Dietary omega-3 and omega-9 fatty acids uniquely enhance allograft survival in cyclosporine-treated and donor-specific transfusion-treated rats.


BACKGROUND:Both laboratory and clinical studies have shown that dietary lipids may affect immunologic responses. This study was conducted to compare different classes of long-chain unsaturated fatty acids for their effect on allograft survival in animals receiving a donor-specific transfusion and a short course of low-dose cyclosporine (CsA). METHODS:Heterotopic ACI strain cardiac allografts were transplanted to Lewis strain rat recipients given diets with different lipid composition. In experiment 1, animals received CsA for 14 days and different diets were enriched with lipids with high concentrations of omega-3, omega-6, or omega-9 fatty acids. In experiment 2, animals received CsA for only 8 days and different diets were enriched with corn oil (omega-6), canola oil (omega-3 and omega-9), fish oil (omega-3) or a mixture of sunflower oil and fish oil (omega-3 and omega-9). RESULTS:In experiment 1, animals receiving the diet with 30% sunflower oil had the best allograft survival (200+/-42 days vs. 53+/-8 days for regular chow plus donor-specific transfusion and CsA, P<0.05). In experiment 2, diets containing canola oil (a mixture of omega-3 and omega-9 fatty acids) were associated with the best survival (P=0.0011 vs. regular chow). CONCLUSION:Dietary omega-3 and omega-9 fatty acids both enhanced cardiac allograft survival in a stringent rat strain combination. Canola oil is a convenient oil for administering both alpha-linoleic acid (omega-3) and oleic acid (omega-9) in a palatable form for human consumption. Further investigation of the potential usefulness of lipids in transplant therapy is warranted.






Alexander JW,Valente JF,Greenberg NA,Custer DA,Ogle CK,Gibson SW,Babcock GF




Has Abstract


1998-05-27 00:00:00












  • Analysis of the interactions of immunosuppressive drugs with cyclosporine in inhibiting DNA proliferation.

    abstract::Though the high immunosuppressive efficacy of cyclosporine has revolutionized clinical transplantation, renal, hepatic, and neural toxicities limit its therapeutic potential. One approach to this problem is to combine CsA therapy with immunosuppressive agents that act synergistically with it, thereby permitting lower ...


    pub_type: 杂志文章


    authors: Vathsala A,Chou TC,Kahan BD

    更新日期:1990-02-01 00:00:00

  • Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients.

    abstract::High levels of tumor necrosis factor-alpha, interleukin-2, and gamma-interferon appeared in the circulation of kidney transplant recipients after the first injection of the monoclonal antibody OKT3. This initial injection was systematically followed by fever. The three cytokines were released in all patients (n = 9), ...


    pub_type: 杂志文章


    authors: Abramowicz D,Schandene L,Goldman M,Crusiaux A,Vereerstraeten P,De Pauw L,Wybran J,Kinnaert P,Dupont E,Toussaint C

    更新日期:1989-04-01 00:00:00

  • Suppressor T cells in rats with prolonged cardiac allograft survival after treatment with cyclosporine.

    abstract::DA rats treated with cyclosporine for 2 weeks after being grafted with an RT1-incompatible PVG heart graft did not reject the graft and developed a state of specific unresponsiveness to graft antigens. The cellular mechanisms maintaining this state of unresponsiveness were studied by testing the capacity of lymphocyte...


    pub_type: 杂志文章


    authors: Hall BM,Jelbart ME,Dorsch SE

    更新日期:1984-06-01 00:00:00

  • Pattern of liver, kidney, heart, and intestine allograft rejection in different mouse strain combinations.

    abstract::With advances in microsurgery and molecular biology, the mouse model for organ transplantation has become increasingly popular. However, knowledge about these models is limited, as only a small number of centers have experience with murine models. In this study, we compared the rejection pattern after liver, kidney, h...


    pub_type: 杂志文章


    authors: Zhang Z,Zhu L,Quan D,Garcia B,Ozcay N,Duff J,Stiller C,Lazarovits A,Grant D,Zhong R

    更新日期:1996-11-15 00:00:00

  • Heart transplantation in diabetic recipients.

    abstract::Preexisting diabetes mellitus (DM) has been regarded as a contraindication to heart transplantation (HT). This prejudice has been based upon concern over increased infection rates and worsening DM with the initiation of prednisone immunosuppression. To better evaluate these suppositions, we reviewed our experience wit...


    pub_type: 杂志文章


    authors: Ladowski JS,Kormos RL,Uretsky BF,Griffith BP,Armitage JM,Hardesty RL

    更新日期:1990-02-01 00:00:00

  • Pretransplant Cancer in Kidney Recipients in Relation to Recurrent and De Novo Cancer Incidence Posttransplantation and Implications for Graft and Patient Survival.

    abstract:BACKGROUND:Whether kidney transplant recipients who were treated for a malignant tumor before transplantation are at an increased risk of developing a tumor posttransplantation has not been adequately quantified and characterized. METHODS:We studied more than 270 000 patients on whom pretransplant and posttransplant m...


    pub_type: 杂志文章


    authors: Unterrainer C,Opelz G,Döhler B,Süsal C,Collaborative Transplant Study.

