The clinical impact of chronic transplant glomerulopathy in cyclosporine era.

abstract：:Like FK506, rapamycin, a structural analog of FK506, is a strong immunosuppressant. The immunosuppressive effect of Rapa in in vitro IgG, IgM, and IgA production by human lymphocytes was examined in this study. To inhibit spontaneous or pokeweed mitogen-stimulated production of Ig by human peripheral blood lymphocytes...

journal_title：Transplantation

authors： Luo H,Chen H,Daloze P,Chang JY,St-Louis G,Wu J

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (HCMV) infection is associated with allograft vasculopathy and rejection. One potential mechanism is vascular injury from immunologically mediated processes. HCMV infection has been shown to increase the constitutive expression of intercellular adhesion molecule-1 (ICAM-1). The objectiv...

journal_title：Transplantation

authors： Burns LJ,Pooley JC,Walsh DJ,Vercellotti GM,Weber ML,Kovacs A

更新日期：1999-01-15 00:00:00

abstract：:Considerable variations in the suppression of graft-versus-host disease with monoclonal anti-Thy-1 antibodies were found to relate to substantial differences noted in the expression of mouse Thy-1 marker on lymph node and spleen cells of Thy-1.1 (AKR/J, C57BL/6.Thy-1.1) and Thy 1.2 (AKR/Cu, C57BL/6) mice. Thy-1.1 mice...

journal_title：Transplantation

authors： Mysliwietz J,Thierfelder S,Hoffmann-Fezer G,Kummer U

更新日期：1990-04-01 00:00:00

abstract：:This study was undertaken to examine the humoral immune response against endothelial antigens of the donor kidney in human renal allograft recipients. Sera from 61 transplant recipients who received 62 grafts were studied for the presence of circulating endothelial antibodies (CEAb) using an indirect immunofluorescenc...

journal_title：Transplantation

authors： Paul LC,van Es LA,van Rood JJ,van Leeuwen A,de la Rivière GB,de Graeff J

更新日期：1979-03-01 00:00:00

abstract：:Recent reports have demonstrated that humoral factors, especially antibodies elicited by xenoantigens, play an important role in the rejection of concordant cardiac xenografts. These induced antibodies, however, have not been well characterized. Therefore, we investigated the rejection mechanism, especially the role o...

journal_title：Transplantation

authors： Matsumiya G,Shirakura R,Miyagawa S,Izutani H,Sawa Y,Nakata S,Matsuda H

更新日期：1994-06-15 00:00:00

abstract：:Nonmajor histocompatibility complex (non-MHC) antigens are important targets of graft rejection and graft-versus-host disease in clinical transplantation. Little is known regarding immunity to non-MHC antigens. To study this problem we evaluated the effect of antihuman thymocyte globulin (ATG) on reactivity in autolog...

journal_title：Transplantation

authors： Harada M,Gale RP

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:There is a relative lack of donor organs for liver transplantation. Ideally, to maximize the utility of those livers that are offered, donor and recipient characteristics should be matched to ensure the best possible posttransplant survival of the recipient. METHODS:With prospectively collected data on 827 ...

journal_title：Transplantation

authors： Haydon GH,Hiltunen Y,Lucey MR,Collett D,Gunson B,Murphy N,Nightingale PG,Neuberger J

更新日期：2005-01-27 00:00:00

abstract：:Loss of renal mass has been associated with the development of glomerular sclerosis in animals and human beings. The pathophysiology of this renal injury is unknown, but glomerular sclerosis in animals can be aggravated or accelerated following exposure to nephrotoxic antibodies, puromycin aminoglycoside or renal irra...

journal_title：Transplantation

authors： Parfrey PS,Hollomby DJ,Gilmore NJ,Knaack J,Schur PH,Guttmann RD

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:At our transplant center, cardiac allograft recipients undergo transplantation following a negative IgG anti-human globulin (AHG) crossmatch (XM). Flow cytometry crossmatching (FCXM) is a more sensitive XM procedure than the AHG XM procedure, yet there is limited information regarding the clinical relevance ...

journal_title：Transplantation

authors： Przybylowski P,Balogna M,Radovancevic B,Frazier OH,Susskind B,Van Buren C,Katz S,Kahan BD,Kerman R

更新日期：1999-01-27 00:00:00

abstract：BACKGROUND:Donor hepatectomy and liver implantation time reduce long-term graft and patient survival after liver transplantation. It is not known whether these surgical times influence early outcomes after liver transplantation. METHODS:This single-center study evaluated the effect of donor hepatectomy and implantatio...

journal_title：Transplantation

authors： Gilbo N,Fieuws S,Meurisse N,Nevens F,van der Merwe S,Laleman W,Verslype C,Cassiman D,van Malenstein H,Roskams T,Sainz-Barriga M,Pirenne J,Jochmans I,Monbaliu D

