Inhibition of human monocyte spreading. An in vitro test for immunosuppressive potency of antihum lymphocyte globulin.

abstract：BACKGROUND:Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examined correlates and outcomes associated with low PA (ie, not meeting individual study's definition of being physically acti...

journal_title：Transplantation

authors： Berben L,Engberg SJ,Rossmeissl A,Gordon EJ,Kugler C,Schmidt-Trucksäss A,Klem ML,Sereika SM,De Simone P,Dobbels F,De Geest SM,B-SERIOUS consortium.

更新日期：2019-04-01 00:00:00

abstract：:To determine whether a disparity at a single miH genetic loci are sufficient to generate GVHD in mice, we focused on well-known genetic alleleic differences at the miH gene loci, H3 and H4. For H3 congenic GVHD studies, C57BL/10 (H2b) mice were used as recipients of miH-disparate B10.LP-H3b donor cells. For H4 congeni...

journal_title：Transplantation

authors： Blazar BR,Roopenian DC,Taylor PA,Christianson GJ,Panoskaltsis-Mortari A,Vallera DA

更新日期：1996-02-27 00:00:00

abstract：INTRODUCTION:Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IA patients from one UK region who received overseas transplants with IA patients receiving local living donor (LD) kidney transplantation, deceased donor (DD)...

journal_title：Transplantation

authors： Krishnan N,Cockwell P,Devulapally P,Gerber B,Hanvesakul R,Higgins R,Ready A,Carmichael P,Tomlinson K,Kumar S,Baharani J,Dasgupta I

更新日期：2010-06-27 00:00:00

abstract：:Based upon encouraging experimental results, we began employing a synthetic perfusate for cadaver kidney preservation. The new perfusate contains hydroxyethyl starch (HES) as the sole colloid for oncotic support; 107 cadaver kidneys were preserved and transplanted (93 primary, 14 nonprimary) using the HES solution and...

journal_title：Transplantation

authors： Hoffmann RM,Stratta RJ,D'Alessandro AM,Sollinger HW,Kalayoglu M,Pirsch JD,Southard JH,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:AGI-1096 is a novel phenolic intracellular antioxidant with anti-inflammatory and antiproliferative properties. In vitro, AGI-1096 inhibited the inducible expression of vascular cell adhesion molecule (VCAM)-1, E-selectin, and monocyte chemoattractant protein (MCP)-1 in endothelial cells and tumor necrosis f...

journal_title：Transplantation

authors： Murata S,Sundell CL,Lijkwan MA,Balsam LB,Hammainen P,Coleman C,York C,Luchoomun J,Suen KL,Howard R,Somers PK,Morris RE,Robbins RC

更新日期：2004-05-27 00:00:00

abstract：BACKGROUND:Donor pigs transgenic for human decay-accelerating factor (hDAF) were used in a xenogeneic ex vivo liver perfusion model to study the effect of this modification on the development of hyperacute rejection. METHODS:Three transgenic pigs were hepatectomized after hypothermic portal and transaortal gravity per...

journal_title：Transplantation

authors： Pascher A,Poehlein C,Storck M,Prestel R,Mueller-Hoecker J,White DJ,Abendroth D,Hammer C

更新日期：1997-08-15 00:00:00

abstract：:Sensitized patients awaiting renal transplantation have a markedly reduced probability of receiving a crossmatch (XM)-negative renal allograft, and, even if transplanted with a negative complement-dependent cytotoxicity (CDC)-XM, they are at an increased risk of antibody-mediated humoral rejection with early graft los...

journal_title：Transplantation

authors： Beimler JH,Morath C,Schmidt J,Ovens J,Opelz G,Rahmel A,Zeier M,Süsal C

更新日期：2009-03-15 00:00:00

abstract：:The influence of continuous immunosuppression on the immune system of 2 neonates born to heart-lung transplant recipients was analyzed. T cells, T cell subpopulations, B cells and cyclosporine levels were measured in maternal and cord blood at the time of delivery. Cyclosporine, both parent compound, and metabolites w...

journal_title：Transplantation

authors： Rose ML,Dominguez M,Leaver N,Lachno R,Yacoub MH

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Insults to the airway epithelium play a key role in constrictive bronchiolitis after lung transplantation, the typical hallmark of chronic rejection. Our hypothesis is that immunosuppressives might affect airway integrity. METHODS:A biculture of human bronchial epithelial cells and lung microvascular endoth...

journal_title：Transplantation

authors： Bellon H,Vandermeulen E,Verleden SE,Heigl T,Vriens H,Lammertyn E,Verlinden L,Vanhove T,Verstuyf M,Hoet P,Vos R,Verleden GM,Vanaudenaerde BM

