The effect of cyclosporine on agonist-stimulated glomerular and mesangial cell vasodilatory prostaglandin production.

Abstract:

:Cyclosporine A administration produces an increase in renal vascular resistance and a decrease in glomerular filtration rate in both human and animal models. CsA usage in humans has also been shown to alter the ability of the kidney to adapt to alterations in renal hemodynamics. CsA alters the production of prostaglandins by isolated rat glomeruli. Normally, vasoconstrictive agents stimulate the production of vasodilatory glomerular and mesangial cell PG. To determine if CsA alters glomerular and mesangial cell (MC) vasodilatory PG production in response to vasoconstrictive agents, we administered CsA, 20 mg/kg, or vehicle to rats for 7 days, or incubated mesangial cells with CsA 1 mcg/ml for 24 hr. Ex vivo glomerular PGE2 and 6-keto-PGF1a production was determined in the presence or absence of angiotensin II 10(-6) M and norepinephrine 10(-5)M. CsA administration decreased glomerular production of both eicosanoids in the basal and stimulated state. Incubation of MC with CsA markedly suppressed PGE2 and 6-keto-PGF1a production in response to stimulation with 200 nM angiotensin II. To determine if CsA inhibits angiotensin II-stimulated PG production prior to protein kinase C, we incubated glomeruli and MC with the diacylglycerol mimetic OAG. CsA depressed OAG-stimulated glomerular and MC PGE2 and 6-keto-PGF1a production. Conversely, CsA stimulated the production of PGE2 by renal medullary slices. We conclude that CsA blunts the vasoconstrictor-induced increase in glomerular and mesangial cell vasodilatory PG production, thereby removing a compensatory mechanism that maintains GFR in states of vasoconstrictor excess.

journal_name

Transplantation

journal_title

Transplantation

authors

Bunke M,Wilder L,Martin A

doi

10.1097/00007890-199110000-00025

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

718-22

issue

4

eissn

0041-1337

issn

1534-6080

journal_volume

52

pub_type

杂志文章
  • Measurement of mycophenolate mofetil effect in transplant recipients.

    abstract:BACKGROUND:Immunosuppression involves the nature of the immunosuppressive agents and individual differences in patient factors. We investigated whether the effect of mycophenolate mofetil (MMF) is measurable using an in vitro measure of immunocompetence and related its effects to cyclosporine (CsA) in vitro. METHODS:L...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200108150-00011

    authors: Ogawa N,Nagashima N,Nakamura M,Shalabi A,Maley WR,Burdick JF

    更新日期:2001-08-15 00:00:00

  • The effect of two new immunosuppressive agents, FK506 and didemnin B, in murine pregnancy.

    abstract::The purpose of this study was to investigate two promising immunosuppressive agents, didemnin B (DB) and FK506 (FK), during pregnancy to assess potential adverse maternal or fetal effects. Pregnant C3H mice were randomized into control and high- and low-dose treatment groups for each drug. Animals received daily injec...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199107000-00022

    authors: Farley DE,Shelby J,Alexander D,Scott JR

    更新日期:1991-07-01 00:00:00

  • Immunoregulatory abnormalities in patients with Epstein-Barr virus-associated B cell lymphoproliferative disorders.

    abstract::EBVirus-associated B cell lymphoproliferative disorder (BLPD) is a recognized complication of primary immunodeficiency and organ as well as bone marrow transplantation. Although the nature of the immune defects that predispose to the development of BLPD are unknown, it is postulated that aberrant T cell responses are ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Mathur A,Kamat DM,Filipovich AH,Steinbuch M,Shapiro RS

    更新日期:1994-04-15 00:00:00

  • Superiority of the two-layer method before islet isolation confirmed by in vivo viability assessment.

    abstract:BACKGROUND:Although the outcome of islet transplantation has improved, there remains a major obstacle in isolating viable islets from prolonged preserved pancreas. We previously reported that the two-layer cold storage method (TLM) improved the yield and in vitro function. In this study, we performed in vivo accurate f...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000154914.34121.72

    authors: Kakinoki K,Fujino Y,Suzuki Y,Li S,Tanioka Y,Sakai T,Kuroda Y

    更新日期:2005-06-15 00:00:00

  • Effects of a short course of leflunomide on T-independent B-lymphocyte xenoreactivity and on susceptibility of xenografts to acute or chronic rejection.

    abstract:BACKGROUND:Leflunomide is a novel immunosuppressive agent with promising activity for xenotransplantation. It is not clear yet which mechanisms of action of leflunomide are responsible for that. METHODS:In a hamster-to-C57BL/6 nude mouse heart transplantation model, a 2-week course of leflunomide was used after transp...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000147464.63188.4b

    authors: Yan Y,Verbeken E,Yu L,Rutgeerts O,Goebels J,Segers C,Lin Y,Waer M

    更新日期:2005-01-27 00:00:00

  • Survival gain after liver transplantation for patients with alcoholic liver disease: a comparison across models and centers.

