Establishment of an immortalized human-liver endothelial cell line with SV40T and hTERT.

abstract：:Athymic PVG-rnu/rnu (RT1c) rats were grafted with skin bearing isolated MHC disparities 7-14 days in advance of cell transfer. The ability of naive CD4+ or CD8+ thoracic duct lymphocytes to induce rejection was assessed by adoptive transfer of one or both T cell subsets into nude recipients bearing congenic PVG.r1 (MH...

journal_title：Transplantation

authors： Bell EB,Rejali D,Whitby EH,Sparshott SM,Yang CP

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Perioperative renal dysfunction in liver transplant recipients complicates maintenance immunosuppressive therapy, particularly in patients with hepatitis C. Calcineurin inhibitors exacerbate renal dysfunction and mammalian target-of-rapamycin inhibitors are generally avoided because of perceived perioperativ...

journal_title：Transplantation

authors： LaMattina JC,Jason MP,Hanish SI,Ottmann SE,Klassen DK,Potosky D,Hutson WR,Barth RN

更新日期：2014-01-27 00:00:00

abstract：BACKGROUND:A quantitative model of immunosuppression was previously developed based on the rejection of the allogeneic A/J murine tumor sarcoma 1 (Sa1) in immunocompetent mice. Here, the model is used to evaluate the immunologic mechanisms of graft rejection and to determine the potential of this model to detect synerg...

journal_title：Transplantation

authors： Hammond-McKibben D,Saulnier M,Zhang J,Risher N,Lake P,Weetall M

更新日期：2005-04-27 00:00:00

abstract：BACKGROUND:Recurrent hepatitis C virus (HCV) after liver transplantation (OLT) is a major cause of graft loss in HCV-positive patients. In this study, we evaluated the efficacy and safety of pegylated interferon alfa-2b (peginterferon) and ribavirin treatment for recurrent HCV after OLT and analyzed the influence of an...

journal_title：Transplantation

authors： Neumann U,Puhl G,Bahra M,Berg T,Langrehr JM,Neuhaus R,Neuhaus P

更新日期：2006-07-15 00:00:00

abstract：:To determine the importance of static lung inflation during storage, graft performance was evaluated at different levels of intratracheal pressure and varying ischemic intervals. Lewis rat lungs were perfused with low-potassium Euro-Collins and stored for 4 or 8 hr either in atelectasis (4 hr: group I; 8 hr: group IV,...

journal_title：Transplantation

authors： Hausen B,Ramsamooj R,Hewitt CW,Schroder F,Beuke M,Poets CF,Schafers HJ

更新日期：1996-12-27 00:00:00

abstract：BACKGROUND:Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually ref...

journal_title：Transplantation

authors： Kuball J,Theobald M,Ferreira EA,Hess G,Burg J,Maccagno G,Barreiros AP,Lüth S,Schimanski CC,Schuchmann M,Schwarting A,Neurath M,Otto G,Galle PR,Lohse AW

更新日期：2004-12-27 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) is a strong predictor of cardiovascular disease, all-cause mortality, and renal allograft loss. Little is known about the effects of immunosuppressive and cardiovascular risk-modifying drugs on CRP in renal transplant recipients. METHODS:We retrospectively identified stable patients...

journal_title：Transplantation

authors： Wong BM,Huang M,Zaltzman JS,Prasad GV

更新日期：2007-01-15 00:00:00

abstract：:We report on the to date largest recovery of 11 organs from a single deceased donor with the transplantation of face, bilateral upper extremities, heart, 1 lung, liver (split for 2 recipients), kidneys, pancreas, and intestine. Although logistically challenging, this case demonstrates the feasibility and safety of the...

journal_title：Transplantation

authors： Tullius SG,Pomahac B,Kim HB,Carty MJ,Talbot SG,Nelson HM,Delmonico FL

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Cardiac allograft vasculopathy (CAV) has an incidence of 43% at 8 years after heart transplantation with extremely limited treatment options and unclear pathogenesis. CAV constitutes a significant complication that limits the long-term survival of heart recipients. Insulin-like growth factor-1 (IGF-1) is ass...

journal_title：Transplantation

authors： Aharinejad S,Salama M,Rödler S,Ehrlich M,Zuckermann A,Laufer G

更新日期：2012-02-15 00:00:00

abstract：:Donor-specific transfusion was performed with and without cyclosporine between haplomismatched relatives prior to living-donor renal transplantation. Red cell antigen mismatching was not taken as a contraindication to DST. Of 80 patients included in the trial; eleven were ABO-mismatched, 15 were Rh(D)-mismatched, and ...

