Abstract:
:We have investigated retrospectively sera from 70 renal allograft recipients for the presence of antibodies binding to a preanastomosis biopsy of the donor kidney by an indirect immunoperoxidase technique. All recipients had a negative T cell lymphocytotoxic crossmatch. A positive immunoperoxidase crossmatch for kidney-reactive antibodies was seen in 13/70 (18.6%) recipients--6 reacting with endothelium, 4 with epithelium, and 3 with both cell types. Neither the presence of these antibodies nor their pattern of staining correlated with recipient graft outcome. Following transplantation endothelial reactive antibodies developed in 15/43 (35%) patients, whereas tubular epithelial antibodies occurred in 5/43 (12%). The antibodies were persistent and accompanied graft failure in 10/14 (71%) patients, while transient antibodies were only associated with graft failure in 2/12 (17%) recipients. Development of lymphocytotoxic antibodies did not correlate with the presence of renal reactive antibodies or eventual graft outcome. Smooth muscle and antinuclear antibodies in recipient sera prior to transplantation were associated with improved graft survival. Eluates of 8/14 rejected grafts confirmed the presence of renal reactive antibodies, with patterns of staining similar to those observed in recipient sera. Antibodies in 7/8 recipients were shown by absorption studies to have HLA class I and/or II specificity, the remaining recipient having proximal tubular brush border antibodies.
journal_name
Transplantationjournal_title
Transplantationauthors
Evans PR,Trickett LP,Gosney AR,Hodges E,Shires S,Wilson PJ,MacIver AG,Gardner B,Slapak M,Smith JLdoi
10.1097/00007890-198812000-00011subject
Has Abstractpub_date
1988-12-01 00:00:00pages
844-52issue
6eissn
0041-1337issn
1534-6080journal_volume
46pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::We report an unusual case of massive pseudolymphomatous pericardial effusion in a cardiac transplant recipient. The near-coincidental development of the lymphocytic effusion and an EBV-associated tonsillar lymphoproliferative disorder suggested that the effusion was a manifestation of a posttransplant B cell lymphopro...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199606270-00020
更新日期:1996-06-27 00:00:00
abstract::Cadaveric kidney transplants with delayed graft function have poorer graft survival by an unknown mechanism. Nitric oxide, produced by nitric oxide synthase (NOS), has a proven role in both recovery of ischemia and promotion of rejection. We therefore wished to study the patterns of NOS activity in a model of renal is...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199702270-00002
更新日期:1997-02-27 00:00:00
abstract::A patient with short gut syndrome presented with end-stage liver disease. She underwent an isolated liver transplantation at the age of 3.5 years. Parenteral nutrition was discontinued 1.5 years after surgery. At 7 years of age, the patient has maintained normal nutritional indices and growth while on a normal oral di...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199902270-00025
更新日期:1999-02-27 00:00:00
abstract::Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the presence of donor specific antibodies to human leukocyte antigen (HLA) or non-HLA antigens. High...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003551
更新日期:2020-11-17 00:00:00
abstract:BACKGROUND:Waiting time to deceased donor kidney transplant varies greatly across the United States. This variation violates the final rule, a federal mandate, which demands geographic equity in organ allocation for transplantation. METHODS:Retrospective analysis of the United States Renal Data System and United Netwo...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/01.tp.0000438623.89310.dc
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Kidney transplantation (KT) of human immunodeficiency virus (HIV)-positive patients has transformed the management of end-stage kidney disease in this population. Although favourable outcomes have been reported, patients experience high rates of acute allograft rejection (AR). We examined factors associated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000879
更新日期:2016-04-01 00:00:00
abstract::The CD154-CD40 pathway is one of the critical costimulatory pathways that are required for full activation of T cells during alloimmune responses. Blockade of this pathway with anti-CD154 antibodies has been reported to prolong allograft survival in experimental transplantation models and to induce tolerance in some i...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-200201151-00012
更新日期:2002-01-15 00:00:00
abstract::We have tested the predictive model for risk of sensitization by donor-specific transfusions developed at the University of California, San Francisco for its applicability to the DST experience at UW/Madison. Patient sample sizes between the two groups were similar (n = 249 for UW/Madison, n = 261 for UCSF) and the tw...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00031
更新日期:1989-01-01 00:00:00
abstract::Three strains of miniature swine, each homozygous for a different allele of the major histocompatibility locus (MHC), have been developed by a selective breeding scheme based on tissue typing of the offspring of each generation. Prior to breeding, the original parents were reciprocally immunized by skin grafts and lym...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197612000-00004
更新日期:1976-12-01 00:00:00
abstract::Solid organ and allogeneic hematopoietic cell transplantation have become standard therapeutic interventions that save patient lives and improve quality of life. Our enhanced understanding of transplantation immunobiology has refined clinical management and improved outcomes. However, organ rejection and graft-versus-...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001468
更新日期:2016-12-01 00:00:00
abstract::Shortage of organ donors limits the number of possible liver transplantations. Alternative therapies for treatment of liver failure are currently being developed: (i) extracorporeal artificial liver devices; (ii) bioartificial liver devices using hepatocytes; and (iii) hepatocyte transplantation. The objective of thes...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e3181963ad3
更新日期:2009-02-27 00:00:00
abstract:BACKGROUND:More than 30% of potential kidney transplant recipients have pre-existing anti-human leukocyte antigen antibodies. This subgroup has significantly lower transplant rates and increased mortality. Desensitization has become an important tool to overcome this immunological barrier. However, limited data is avai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000442782.98131.7c
更新日期:2014-06-27 00:00:00
