Abstract:
:To determine the nature and sequence of the histologic changes in the early rejection of pancreaticoduodenal allografts and to assess the correlation between pancreaticoduodenal biopsy findings and the pathologic changes in the graft, we performed serial cystoscopically directed needle biopsies of pancreaticoduodenal allografts in 18 dogs and compared the findings with the histologic changes in 16 autografts as controls. Tissue adequate for evaluation was obtained by the biopsy technique in 70% of instances. The earliest and most characteristic manifestation of rejection was diffuse mixed inflammatory infiltrates involving the pancreatic acinar tissue and duodenum. The biopsy findings correlated well with the changes in the resected pancreatic specimens. Cellular rejection in the duodenum correlated with rejection in the pancreatic graft. There were no changes in the autografts that resembled cellular rejection. We conclude that, in the canine model, cystoscopically directed needle biopsy of pancreaticoduodenal allografts consistently provides adequate tissue for the diagnosis of rejection; the status of the graft can be monitored by serial biopsies of pancreatic acinar tissue and, possibly, by serial biopsies of the duodenal wall alone.
journal_name
Transplantationjournal_title
Transplantationauthors
Carpenter HA,Barr D,Marsh CL,Miller AR,Perkins JDdoi
10.1097/00007890-198911000-00008subject
Has Abstractpub_date
1989-11-01 00:00:00pages
764-8issue
5eissn
0041-1337issn
1534-6080journal_volume
48pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Hematopoietic growth factors (HGF) mobilize potential tolerogenic cells in transplant donors. Fms-like tyrosine kinase 3 ligand (Flt3L) mobilizes stem cells and dendritic cells (DCs) in human and nonhuman primate blood. Blood and renal and liver biopsies were obtained from untreated and Flt3L-mobilized rhesus macaques...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000255320.00061.e9
更新日期:2007-03-15 00:00:00
abstract:BACKGROUND:Altered expression of murine MD-1, a molecule controlling expression of members of the interleukin (IL)-1 receptor family of signaling proteins, regulates antigen-presenting cell-induced alloreactions. We investigated the effect of treatment with antisense deoxyoligonucleotides or antibodies to MD-1 in vivo ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200206150-00013
更新日期:2002-06-15 00:00:00
abstract::In an attempt to investigate the nonspecificity of the effect of administration of donor splenocytes treated with mitomycin C (MMC) 7 days before transplantation in inducing immunological unresponsiveness, the survival rates of liver, heart, small bowel, and skin allografts were compared in the RT1-incompatible ACI(RT...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198902000-00036
更新日期:1989-02-01 00:00:00
abstract::T cell surface proteins involved in transmembrane signalling resulting in the activation of T cells were investigated utilizing as probes monoclonal antibodies directed at T cell surface antigens. Here we report that mAbs that react with a framework determinant of alpha/beta heterodimer of T cell receptor for antigen,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198902000-00033
更新日期:1989-02-01 00:00:00
abstract::The majority of skin tumors induced in mice by ultraviolet (UV) light are rejected when implanted into normal syngeneic recipients. Subcarcinogenic levels of UV light exposure render the normally resistant mice susceptible to tumor challenge. The immunoregulatory effect of UV light appears to be additive, since the gr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00008
更新日期:1977-04-01 00:00:00
abstract::BK polyoma virus causes allograft dysfunction as a result of tubulo-interstitial nephritis in 2% to 5% of renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in India is unknown. We used routine histologic examination, immunohistochemistry, and electron microscopy to retr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000113163.02039.30
更新日期:2004-02-15 00:00:00
abstract:BACKGROUND:Randomized controlled trials and U.S. Registry data have demonstrated that mycophenolate mofetil (MMF) reduces acute rejection rates and improves graft survival. We undertook the first paired kidney analysis comparing the effects of MMF and azathioprine on graft outcome in the United Kingdom. METHODS:In all...
journal_title:Transplantation
pub_type: 杂志文章,meta分析
doi:10.1097/01.tp.0000250713.65004.35
更新日期:2006-12-27 00:00:00
abstract:BACKGROUND:Alterations in microcirculation are considered central to the pathogenesis of hyperacute xenogeneic rejection (HXR) of vascularized xenografts, but currently there exist no data describing these microhemodynamic alterations. METHODS:Rat livers were perfused in situ with either isogeneic rat blood or xenogen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199702150-00022
更新日期:1997-02-15 00:00:00
abstract:BACKGROUND:In an effort to improve outcomes associated with living kidney donation, the Kidney Diseases Improving Global Outcomes (KDIGO) assembled a Work Group to develop comprehensive guidelines addressing the evaluation and care of living kidney donors. We conducted this systematic review to inform guideline develop...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001252
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Several technical modifications in portal vein (PV) reconstruction have shown excellent outcomes in pediatric liver transplantation (LT); however, which procedure is the best for PV reconstruction of the hypoplastic PV in pediatric LT remains unclear. METHODS:One hundred sixteen pediatric patients aged 1 or...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002793
更新日期:2020-01-01 00:00:00
abstract::Endothelial chimerism in transplanted organs is a fascinating phenomenon, indicative of a mechanism by which progenitor recipient cells replace the donor endothelium. It has been hypothesized that this replacement could lead to a decrease in alloreactivity and thus would positively influence graft outcome. However, re...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000231446.41051.98
更新日期:2006-07-15 00:00:00
abstract:BACKGROUND:Urologic complications cause substantial morbidity in the pediatric population after renal transplantation, but their impact on graft survival and transplant costs is poorly understood. In this retrospective review, we evaluated the records of all pediatric renal transplant recipients at our center from 1995...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818b63da
更新日期:2008-12-15 00:00:00
