Acute renal injury in the interferon-gamma gene knockout mouse: effect on cytokine gene expression.

abstract：:A 22-year-old previously nonsensitized female patient (HLA-A2,28; B7,14; DR1,2) received a kidney from her HLA-identical brother. She irreversibly rejected the graft 2 1/2 weeks later. In vitro tests performed 6 weeks after the graft loss, using recipient responding and donor-stimulating and target cells, revealed a w...

journal_title：Transplantation

authors： Pfeffer PF,Thorsby E

更新日期：1982-01-01 00:00:00

abstract：:Suppressor cell activity in the spleen of 4-5-day-old mice is high and can be assayed in mixed lymphocyte cultures. The suppressor cells inhibit the proliferation of adult mouse spleen cells responding in vitro to an allogeneic stimulus. This suppressor cell activity can be increased by injecting the mice, on the day ...

journal_title：Transplantation

authors： Argyris BF

更新日期：1984-09-01 00:00:00

abstract：:To investigate whether graft-versus-host reactivity (GVHR) and the graft-versus-leukemia (GVL) effect can be differentiated, C3H-->AKR mixed bone marrow (BM) chimeras were prepared using two different conditioning regimens. Total body irradiation (TBI) chimeras were induced by infusing 5 x 1O(6) T cell depleted syngen...

journal_title：Transplantation

authors： Salam A,Waer M

更新日期：1996-03-15 00:00:00

abstract：BACKGROUND:Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised. METHODS:Forty-three hepatitis B virus car...

journal_title：Transplantation

authors： Chen PM,Chiou TJ,Fan FS,Liu JM,Hsieh RK,Yen CC,Wang WS,Liu JH

更新日期：1999-06-15 00:00:00

abstract：:Cultured neonatal rat islets were transplanted across six strain combinations into nonimmunosuppressed allogeneic recipients. Islets were isolated nonenzymatically by an in vitro method and were cultured at 37 degrees C in 5% CO2 in air for 10 days prior to transplant. Transplants to nondiabetic recipients across four...

journal_title：Transplantation

authors： Serie JR,Hegre OD,Eide CR,Weinhaus AJ,Marshall S

更新日期：1987-12-01 00:00:00

abstract：:Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that c...

journal_title：Transplantation

authors： Hebert MF,Zheng S,Hays K,Shen DD,Davis CL,Umans JG,Miodovnik M,Thummel KE,Easterling TR

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:The role of anti-human leukocyte antigen (HLA) donor-specific antibodies (DSA) detected by Luminex in the development of rejection is not fully understood. METHODS:A study including 369 patients who received transplants from deceased donors with a negative complement-dependent cytotoxicity crossmatch (XM) w...

journal_title：Transplantation

authors： Caro-Oleas JL,González-Escribano MF,Gentil-Govantes MÁ,Acevedo MJ,González-Roncero FM,Blanco GB,Núñez-Roldán A

更新日期：2012-08-27 00:00:00

abstract：:Mouse thyroid tissue was dissociated with collagenase, fixed in periodate-lysine-paraformaldehyde (PLP), and further dissociated with EDTA and trypsin to yield cell suspensions containing mainly follicle epithelial cells and vascular endothelial cells. H-2 complex antigens were detected on the vascular endothelial cel...

journal_title：Transplantation

authors： Parr EL,Lafferty KJ,Bowen KM,McKenzie IF

更新日期：1980-08-01 00:00:00

abstract：:The new class of immunosuppressants--inhibitors of the mammalian target of rapamycin--has no nephrotoxicity and the capacity to inhibit vascular smooth cell proliferation. These characteristics may afford considerable clinical advantages in the transplantation of kidneys from expanded criteria donors (ECD). Six clinic...

journal_title：Transplantation

authors： Rigotti P,Kahan BD

更新日期：2009-04-27 00:00:00

abstract：BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...

journal_title：Transplantation

authors： Smith JD,Hamour IM,Burke MM,Mahesh B,Stanford RE,Haj-Yahia S,Robinson DR,Kaul P,Yacoub MH,Banner NR,Rose ML

更新日期：2009-03-27 00:00:00

abstract：BACKGROUND:Alpha-glutathione-S-transferase (alphaGST) has been suggested as a sensitive marker of acute cellular rejection in liver transplantation. This study evaluated the usefulness of alphaGST as a marker of acute rejection in comparison with standard liver function tests. METHODS:Daily measurements of liver funct...

