Abolition of the effect of cyclosporine on rat cardiac allograft rejection by the new immunomodulator LS-2616 (Linomide).

abstract：BACKGROUND:Human herpesvirus 6 (HHV-6) is susceptible to latency and reactivation in hematopoietic stem cell transplant (HSCT) recipients. We investigated the incidence of HHV-6 DNAemia and factors related to HHV-6 DNAemia and death after allogeneic stem cell transplantations. We also explored the relationship between ...

journal_title：Transplantation

authors： Jeulin H,Agrinier N,Guery M,Salmon A,Clément L,Bordigoni P,Venard V

更新日期：2013-05-27 00:00:00

abstract：BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

journal_title：Transplantation

authors： Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the efficacy of cariporide (a sodium-hydrogen exchanger inhibitor), BMS180448 (a pharmacologic ischemic preconditioning agent), and the combination thereof, as adjuvant therapies for extended cardiac allograft preservation. METHODS:A porcine model of donor brain death ...

journal_title：Transplantation

authors： Ryan JB,Hicks M,Cropper JR,Garlick SR,Kesteven SH,Wilson MK,Feneley MP,Macdonald PS

更新日期：2003-09-15 00:00:00

abstract：:Natural suppressor (NS) activity is detected in tissues undergoing intense hematopoietic regeneration. This includes the spleens of mice recovering from total lymphoid irradiation or cyclophosphamide treatment, or after induction of chronic graft-versus-host disease against minor histocompatibility antigens. NS cells ...

journal_title：Transplantation

authors： Schreiber KL,Forman J

更新日期：1993-09-01 00:00:00

abstract：:Glutathione and glyoxalase II levels were evaluated in cytosolic and mitochondrial compartments of rat liver after 7 and 24 hr of cold storage in University of Wisconsin (UW) and Euro-Collins solutions. 1-4 A similar time-dependent depletion of cytosolic glutathione up to about 60% of control values was observed in bo...

journal_title：Transplantation

authors： Jassem W,Ciarimboli C,Cerioni PN,Saba V,Norton SJ,Principato G

更新日期：1996-05-15 00:00:00

abstract：:Cross sensitization between the products of the H-2K and H-2D loci has been demonstrated by an experimental design in which recipients were sensitized with tissue bearing determinants controlled by one locus (e.g., H-2K), and then challenged with skin grafts expressing determinants controlled by the other locus (e.g.,...

journal_title：Transplantation

authors： Murphy DB,Shreffler DC

更新日期：1975-07-01 00:00:00

abstract：:Human epidermal cells were grown serially in surface culture by inoculation of suspensions of disaggregated cells. Single cells grew into colonies and the colonies fused to make a confluent epithelium. The epithelium was detached as a unit and transplanted onto a graft bed prepared in athymic mice. Such grafts formed ...

journal_title：Transplantation

authors： Banks-Schlegel S,Green H

更新日期：1980-04-01 00:00:00

abstract：:A portable hypothermic perfusion system for storage of hearts has been developed. The system uses the airlift pump principle, whereby the flow of gas maintains circulation of the perfusate through the heart; no other energy source is required. Performance on ex vivo functional testing of 10 pig hearts stored for 20 to...

journal_title：Transplantation

authors： Wicomb WN,Cooper DK,Barnard CN

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:To optimize the methods used for human islet isolation for transplantation, it is important to improve our understanding of the structure of the islet-exocrine interface. In this study, the composition of collagen subtypes in the interface have been characterized and quantified in human pancreas. METHODS:Hu...

journal_title：Transplantation

authors： Hughes SJ,Clark A,McShane P,Contractor HH,Gray DW,Johnson PR

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:It has been proposed that hyperacute rejection (HAR) of pig-to-primate vascularized xenografts is due in large part to ineffective regulation of recipient complement by pig complement regulatory proteins (CRPs), and indeed transgenic expression of human CRPs in pigs can prevent hyperacute rejection. However,...

journal_title：Transplantation

authors： Fisicaro N,Aminian A,Hinchliffe SJ,Morgan BP,Pearse MJ,D'Apice AJ,Cowan PJ

更新日期：2000-09-27 00:00:00

abstract：BACKGROUND:The impact of major histocompatibility class I chain-related A (MICA) antibodies on renal graft outcomes is unclear. The goal of this work was to assess the impact of posttransplant MICA antibodies, assayed at 1 year, with two commercially available kits, on long-term renal graft outcomes. METHODS:We retros...