更新日期：2020-05-28 00:00:00

abstract：BACKGROUND:The risk associated with transplantation of renal allografts from hepatitis B virus core antibody-positive (HBcAb(+)), hepatitis B virus surface antigen-negative (HBsAg(-)) donors is not well defined. METHODS:Over 4 years, we performed 45 kidney transplants from IgG HBcAb(+), IgM HBcAb(-), HBsAg(-) donors i...

journal_title：Transplantation

authors： Madayag RM,Johnson LB,Bartlett ST,Schweitzer EJ,Constantine NT,McCarter RJ Jr,Kuo PC,Keay S,Oldach DW

更新日期：1997-12-27 00:00:00

abstract：BACKGROUND:To define whether immunosuppressive agents that block the interleukin (IL)-2 pathway could prevent activation-induced cell death of activated T cells in the graft, we measured expression of IL-2, IL-2 receptor alpha chain (CD25), IL-15, Fas, and Fas ligand by real time reverse transcription-polymerase chain ...

journal_title：Transplantation

authors： Baan CC,Balk AH,van Riemsdijk IC,Vantrimpont PJ,Maat AP,Niesters HG,Zondervan PE,van Gelder T,Weimar W

更新日期：2003-05-27 00:00:00

abstract：BACKGROUND:The literature indicates few studies on kidney patients' perception of the donor kidney. In light of this fact, we decided to explore this issue with adult patients. METHODS:We carried out a phenomenological study with 40 adult kidney patients. RESULTS:In this study, three main themes became apparent: the ...

journal_title：Transplantation

authors： Buldukoglu K,Kulakac O,Kececioglu N,Alkan S,Yilmaz M,Yucetin L

更新日期：2005-08-27 00:00:00

abstract：BACKGROUND:HLA-specific antibodies detected by solid phase assays are increasingly used to define unacceptable HLA antigen mismatches (UAM) before renal transplantation. The accuracy of this approach is unclear. METHODS:Day of transplant sera from 211 complement-dependent cytotoxicity crossmatch-negative patients were...

journal_title：Transplantation

authors： Zecher D,Bach C,Preiss A,Staudner C,Utpatel K,Evert M,Jung B,Bergler T,Böger CA,Spriewald BM,Banas B

更新日期：2018-06-01 00:00:00

abstract：:Shortage of organ donors limits the number of possible liver transplantations. Alternative therapies for treatment of liver failure are currently being developed: (i) extracorporeal artificial liver devices; (ii) bioartificial liver devices using hepatocytes; and (iii) hepatocyte transplantation. The objective of thes...

journal_title：Transplantation

authors： Sgroi A,Serre-Beinier V,Morel P,Bühler L

更新日期：2009-02-27 00:00:00

abstract：:Cyclosporine treatment of BALB/c mice (at a dose of 20 mg/kg every other day for 3 weeks) caused a remarkable reduction in the PNA-, L3T4+Lyt-2- subset of thymocytes. A significant reduction of the L3T4+Lyt-2-subset was also observed in both the lymph node and spleen cells of CsA-treated mice, though the degree of the...

journal_title：Transplantation

authors： Hiramine C,Hojo K,Matsumoto H,Koseto M,Itoh M

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:The prevalence of renal posttransplantation amputation and its impact on allograft and patient survival have not been widely reported. METHODS:We used an incident cohort of patients who underwent renal transplantation between June 2004 and September 2009. Amputation data were obtained using Medicare institu...

journal_title：Transplantation

authors： Brar A,Jindal RM,Sumrani N,John D,Mondal Z,Tedla F,Salifu MO

更新日期：2013-05-27 00:00:00

abstract：BACKGROUND:The first human hand allograft, performed in Lyon, France, on September 23, 1998, was removed during month 29 posttransplantation as the result of rejection because the patient did not comply with the immunosuppressive treatment. METHODS:The patient was regularly examined from the day of transplantation to ...

journal_title：Transplantation

authors： Kanitakis J,Jullien D,Petruzzo P,Hakim N,Claudy A,Revillard JP,Owen E,Dubernard JM

更新日期：2003-08-27 00:00:00

abstract：BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...

journal_title：Transplantation

authors： Scheepstra C,Bemelman FJ,van der Loos C,Rowshani AT,van Donselaar-Van der Pant KA,Idu MM,ten Berge IJ,Florquin S

更新日期：2008-09-27 00:00:00

abstract：BACKGROUND:This study addresses the question of the mechanism for maintaining tolerance to donor alloantigen in the absence of antigen and the role of secondary lymphoid tissues. METHODS:Depleting anti-CD4 antibody administration in conjunction with allogeneic heart transplantation generates donor-specific operational...