abstract::Two patients at our institution underwent single lung transplantation. The procedure and the patient's postoperative course were uncomplicated in each case. Pathological examination of each pneumonectomy specimen revealed a well-differentiated adenocarcinoma; both were less than 1 cm in size. The remainder of each lun...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199810270-00024
更新日期:1998-10-27 00:00:00
abstract:BACKGROUND:There is growing interest in new therapeutic options for the treatment of end-stage liver diseases. In addition to mechanical devices supporting liver function, such as bioreactors, the transplantation of hepatocyte-like cells derived from (adult) stem cells offer great perspectives. We have generated hepato...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000157362.91322.82
更新日期:2005-05-15 00:00:00
abstract::The recipients of combined kidney-pancreas transplants (SPK) are unique because they routinely receive two allografts from the same donor. In a previous study, we found that the long-term graft survival of the two allografts was different, with better graft survival seen in the pancreas allograft. In an attempt to und...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199408270-00006
更新日期:1994-08-27 00:00:00
abstract:BACKGROUND:Generation of non-human primate regulatory T cells (Treg) with alloantigen (alloAg) specificity would allow their testing in preclinical transplant models. Low recovery of Treg from peripheral blood limits their potential utility. In small animals and humans, conventional myeloid dendritic cells (DC) have be...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ba6b1f
更新日期:2009-11-15 00:00:00
abstract::A single posttransplant test for human leukocyte antigen (HLA) antibodies in heart and lung graft patients was examined for its predictive value for graft survival as part of the 13th and 14th international histocompatibility workshops. We included patients with HLA antibodies who were tested 6 or more months after tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181605cd9
更新日期:2008-02-15 00:00:00
abstract:BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001005
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:We examined whether oral administration of alloantigen could induce the prolonged survival of cardiac allografts. METHODS:Hearts from CBK (H2k+Kb) transgenic or (C57BL/10xCBA)F1 (H2bxH2k) mice were transplanted into CBA (H2k) recipients pretreated orally with 1 x 10(7) donor splenocytes in the presence or a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200011270-00021
更新日期:2000-11-27 00:00:00
abstract::The interactions of rapamycin (Rapa), CsA, and donor-specific transfusion (DST) were examined in an ACI to Lewis rat heterotopic cardiac allograft model. Survival data were truncated at 175 days for the purpose of statistical comparisons. Vehicle (Veh)-treated animals rejected at a mean of 7.3 +/- 0.2 days. Treatment ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199305000-00033
更新日期:1993-05-01 00:00:00
abstract::Hepatic grafts from non-heartbeating donors may alleviate the organ shortage, but they inherently suffer from warm ischemia. In the present study, we tested our hypothesis that augmentation of endogenous adenosine by inhibition of nucleoside transport with R75231 attenuates ischemic liver injury. Adult female beagle d...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199701270-00007
更新日期:1997-01-27 00:00:00
abstract:BACKGROUND:Accurate and rapid diagnosis of human cytomegalovirus (HCMV) disease in solid organ transplant patients remains a challenge. We evaluated the clinical utility of a quantitative polymerase chain reaction (QPCR) method to diagnose transplant patients with HCMV disease. METHODS:A total of 429 plasma samples fr...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199910150-00016
更新日期:1999-10-15 00:00:00
abstract:BACKGROUND:Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000250936.73034.98
更新日期:2006-12-27 00:00:00
abstract:BACKGROUND:We have previously shown that an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts generates a tryptophan-deficient environment that selectively inhibits proliferation and induces apoptosis of bystander CD4+ and CD8+ T cells, but not pancreatic islets. Because these immune cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000661
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Recent advances in the understanding of immunomodulatory properties of phosphodiesterase 4 (PDE4) inhibitors recommend these drugs for immunosuppressive therapy after lung transplantation. The potency of three PDE4 inhibitors was tested using an established model of heterotopic tracheal transplantation in ra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208150-00007
更新日期:2002-08-15 00:00:00
abstract:BACKGROUND AND AIMS:Liver endothelial cells (LECs) perform an essential role in important pathophysiologic functions in the liver. Establishment of a human LEC line facilitates advances in LEC research. Here, we present immortalization of human LECs using retroviral gene transfer of simian virus 40 large T antigen (SV4...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000124286.82961.7e
更新日期:2004-05-15 00:00:00
abstract:BACKGROUND:The timing of an acute rejection may have a variable impact on renal allograft survival. To determine whether the time of first acute transplant rejection (ATR) is an independent predictor of long-term allograft survival, we studied 31,600 first cadaveric renal transplants that were functional on the first t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199705150-00013
更新日期:1997-05-15 00:00:00
abstract:BACKGROUND:The influence of donor hematopoietic cell microchimerism on organ allograft survival has been studied largely in vascularized transplant models. Here, we examine the impact of donor bone marrow (BM) cells administered intravenously together with transient systemic tacrolimus therapy on microchimerism, the su...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802270-00005
更新日期:1998-02-27 00:00:00
abstract::Three hundred thirty-two marrow graft recipients and 241 healthy marrow donors were studied by skin testing with recall and neoantigens. Two hundred thirty patients with leukemia and seventy-eight patients with aplastic anemia received allogeneic HLA-identical sibling marrow. Twenty-four patients with leukemia receive...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198402000-00006
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:The impact of community-acquired respiratory virus (CARV) infections on bronchiolitis obliterans syndrome (BOS) and outcome after lung transplantation (LTx) and diagnostic techniques were prospectively evaluated. METHODS:A single-center prospective cohort study was performed in LTx-outpatients between Octob...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a4857d
更新日期:2009-05-27 00:00:00