Abstract:
:We report the successful application of a hybrid artificial pancreas device for the treatment of severe diabetes mellitus induced by total pancreatectomy in two dogs. Control of the blood sugar was achieved for more than 1 year in these two animals without any immunosuppressive therapy. Although exogenous insulin was required therapy. Although exogenous insulin was required during the latter part of the study period, removal of the devices resulted in a rapid increase in the fasting blood sugar levels and the exogenous insulin requirements (P < 0.001 versus weeks 1-52 in both dogs). Metabolic studies, postexplant in vitro studies, and histologic analyses confirmed islet cell survival and insulin production by the devices. This hybrid artificial pancreas has a clear clinical potential for islet cell transplantation without immunosuppression.
journal_name
Transplantationjournal_title
Transplantationauthors
Maki T,Lodge JP,Carretta M,Ohzato H,Borland KM,Sullivan SJ,Staruk J,Muller TE,Solomon BA,Chick WLdoi
10.1097/00007890-199304000-00005subject
Has Abstract,Author List Incompletepub_date
1993-04-01 00:00:00pages
713-7; discussion 717-8issue
4eissn
0041-1337issn
1534-6080journal_volume
55pub_type
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