Abstract:
:Platelet activating factor (PAF, 1-alkyl-2(R)-acetyl-glycero-3- phosphorylcholine) is a phospholipid that is released by a variety of cells. The similarity between the pathophysiological effects of PAF and posttransplant pulmonary dysfunction led to an evaluation of a PAF antagonist as an adjunct to lung preservation. The ginkgolide B, BN 52021, was selected as the PAF antagonist to be studied because of the large data base available on this compound. BN 52021 was given to the donor and recipient (10 mg/kg i.v.) prior to harvest and transplantation and was included in 1 L of preservation solution (10 mg/kg) used for flushing the pulmonary artery and for storage. Left single-lung transplantation was performed following a 22-hr preservation period at 10 degrees C. Arterial oxygen tension (pO2), pulmonary vascular resistance (PVR), alveolar arterial oxygen difference (A-aDO2), and dynamic lung compliance (DLC) were recorded for 6 hours following ligation of the native pulmonary artery. At the end of 6 hr pO2 was 243.5 +/- 61.5 vs. 71.7 +/- 10.2 mmHg (P less than 0.02) for the controls. A-aDO2 was less in the BN 52021 groups: 431.8 +/- 58.3 vs. 606.0 +/- 9.8 mmHg in the control groups (P less than 0.001), and PVR was significantly less in the BN 52021 group: 346 +/- 70.8 vs. 663 +/- 64.3 dynes/sec/cm-5 (P less than 0.035). We conclude that PAF antagonists like BN 52021 may be useful adjuncts for lung preservation. The effects of BN 52021 are easily explained by PAF antagonist activity in ischemic and reperfusion-induced pulmonary dysfunction. However this study does not exclude that BN 52021 may have direct effects.
journal_name
Transplantationjournal_title
Transplantationauthors
Conte JV Jr,Katz NM,Wallace RB,Foegh MLdoi
10.1097/00007890-199106000-00002subject
Has Abstractpub_date
1991-06-01 00:00:00pages
1152-6issue
6eissn
0041-1337issn
1534-6080journal_volume
51pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::The interactions of steroid hormones and human peripheral blood lymphocytes (PBLs) have been investigated following glass-wool column separation of PBLs and incubation in a serum-free medium in the presence of phytohemagglutinin (PHA). Addition of hydrocortisone or progesterone above physiological concentrations resul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197905000-00004
更新日期:1979-05-01 00:00:00
abstract::We describe a patient transfused with 200 ml of donor fresh whole blood three times at 2-week intervals. Three weeks after the last transfusion, transplantation and splenectomy were done at the same time. Splenic cells from this DST pretreated patient were fused with murine myeloma cells (X63-Ag8, 653). With DST pretr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198909000-00022
更新日期:1989-09-01 00:00:00
abstract::Recent suggestions that the rat prostate is an alymphatic, immunologically privileged site stimulated further investigation of its status using a variety of techniques. Fixation of certain organs by vascular perfusion of glutaraldehyde followed by plastic embedding avoids the distortion and stromal reorganization that...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197902000-00011
更新日期:1979-02-01 00:00:00
abstract::Serologic evidence of resolved hepatitis B virus (HBV) infection (HBV surface antigen negative, anti-HBV core antibody [HBc] positive) in a liver donor can be regarded as an occult infection with episomal HBV in the liver. The purpose of this study was to evaluate the safety of anti-HBc-positive living donors. Between...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000047030.38665.0D
更新日期:2003-02-15 00:00:00
abstract:BACKGROUND:Many models of transplant tolerance have been found to depend on the induction of regulatory T cells (Tregs). Innate immune signals are known to suppress Tregs thereby augmenting immunity by abrogating Treg function. Such signals may also provide a barrier to transplantation tolerance mediated by Tregs. A nu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ba6f85
更新日期:2009-11-27 00:00:00
abstract::The new class of immunosuppressants--inhibitors of the mammalian target of rapamycin--has no nephrotoxicity and the capacity to inhibit vascular smooth cell proliferation. These characteristics may afford considerable clinical advantages in the transplantation of kidneys from expanded criteria donors (ECD). Six clinic...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a058a1
更新日期:2009-04-27 00:00:00
abstract::Although the cornea is considered to be an immunological privileged site, corneal transplantation can result in immunological rejection followed by graft failure, especially in patients with vascularized corneas. Several studies suggest a beneficial effect of matching for the HLA class I antigens on corneal graft surv...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199504150-00021
更新日期:1995-04-15 00:00:00
abstract:INTRODUCTION:This is a follow-up of a withdrawal study that we previously performed on 104 liver transplant patients in which immunosuppression was gradually withdrawn over a period of 3 years. Eighty-one patients were not able to be withdrawn (rejectors), and 23 patients were successfully weaned off immunosuppression ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182003db7
更新日期:2010-12-27 00:00:00
abstract:BACKGROUND:Recent data indicate that factors other than erythropoietin (EPO), such as insulin-like growth factor 1 (IGF-1), can promote erythropoiesis in vitro and correct the anemia of chronic renal failure in vivo. IGF-1 is produced by the liver under growth hormone control, as well as by other sources, including the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199709270-00021
更新日期:1997-09-27 00:00:00
abstract::The absorption of oral cyclosporine (CsA) was studied in a canine small intestinal transplantation model. Absorption of CsA was almost absent in bowel-resected dogs. Autotransplanted dogs showed a persisting malabsorption of CsA (mean peak of 687 +/- 348 ng/ml vs. 1683 +/- 154 ng/ml in control dogs). Allotransplanted ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198505000-00007
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:The clinical impact of chronic transplant glomerulopathy (CTG) on the outcome of kidney allograft receiving calcineurin inhibitors (CNIs) remains uncertain. A retrospective study of renal transplant recipients at Ospedale Maggiore of Milan was undertaken to evaluate the clinical outcome of patients with CTG....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000181167.88133.d2
更新日期:2005-11-27 00:00:00
abstract:BACKGROUND:This study evaluates whether surgical strategies such as the portosystemic shunt and ischemic preconditioning can protect against hepatic and pulmonary injury associated with liver transplantation. METHODS:The effect of the portosystemic shunt, ischemic preconditioning, and both surgical procedures together...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000067529.82245.4E