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Recipients of vascularized composite allografts require aggressive and lifelong immunosuppression, and because the surgery is usually performed in nonlife-threatening situations, the development of strategies to minimize immunosuppression is especially pertinent for this procedure. We investigated how comple...

journal_title：Transplantation

authors： Zhu P,Bailey SR,Lei B,Paulos CM,Atkinson C,Tomlinson S

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Lipid peroxidation by free radicals is a key step in the development of atherosclerosis. Chronic graft nephropathy (CGN) is a common cause of allograft failure and shares many histologic features with atherosclerosis. Although hyperlipidemia is a common finding in renal transplant recipients, not all patient...

journal_title：Transplantation

authors： Morris-Stiff GJ,Oleesky D,Jurewicz WA

更新日期：2003-10-15 00:00:00

abstract：:Cross sensitization between the products of the H-2K and H-2D loci has been demonstrated by an experimental design in which recipients were sensitized with tissue bearing determinants controlled by one locus (e.g., H-2K), and then challenged with skin grafts expressing determinants controlled by the other locus (e.g.,...

journal_title：Transplantation

authors： Murphy DB,Shreffler DC

更新日期：1975-07-01 00:00:00

abstract：:The interactions of steroid hormones and human peripheral blood lymphocytes (PBLs) have been investigated following glass-wool column separation of PBLs and incubation in a serum-free medium in the presence of phytohemagglutinin (PHA). Addition of hydrocortisone or progesterone above physiological concentrations resul...

journal_title：Transplantation

authors： Neifeld JP,Tormey DC

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:Malnutrition is common in patients with end-stage liver disease considered for transplantation, but it is unclear whether this affects the outcome after transplantation. AIM.: To determine whether the severity of malnutrition in liver transplant candidates affects outcome after transplantation. METHODS:We d...

journal_title：Transplantation

authors： Shahid M,Johnson J,Nightingale P,Neuberger J

更新日期：2005-02-15 00:00:00

abstract：:: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...

journal_title：Transplantation

authors： Carbone M,Mutimer D,Neuberger J

更新日期：2013-03-27 00:00:00

abstract：:The aim of this study was to investigate the combined effect of DLA matching and immunosuppressive therapy on the survival of segmental small-bowel allografts in dogs. Orthotopic segmental small-bowel transplantations (25 to 30% of total small bowel length) were performed in two stages: first a heterotopic segmental s...

journal_title：Transplantation

authors： Meijssen MA,Heineman E,de Bruin RW,Wolvekamp MC,Marquet RL,Molenaar JC

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:After allogeneic hematopoietic stem-cell transplantation (HSCT), donor-derived T cells may elicit graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) responses. The main targets of GVHD and GVT responses after human leukocyte antigen (HLA)-identical HSCT are minor histocompatibility antigens (mHAgs...

journal_title：Transplantation

authors： Milosevic S,Bachnick B,Karim K,Bornkamm GW,Witter K,Gerbitz A,Mautner J,Behrends U

更新日期：2010-11-15 00:00:00

abstract：BACKGROUND:Early allograft dysfunction (EAD) defined by serum total bilirubin (TB) of 10 mg/dL or greater or prothrombin time-international normalized ratio (PT-INR) of 1.6 or greater on postoperative day 7 (POD 7) or aminotransferase greater than 2000 IU/L within the first week, is associated with early graft loss aft...

journal_title：Transplantation

authors： Okamura Y,Yagi S,Sato T,Hata K,Ogawa E,Yoshizawa A,Kamo N,Yamashiki N,Okajima H,Kaido T,Uemoto S

更新日期：2018-03-01 00:00:00

abstract：:The influence of race on the outcome of cadaver renal transplantation (CRT) continues to be controversial even in the cyclosporine era. The present study examines the effect of race in 343 adult CRT performed from 1/1/82 through 10/1/88 with regard to the incidence of delayed function (DF), graft survival (GS), and pa...

journal_title：Transplantation

authors： Dawidson IJ,Coorpender L,Fisher D,Helderman H,Hull A,Palmer B,Peters P,Sagalowsky A,Sandor ZF,Toto R

更新日期：1990-01-01 00:00:00

abstract：:We have investigated retrospectively sera from 70 renal allograft recipients for the presence of antibodies binding to a preanastomosis biopsy of the donor kidney by an indirect immunoperoxidase technique. All recipients had a negative T cell lymphocytotoxic crossmatch. A positive immunoperoxidase crossmatch for kidne...

journal_title：Transplantation

authors： Evans PR,Trickett LP,Gosney AR,Hodges E,Shires S,Wilson PJ,MacIver AG,Gardner B,Slapak M,Smith JL