journal_title：Transplantation

authors： Lemy A,Andrien M,Lionet A,Labalette M,Noel C,Hiesse C,Delahousse M,Suberbielle-Boissel C,De Meyer M,Latinne D,Mourad M,Delsaut S,Racapé J,Wissing KM,Toungouz M,Abramowicz D

更新日期：2012-06-27 00:00:00

abstract：:The use of real-time reverse transcription polymerase chain reaction to compare gene expression in different tissues and conditions requires normalization to an internal control that must be expressed at a constant level. Although a previous validation step is required to confirm that an internal control is appropriat...

journal_title：Transplantation

authors： Rodriguez-Mulero S,Montanya E

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND:Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial. METHODS:We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of dd-cfDNA. Relevant literature was ...

journal_title：Transplantation

authors： Xiao H,Gao F,Pang Q,Xia Q,Zeng X,Peng J,Fan L,Liu J,Wang Z,Li H

更新日期：2020-09-02 00:00:00

abstract：BACKGROUND:Given growth in kidney transplant waitlists and discard rates, donor kidney acceptance is an important problem. We used network analysis to examine whether organ procurement organization (OPO) network centrality affects discard and outcomes. METHODS:We identified 106,160 deceased donor kidneys recovered for...

journal_title：Transplantation

authors： Butala NM,King MD,Reitsma W,Formica RN,Abt PL,Reese PP,Parikh CR

更新日期：2015-12-01 00:00:00

abstract：:Clinical as well as experimental studies have shown a great interindividual variability in the immunosuppressive efficacy of CsA. Evaluating previous in vitro findings of a correlation between sensitivity of alloresponsiveness to CsA and the HLA-DR phenotype CsA levels were compared in kidney transplant recipients wit...

journal_title：Transplantation

authors： Zlabinger GJ,Kudlacek S,Pohanka E,Franz M,Hamilton G,Rosenmayr A,Kovarik J

更新日期：1992-04-01 00:00:00

abstract：:In vitro studies have shown that calcium channel blockers (CCB) exert inhibitory effects on immunocompetent cells but conflicting results have been reported as to the translation of these effects into significant in vivo immunosuppression. In this study we evaluated the effects of the benzothiazepine-like calcium bloc...

journal_title：Transplantation

authors： Dumont L,Chen H,Daloze P,Xu D,Garceau D

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:HLA-G is a nonclassical MHC class I molecule and its physiological expression restricted to placental extravillous trophoblasts contributes to maternal tolerance to the semiallogeneic fetus. Aberrant expression of HLA-G in human organ grafts has been proposed to contribute to graft acceptance. METHODS:We st...

journal_title：Transplantation

authors： Moroso V,van Cranenbroek B,Mancham S,Sideras K,Boor PP,Biermann K,de Vogel L,de Knegt RJ,van der Eijk A,van der Laan LJ,de Jonge J,Metselaar HJ,Joosten I,Kwekkeboom J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Calcineurin inhibitors (CNIs) are the first-line immunosuppressive agents administered after liver transplantation, but they cause renal impairment. Two recent randomized trials report cellular rejection and liver graft loss when mycophenolate mofetil (MMF) monotherapy was used as a renal-sparing agent. Our ...

journal_title：Transplantation

authors： Raimondo ML,Dagher L,Papatheodoridis GV,Rolando N,Patch DW,Davidson BR,Rolles K,Burroughs AK

更新日期：2003-01-27 00:00:00

abstract：BACKGROUND:End-stage renal disease (ESRD) is an increasing problem in patients infected with the human immunodeficiency virus (HIV). The use of highly active antiretroviral therapy (HAART) has decreased the morbidity associated with HIV and has prompted renewed interest in renal transplantation. METHODS:We performed f...

journal_title：Transplantation

authors： Tan HP,Kaczorowski DJ,Basu A,Khan A,McCauley J,Marcos A,Fung JJ,Starzl TE,Shapiro R

更新日期：2004-12-15 00:00:00

abstract：:This study describes VG01, a monoclonal antibody to a novel lymphocyte activation antigen. The cells reacting with VG01 were first characterized by indirect immunofluorescence and fluorescence-activated cell sorter analysis. The antigen defined by VG01 was expressed on circulating T lymphocytes (23.8 +/- 9.0) and on t...

journal_title：Transplantation

authors： Denegri JF,Gilks CB,Altin M,Peterson J,Lafleur L

更新日期：1988-05-01 00:00:00

abstract：:Monocytes from human peripheral blood, when incubated in vitro, spread onto the surface of the glass. Horse antihuman lymphocyte globulin (ALG) added to the incubation chamber inhibits the spreading, while normal horse globulin (NHG) does not. The inhibition depends on the concentration of ALG admixed to the mononucle...

