Abstract:
BACKGROUND:Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (IPV) on graft and patient outcomes after LT. METHODS:We retrospectively analyzed 812 LT recipients treated with TAC. The IPV of TAC concentrations was estimated by calculating the coefficient of variation (CV) of whole blood trough concentrations. Patients were categorized in 2 groups: low IPV (CV < 40%) and high IPV (CV ≥ 40%). RESULTS:There were significantly more neurologic complications (31.2% vs 16.6%, P < 0.001), cardiovascular complications (19.7% vs 9.7%, P < 0.001), and acute renal failure requiring dialysis (8.5% vs 2.2%, P < 0.001) in the high CV group than in the low CV group. Moreover, graft survival was significantly poorer in the high CV group (hazard ratio, 1.42; 95% confidence interval, 1.04-1.95; P = 0.03). A pretransplantation elevated Model for End-Stage Liver Disease score (P < 0.001) and Child-Pugh grade (P < 0.001) were identified as risk factors for presenting a high CV. CONCLUSIONS:A high CV of TAC concentrations was found to be predictive of TAC-related toxicity and poorer survival.
journal_name
Transplantationjournal_title
Transplantationauthors
Rayar M,Tron C,Jézéquel C,Beaurepaire JM,Petitcollin A,Houssel-Debry P,Camus C,Verdier MC,Dehlawi A,Lakéhal M,Desfourneaux V,Meunier B,Sulpice L,Bellissant E,Boudjema K,Lemaitre Fdoi
10.1097/TP.0000000000002052subject
Has Abstractpub_date
2018-03-01 00:00:00pages
e108-e114issue
3eissn
0041-1337issn
1534-6080journal_volume
102pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Hepatic artery thrombosis is a dreadful complication of orthotopic liver transplantation. It should be suspected in cases of fulminant liver failure, delayed bile leak, or intermittent sepsis of unknown cause after liver transplantation. Accurate diagnosis is assisted by ultrasound and computerized tomography scans, b...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198512000-00019
更新日期:1985-12-01 00:00:00
abstract::We have tested the effects of FK506 (FK), a new immunosuppressive agent, on a rat limb allograft model. Histoincompatible BN limb allografts were rejected in untreated F344 hosts within 11 +/- 1 days (mean +/- SD) after operation. A single injection of 2 mg/kg, 10 mg/kg, or 50 mg/kg of FK on the day of limb transplant...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198911000-00011
更新日期:1989-11-01 00:00:00
abstract::The presence of major histocompatibility complex (MHC)-encoded antigens (RT1) on endothelium of rat kidneys was investigated using hyperimmune allogeneic rat sera (HIS) in an indirect immunofluorescence technique with kidney sections. Endothelial antigens detected with anti-MHC sera segregated in an F2 generation with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198209000-00002
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND:The incidence and impact of cytomegalovirus (CMV) disease that occurs despite CMV prophylaxis among liver transplant recipients have been incompletely defined. METHODS:The incidence and risk factors for CMV disease during the first posttransplant year in a cohort of liver transplant recipients who received ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000145989.22373.03
更新日期:2004-11-15 00:00:00
abstract:BACKGROUND:This study examined the relationship between transplant vascular sclerosis (TVS) and tissue fibrosis, features of chronic rejection that can develop rapidly in accepted heterotopic murine cardiac allografts. METHODS:The rate of development of interstitial fibrosis or TVS development was determined by comput...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199710270-00020
更新日期:1997-10-27 00:00:00
abstract::Control mechanisms that regulate the induction of T helper cells are a key component of conceptual schemes to understand the network of interactions controlling the immune response. In this work, using a sequential three-step culture system, we demonstrate that the generation of the T helper cells that participate in ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198509000-00017
更新日期:1985-09-01 00:00:00
abstract::Published data on the guinea pig-to-rat hepatic xenotransplant model describe problems concerning poor graft reperfusion. To further investigate this phenomenon, orthotopic liver xenotransplantation between weight-matched guinea pigs and rats were performed using Kamada's technique. On reperfusion, all cases had porta...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199807150-00017
更新日期:1998-07-15 00:00:00
abstract::The effects of dietary (10% calories) safflower (SAF), evening primrose (EPO), and fish oil (F) as sources of linoleic acid (control), gamma-linolenic acid, and long-chain n-3 fatty acids, respectively, on cardiovascular and renal responses to chronic (5 weeks) cyclosporine administration were studied in male borderli...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199203000-00030
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Longest bipolar length of the kidney graft is routinely measured for ultrasonographic assessment of graft size (GS), although the value of the graft length remains unclear. METHODS:In a single-center, observational study involving 319 deceased-donor kidney transplant recipients, we assessed variations in ab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000977
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Rat lung allograft rejection is mediated by collagen type V (col(V)) specific T-helper-cell 17 (Th17) cells. Adoptive transfer of these cells is sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allograft rejection. Therefore, we tested whether regulatory T cells f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bcde7b
更新日期:2009-12-27 00:00:00
abstract::We describe a patient transfused with 200 ml of donor fresh whole blood three times at 2-week intervals. Three weeks after the last transfusion, transplantation and splenectomy were done at the same time. Splenic cells from this DST pretreated patient were fused with murine myeloma cells (X63-Ag8, 653). With DST pretr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198909000-00022
更新日期:1989-09-01 00:00:00
abstract::Interferon gamma and tumor necrosis factor alpha play a significant role in the upregulation of host immunity and inflammation, for example by induction and enhancement of the expression of major histocompatibility complex class I and II antigens on a wide variety of cell types, both in vitro and in vivo. In this stud...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199011000-00022
更新日期:1990-11-01 00:00:00
abstract::Weight gain following renal transplantation occurs frequently but has not been investigated quantitatively. A retrospective chart review of 115 adult renal transplant recipients was used to describe patterns of weight gain during the first 5 years after transplantation. Only 23 subjects (21%) were overweight before th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199310000-00008