    更新日期:2019-03-01 00:00:00

  • The impact of donor age on living donor liver transplantation.

    abstract:BACKGROUND:The impact of the age of the donor on the outcome of living related liver transplantation is yet to be clarified. METHODS:During October 14, 1996 and December 20, 1999, 34 living related liver transplantations were performed. Of these, 26 cases were performed using the extended left lobe graft, which were c...


    pub_type: 杂志文章


    authors: Ikegami T,Nishizaki T,Yanaga K,Shimada M,Kishikawa K,Nomoto K,Uchiyama H,Sugimachi K

    更新日期:2000-12-27 00:00:00

  • Failure of cyclosporine-treated renal allograft recipients to increase glomerular filtration rate following an amino acid infusion.

    abstract::Renal allograft recipients treated with cyclosporine (CsA) have increased renal vascular resistance that falls when CsA is stopped. With the aim of identifying whether CsA-treated patients with excellent renal function also have an alteration in renal vascular tone and to investigate which vessels are affected, we hav...


    pub_type: 杂志文章


    authors: Cairns HS,Raval U,Neild GH

    更新日期:1988-07-01 00:00:00

  • Prediction of graft versus host disease by frequency analysis of cytotoxic T cells after unrelated donor bone marrow transplantation.

    abstract::HLA "matched" unrelated donor bone marrow transplants are associated with an increased incidence and severity of graft-versus-host disease in comparison with HLA-identical sibling transplants. This is presumably due to HLA and non-HLA histocompatibility differences between donor and recipient. Using a limiting dilutio...


    pub_type: 杂志文章


    authors: Kaminski E,Hows J,Man S,Brookes P,Mackinnon S,Hughes T,Avakian O,Goldman JM,Batchelor JR

    更新日期:1989-10-01 00:00:00

  • Comparison of Preemptive Therapy and Antiviral Prophylaxis for Prevention of Cytomegalovirus in Seropositive Liver Transplant Recipients.

    abstract:BACKGROUND:Few studies have directly compared preemptive therapy (PET) and antiviral prophylaxis (AP) for prevention of cytomegalovirus (CMV) disease in CMV seropositive (R+) orthotopic liver transplant (OLT) recipients. METHODS:We prospectively assessed CMV disease and clinical outcomes among 160 consecutive R+ OLT r...


    pub_type: 杂志文章


    authors: Liu AW,Jutivorakool K,Fisher CE,Rakita RM,Reyes JD,Bhattacharya RB,Jerome KR,Limaye AP

    更新日期:2018-04-01 00:00:00

  • Epitope specificity of HLA class I alloantibodies: II. Stability of cross-reactive group antibody patterns over extended time periods.

    abstract::The stability of HLA alloantibodies was studied in 128 antibody-positive, potential kidney transplant recipients over an average period of 3 years. Antibody detection was performed using an anti-human globulin-complement-dependent cytotoxicity technique. In this study, the specificity of antibodies was categorized as ...


    pub_type: 杂志文章


    authors: Rodey GE,Revels K,Fuller TC

    更新日期:1997-03-27 00:00:00

  • Hepatitis C virus and nonliver solid organ transplantation.

    abstract::: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...


    pub_type: 杂志文章,评审


    authors: Carbone M,Mutimer D,Neuberger J

    更新日期:2013-03-27 00:00:00

  • Solid Organ Transplantation in Patients With Preexisting Malignancies in Remission: A Propensity Score Matched Cohort Study.

    abstract:BACKGROUND:Solid-organ transplant recipients with pretransplant malignancies (PTM) have worse overall survival (OS) compared to recipients without history of malignancy. However, it is unknown whether the increased risk of mortality is due to recurrent cancer-related deaths. METHODS:All solid-organ transplant recipien...


    pub_type: 杂志文章


    authors: Acuna SA,Sutradhar R,Kim SJ,Baxter NN

    更新日期:2018-07-01 00:00:00

  • Pretransplant immunologic risk assessment of kidney transplant recipients with donor-specific anti-human leukocyte antigen antibodies.

    abstract:BACKGROUND:Patients with pretransplantation strong donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) are at higher risk for rejection. We aimed to study the safety of kidney transplantation in patients with lower strength DSAs in a prospective cohort study. METHODS:Three hundred and seventy-three cons...