journal_title：Transplantation

authors： Silobrcić V,Mazuran R,Dekaris D,Balner H

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Airway complications continue to be an important source of morbidity and mortality after lung transplantation (LTx). Different approaches have been used for their nonsurgical management. We describe our experience using self-expandable metallic stents (SEMSs) in patients with airway complications post-LTx. ...

journal_title：Transplantation

authors： Saad CP,Ghamande SA,Minai OA,Murthy S,Pettersson G,DeCamp M,Mehta AC

更新日期：2003-05-15 00:00:00

abstract：BACKGROUND:To define whether immunosuppressive agents that block the interleukin (IL)-2 pathway could prevent activation-induced cell death of activated T cells in the graft, we measured expression of IL-2, IL-2 receptor alpha chain (CD25), IL-15, Fas, and Fas ligand by real time reverse transcription-polymerase chain ...

journal_title：Transplantation

authors： Baan CC,Balk AH,van Riemsdijk IC,Vantrimpont PJ,Maat AP,Niesters HG,Zondervan PE,van Gelder T,Weimar W

更新日期：2003-05-27 00:00:00

abstract：:To determine the nature and sequence of the histologic changes in the early rejection of pancreaticoduodenal allografts and to assess the correlation between pancreaticoduodenal biopsy findings and the pathologic changes in the graft, we performed serial cystoscopically directed needle biopsies of pancreaticoduodenal ...

journal_title：Transplantation

authors： Carpenter HA,Barr D,Marsh CL,Miller AR,Perkins JD

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Neuromuscular blockade (NMB) reversal with neostigmine and glycopyrrolate has been reported to cause cardiac arrest in patients with a history of cardiac transplantation. The purpose of this study was to examine the safety of NMB reversal with acetylcholinesterase inhibitors and muscarinic anticholinergics i...

journal_title：Transplantation

authors： Barbara DW,Christensen JM,Mauermann WJ,Dearani JA,Hyder JA

更新日期：2016-12-01 00:00:00

abstract：:We retrospectively reviewed the clinical data of all renal transplant patients treated with cyclosporine as their main chronic immunosuppressive agent between 12/83 and 11/85 to identify cytomegalovirus-negative patients at our institutions who received cytomegalovirus (CMV)-positive kidneys. Using a latex agglutinati...

journal_title：Transplantation

authors： Weir MR,Irwin BC,Maters AW,Genemans G,Shen SY,Charache P,Williams GM

更新日期：1987-02-01 00:00:00

abstract：:We describe a substrain of BB rats, BB/Pfd, characterized by a loss of autoimmune potential soon after onset of diabetes. When fresh syngeneic (BB/Pfd) islets (6 islets/g body weight) were transplanted under the kidney capsule of diabetic BB/Pfd rats 1-2 weeks after diabetes onset (n = 14), no recurrence of diabetes o...

journal_title：Transplantation

authors： Mathieu C,Kuttler B,Waer M,Bouillon R,Hahn HJ

更新日期：1994-08-15 00:00:00

abstract：:Transplantation tolerance can be induced in the adult mouse by the selective manipulation of the CD4+ T cell subset. C3H/He recipients with prolonged survival (> 120 days) of C57BL/10 cardiac allografts induced by treatment, at the time of transplantation, with the anti-CD4 mAb, YTS 191.1, were skin grafted simultaneo...

journal_title：Transplantation

authors： Pearson TC,Darby CR,Bushell AR,West LJ,Morris PJ,Wood KJ

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:The urinary CXC chemokine ligand (CXCL)10 detects renal transplant inflammation noninvasively, but has limited sensitivity and specificity. In this study, we performed urinary proteomic analysis to identify novel biomarkers that may improve the diagnostic performance of urinary CXCL10 for detecting alloimmun...

journal_title：Transplantation

authors： Ho J,Rush DN,Krokhin O,Antonovici M,Gao A,Bestland J,Wiebe C,Hiebert B,Rigatto C,Gibson IW,Wilkins JA,Nickerson PW

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Human intravenous immunoglobulin G delayed xenogeneic hyperacute rejection (HAR) in the guinea pig-to-rat combination. We investigated the respective roles of the Fc and Fab fragments of the IgG molecule in this inhibitory effect. METHODS:By using a guinea pig-to-rat heart transplantation model, the efficie...

journal_title：Transplantation

authors： Urbani L,Fabre M,Cardoso J,Lambin P,Devillier P,Soubrane O,Houssin D,Gautreau C

更新日期：1998-08-15 00:00:00