journal_title：Transplantation

authors： Duguid JK,Hillis AN,Bone JM

更新日期：1990-08-01 00:00:00

abstract：:After the progressive improvement in the results of organ transplantation we now face the challenge of shortage in organ supply. The decreasing number of organ retrievals performed in 1990 at our hospital has raised questions concerning loss of potential organ donors and opposition to donation by the next of kin. We i...

journal_title：Transplantation

authors： Faltin DL,Jeannet M,Suter PM

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The prevalence of renal posttransplantation amputation and its impact on allograft and patient survival have not been widely reported. METHODS:We used an incident cohort of patients who underwent renal transplantation between June 2004 and September 2009. Amputation data were obtained using Medicare institu...

journal_title：Transplantation

authors： Brar A,Jindal RM,Sumrani N,John D,Mondal Z,Tedla F,Salifu MO

更新日期：2013-05-27 00:00:00

abstract：:First cadaver, unrelated kidney graft survival at one year from 50 Eurotransplant centers was analyzed and found to show marked changes in survival rates over the 20-year period from 1967 to 1986 inclusive. Full information on HLA-A, -B, and -DR matching and use of cyclosporine therapy was only available for the perio...

journal_title：Transplantation

authors： Thorogood J,van Houwelingen JC,van Rood JJ,Persijn GG

更新日期：1988-11-01 00:00:00

abstract：:Heterologous anti-immunoglobulin (AI) is a potent immunosuppressive agent which compares favorably to anti-thymocyte serum (ATS) in inhibiting E and EAC-rosette formation and diminishing the secondary antibody response to sheep erythrocytes and E. coli lipopolysaccharide. AI prolongs H-2 incompatible skin allograft su...

journal_title：Transplantation

authors： Constantian MB,Couser WG,French PJ,Davis RC

更新日期：1976-09-01 00:00:00

abstract：:Allograft recipients who have preformed antibodies to MHC determinants or develop these antibodies post-transplantation have a higher incidence of cellular rejection and graft loss. It is unclear whether this association is an etiologic one or whether the presence of these antibodies solely identifies individuals with...

journal_title：Transplantation

authors： Hosenpud JD,Shipley GD,Morris TE,Hefeneider SH,Wagner CR

更新日期：1993-02-01 00:00:00

abstract：:Recent reports have demonstrated that humoral factors, especially antibodies elicited by xenoantigens, play an important role in the rejection of concordant cardiac xenografts. These induced antibodies, however, have not been well characterized. Therefore, we investigated the rejection mechanism, especially the role o...

journal_title：Transplantation

authors： Matsumiya G,Shirakura R,Miyagawa S,Izutani H,Sawa Y,Nakata S,Matsuda H

更新日期：1994-06-15 00:00:00

abstract：:We studied major histocompatibility complex (MHC) and cytokine mRNA induction after renal injury in the absence of interferon-gamma (IFN-gamma) using IFN-gamma gene knockout (GKO) mice. The left renal pedicle of normal (wild-type) and GKO BALB/c mice was clamped for 60 minutes; cytokine and MHC mRNA expression were mo...

journal_title：Transplantation

authors： Goes N,Urmson J,Vincent D,Halloran PF

更新日期：1995-12-27 00:00:00

abstract：BACKGROUND:There is a lack of information about survival after dropout from the liver transplant waiting list. Therefore, we aimed to assess the overall survival, and risk factors for death, after waiting list dropout due to hepatocellular carcinoma (HCC) progression. METHODS:We assessed patients who dropped out of th...

journal_title：Transplantation

authors： Gorgen A,Rosales R,Sadler E,Beecroft R,Knox J,Dawson LA,Ghanekar A,Grant D,Greig PD,Sapisochin G

更新日期：2019-10-01 00:00:00

abstract：:The beneficial effect of deoxyspergualin (DSG, NKT-01) on lethal graft-versus-host disease in mice has been studied in a major histoincompatible donor-recipient combination. Suppression of the effector mechanisms responsible for the lethal outcome in this GVHD model is also noted. This study reveals: (1) DSG has a mar...

journal_title：Transplantation

authors： Nemoto K,Hayashi M,Ito J,Sugawara Y,Mae T,Fujii H,Abe F,Fujii A,Takeuchi T

更新日期：1991-03-01 00:00:00

abstract：:Cultured neonatal rat islets were transplanted across six strain combinations into nonimmunosuppressed allogeneic recipients. Islets were isolated nonenzymatically by an in vitro method and were cultured at 37 degrees C in 5% CO2 in air for 10 days prior to transplant. Transplants to nondiabetic recipients across four...