journal_title：Transplantation

authors： Chosa E,Hara M,Watanabe A,Matsuzaki Y,Nakamura K,Hamano K,Wood KJ,Onitsuka T

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:In the present study we examined the effect of the timing of marrow infusion on engraftment in nonmyeloablatively conditioned mice. METHODS:B10 mice were conditioned with decreasing doses of total body irradiation (TBI) and reconstituted with bone marrow cells (BMCs) from major histocompatibility complex-di...

journal_title：Transplantation

authors： Xu H,Exner BG,Chilton PM,Tanner MK,Mueller YM,Rezzoug F,Ildstad ST

更新日期：2004-03-27 00:00:00

abstract：BACKGROUND:After cold ischemia, electrons transferred in the electron transport chain may leak out of the mitochondria in proportion to the deterioration of mitochondrial oxidative phosphorylation. This seems to be one major cause of the lipid peroxidation that occurs mainly in the hepatocytes at reperfusion in liver t...

journal_title：Transplantation

authors： Ohkohchi N,Endoh T,Oikawa K,Seya K,Satomi S

更新日期：1999-04-27 00:00:00

abstract：BACKGROUND:The benefit of conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) in terms of gastrointestinal symptom burden has been evaluated previously using patient-reported outcomes. However, data are lacking concerning the sustained effect of conversion over time, and the pote...

journal_title：Transplantation

authors： Bolin P,Tanriover B,Zibari GB,Lynn ML,Pirsch JD,Chan L,Cooper M,Langone AJ,Tomlanovich SJ

更新日期：2007-12-15 00:00:00

abstract：:Hematopoietic growth factors (HGF) mobilize potential tolerogenic cells in transplant donors. Fms-like tyrosine kinase 3 ligand (Flt3L) mobilizes stem cells and dendritic cells (DCs) in human and nonhuman primate blood. Blood and renal and liver biopsies were obtained from untreated and Flt3L-mobilized rhesus macaques...

journal_title：Transplantation

authors： Morelli AE,Coates PT,Shufesky WJ,Barratt-Boyes SM,Fung JJ,Demetris AJ,Thomson AW

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Living kidney donors have donation-related out-of-pocket costs (direct costs) and/or ongoing daily expenses while losing income (indirect costs). Yet there is little information about how much of a subjective burden these constitute for the donors. METHODS:From December 2003 through December 2014, we survey...

journal_title：Transplantation

authors： Wiseman JF,Jacobs CL,Larson DB,Berglund DM,Garvey CA,Ibrahim HN,Matas AJ

更新日期：2017-09-01 00:00:00

abstract：:The use of cyclosporine has been associated with an increased incidence of thrombosis and endothelial cell perturbation. To explore possible mechanisms involved, we examined the effects of CSA on the activation of protein C by thrombomodulin. Cultured bovine aortic endothelial cell monolayers were incubated for 24 hr ...

journal_title：Transplantation

authors： Garcia-Maldonado M,Kaufman CE,Comp PC

更新日期：1991-03-01 00:00:00

abstract：:The humoral theory states that antibodies cause the rejection of allografts. From 1917 to 1929, extensive efforts were made to produce antibodies against tumors. It was finally realized that the antibodies were produced against the transplant antigens present on transplantable tumors, not against the tumor-specific an...

journal_title：Transplantation

authors： Terasaki PI

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND AND METHODS:To investigate the frequency of apoptosis and the expression of Fas/Fas ligand (FasL) in liver allografts, we examined 97 biopsy specimens from 62 patients after orthotopic liver transplantation. The results of the biopsies were as follows: acute allograft rejection (n=32); hepatitis C virus (HCV...

journal_title：Transplantation

authors： Tannapfel A,Kohlhaw K,Ebelt J,Hauss J,Liebert U,Berr F,Wittekind C

更新日期：1999-04-15 00:00:00

abstract：:High levels of tumor necrosis factor-alpha, interleukin-2, and gamma-interferon appeared in the circulation of kidney transplant recipients after the first injection of the monoclonal antibody OKT3. This initial injection was systematically followed by fever. The three cytokines were released in all patients (n = 9), ...

journal_title：Transplantation

authors： Abramowicz D,Schandene L,Goldman M,Crusiaux A,Vereerstraeten P,De Pauw L,Wybran J,Kinnaert P,Dupont E,Toussaint C

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:To reduce the morbidity of living kidney donors we introduced ketorolac-based analgesia for patients undergoing open donor nephrectomy in August 1999. There are no prior reports on the use of ketorolac for patients undergoing donor nephrectomy. METHODS:We conducted a retrospective review of all 198 consecut...

journal_title：Transplantation

authors： Freedland SJ,Blanco-Yarosh M,Sun JC,Hale SJ,Elashoff DA,Litwin MS,Smith RB,Rajfer J,Gritsch HA

更新日期：2002-03-15 00:00:00