abstract:BACKGROUND:The impact of nutritional status on outcome of allogeneic stem cell transplantation (alloSCT) is controversial. This study investigates the influence of pretransplant weight loss and serologic indicators of nutritional homeostasis on relapse and death of acute myeloid leukemia (AML) after alloSCT. METHODS:P...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000471
更新日期:2015-05-01 00:00:00
abstract::We report the successful application of a hybrid artificial pancreas device for the treatment of severe diabetes mellitus induced by total pancreatectomy in two dogs. Control of the blood sugar was achieved for more than 1 year in these two animals without any immunosuppressive therapy. Although exogenous insulin was ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199304000-00005
更新日期:1993-04-01 00:00:00
abstract::The effect of the quinoline-3-carboxamide LS-2616 (Linomide), given alone or together with cyclosporine, was studied in the first set cardiac allograft transplantation model in the rat. PVG rat hearts were transplanted heterotopically to Wistar/Kyoto rat recipients on day 0. The recipients were given LS-2616 orally on...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198902000-00003
更新日期:1989-02-01 00:00:00
abstract::The aim of this study was to analyze the possible protective effects of a glutamine and arginine precursor (ornithine-alpha-ketoglutarate [OKG]) on the mucosa of a transplanted intestine when administered with either a defined formula oral diet (DFD) or a standard chow. Isogenic male Lewis rats (250 g) were submitted ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199703150-00004
更新日期:1997-03-15 00:00:00
abstract::The effect of long-term pharmacologic immunosuppression (PI) on anti-Galalpha1-3Gal (alphaGal) antibody (Ab) levels has not been determined previously in humans. In this study, we measured alpha Gal Ab levels by ELISA in 14 healthy volunteers (controls) and in 70 patients with grafts (kidney, heart, liver) who had rec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003150-00042
更新日期:2000-03-15 00:00:00
abstract::One major limitation in pancreatic islet transplantation is availability of donor tissue. Donor shortage is exacerbated by islet apoptosis from the stresses of islet isolation and transplantation. Furthermore, the side effects of immunosuppressive drugs preclude transplants into patients whose diabetes is controlled b...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000132283.95107.9c
更新日期:2004-05-27 00:00:00
abstract:BACKGROUND:Macroencapsulated islets can reverse hyperglycemia in diabetic animals when transplanted i.p. or into the fat pad. The s.c. space is an attractive site for such transplantation because macrocapsules can be implanted with local anesthesia and be easily removed or reloaded with fresh islets. METHODS:Immunopro...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199903150-00005
更新日期:1999-03-15 00:00:00
abstract:BACKGROUND:The effective use of new steroid-sparing immunosuppressive regimens may lower cumulative glucocorticoid use among renal transplant recipients. However, it is unknown what effect this therapeutic trend has had on bone disease. METHODS:Unselected newly transplanted inpatients (n=45) were identified and compre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200301150-00009
更新日期:2003-01-15 00:00:00
abstract:BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000178378.53616.ca
更新日期:2005-11-15 00:00:00
abstract::We have previously demonstrated that the placental spongiotrophoblast and yolk sac venous plexus express paternally derived H-2K and D (class I) antigens in a manner accessible to maternal circulation, and that the placenta serves to prevent antipaternal antibodies from reaching the fetus. Kinetic studies indicated th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198403000-00016
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Organ donors are frequently trauma victims, but the impact of donor hemorrhagic shock and resuscitation (HSR) on pulmonary graft function has not been assessed. L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Objec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a52ce1
更新日期:2009-06-15 00:00:00
abstract:BACKGROUND:Immunomodulatory protocols including intravenous immunoglobulin/rituximab (IVIG/R) are employed to decrease anti-human leukocyte antigen (HLA) antibody levels for patients broadly sensitized to HLA and increase chances for transplantation with a compatible deceased donor (DD). The aim of our study was to ide...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31821eab8a
更新日期:2011-07-15 00:00:00
abstract::The use of immunosuppressive agents (primarily azathioprine and prednisone) to promote human allograft survival is known to be associated with an enhanced rate of skin cancer development by ultraviolet radiation (UVR). These observations raise the question of whether the immunosuppressive agents are functioning as coc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198708000-00022
更新日期:1987-08-01 00:00:00
abstract::Natural killer (NK) cells effect hybrid resistance, in which parental hematopoietic cell grafts are rejected by F1 recipients. NK cells can also resist engraftment of fully MHC-mismatched allogeneic marrow. However, studies of NK cell-mediated alloresistance have relied on short-term proliferation, colony, or survival...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601150-00024
更新日期:1996-01-15 00:00:00
abstract::A technique of orthotopic renal transplantation in rabbits is described. The technique has been evolved in an experience of over 400 grafts, and difficulties encountered in producing satisfactory anaesthesia and techniques of anastomosis and in obtaining reliable graft function postoperatively have been defined and ov...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197611000-00003
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:Allogeneic bone marrow transplantation (BMT) and donor lymphocyte infusion (DLI) provide valuable treatments for a range of diseases. However, the therapeutic utility of BMT and DLI is reduced by the high incidence of graft-versus-host disease (GvHD) mediated by activated donor T lymphocytes directed against...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000229435.58898.c5
更新日期:2006-08-27 00:00:00
abstract::Renal allografts were performed in miniature swine that were identical at their major histocompatibility locus and were presensitized by skin grafts from their prospective renal donors. All of these renal grafts were rejected in a hyperacute or markedly accelerated manner compared to the survival of comparable grafts ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplants to how to conduct them ethically. METHODS:Leaders of each program performing and/or evaluating VCA ...
journal_title:Transplantation
pub_type: 共识发展会议,杂志文章,评审
doi:10.1097/TP.0000000000002478
更新日期:2019-06-01 00:00:00