    abstract:BACKGROUND:Prognostic models, which estimate survival probabilities, enable the survival benefit from a procedure to be assessed and allow the comparison of outcomes between centers. We therefore compared three models that estimate survival in the absence of transplantation for patients with alcoholic liver disease (AL...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.TP.0000089236.78772.57

    authors: Young TA,Neuberger J,Longworth L,Ratcliffe J,Buxton MJ,Cost-Effectiveness in Liver Transplantation Study Team.

    更新日期:2003-11-27 00:00:00

  • Prolongation of cardiac xenograft survival in rats receiving cyclosporin A.

    abstract::The effect of cyclosporin A was tested in a heterotopic cardiac xenograft model, in which hamster hearts were implanted into LEW rats. Despite the presence of low titers of rat anti-hamster lymphocytotoxic antibodies immediate rejection of the hamster hearts did not occur, suggesting that this model represented a xeno...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198103000-00004

    authors: Homan WP,Williams KA,Fabre JW,Millard PR,Morris PJ

    更新日期:1981-03-01 00:00:00

  • Improved phagocyte response by co-amoxiclav in renal transplant recipients.

    abstract:BACKGROUND:Infectious diseases are a major source of morbidity and mortality for immunosuppressed transplant recipients and the antimicrobial chemotherapy can be often less effective in these individuals, because the contribution of underlying host defenses is absent. METHODS:The influence of co-amoxiclav on the funct...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200102270-00016

    authors: Cuffini AM,Tullio V,Giacchino F,Bonino A,Mandras N,Bianchi N,Roana J,Scalas D,Bonello F,Carlone NA

    更新日期:2001-02-27 00:00:00

  • Toxicity of rapamycin--a comparative and combination study with cyclosporine at immunotherapeutic dosage in the rat.

    abstract::Sprague-Dawley rats were treated for 14 days with rapamycin (RAP; 1.5 mg/kg/day i.p.), cyclosporine (15 mg/kg/day by gavage), both drugs in combination, or appropriate drug vehicles. Hematological parameters and biochemical indices of renal and hepatic function were determined throughout the experimental period, at th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199108000-00004

    authors: Whiting PH,Woo J,Adam BJ,Hasan NU,Davidson RJ,Thomson AW

    更新日期:1991-08-01 00:00:00

  • A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes.

    abstract::A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes in vitro is described. Responding lymphocytes are cultured with mitomycin-C treated allogeneic stimulating cells in wells of replicate microtrays for both one-way mixed leukocyte culture (MLC) and cell-mediated lymph...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197606000-00005

    authors: Zarling JM,McKeough M,Bach FH

    更新日期:1976-06-01 00:00:00

  • Transplantation of pediatric en bloc cadaver kidneys into adult recipients.

    abstract:BACKGROUND:To maximize the renal donor pool, cadaveric pediatric en bloc kidneys have been transplanted as a dual unit by some transplant centers. We compared the short- and long-term outcomes of adult recipients of cadaveric pediatric en bloc renal transplants versus those of matched recipients of cadaveric adult kidn...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199812270-00020

    authors: Hobart MG,Modlin CS,Kapoor A,Boparai N,Mastroianni B,Papajcik D,Flechner SM,Goldfarb DA,Fischer R,O'Malley KJ,Novick AC

    更新日期:1998-12-27 00:00:00

  • Immunohistochemical study of actin binding protein (p55) in the human kidney.

    abstract:BACKGROUND:In clinical transplantation, "passenger" dendritic cells (DCs) in the allograft have been thought to induce allograft rejection. However, the presence of DCs in the normal human kidney is controversial. Most reports have relied on the examination of MHC class I and II antigen expression in combination with D...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199804150-00025

    authors: Sonderbye L,Meehan S,Palsson R,Ahsan N,Ladefoged J,Langhoff E

    更新日期:1998-04-15 00:00:00

  • Defunctioning polymorphism in the immunoglobulin G inhibitory receptor (FcγRIIB-T/T232) does not impact on kidney transplant or recipient survival.

    abstract:BACKGROUND:There is an increasing appreciation of the deleterious effects of antibody and B cells on acute and chronic transplant outcomes. Many effector functions of antibody are mediated by a family of receptors (FcγRs) that are expressed on most immune cells, including neutrophils, natural killer cells, and B cells....