journal_title：Transplantation

authors： Nagral A,Butler P,Sabin CA,Rolles K,Burroughs AK

更新日期：1998-02-15 00:00:00

abstract：BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...

journal_title：Transplantation

authors： Aharinejad S,Andrukhova O,Gmeiner M,Thomas A,Krenn K,Zuckermann A,Grimm M

更新日期：2010-01-27 00:00:00

abstract：:Pre-existing alloantibodies against the mismatched HLA-A and HLA-B antigens of the donor, when present in current sera, are believed to be detrimental to kidney graft survival. When these antibodies are present only in historical sera, their immunoglobulin class has reported to be important with respect to the expecte...

journal_title：Transplantation

authors： Roelen DL,van Bree J,Witvliet MD,Habraken I,van Beelen E,van't Sant PH,de Waal LP,van Rood JJ,Claas FH

更新日期：1994-05-15 00:00:00

abstract：:One major limitation in pancreatic islet transplantation is availability of donor tissue. Donor shortage is exacerbated by islet apoptosis from the stresses of islet isolation and transplantation. Furthermore, the side effects of immunosuppressive drugs preclude transplants into patients whose diabetes is controlled b...

journal_title：Transplantation

authors： Sutherland RM,Allison J,Thomas HE,Brady JL,Kay TW,Lew AM

更新日期：2004-05-27 00:00:00

abstract：BACKGROUND:Hyperacute rejection (HAR) of pig-to-primate discordant xenografts is caused by the deposition of preexisting natural antibodies that recognize Galalpha1-3Gal (alphaGal)-terminating oligosaccharides on glycoproteins and glycolipids, followed by complement-mediated lysis of the graft's endothelium. In vitro, ...

journal_title：Transplantation

authors： Simon PM,Neethling FA,Taniguchi S,Goode PL,Zopf D,Hancock WW,Cooper DK

更新日期：1998-02-15 00:00:00

abstract：:Platelet activating factor (PAF, 1-alkyl-2(R)-acetyl-glycero-3- phosphorylcholine) is a phospholipid that is released by a variety of cells. The similarity between the pathophysiological effects of PAF and posttransplant pulmonary dysfunction led to an evaluation of a PAF antagonist as an adjunct to lung preservation....

journal_title：Transplantation

authors： Conte JV Jr,Katz NM,Wallace RB,Foegh ML

更新日期：1991-06-01 00:00:00

abstract：:Histoincompatible-complete radiation chimeras, after resolving acute graft-versus-host disease (GVHD), establish specific tolerance to host and donor alloantigens. This tolerance can be perturbed with immunosuppressive agents and infusions of small numbers of donor-type cells, with infusions of massive numbers of dono...

journal_title：Transplantation

authors： Tutschka PJ,Hess AD,Beschorner WE,Santos GW

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:The relationship between institutional case volume and clinical outcomes after living donor liver transplantation is not clarified. METHODS:We conducted a nationwide retrospective cohort study using the database of Korean National Healthcare Insurance Service. Between January 2007 and December 2016, 7073 ad...

journal_title：Transplantation

authors： Yoo S,Jang EJ,Yi NJ,Kim GH,Kim DH,Lee H,Jung CW,Ryu HG

更新日期：2019-05-01 00:00:00

abstract：:Clearance studies were performed in 32 transplanted children treated with CsA in combination with low-dose prednisolone (CsA group), and the results were compared with those of 29 children transplanted earlier and treated with azathioprine and prednisolone (CIS group). Serum creatinine and urea levels 6 weeks and 1 ye...

journal_title：Transplantation

authors： Hoyer PF,Krohn HP,Offner G,Byrd DJ,Brodehl J,Wonigeit K,Pichlmayr R

更新日期：1987-04-01 00:00:00

abstract：INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...

journal_title：Transplantation

authors： Andreev VP,Tryphonopoulos P,Blomberg BB,Tsinoremas N,Weppler D,Neuman DR,Volsky A,Nishida S,Tekin A,Selvaggi G,Levi DM,Tzakis AG,Ruiz P

更新日期：2011-12-27 00:00:00

abstract：:The major role of anti-alphaGal antibodies in the hyperacute rejection of pig organs by humans and baboons has been clearly demonstrated. Spacered alpha-galactose disaccharide (Gal(alpha1)-3Gal) hapten was produced by chemical synthesis and covalently attached to a flexible, hydrophilic polymer (PAA), which in turn wa...