    pub_type: 杂志文章


    authors: Marfo K,Ajaimy M,Colovai A,Kayler L,Greenstein S,Lubetzky M,Gupta A,Kamal L,de Boccardo G,Masiakos P,Kinkhabwala M,Akalin E

    更新日期:2014-11-27 00:00:00

  • Increased infections in liver transplant recipients with recurrent hepatitis C virus hepatitis.

    abstract::Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...


    pub_type: 杂志文章


    authors: Singh N,Gayowski T,Wagener MM,Marino IR

    更新日期:1996-02-15 00:00:00

  • Angiotensin blockade is associated with early graft dysfunction after live donor renal transplantation.

    abstract:BACKGROUND:Activation of the renin angiotensin system may contribute to the development of delayed graft function after renal transplantation. We, therefore, examined the impact of pretransplant treatment with blockers of the renin angiotensin system on early graft function after renal transplantation. METHOD:The case...


    pub_type: 杂志文章


    authors: Stevens KK,Patel RK,Clancy M,Jardine AG

    更新日期:2010-03-27 00:00:00

  • Rapamycin: immunosuppression, hyporesponsiveness, and side effects in a porcine renal allograft model.

    abstract::Rapamycin prolongs allograft survival and induces donor-specific tolerance in some small animal transplant models. Large animal studies, however, are limited. We studied rapamycin in a porcine renal allograft model. Donor-recipient combinations were chosen based on high response in pretransplant MLCs. Allografts were ...


    pub_type: 杂志文章


    authors: Almond PS,Moss A,Nakhleh RE,Melin M,Chen S,Salazar A,Shirabe K,Matas AJ

    更新日期:1993-08-01 00:00:00

  • The role of donor-recipient relationship in long-term outcomes of living donor renal transplantation.

    abstract:BACKGROUND:Graft failure related to acute and chronic rejection remains an important problem in transplantation. An association has been reported between microchimerism and the development of tolerance. Since it has been established that cells of fetal origin can be found in maternal tissues long after parturition, and...


    pub_type: 杂志文章


    authors: Miles CD,Schaubel DE,Liu D,Port FK,Rao PS

    更新日期:2008-05-27 00:00:00

  • Optical determination of fatty change of the graft liver with near-infrared time-resolved spectroscopy.

    abstract::A novel method for quantifying the fatty change of the graft liver by characterizing the optical property of the tissue was introduced. A wide range of lipid content in the rat liver was obtained by using different feeding regimens, with lipotropic chow (choline/methionine deficient or low chow). The liver was removed...


    pub_type: 杂志文章


    authors: Kitai T,Beauvoit B,Chance B

    更新日期:1996-09-15 00:00:00

  • Differential effects of injections of anti-mu and anti-delta monoclonal antibodies on B-cell populations in adult mice: regulation of xenoreactive natural antibody-producing cells.

    abstract:BACKGROUND:The depletion of differential B cell and xenoreactive natural antibodies (XNA) by anti-delta and anti-mu injections was analyzed in adult mice. Sequential treatment with anti-delta and then anti-mu induces a complete depletion of B cells and XNA and represents a potential approach to induce xenograft toleran...


    pub_type: 杂志文章


    authors: Chentoufi AA,Nizet Y,Havaux X,De La Parra B,Cormont F,Hermans D,Bazin H,Latinne D

    更新日期:1999-12-15 00:00:00

  • Everolimus with reduced cyclosporine versus MMF with standard cyclosporine in de novo heart transplant recipients.

    abstract:BACKGROUND:Pharmacokinetic modeling supports trough monitoring of everolimus, but prospective data comparing this approach versus mycophenolate mofetil (MMF) in de novo cardiac transplant recipients are currently unavailable. METHODS:In a 12-month multicenter open-label study, cardiac transplant patients received ever...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lehmkuhl HB,Arizon J,Viganò M,Almenar L,Gerosa G,Maccherini M,Varnous S,Musumeci F,Hexham JM,Mange KC,Livi U,2411 Study Investigators.

    更新日期:2009-07-15 00:00:00

  • Frequency of kidney rejection in diabetic patients undergoing simultaneous kidney and pancreatic islet cell transplantation.

    abstract::An increased frequency of kidney rejection has been reported in diabetic patients who have simultaneous pancreas and kidney transplantation compared with patients who have a kidney transplant alone. Kidney graft outcome is similar in the two groups. The mechanism for increased kidney graft rejection with a simultaneou...


    pub_type: 杂志文章


    authors: Carroll PB,Ricordi C,Shapiro R,Rilo HR,Fontes P,Scantlebury V,Irish W,Tzakis AG,Starzl TE

    更新日期:1993-04-01 00:00:00

  • Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs.

    abstract:BACKGROUND:Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA). METHODS:Peripheral blood mononuclear cells from SLA identical wild type (WT), α1, 3-galactos...