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000287

    authors: Clatworthy MR,Matthews RJ,Doehler B,Willcocks LC,Opelz G,Smith KGC

    更新日期:2014-08-15 00:00:00

  • Augmenter of liver regeneration enhances the success rate of fetal pancreas transplantation in rodents.

    abstract:BACKGROUND:Treatment of fetal pancreas (FP) isografts with insulin-like growth factor-I greatly improves the rate of conversion to euglycemia in diabetic rats. Complete knowledge of other factors that may facilitate the engraftment and function of FP in vivo is still embryonic. Augmenter of liver regeneration (ALR) is ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199801150-00007

    authors: Adams GA,Maestri M,Squiers EC,Alfrey EJ,Starzl TE,Dafoe DC

    更新日期:1998-01-15 00:00:00

  • Tacrolimus in cardiac transplantation: efficacy and safety of a novel dosing protocol.

    abstract:BACKGROUND:Although used for more than 20 years, optimal dosing strategies of most immunosuppressants have never been determined. Tacrolimus, one of the newer agents used in solid-organ transplantation, is gaining increasing popularity because of its ability to reverse refractory rejection in cyclosporine-treated patie...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-200210270-00014

    authors: Baran DA,Galin I,Sandler D,Segura L,Cheng J,Courtney MC,Correa R,Chan M,Fallon JT,Spielvogel D,Lansman SL,Gass AL

    更新日期:2002-10-27 00:00:00

  • Development of IgA deficiency after bone marrow transplantation. The influence of acute and chronic graft-versus-host disease.

    abstract::Serum IgA levels were monitored at 3, 6, 12, and 24 months after BMT in 131 allogeneic and 3 syngeneic bone marrow transplant recipients. In general, IgA levels were low during the first 6 months and did not return to normal levels until 1-2 years after transplantation. Children (less than 15 years) had lower IgA leve...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199009000-00012

    authors: Abedi MR,Hammarström L,Ringdén O,Smith CI

    更新日期:1990-09-01 00:00:00

  • The CD154-CD40 costimulatory pathway in transplantation.

    abstract::The CD154-CD40 pathway is one of the critical costimulatory pathways that are required for full activation of T cells during alloimmune responses. Blockade of this pathway with anti-CD154 antibodies has been reported to prolong allograft survival in experimental transplantation models and to induce tolerance in some i...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/00007890-200201151-00012

    authors: Yamada And A,Sayegh MH

    更新日期:2002-01-15 00:00:00

  • Control of organ transplant-associated graft-versus-host disease by activated host lymphocyte infusions.

    abstract:BACKGROUND:Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually ref...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000144183.77279.ec

    authors: Kuball J,Theobald M,Ferreira EA,Hess G,Burg J,Maccagno G,Barreiros AP,Lüth S,Schimanski CC,Schuchmann M,Schwarting A,Neurath M,Otto G,Galle PR,Lohse AW

    更新日期:2004-12-27 00:00:00

  • Reduction of fatal graft-versus-host disease by 3H-thymidine suicide of donor cells cultured with host cells.

    abstract::The effect of the tritiated thymidine (3H-TdR) suicide technique on the ability of donor cells to induce fatal graft-versus-host disease (GVHD) was studied. C57BL/6 (H-2b) spleen cells were stimulated in vitro with irradiated BALB/c (H-2d) Moloney lymphoma cells in mixed culture and 3H-TdR of high-specific activity ad...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197704000-00001

    authors: Cheever MA,Einstein AB Jr,Kempf RA,Fefer A

    更新日期:1977-04-01 00:00:00

  • Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury.

    abstract:BACKGROUND:In kidney transplant recipients with alemtuzumab induction maintained on mycophenolate mofetil (MMF) immunosuppression, sirolimus (SRL) promotes significant expansion of circulating CD4+CD25high regulatory T cells (Treg). This might translate into more effective protection against chronic graft injury compar...

    journal_title:Transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.tp.0000284808.28353.2c

    authors: Ruggenenti P,Perico N,Gotti E,Cravedi P,D'Agati V,Gagliardini E,Abbate M,Gaspari F,Cattaneo D,Noris M,Casiraghi F,Todeschini M,Cugini D,Conti S,Remuzzi G

    更新日期:2007-10-27 00:00:00

  • The distribution of HLA antigens and phenotypes among donors and patients in the UNOS registry.

    abstract::We have analyzed HLA data from the UNOS registry on 20,230 patients on the renal waiting list in 1991 and 18,708 donors from 1988-1992. Significant differences were found in the distribution of HLA antigens for comparisons of the total donor pool and the various racial groups of patients as well as for inter- and intr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Leffell MS,Steinberg AG,Bias WB,Machan CH,Zachary AA

    更新日期:1994-11-27 00:00:00

  • The Relationships Between Cold Ischemia Time, Kidney Transplant Length of Stay, and Transplant-related Costs.

