Abstract:
:To test the importance of B lymphocytes in immunity to major histocompatibility complex class I alloantigens, B cell-deficient mice were generated by reconstituting severe combined immunodeficiency mice, which lack functional B and T lymphocytes, with T cells or with both T and B cells. The reconstituted mice were challenged with a cancer that expresses an MHC class I alloantigen at a low level and is susceptible to killing by CD8+ cytotoxic T lymphocytes. Tumors grew more slowly in and were rejected more frequently by the mice lacking B cells. Understanding the mechanism by which B cells suppress tumor allograft rejection may lead to new approaches for suppressing immune attack on transplanted tissues.
journal_name
Transplantationjournal_title
Transplantationauthors
Monach PA,Schreiber H,Rowley DAsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
1356-61issue
6eissn
0041-1337issn
1534-6080journal_volume
55pub_type
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