Peri-operative blood lactate levels in recipients of living-related liver transplantation.

abstract：BACKGROUND:Because CD4CD25Foxp3 regulatory T cells (Tregs) are essential for the maintenance of self-tolerance, significant interest surrounds the developmental cues for thymic-derived natural Tregs (nTregs) and periphery-generated adaptive Tregs (aTregs). In the transplant setting, the allograft may play a role in the...

journal_title：Transplantation

authors： Kim JI,O'connor MR,Duff PE,Zhao G,Lee KM,Eliades P,Deng S,Yeh H,Caton AJ,Markmann JF

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND:Most transplant centers in the United States, including our own, use creatinine clearance (Ccr) to estimate glomerular filtration rate (GFR) in potential living kidney donors. The purpose of this study was to evaluate our experience with estimation of donor GFR by Ccr and to explore other potential strategie...

journal_title：Transplantation

authors： Bertolatus JA,Goddard L

更新日期：2001-01-27 00:00:00

abstract：BACKGROUND:Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagula...

journal_title：Transplantation

authors： Bongoni AK,Kiermeir D,Schnider J,Jenni H,Garimella P,Bähr A,Klymiuk N,Wolf E,Ayares D,Voegelin E,Constantinescu MA,Seebach JD,Rieben R

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplants to how to conduct them ethically. METHODS:Leaders of each program performing and/or evaluating VCA ...

journal_title：Transplantation

authors： Caplan AL,Parent B,Kahn J,Dean W,Kimberly LL,Lee WPA,Rodriguez ED

更新日期：2019-06-01 00:00:00

abstract：:A murine IgG1 antibody specific for the IL-2-binding site on the human lymphocyte IL-2 receptor beta chain (CD25) was evaluated in 11 patients who developed acute graft-versus-host disease following allogeneic marrow transplantation. All patients had received cyclosporine and methotrexate for prophylaxis of GVHD, eith...

journal_title：Transplantation

authors： Anasetti C,Martin PJ,Hansen JA,Appelbaum FR,Beatty PG,Doney K,Harkonen S,Jackson A,Reichert T,Stewart P

更新日期：1990-07-01 00:00:00

abstract：:Renal transplantation is the preferred treatment for end-stage renal disease in children. Most transplant failures are due to allograft rejection. To date, only histopathological findings on renal biopsy can establish this diagnosis. Prior to the availability of cyclosporine, technetium-99m sulfur colloid nuclear scan...

journal_title：Transplantation

authors： Massengill SF,Pena DR,Drane WE,Fennell RS,Richard GA

更新日期：1992-12-01 00:00:00

abstract：:A role for cytomegalovirus (CMV) infection in the etiologies of acute and chronic rejection in renal allograft recipients has been suggested. We previously reported that preemptive treatment of CMV infection with ganciclovir in kidney transplant patients was safe and effective. We now present a retrospective analysis ...

journal_title：Transplantation

authors： Akposso K,Rondeau E,Haymann JP,Peraldi MN,Marlin C,Sraer JD

更新日期：1997-04-15 00:00:00

abstract：:FK-506 is known to suppress the transcription of several genes encoding cytokines (e.g., IL-2, IFN-gamma) thought to play an important role in the allograft response. This general inhibition of cytokine gene transcription and protein production was previously thought to be the main mechanism by which FK-506 suppressed...

journal_title：Transplantation

authors： Wang SC,Morel PA,Wang Q,Jordan ML,Simmons RL,Tweardy DJ

更新日期：1993-10-01 00:00:00

abstract：:Research in hepatocellular gene therapy requires a consistently reproducible cell marker to detect transplanted hepatocytes. We have used a Y-specific genomic DNA probe to accomplish this goal. This technique enables the identification of transplanted male cells in recipient female tissues. Donor hepatocytes from male...

journal_title：Transplantation

authors： Eckert JW,Buerkle CJ,Major AM,Finegold MJ,Brandt ML

更新日期：1995-01-15 00:00:00

abstract：:The beneficial effect of deoxyspergualin (DSG, NKT-01) on lethal graft-versus-host disease in mice has been studied in a major histoincompatible donor-recipient combination. Suppression of the effector mechanisms responsible for the lethal outcome in this GVHD model is also noted. This study reveals: (1) DSG has a mar...

journal_title：Transplantation

authors： Nemoto K,Hayashi M,Ito J,Sugawara Y,Mae T,Fujii H,Abe F,Fujii A,Takeuchi T

