Safety of anti-hepatitis B core antibody-positive donors for living-donor liver transplantation.

abstract：INTRODUCTION:The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice. METHODS:Allogeneic hepatocytes (FVB/N, H-2q) were transplanted into C57BL/6....

journal_title：Transplantation

authors： Bumgardner GL,Gao D,Li J,Baskin JH,Heininger M,Orosz CG

更新日期：2000-12-27 00:00:00

abstract：BACKGROUND:Although clinical data suggest its existence, little is known about the effect of rapamycin derivatives on wound repair. This study aims to delineate the influence of the mammalian target of rapamycin inhibitor everolimus on wound healing in the rat intestine. METHODS:Four groups of 26 male Wistar rats rece...

journal_title：Transplantation

authors： van der Vliet JA,Willems MC,de Man BM,Lomme RM,Hendriks T

更新日期：2006-12-15 00:00:00

abstract：:Sensitized patients awaiting renal transplantation have a markedly reduced probability of receiving a crossmatch (XM)-negative renal allograft, and, even if transplanted with a negative complement-dependent cytotoxicity (CDC)-XM, they are at an increased risk of antibody-mediated humoral rejection with early graft los...

journal_title：Transplantation

authors： Beimler JH,Morath C,Schmidt J,Ovens J,Opelz G,Rahmel A,Zeier M,Süsal C

更新日期：2009-03-15 00:00:00

abstract：BACKGROUND:The first human hand allograft, performed in Lyon, France, on September 23, 1998, was removed during month 29 posttransplantation as the result of rejection because the patient did not comply with the immunosuppressive treatment. METHODS:The patient was regularly examined from the day of transplantation to ...

journal_title：Transplantation

authors： Kanitakis J,Jullien D,Petruzzo P,Hakim N,Claudy A,Revillard JP,Owen E,Dubernard JM

更新日期：2003-08-27 00:00:00

abstract：:Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the ex...

journal_title：Transplantation

authors： Benke K,Sayour AA,Mátyás C,Ágg B,Németh BT,Oláh A,Ruppert M,Hartyánszky I,Szabolcs Z,Radovits T,Merkely B,Szabó G

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...

journal_title：Transplantation

authors： Briceno PJ,Ortiz JA,Manzarbeitia C,Jeon H,Munoz SJ,Rothstein KD,Araya V,Gala I,Reich DJ

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:T lymphocyte activation mediated by CD28 costimulation plays a critical role in graft rejection. Plant alkaloid tetrandrine, purified from a Chinese antirheumatic herb, is a potent immunosuppressant. Here, we examined its effects on several CD28-costimulated T-cell activities. In addition, such effects were ...

journal_title：Transplantation

authors： Lai JH,Ho LJ,Kwan CY,Chang DM,Lee TC

更新日期：1999-11-15 00:00:00

abstract：BACKGROUND:In kidney transplantation, dynamic prediction of patient and kidney graft survival (DynPG) may help to promote therapeutic alliance by delivering personalized evidence-based information about long-term graft survival for kidney transplant recipients. The objective of the current study is to externally valida...

journal_title：Transplantation

authors： Lenain R,Dantan E,Giral M,Foucher Y,Asar Ö,Naesens M,Hazzan M,Fournier MC

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Short-term outcomes using steroid-free immunosuppression after renal transplantation have been promising. No studies have examined the incidence of and reasons for steroid-avoidance protocol failures. METHODS:We present a single-center analysis of steroid-free immunosuppression failures among 129 pediatric ...

journal_title：Transplantation

authors： Sutherland S,Li L,Concepcion W,Salvatierra O,Sarwal MM

更新日期：2009-06-15 00:00:00

abstract：BACKGROUND:Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptimal donor livers before implantation. Our aim was to assess the diagnostic accuracy of bile biochemistry for the assessment of bile duct injury (BDI). METHODS:In a preclinical study, 23 human donor livers underwent 6 hour...

journal_title：Transplantation

authors： Matton APM,de Vries Y,Burlage LC,van Rijn R,Fujiyoshi M,de Meijer VE,de Boer MT,de Kleine RHJ,Verkade HJ,Gouw ASH,Lisman T,Porte RJ

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Posttransplantation measurement of soluble CD30 (sCD30) may be useful for identifying kidney graft recipients at risk of impending graft rejection in the early posttransplantation period. METHODS:We measured plasma sCD30 levels and evaluated the levels in relation to the diagnosis of rejection. RESULTS:Rec...