    pub_type: 杂志文章


    authors: Martens GR,Reyes LM,Li P,Butler JR,Ladowski JM,Estrada JL,Sidner RA,Eckhoff DE,Tector M,Tector AJ

    更新日期:2017-04-01 00:00:00

  • Preemptive living donor kidney transplantation: do the benefits extend to all recipients?

    abstract:BACKGROUND:Preemptive kidney transplantation (prior to the institution of dialysis) avoids the morbidity and mortality of dialysis; however, detailed studies of high-risk patients are lacking. The aim of the current study was to compare recent outcomes of preemptive (P) versus nonpreemptive (NP) living donor kidney tra...


    pub_type: 杂志文章


    authors: Innocenti GR,Wadei HM,Prieto M,Dean PG,Ramos EJ,Textor S,Khamash H,Larson TS,Cosio F,Kosberg K,Fix L,Bauer C,Stegall MD

    更新日期:2007-01-27 00:00:00

  • Non-major histocompatibility system immunogenetic influences in rat renal allograft survival.

    abstract::H-1-incompatible rat renal allograft survival rates are strongly influenced by the non-major histocompatibility system (MHS) genes. The same H-1 (MHS) incompatibility tested on four different non-MHS backgrounds gave widely differing results ranging from 11 to 60% fractional survival between the best and the poorest (...


    pub_type: 杂志文章


    authors: Paris AM,Bishop C,Festenstein H,Gunther E

    更新日期:1978-05-01 00:00:00

  • The management of T tube leaks in orthotopic liver transplant recipients with endoscopically placed nasobiliary catheters.

    abstract::Biliary tract problems remain an important cause of complication following orthotopic hepatic transplantation. We describe 12 liver transplantation patients who developed bile peritonitis secondary to a biliary leak after T tube removal. Each of these patients underwent an urgent ERCP that exhibited leakage outside th...


    pub_type: 杂志文章


    authors: Ostroff JW,Roberts JP,Gordon RL,Ring EJ,Ascher NL

    更新日期:1990-05-01 00:00:00

  • Prominent HLA-G Expression in Liver Disease But Not After Liver Transplantation.

    abstract:BACKGROUND:HLA-G is a nonclassical MHC class I molecule and its physiological expression restricted to placental extravillous trophoblasts contributes to maternal tolerance to the semiallogeneic fetus. Aberrant expression of HLA-G in human organ grafts has been proposed to contribute to graft acceptance. METHODS:We st...


    pub_type: 杂志文章


    authors: Moroso V,van Cranenbroek B,Mancham S,Sideras K,Boor PP,Biermann K,de Vogel L,de Knegt RJ,van der Eijk A,van der Laan LJ,de Jonge J,Metselaar HJ,Joosten I,Kwekkeboom J

    更新日期:2015-12-01 00:00:00

  • Increased hyaluronan in acutely rejecting human kidney grafts.

    abstract::The glycosaminoglycan hyaluronan is not only involved in cellular differentiation and migration but may also play a role in several inflammatory diseases. We have previously demonstrated an increased local production of hyaluronan in chronically rejected kidneys and the correspondingly affected renal vessels. In this ...


    pub_type: 杂志文章


    authors: Wells A,Larsson E,Hanás E,Laurent T,Hällgren R,Tufveson G

    更新日期:1993-06-01 00:00:00

  • Reconstitution of 6-sulfo LacNAc dendritic cells after allogeneic stem-cell transplantation.

    abstract:BACKGROUND:Infections and acute graft-versus-host disease (GvHD) represent major complications of allogeneic stem-cell transplantation (SCT). Dendritic cells (DCs) display an extraordinary capacity to induce innate and adaptive immune responses. Therefore, they play a crucial role in the elimination of pathogens and in...


    pub_type: 杂志文章


    authors: Mager K,Wehner R,Bahr F,Oelschlägel U,Platzbecker U,Wermke M,Shayegi N,Middeke JM,Radke J,Röllig C,Schetelig J,Thiede C,Ehninger G,Schmitz M,Bornhäuser M,Tuve S

    更新日期:2012-06-27 00:00:00

  • Combined immunosuppression with cyclosporine and methotrexate in dogs given bone marrow grafts from DLA-haploidentical littermates.

    abstract::We examined the effect of methotrexate (MTX) combined with cyclosporine (CSP) on the prevention of graft-versus-host disease (GVHD) in dogs. Ten recipients were prepared for grafting with 9 Gy of total-body irradiation and given marrow and buffy coat cells from littermate donors differing for one DLA haplotype (AA lea...


    pub_type: 杂志文章


    authors: Deeg HJ,Storb R,Appelbaum FR,Kennedy MS,Graham TC,Thomas ED

    更新日期:1984-01-01 00:00:00