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Preconditioning protects against both liver and lung damage after hepatic ischemia-reperfusion (I/R). Xanthine and xanthine oxidase (XOD) may contribute to the development of hepatic I/R. OBJECTIVE:To evaluate whether preconditioning could modulate the injurious effects of xanthine/XOD on the liver and lung...

journal_title：Transplantation

authors： Peralta C,Bulbena O,Xaus C,Prats N,Cutrin JC,Poli G,Gelpi E,Roselló-Catafau J

更新日期：2002-04-27 00:00:00

abstract：:Hepatocyte transplantation is an investigational alternative to orthotopic liver transplantation to treat liver based inborn errors of metabolism. We report successful hepatocyte transplantation in a 4-year-old girl with infantile Refsum disease. Hepatocytes were isolated from the left liver segment of two male donors...

journal_title：Transplantation

authors： Sokal EM,Smets F,Bourgois A,Van Maldergem L,Buts JP,Reding R,Bernard Otte J,Evrard V,Latinne D,Vincent MF,Moser A,Soriano HE

更新日期：2003-08-27 00:00:00

abstract：BACKGROUND:The hepatic arteries (HAs) in a hepatic graft are usually reconstructed using the recipient's left or right HAs in living donor liver transplantation (LDLT). There have been no apparent selection criteria concerning which of the recipient's HAs should be used. This study retrospectively investigated whether ...

journal_title：Transplantation

authors： Uchiyama H,Ikegami T,Soejima Y,Ninomiya M,Kayashima H,Taketomi A,Shirabe K,Maehara Y

更新日期：2010-04-27 00:00:00

abstract：BACKGROUND:Chronic renal allograft failure remains a major challenge to overcome. Factors such as donor quality, delayed graft function (DGF), acute rejection, and immunosuppression are known to affect long-term outcome, but their relationship to histological damage to graft outcome is unclear. METHODS:Protocol kidney...

journal_title：Transplantation

authors： Nankivell BJ,Fenton-Lee CA,Kuypers DR,Cheung E,Allen RD,O'Connell PJ,Chapman JR

更新日期：2001-02-27 00:00:00

abstract：BACKGROUND:The use of anti-B-cell and T-cell immunosuppressive agents leads to only a few weeks' survival of mouse-to-rat cardiac xenografts. METHODS:BALB/c cardiac xenografts were transplanted to Lewis rats treated with cyclosporine (CsA) and/or cobra venom factor (CVF). RESULTS:CsA alone did not prolong xenograft s...

journal_title：Transplantation

authors： Koyamada N,Miyatake T,Candinas D,Mark W,Hechenleitner P,Hancock WW,Soares MP,Bach FH

更新日期：1998-05-15 00:00:00

abstract：:The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA...

journal_title：Transplantation

authors： Rose ML,West LJ

更新日期：2012-02-15 00:00:00

abstract：:Acute antibody-mediated rejection (AAR) of mouse skin allografts was studied in nine donor-recipient combinations with increasing histoincompatibility ranging from an H-Y to a complete H-2 plus on-H-2 disparity. AAR was induced by the injection of specific alloantiserum along with a heterologous complement on day 7 af...

journal_title：Transplantation

authors： Berden JH,Gerlag PG,Hagemann JF,Koene RA

更新日期：1977-09-01 00:00:00

abstract：:Solid organ and allogeneic hematopoietic cell transplantation have become standard therapeutic interventions that save patient lives and improve quality of life. Our enhanced understanding of transplantation immunobiology has refined clinical management and improved outcomes. However, organ rejection and graft-versus-...

journal_title：Transplantation

authors： Radojcic V,Maillard I

更新日期：2016-12-01 00:00:00

abstract：:Subsets of T cells have been identified by the expression of different isoforms of CD45. Some T cells expressing CD45RA (gp220) have been characterized as "naive" in their response to antigens including alloantigens, whereas T cells expressing CD45RO (gp180) have been characterized as "memory" T cells. To examine the ...

journal_title：Transplantation

authors： Ibrahim S,Dawson DV,Sanfilippo F

更新日期：1995-03-15 00:00:00

abstract：BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...

journal_title：Transplantation

authors： Smith JD,Hamour IM,Burke MM,Mahesh B,Stanford RE,Haj-Yahia S,Robinson DR,Kaul P,Yacoub MH,Banner NR,Rose ML