更新日期:2003-07-27 00:00:00
abstract::Endothelial chimerism in transplanted organs is a fascinating phenomenon, indicative of a mechanism by which progenitor recipient cells replace the donor endothelium. It has been hypothesized that this replacement could lead to a decrease in alloreactivity and thus would positively influence graft outcome. However, re...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000231446.41051.98
更新日期:2006-07-15 00:00:00
abstract:BACKGROUND:Rat lung allograft rejection is mediated by collagen type V (col(V)) specific T-helper-cell 17 (Th17) cells. Adoptive transfer of these cells is sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allograft rejection. Therefore, we tested whether regulatory T cells f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bcde7b
更新日期:2009-12-27 00:00:00
abstract::Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for bleeding complications after reperfusion of the liver graft. In 10 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199109000-00018
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:The effect of height and sex on liver transplantation (LT) for hepatocellular carcinoma (HCC) remains unclear. METHODS:Using United Network for Organ Sharing (UNOS) data, 14 844 HCC patients listed for LT from 2005 to 2015 were identified. Cumulative incidence of waitlist events (LT and dropout for death or...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000002975
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Bronchiolitis obliterans syndrome (BOS) is the leading cause of late mortality after lung transplantation. METHODS:We added azithromycin (AZI) (250 mg/day for 5 days, followed by 250 mg every other day) to the current immunosuppressive therapy in eight lung transplant recipients (mean age 36 years) with est...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000122412.80864.43
更新日期:2004-05-15 00:00:00
abstract:BACKGROUND:Prognostic models, which estimate survival probabilities, enable the survival benefit from a procedure to be assessed and allow the comparison of outcomes between centers. We therefore compared three models that estimate survival in the absence of transplantation for patients with alcoholic liver disease (AL...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/01.TP.0000089236.78772.57
更新日期:2003-11-27 00:00:00
abstract::Natural suppressor (NS) activity is detected in tissues undergoing intense hematopoietic regeneration. This includes the spleens of mice recovering from total lymphoid irradiation or cyclophosphamide treatment, or after induction of chronic graft-versus-host disease against minor histocompatibility antigens. NS cells ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00038
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:We have previously shown that an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts generates a tryptophan-deficient environment that selectively inhibits proliferation and induces apoptosis of bystander CD4+ and CD8+ T cells, but not pancreatic islets. Because these immune cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000661
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants of willingness to accept HCV-infected kidneys among HCV-negative patients. METHODS:At 2 centers, 189 patients undergoing initial or reev...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002099
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000101510.01404.F0
更新日期:2004-01-15 00:00:00
abstract:BACKGROUND:Accelerated arteriosclerosis limits the survival of transplanted hearts. We hypothesized that insulin-like growth factor-I (IGF-I) is crucial in accelerating transplant arteriosclerosis. Recently, we reported that exposure to IGF-I prior to transplantation accelerates transplant arteriosclerosis in the rat a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199804270-00003
更新日期:1998-04-27 00:00:00
abstract:BACKGROUND:In response to a longstanding Federal mandate to minimize the role of geography in access to transplant in the United States, we assessed whether patient travel distance was associated with lung transplant outcomes. We focused on the posttransplant time period, when the majority of patient visits to a transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003129
更新日期:2020-11-01 00:00:00
abstract::Natural anti-carbohydrate antibodies are central to hyperacute rejection in ABO-incompatible allotransplantation and in discordant xenotransplantation. ABO-incompatible rejection has been inhibited successfully using intravenous soluble carbohydrates as antibody inhibitors. The approach has been less successful previo...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-12-15 00:00:00
abstract::We have used a polymerase chain reaction-based assay measuring polymorphic (CA)n repeats, a class of simple sequence repeats, to assess the success of allogeneic canine marrow transplants. Results were compared with those obtained with karyotype analysis of dividing cells in recipients that were sex mismatched with th...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-09-27 00:00:00
abstract:BACKGROUND:To reduce the morbidity of living kidney donors we introduced ketorolac-based analgesia for patients undergoing open donor nephrectomy in August 1999. There are no prior reports on the use of ketorolac for patients undergoing donor nephrectomy. METHODS:We conducted a retrospective review of all 198 consecut...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200203150-00014
更新日期:2002-03-15 00:00:00
abstract:BACKGROUND:In previous studies of cynomolgus monkey lung allograft recipients, we demonstrated significant immunosuppressive efficacy but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin). The current study was designed to com...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002270-00005
更新日期:2000-02-27 00:00:00
abstract:BACKGROUND:Data regarding the onset of puberty in children receiving mammalian target of rapamycin (mTOR) inhibitors are limited. METHODS:Kidney transplant patients aged <14 years were analyzed retrospectively to a maximum age of 18 years, with a minimal observation period of 1 year. Immunosuppression comprised (1) st...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001037
更新日期:2016-11-01 00:00:00
abstract::Experiments were performed on the quality of renal functional recovery after 24, 48, or 72-hr hypothermic storage preservation of canine kidneys in Euro-Collins solution (EC), Collins' solution C2, hypertonic citrate solutions (HC, HC-D2O), or our new flush solution 2 (F.2). Clearance tests (inulin, paraaminohippuric ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198502000-00003
更新日期:1985-02-01 00:00:00