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Warm ischemia/reperfusion injury during liver transplantation is the most important cause of primary nonfunction of liver allografts. Tumor-necrosis factor (TNF)-alpha apparently mediates tissue damage by inducing apoptosis and/or necrosis in liver transplants. The aim of the study was to determine, using an...

journal_title：Transplantation

authors： Ben-Ari Z,Hochhauser E,Burstein I,Papo O,Kaganovsky E,Krasnov T,Vamichkim A,Vidne BA

更新日期：2002-06-27 00:00:00

abstract：:The generation of Gal knockout (KO) pigs is likely to be an important advance in xenotransplantation. However, recent reports suggesting that expression of Gal may not be completely eliminated raise the possibility of a continuing anti-Gal immune response. The authors used a Gal-mismatched skin graft model to study ce...

journal_title：Transplantation

authors： Gock H,Murray-Segal L,Salvaris E,Cowan P,D'Apice AJ

更新日期：2004-03-15 00:00:00

abstract：BACKGROUND:A quantitative model of immunosuppression was previously developed based on the rejection of the allogeneic A/J murine tumor sarcoma 1 (Sa1) in immunocompetent mice. Here, the model is used to evaluate the immunologic mechanisms of graft rejection and to determine the potential of this model to detect synerg...

journal_title：Transplantation

authors： Hammond-McKibben D,Saulnier M,Zhang J,Risher N,Lake P,Weetall M

更新日期：2005-04-27 00:00:00

abstract：:In 33 renal allograft recipient-donor pairs, B and T lymphocyte complement-dependent cytotoxicity crossmatches and mixed lymphocyte culture (MLC) blocking experiments were performed and the results were correlated with graft outcome. MLC blocking particularly in the unidirectional culture against donor-stimulating cel...

journal_title：Transplantation

authors： Ettenger RB,Opelz G,Walker J,Terasaki PI,Uittenbogaart C,Pennisi AJ,Malekzadeh MH,Fine RN

更新日期：1978-04-01 00:00:00

abstract：:Recipient dogs were conditioned with 9.2 Gy of total-body irradiation followed by the infusion of bone marrow and peripheral blood leukocytes from a DLA-haploidentical littermate (N = 10) or a completely allogeneic unrelated donor (n = 9). Graft-vs.-host disease (GVHD) prophylaxis consisted of methotrexate (MTX) and c...

journal_title：Transplantation

authors： Deeg HJ,Severns E,Raff RF,Sale GE,Storb R

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Our goal was to test the intragraft mRNA expression and production of two chemokines that are potent chemoattractants for antigen-primed T cells, interferon-gamma inducible protein 10 (IP-10) and monokine-induced by IFN-gamma, (Mig), in allogeneic heart grafts. METHODS:Syngeneic or allogeneic A/J (H-2a) hea...

journal_title：Transplantation

authors： Kapoor A,Morita K,Engeman TM,Koga S,Vapnek EM,Hobart MG,Fairchild RL

更新日期：2000-03-27 00:00:00

abstract：BACKGROUND:Waiting time to deceased donor kidney transplant varies greatly across the United States. This variation violates the final rule, a federal mandate, which demands geographic equity in organ allocation for transplantation. METHODS:Retrospective analysis of the United States Renal Data System and United Netwo...

journal_title：Transplantation

authors： Davis AE,Mehrotra S,McElroy LM,Friedewald JJ,Skaro AI,Lapin B,Kang R,Holl JL,Abecassis MM,Ladner DP

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...

journal_title：Transplantation

authors： Zaitsu M,Yamashita K,Shibasaki S,Tsunetoshi Y,Fukai M,Ogura M,Yoshida T,Igarashi R,Kobayashi N,Umezawa K,Todo S

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Despite the prevalent use of rabbit antithymocyte globulin (rATG) as an induction agent in kidney transplantation, the appropriate dose for preventing acute rejection in high-risk patients is not known. Few studies have examined total exposure of rATG less than 6 mg/kg, with fewer studies examining lower dos...

journal_title：Transplantation

authors： Klem P,Cooper JE,Weiss AS,Gralla J,Owen P,Chan L,Wiseman AC

更新日期：2009-10-15 00:00:00

abstract：:To examine whether cyclosporine (CsA) has mutagenic potential against human cells, we analyzed sister chromatid exchange (SCE) induction by CsA using human lymphocytes in vitro. SCE frequencies increased significantly in the lymphocytes treated with 1 microgram/ml and 5 micrograms/ml CsA, though the frequencies seemed...

journal_title：Transplantation

authors： Yuzawa K,Kondo I,Fukao K,Iwasaki Y,Hamaguchi H

更新日期：1986-07-01 00:00:00