abstract::Pseudoaneurysms of the hepatic artery are a rare complication of liver transplantation. Early diagnosis and treatment are essential to avoid life-threatening hemorrhage. Conventional treatment consists of surgical resection and vascular reconstruction or transarterial coil embolization. More recently, percutaneous thr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000063936.94587.10
更新日期:2003-05-27 00:00:00
abstract::Anti-CD3 mAbs are potent inhibitors of T cell function; however, administration of mitogenic mAb can cause significant morbidity secondary to T cell activation and cytokine release. Nonmitogenic anti-CD3 mAb is immunosuppressive in mice without inducing detectable morbidity, and may thus be preferable for in vivo T ce...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-12-15 00:00:00
abstract::The mixed leukocyte culture (MLC) of peripheral blood lymphocytes (PBLs) from two prospective kidney transplant recipients and their respective donors, produced a primed cell population that functioned as suppressors. The primed cells suppressed the primary and secondary MLC when added as third components, without dem...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198001000-00012
更新日期:1980-01-01 00:00:00