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. METHODS:During 27 months, 30 consecutive heart-lung- and lung-transplant recipients were included on the day of transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000058809.42027.66
更新日期:2003-06-27 00:00:00
abstract:BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000251646.09702.ec
更新日期:2007-02-27 00:00:00
abstract:BACKGROUND:Recent insights suggest that endothelial cell (EC) activation plays a major role in renal ischemia-reperfusion (I/R) injury. Interactions between ECs and pericytes via signaling molecules, including angiopoietins, are involved in maintenance of the vascular integrity. Experimental data have shown that enhanc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829854d5
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:Organ donors are frequently trauma victims, but the impact of donor hemorrhagic shock and resuscitation (HSR) on pulmonary graft function has not been assessed. L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Objec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a52ce1
更新日期:2009-06-15 00:00:00
abstract::Using antisera to human beta2-microglobulin and an immunofluorescent technique, beta2-microglobulin was found to be localized along tubular and glomerular basement membranes of renal bipsies studied. Since beta2-microglobulin is a subunit of HLA preparations, it may also serve as an indirect marker for the presence of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197707000-00001
更新日期:1977-07-01 00:00:00
abstract::Intercellular adhesion molecule-1 (ICAM-1) induction on hepatocytes was investigated in relation to acute liver allograft rejection, CMV infection, and systemic bacterial infections. Twenty-four liver transplant recipients underwent an episode of acute rejection, 13 developed a symptomatic clinical CMV infection, and ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199312000-00041
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Primary hyperoxaluria is a rare autosomal recessive metabolic disease that often progresses to end-stage renal disease (ESRD). Liver transplantation is curative for patients with the alanine: glyoxylate aminotransferase deficiency. For oxalosis patients with minor enzyme deficiencies, renal transplantation m...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/00007890-200209150-00020
更新日期:2002-09-15 00:00:00
abstract::The current shortage of donor organs has stimulated investigation of pig-to-human xenotransplantation as a practical alternative to allotransplantation. However, a major obstacle to this xenotransplantation is hyperacute rejection, which is believed to be initiated by the interaction of natural anti-alpha-galactosyl (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611150-00026
更新日期:1996-11-15 00:00:00
abstract::Long-term graft survival is mainly influenced by early graft rejection and posttransplant graft function. The ability of both complement-dependent cytotoxicity cross-match (CDC) and flow cytometry cross-match (FCXM) to predict acute rejection episodes has been evaluated by cross-matching 40 patients who received cadav...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199702270-00012
更新日期:1997-02-27 00:00:00
abstract::Total lymphoid irradiation (TLI) induces a unique state of immunosuppression. Although permanent bone marrow chimerism has been obtained in rodents prepared by TLI, uniform marrow engraftment has been more difficult to obtain in larger mammals. Accordingly, studies were performed to assess the immunologic perturbation...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198307000-00004
更新日期:1983-07-01 00:00:00
abstract::Several studies have reported the development of antiidiotypic antibodies to anti-HLA alloantibodies in renal allograft transplant recipients, postulating their potential beneficial role in allograft survival. In order to evaluate the role of anti-HLA antiidiotypic antibodies in human liver transplant recipients and t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199308000-00037
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Subclinical T cell-mediated rejection (subTCMR) is commonly found after liver transplantation and has a good short-term prognosis, even when it is left untreated. Donor-specific antibodies (DSA) are putatively associated with a worse prognosis for recipient and graft after liver transplantation. METHODS:To ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003034
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Blood group-incompatible transplantation is one strategy used when a potential recipient does not have a compatible living donor. Current practice includes desensitization strategies to reduce antibody titers. However, when antibodies are low, in cardiac transplantation in neonates for example, no desensitiz...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825b7608
更新日期:2012-08-27 00:00:00
abstract::Our current knowledge of cytotoxic T lymphocytes (CTL) is largely derived from studies of effector populations generated in allogeneic mixed leukocyte cultures (MLC) and assayed for lytic activity to lymphoid cell (LC) targets. We herein report that the CTL response to allogeneic renal epithelial cell lines (REC) is d...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199607150-00016
更新日期:1996-07-15 00:00:00
abstract::Organ shortage in liver transplantation has led the transplant community to expand the donor organ pool and reduce waiting list mortality by using so-called marginal donor or extended criteria donor (ECD) livers. The exact impact of these criteria on graft function and recipient survival are still under investigation....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318186ad7a
更新日期:2008-10-15 00:00:00
abstract::The potential role of donor's mature T lymphocytes on the recovery of various immunological functions and hematopoiesis was investigated in lethally irradiated BALB/c mice by studying reconstitution with normal, as compared with T-cell-depleted, syngeneic marrow grafts. Recovery of total, as well as mononuclear, perip...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1986-08-01 00:00:00
abstract::A retrospective masked study of 120 consecutive renal transplant biopsies was performed to evaluate the potential associations of cyclosporine (CsA) therapy and other factors on the degree and progression of interstitial fibrosis (IF). Allograft biopsies were obtained from patients receiving CsA (CsA+; n = 59) and not...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198801000-00021
更新日期:1988-01-01 00:00:00