journal_title：Transplantation

authors： Serie JR,Hegre OD,Eide CR,Weinhaus AJ,Marshall S

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) antibodies, especially those that fix complement, are associated with antibody-mediated rejection and graft failure. The C1q assay on single antigen beads detects a subset of HLA antibodies that can fix complement and precede C4d deposition. The aim of this study was to determin...

journal_title：Transplantation

authors： Yabu JM,Higgins JP,Chen G,Sequeira F,Busque S,Tyan DB

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:Posttransplant lymphoproliferative disease (PTLD) is a major complication after bone marrow and solid organ transplantation. The disease encompasses a spectrum of abnormal, Epstein-Barr virus (EBV)-associated B-cell proliferations. We have previously shown that EBV-infected, spontaneous lymphoblastoid cell l...

journal_title：Transplantation

authors： Nepomuceno RR,Snow AL,Robert Beatty P,Krams SM,Martinez OM

更新日期：2002-08-15 00:00:00

abstract：:Two anti-H-2Ld sera were analyzed, BALB/c-H-2dm2 anti-BALB/cBy and (C3H X BALB/c-H-2dm2)F1 anti-BALB/cHe, the latter also containing anti-Qa antibodies. Their reaction patterns were compared with an anti-Qa serum (C3H X BALB/cBy)F1 anti-BALB/cHe. Four H-2 specificities could be detected by the anti-H-2Ld sera, two alr...

journal_title：Transplantation

authors： Oudshoorn-Snoek M,Iványi D,Démant P

更新日期：1981-08-01 00:00:00

abstract：:A cluster of five cases of Legionnaires' disease in renal transplant patients is described. They were treated with erythromycin and rifampicin, and all five survived. Two of them had rejected their grafts prior to their Legionella pneumonia; two rejected their transplants after reduction of immunosuppressive therapy t...

journal_title：Transplantation

authors： Wilczek H,Kallings I,Nyström B,Hoffner S

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Plasma level of plasminogen activator inhibitor (PAI)-1 is genetically determined by a polymorphism in the promoter region, involving two alleles, 4G and 5G. Plasma PAI-1 concentrations are higher in subjects homozygous for the 4G allele than other genotypes (5G/5G and 4G/5G). Such genetic variation in fibri...

journal_title：Transplantation

authors： Chow KM,Szeto CC,Szeto CY,Poon P,Lai FM,Li PK

更新日期：2002-12-27 00:00:00

abstract：:Despite previous attempts there is currently no suitable animal model available for xenogeneic graft versus host disease (XGVHD) mediated via human immunocompetent cells. Recently, we have developed an efficient protocol to engraft SCID mice with human peripheral blood lymphocytes (Hu-PBLs). The engraftment efficiency...

journal_title：Transplantation

authors： Sandhu JS,Gorczynski R,Shpitz B,Gallinger S,Nguyen HP,Hozumi N

更新日期：1995-07-27 00:00:00

abstract：:Glucocorticoids (GC) inhibit IL-2 gene transcription by interfering with the binding of the nuclear factor activator protein-1 on the IL-2 promoter. Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is an essential component of the T cell antigen receptor signal transduction pathway leading to IL-2 gene tr...

journal_title：Transplantation

authors： Paliogianni F,Boumpas DT

更新日期：1995-05-15 00:00:00

abstract：:Progressive microvascular endothelial damage is a characteristic feature of fulminant acute cardiac allograft rejection in the rat. Serial ultrastructural tracer studies using i.v. administered colloidal carbon and horseradish peroxidase have been performed in an adoptive transfer model to determine the role of cellul...

journal_title：Transplantation

authors： Lowry RP,Forbes RD

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:Rising numbers of patients reaching end-stage kidney disease intensify the demand for expansion of the living-kidney-donor pool. On the basis of low risk in white donors with essential hypertension, our transplant center undertook a structured program of accepting hypertensive donors if kidney function and u...

journal_title：Transplantation

authors： Textor SC,Taler SJ,Driscoll N,Larson TS,Gloor J,Griffin M,Cosio F,Schwab T,Prieto M,Nyberg S,Ishitani M,Stegall M

更新日期：2004-07-27 00:00:00

abstract：:Mus caroli blastocysts transferred to pseudopregnant Mus musculus implant but die about midgestation. Death of the M caroli embryos is associated with infiltration of the fetoplacental units by M musculus lymphocytes, including functional cytotoxic T lymphocytes (CTL). To determine if specific maternal antifetal immun...

journal_title：Transplantation

authors： Crepeau MA,Croy BA

更新日期：1988-06-01 00:00:00