    abstract:BACKGROUND:Recent changes in policies guiding allocation of transplant kidneys are predicted to increase sharing between distant geographic regions. The potential exists for an increase in cold ischemia time (CIT) with resulting increases in delayed graft function (DGF) and transplant-related costs (TRC). We sought to ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002309

    authors: Serrano OK,Vock DM,Chinnakotla S,Dunn TB,Kandaswamy R,Pruett TL,Feldman R,Matas AJ,Finger EB

    更新日期:2019-02-01 00:00:00

  • Immunological Determinants of Liver Transplant Outcomes Uncovered by the Rat Model.

    abstract::For many individuals suffering from end-stage liver disease (ESLD), the only treatment option is liver transplantation. However, liver transplant rejection is observed in 24-80% of transplant patients and lifelong drug regimens that follow the transplant procedure lead to serious side effects. Furthermore, the pool of...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003598

    authors: Wang X,MacParland SA,Perciani CT

    更新日期:2021-01-06 00:00:00

  • Defining a Willingness-to-transplant Threshold in an Era of Organ Scarcity: Simultaneous Liver-kidney Transplant as a Case Example.

    abstract:BACKGROUND:Organ scarcity continues in solid organ transplantation, such that the availability of organs limits the number of people able to benefit from transplantation. Medical advancements in managing end-stage organ disease have led to an increasing demand for multiorgan transplant, wherein a patient with multiorga...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002788

    authors: Cheng XS,Goldhaber-Fiebert J,Tan JC,Chertow GM,Kim WR,Wall AE

    更新日期:2020-02-01 00:00:00

  • Predominant role of the Fab fragment in delaying hyperacute rejection in guinea pig-to-rat xenotransplantation.

    abstract:BACKGROUND:Human intravenous immunoglobulin G delayed xenogeneic hyperacute rejection (HAR) in the guinea pig-to-rat combination. We investigated the respective roles of the Fc and Fab fragments of the IgG molecule in this inhibitory effect. METHODS:By using a guinea pig-to-rat heart transplantation model, the efficie...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199808150-00018

    authors: Urbani L,Fabre M,Cardoso J,Lambin P,Devillier P,Soubrane O,Houssin D,Gautreau C

    更新日期:1998-08-15 00:00:00

  • Relationship of cytomegalovirus viral load in blood to pneumonitis in lung transplant recipients.

    abstract::We developed a multiplex, quantitative, real-time, polymerase chain reaction assay for cytomegalovirus (CMV) and used it to measure the CMV viral load in weekly blood specimens from 43 lung transplant recipients. The median viral load in blood samples immediately preceding bronchoscopy was 1150 copies/microg human DNA...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200108270-00030

    authors: Sanchez JL,Kruger RM,Paranjothi S,Trulock EP,Lynch JP,Hicks C,Shannon WD,Storch GA

    更新日期:2001-08-27 00:00:00

  • Accelerated rejection of H-2-incompatible skin allografts in the absence of specific cytotoxic antibodies.

    abstract::Second-set rejection is generally considered to be mediated by cytotoxic humoral antibodies. A few discordant data have been reported, however. To address this question, we have taken advantage of a model in which specific cytotoxic alloantibodies are not produced although transplantation cellular immunity develops. F...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199309000-00003

    authors: Aitouche A,Touraine JL

    更新日期:1993-09-01 00:00:00

  • Heart rate after cardiac transplantation-lessons from the tortoise and the shrew.

    abstract::There is a striking consistency in the total number of heart beats accrued over a lifetime across a range of animal species despite vast differences in size. Moreover, an inverse relationship is observed between heart rate and lifespan, leading to speculation that elevated heart rate could significantly affect longevi...

    journal_title:Transplantation

    pub_type: 社论,评审

    doi:10.1097/TP.0b013e31826bc42a

    authors: Critchley WR,Yonan N,Shaw SM,Fildes JE

    更新日期:2013-01-27 00:00:00

  • Section 2. Small-for-size liver graft and hepatocellular carcinoma recurrence.

    abstract::Liver transplantation (LT) is the most effective treatment for small and unresectable hepatocellular carcinomas (HCCs). With scarcity of deceased donor livers, living donor LT (LDLT) is the alternative to deceased donor LT (DDLT). Animal studies have suggested that regeneration of the partial liver graft encourages HC...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.tp.0000446266.42019.28

    authors: Chan SC

    更新日期:2014-04-27 00:00:00

  • Molecular Imaging of Acute Cardiac Transplant Rejection: Animal Experiments and Prospects.

    abstract::Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several li...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000001780

    authors: Chen Y,Zhang L,Liu J,Zhang P,Chen X,Xie M

    更新日期:2017-09-01 00:00:00