更新日期：2009-03-27 00:00:00

abstract：:In order to better understand the mechanisms of alloimmunization occurring in transplantation, we studied the immune response of an inbred rat strain (WF) to varied presentation of alloantigens (LEW). Hyperimmunized rats acutely reject transplanted allografts and demonstrate direct cytotoxic activity, as well as an ex...

journal_title：Transplantation

authors： Weir MR,Salomon DR,Cohen DJ,Carpenter CB

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Better preservation strategies for the storage of donation after circulatory death grafts are essential to improve graft function and to increase the kidney donor pool. We compared continuous normothermic ex vivo kidney perfusion (NEVKP) with hypothermic anoxic machine perfusion (HAMP) and static cold storag...

journal_title：Transplantation

authors： Urbanellis P,Hamar M,Kaths JM,Kollmann D,Linares I,Mazilescu L,Ganesh S,Wiebe A,Yip PM,John R,Konvalinka A,Mucsi I,Ghanekar A,Bagli DJ,Robinson LA,Selzner M

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Since 1995, dual-kidney transplantation using organs from marginal donors has been used at our center to expand the organ donor pool and decrease the waiting time for deceased donor kidney transplantation. This approach has allowed for a shorter waiting period without compromising outcome in the early posttr...

journal_title：Transplantation

authors： Tan JC,Alfrey EJ,Dafoe DC,Millan MT,Scandling JD

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Treatment with a donor-specific transfusion (DST) and a brief course of anti-mouse CD154 (anti-CD40-ligand) monoclonal antibody (mAb) prolongs the survival of both allografts and rat xenografts in mice. The mechanism by which allograft survival is prolonged is incompletely understood, but depends in part on ...

journal_title：Transplantation

authors： Gordon EJ,Woda BA,Shultz LD,Rossini AA,Greiner DL,Mordes JP

更新日期：2001-01-27 00:00:00

abstract：:The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...

journal_title：Transplantation

authors： Thomas S,Clark SC,Rappeport JM,Nathan DG,Emerson SG

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA). METHODS:Peripheral blood mononuclear cells from SLA identical wild type (WT), α1, 3-galactos...

journal_title：Transplantation

authors： Martens GR,Reyes LM,Li P,Butler JR,Ladowski JM,Estrada JL,Sidner RA,Eckhoff DE,Tector M,Tector AJ

更新日期：2017-04-01 00:00:00

abstract：:Created by the US National Organ Transplant Act in 1984, the Scientific Registry of Transplant Recipients (SRTR) is obligated to publicly report data on transplant program and organ procurement organization performance in the United States. These reports include risk-adjusted assessments of graft and patient survival,...

journal_title：Transplantation

authors： Snyder JJ,Salkowski N,Kim SJ,Zaun D,Xiong H,Israni AK,Kasiske BL

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor. Currently, liver transplantation may be the optimal treatment for HCC in cirrhotic patients. Patient selection is currently based on tumor size. We developed a program to offer liver transplantation to selected patients with HCC...

journal_title：Transplantation

authors： Victor DW 3rd,Monsour HP Jr,Boktour M,Lunsford K,Balogh J,Graviss EA,Nguyen DT,McFadden R,Divatia MK,Heyne K,Ankoma-Sey V,Egwim C,Galati J,Duchini A,Saharia A,Mobley C,Gaber AO,Ghobrial RM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Transplant vasculopathy in kidney and heart allografts is associated with marked elevation of endothelin-1 (ET-1), but a role for ET-1 in the pathogenesis of transplant vasculopathy and chronic rejection has not been established. We, therefore, tested whether inhibition of ET-1-converting enzyme by phosphora...

journal_title：Transplantation

authors： Simonson MS,Herman WH,Robinson A,Schulak J,Hricik DE

更新日期：1999-06-27 00:00:00

abstract：BACKGROUND:Patients at greatest risk of posttransplant lymphoproliferative disorder (PTLD) are those who acquire primary Epstein-Barr virus (EBV) infection after solid organ transplantation. The incidence of PTLD among patients who are EBV-seropositive before transplant is lower, and little is known about the differenc...

journal_title：Transplantation

authors： L'Huillier AG,Dipchand AI,Ng VL,Hebert D,Avitzur Y,Solomon M,Ngan BY,Yeung S,Stephens D,Punnett AS,Barton M,Allen UD

更新日期：2019-11-01 00:00:00