journal_title：Transplantation

authors： Pelzl S,Opelz G,Daniel V,Wiesel M,Süsal C

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:The long-term outcome of simultaneous kidney pancreas transplant recipients is not well established. METHODS:We retrospectively reviewed all patients who underwent simultaneous kidney-pancreas transplantation with bladder drainage at our center between January 1989 and December 1991. A total of 57 patients ...

journal_title：Transplantation

authors： Sudan D,Sudan R,Stratta R

更新日期：2000-02-27 00:00:00

abstract：INTRODUCTION:Anti-CD3-immunotoxin (alpha-CD3-IT) promotes allograft tolerance in nonhuman primates owing to efficient depletion of sessile and circulating T cells. Common side effects of vascular leak syndrome, hepatotoxicity, and nephrotoxicity have limited tolerability of other immunotoxins. We report on preclinical ...

journal_title：Transplantation

authors： Contreras JL,Eckhoff DE,Cartner S,Frenette L,Thomas FT,Robbin ML,Neville DM Jr,Thomas JM

更新日期：1999-07-27 00:00:00

abstract：:The influence of ultraviolet (UVB) irradiation on the survival of H-2 class II-disparate skin grafts was studied in congenic mouse strains. Isolated skin was UVB irradiated in vitro at a dose of 40 mJ/cm2 from both sides to remove Ia immunogenicity. Immediately after irradiation the skin was transplanted onto the flan...

journal_title：Transplantation

authors： Vermeer BJ,Santerse B,Van De Kerckhove BA,Schothorst AA,Claas FH

更新日期：1988-03-01 00:00:00

abstract：:Since major histocompatibility (MHC) antigen matching was introduced in the early 1970s as the key factor determining kidney transplant allocation, several studies, mainly arising from organ-sharing organizations in the United States and Europe, have debated this complex issue. The first fundamental concern is the int...

journal_title：Transplantation

authors： Hiesse C,Pessione F,Houssin D

更新日期：2004-02-27 00:00:00

abstract：:Graft-versus-host disease (GVHD)* is a frequent complication of allogeneic bone marrow transplantation. The potentially beneficial effect of phototherapy for treatment of cutaneous manifestations of GVHD led us to investigate retrospectively the effect of this therapy in a larger series of patients. Eleven patients wi...

journal_title：Transplantation

authors： Aubin F,Brion A,Deconinck E,Plouvier E,Hervé P,Humbert P,Cahn JY

更新日期：1995-01-15 00:00:00

abstract：:A murine IgG1 antibody specific for the IL-2-binding site on the human lymphocyte IL-2 receptor beta chain (CD25) was evaluated in 11 patients who developed acute graft-versus-host disease following allogeneic marrow transplantation. All patients had received cyclosporine and methotrexate for prophylaxis of GVHD, eith...

journal_title：Transplantation

authors： Anasetti C,Martin PJ,Hansen JA,Appelbaum FR,Beatty PG,Doney K,Harkonen S,Jackson A,Reichert T,Stewart P

更新日期：1990-07-01 00:00:00

abstract：:Millions of people want to donate their organs after they die for transplantation, and many of them have registered their wish to do so or told their family and friends about their decision. For most of them, however, this wish is unlikely to be fulfilled, as only a small number of deaths (1% in the United Kingdom) oc...

journal_title：Transplantation

authors： Shaw D,Georgieva D,Haase B,Gardiner D,Lewis P,Jansen N,Wind T,Samuel U,McDonald M,Ploeg R,ELPAT Working Group on Deceased Donation.

更新日期：2017-03-01 00:00:00

abstract：:Up-regulated expression of adhesion molecules on vascular endothelial cells (ECs) is an initial event in leukocyte adhesion to ECs, which is a crucial step in the process of inflammatory or immune reaction leading to organ transplant rejection. Verapamil and other calcium channel blockers have been reported to improve...

journal_title：Transplantation

authors： Yamaguchi M,Suwa H,Miyasaka M,Kumada K

更新日期：1997-03-15 00:00:00

abstract：:We report two cases of Kaposi's sarcoma (KS) after orthotopic liver transplantation for cirrhosis of the liver related to hepatitis C virus. Both cases were Saudi-born Arabs who were negative for human immunodeficiency virus; one patient was receiving FK506 plus prednisolone, and the other patient was receiving FK506....

journal_title：Transplantation

authors： Rezeig MA,Fashir BM,Hainau B,Al Ashgar HI

更新日期：1997-05-27 00:00:00

abstract：BACKGROUND:Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (I...

journal_title：Transplantation

authors： Rayar M,Tron C,Jézéquel C,Beaurepaire JM,Petitcollin A,Houssel-Debry P,Camus C,Verdier MC,Dehlawi A,Lakéhal M,Desfourneaux V,Meunier B,Sulpice L,Bellissant E,Boudjema K,Lemaitre F