journal_title：Transplantation

authors： Taniguchi S,Neethling FA,Korchagina EY,Bovin N,Ye Y,Kobayashi T,Niekrasz M,Li S,Koren E,Oriol R,Cooper DK

更新日期：1996-11-27 00:00:00

abstract：:A cluster of five cases of Legionnaires' disease in renal transplant patients is described. They were treated with erythromycin and rifampicin, and all five survived. Two of them had rejected their grafts prior to their Legionella pneumonia; two rejected their transplants after reduction of immunosuppressive therapy t...

journal_title：Transplantation

authors： Wilczek H,Kallings I,Nyström B,Hoffner S

更新日期：1987-06-01 00:00:00

abstract：:We investigated whether right lobe (RL) liver donation is associated with a higher incidence or severity of donor complications than left lobe (LL) liver and left lateral segment (LLS) liver donations. We studied 80 living donors: 35 RL liver donors and 45 LL/LLS liver donors. A modification of the Clavien classificat...

journal_title：Transplantation

authors： Salvalaggio PR,Baker TB,Koffron AJ,Fryer JP,Clark L,Superina RA,Blei AT,Abecassis MM

更新日期：2004-06-15 00:00:00

abstract：BACKGROUND:Whether cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. METHODS:We prospectively assessed CMV-specific CMI predicting late-...

journal_title：Transplantation

authors： Jarque M,Melilli E,Crespo E,Manonelles A,Montero N,Torras J,Cruzado JM,Luque S,Gil-Vernet S,Grinyó JM,Bestard O

更新日期：2018-11-01 00:00:00

abstract：:Reports of early success with cryopreserved saphenous veins (CSV) as arterial conduits led us to develop cryopreserved iliac veins (CIV) as interposition grafts for portal vein reconstruction in living-related liver transplantation (LRLT). Despite encouraging short-term results, retrospective analysis of long-term cry...

journal_title：Transplantation

authors： Kuang AA,Renz JF,Ferrell LD,Ring EJ,Rosenthal P,Lim RC,Roberts JP,Ascher NL,Emond JC

更新日期：1996-09-27 00:00:00

abstract：BACKGROUND:Cyclosporine A (CsA)-associated oxidative stress has been proposed as an important mechanism of renal injury. This study was designed to examine whether N-acetylcysteine (NAC), a well-known antioxidant, affects Klotho, antiaging gene, expression and its signaling pathway in an experimental model of chronic C...

journal_title：Transplantation

authors： Piao SG,Kang SH,Lim SW,Chung BH,Doh KC,Heo SB,Jin L,Li C,Yang CW

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:The role of changes in peri-operative blood lactate levels in recipients of living-related liver transplants has not yet been clarified. METHODS:Forty-three recipients were included in this study. Blood lactate, plasma total bilirubin, aminotransferase, body temperature, and gastric mucosal PCO2 levels were...

journal_title：Transplantation

authors： Orii R,Sugawara Y,Hayashida M,Yamada Y,Kubota K,Takayama T,Harihara Y,Makuuchi M,Hanaoka K

更新日期：2000-05-27 00:00:00

abstract：BACKGROUND:A previous donor intervention trial found that induction of mild therapeutic hypothermia in the brain-dead donor reduced the dialysis requirement after kidney transplantation. Consequences on the performance of cardiac allografts after transplantation were not explored to date. METHODS:Cohort study investig...

journal_title：Transplantation

authors： Schnuelle P,Benck U,Krämer BK,Yard BA,Zuckermann A,Wagner F,Szabo G,Borggrefe M,Karck M,Gummert J

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:A precise understanding of immunological mechanisms is needed to prevent transplant vasculopathy. METHODS:The developing process of transplant vasculopathy was investigated by retransplanting rat cardiac allografts and measuring the expressions of 21 different genes inside the retransplanted allografts unde...

journal_title：Transplantation

authors： Tori M,Kitagawa-Sakakida S,Li Z,Izutani H,Horiguchi K,Ito T,Matsuda H,Shirakura R

更新日期：2000-09-15 00:00:00

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) can be used to maintain oxygen delivery and provide hemodynamic support in case of circulatory and/or respiratory failure. Although the role of ECMO has emerged in the setting of adult liver transplantation (LT), data in children are limited. We aimed to describe th...

journal_title：Transplantation

authors： Ziogas IA,Johnson WR,Matsuoka LK,Rauf MA,Thurm C,Hall M,Bacchetta M,Godown J,Alexopoulos SP

更新日期：2020-08-13 00:00:00