更新日期：2018-03-01 00:00:00

abstract：:Reduced-size liver transplantation in the rat has been useful in the study of hepatic regeneration. We describe a modified technique for partial liver transplantation in the rat using a 50% reduced-size graft. Male Lewis rats (RT1(1)), weighing 250 to 280 g, were used as donors and recipients. The harvested donor live...

journal_title：Transplantation

authors： Omura T,Ascher NL,Emond JC

更新日期：1996-07-27 00:00:00

abstract：:When normal mice are exposed for short periods to ultraviolet light (UV), they support the progressive growth of transplanted syngeneic UV-induced tumors. Normal nonirradiated mice almost always reject these tumor implants. The UV-mediated suppression of the antitumor response can be adoptively transferred to normal s...

journal_title：Transplantation

authors： Spellman CW,Daynes RA

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:This study analyzes the biochemical, serological, and virological efficacy and the safety of adefovir dipivoxil in patients with renal disturbances. METHODS:Twelve patients with lamivudine-resistant hepatitis B virus (HBV) chronic infection were treated for a median time of 15 (3-19) months. The daily dosag...

journal_title：Transplantation

authors： Fontaine H,Vallet-Pichard A,Chaix ML,Currie G,Serpaggi J,Verkarre V,Varaut A,Morales E,Nalpas B,Brosgart C,Pol S

更新日期：2005-10-27 00:00:00

abstract：:The effect of prophylactic i.v. administration of high doses of human gamma-immunoglobulin (IgG) on kidney graft survival was investigated in rhesus monkeys treated with azathioprine and prednisolone. In nontransfused recipients not treated with IgG (controls), graft survival ranged from 9 to 22 days; if nontreated an...

journal_title：Transplantation

authors： Borleffs JC,Marquet RL,de By-Aghai Z,Dolkart RE,Persijn GG,Balner H

更新日期：1982-01-01 00:00:00

abstract：:BALB/cxDBA/2Wf F1 (CD2F1) mice were lethally irradiated and reconstituted with syngeneic bone marrow cells untreated or treated with 75 micrograms/ml of mafosfamide. One day after bone marrow transplantation some groups of mice were injected with syngeneic splenocytes, peripheral blood leukocytes, or thymocytes. Seven...

journal_title：Transplantation

authors： Skórski T,Kawalec M,Kawiak J

更新日期：1991-04-01 00:00:00

abstract：:Lamivudine combined with hepatitis B immune globulin (HBIg) is the standard of care for preventing the recurrence hepatitis B virus after liver transplant. To determine the risk of hepatitis B virus (HBV) recurrence after early withdrawal of HBIg in patients receiving lamivudine maintenance therapy, 20 patients receiv...

journal_title：Transplantation

authors： Buti M,Mas A,Prieto M,Casafont F,González A,Miras M,Herrero JI,Jardi R,Esteban R

更新日期：2007-09-15 00:00:00

abstract：BACKGROUND:Current insulin therapies for control of glucose metabolism in patients with type I diabetes mellitus prevent major metabolic consequences of insulin deficiency, but none prevents or arrests long-term complications. In experimental models of canine diabetes, retinopathy, neuropathy, and nephropathy have been...

journal_title：Transplantation

authors： Hawthorne WJ,Wilson TG,Williamson P,Stewart GJ,Allen RD,Little JM,Deane SA,Ekberg H

更新日期：1997-10-15 00:00:00

abstract：:The influence of race on the outcome of cadaver renal transplantation (CRT) continues to be controversial even in the cyclosporine era. The present study examines the effect of race in 343 adult CRT performed from 1/1/82 through 10/1/88 with regard to the incidence of delayed function (DF), graft survival (GS), and pa...

journal_title：Transplantation

authors： Dawidson IJ,Coorpender L,Fisher D,Helderman H,Hull A,Palmer B,Peters P,Sagalowsky A,Sandor ZF,Toto R

更新日期：1990-01-01 00:00:00

abstract：:The aim of this study was to analyze, in heart transplant patients, if renal function improvement after cyclosporine replacement by everolimus persists at the middle term and its predictors. We studied prospectively 56 patients in whom conversion was consecutively made. Forty-five patients completed the follow-up peri...

journal_title：Transplantation

authors： Moro López JA,Almenar L,Martínez-Dolz L,Sánchez-Lázaro I,Agüero J,Buendía F,Ortiz V,Salvador A

更新日期：2009-02-27 00:00:00