Associations between cyclosporine therapy and interstitial fibrosis in renal allograft biopsies.

Abstract:

:A retrospective masked study of 120 consecutive renal transplant biopsies was performed to evaluate the potential associations of cyclosporine (CsA) therapy and other factors on the degree and progression of interstitial fibrosis (IF). Allograft biopsies were obtained from patients receiving CsA (CsA+; n = 59) and not receiving CsA (CsA-; n = 46); pretransplant donor biopsies were used as controls (n = 15). IF was evaluated by histologic grading (0-3+) as well as by quantitative morphometric measurements of Masson's trichrome stain positive material. Other biopsy measurements included the pattern of IF (focal, diffuse; graded 0-3+), and tubular epithelial cell reactivity, necrosis, and vacuolization (each graded 0-3+). Potential confounding variables were also considered, including time interval between transplant and biopsy; creatinine levels at the time of biopsy, 2 weeks and 10 weeks postbiopsy, and the last stable (baseline) creatinine prior to biopsy; recipient age, clinical evidence of rejection, and duration of rejection reactions; transplant number; and postbiopsy graft outcome. No significant difference in any measure of IF was found between all CsA+ vs. CsA- patients, although both groups showed a highly significant increase in IF compared with control pretransplant donor biopsies. Similarly, no differences in tubular changes or the patterns of fibrosis were identified between CsA groups. However, since the mean interval between transplant and biopsy was significantly (P less than 0.04) greater for the CsA- group, measures of creatinine and IF were normalized by the time interval between transplant and biopsy, and were stratified into biopsies obtained before or after 6 months posttransplant. By this stratification and normalization, both the baseline creatinine (P less than 0.01) and the degree of IF as measured by morphometry (P less than 0.04) were significantly higher in the CsA+ group, but only for biopsies obtained greater than 6 months posttransplant. Evaluation of biopsies less than 6 months posttransplant normalized by interval showed no suggested differences between the CsA+ and CsA- groups in terms of creatinine levels or any measure of IF. Tubular epithelial changes were not different in the CsA+ and CsA- groups within either period. These results suggest that CsA therapy is not associated with increased interstitial fibrosis in renal allografts prior to 6 months posttransplant, after which there is a significant increase in fibrosis relative to patients not receiving CsA.

journal_name

Transplantation

journal_title

Transplantation

authors

Ruiz P,Kolbeck PC,Scroggs MW,Sanfilippo F

doi

10.1097/00007890-198801000-00021

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

91-5

issue

1

eissn

0041-1337

issn

1534-6080

journal_volume

45

pub_type

杂志文章
  • Endoscopic evaluation of small intestine transplant grafts.

    abstract:BACKGROUND:The management of small bowel transplantation is unique because signs of rejection can be obtained visually by endoscopy. The aim of this study was to evaluate the accuracy of endoscopic appearance in assessing histologic evidence of acute cellular rejection (ACR). METHODS:Endoscopies were performed in 66 a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31825f4410

    authors: O'Keefe SJ,El Hajj II,Wu T,Martin D,Mohammed K,Abu-Elmagd K

    更新日期:2012-10-15 00:00:00

  • The poly(adenosine diphosphate-ribose) polymerase inhibitor PJ34 reduces pulmonary ischemia-reperfusion injury in rats.

    abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen species. We evaluate...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000305

    authors: Hatachi G,Tsuchiya T,Miyazaki T,Matsumoto K,Yamasaki N,Okita N,Nanashima A,Higami Y,Nagayasu T

    更新日期:2014-09-27 00:00:00

  • Antibody testing strategies for deceased donor kidney transplantation after immunomodulatory therapy.

    abstract:BACKGROUND:Immunomodulatory protocols including intravenous immunoglobulin/rituximab (IVIG/R) are employed to decrease anti-human leukocyte antigen (HLA) antibody levels for patients broadly sensitized to HLA and increase chances for transplantation with a compatible deceased donor (DD). The aim of our study was to ide...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31821eab8a

    authors: Lai CH,Cao K,Ong G,Naim M,Wang Q,Mirocha J,Vo A,Jordan SC,Reinsmoen NL

    更新日期:2011-07-15 00:00:00

  • Identification of I-E alpha genes in H-2 recombinant mouse strains by F1 complementation.

    abstract::Nine recombinant H-2 mouse strains with crossovers in the I region between I-E-negative haplotypes f,q and I-E-positive haplotypes p,k were examined for I-E expression by microcytotoxicity dye exclusion assay. These recombinants were found to be negative for I-E expression. There are two possible genotypes in these re...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198702000-00026

    authors: Lafuse WP,Savarirayan S,McCormick JF,David CS

    更新日期:1987-02-01 00:00:00

  • Cryopreservation of rat pancreatic islets: effect of ethylene glycol on islet function and cellular composition.

    abstract:BACKGROUND:Inasmuch as cryopreservation can facilitate clinical islet transplantation by providing a means of storing supplemental islets in order to augment marginally adequate grafts, protocols are needed to allow for a minimal loss in viable beta cells. By replacing the cryoprotectant dimethyl sulfoxide (DMSO) with ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199710150-00020

    authors: Korbutt GS,Rayat GR,Ezekowitz J,Rajotte RV

    更新日期:1997-10-15 00:00:00

  • Fulminant hepatitis is significantly increased in hepatitis B carriers after allogeneic bone marrow transplantation.

    abstract:BACKGROUND:Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised. METHODS:Forty-three hepatitis B virus car...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199906150-00006

    authors: Chen PM,Chiou TJ,Fan FS,Liu JM,Hsieh RK,Yen CC,Wang WS,Liu JH

    更新日期:1999-06-15 00:00:00

  • Clinical results of an organ procurement organization effort to increase utilization of donors after cardiac death.

    abstract:BACKGROUND:To stimulate organ donation, an organ procurement organization (OPO)-wide effort was undertaken to increase donors after cardiac death (DCD) over a 5-year period. This included commonality of protocols, pulsatile perfusion of kidneys, centralization of data and a regional allocation variance designed to mini...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000179641.82031.ea

    authors: Whiting JF,Delmonico F,Morrissey P,Basadonna G,Johnson S,Lewis WD,Rohrer R,O'Connor K,Bradley J,Lovewell TD,Lipkowitz G

    更新日期:2006-05-27 00:00:00

  • T-cell and major histocompatibility complex requirements for obliterative airway disease in heterotopically transplanted murine tracheas.

    abstract:BACKGROUND:One third of human lung allografts develop chronic rejection manifested as obliterative bronchiolitis. Heterotopically transplanted allogeneic murine tracheas develop obliterative airway disease (OAD) leading to a lesion resembling human obliterative bronchiolitis. The purpose of this study was to determine ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199809270-00011

    authors: Kelly KE,Hertz MI,Mueller DL

    更新日期:1998-09-27 00:00:00

  • 17β-Estradiol Treatment Protects Lungs Against Brain Death Effects in Female Rat Donor.

    abstract:BACKGROUND:Brain death (BD) affects the viability of lungs for transplantation. A correlation exists between high lung inflammation after BD and the decrease in female sex hormones, especially estradiol. Therefore, we investigated the effects of 17β-estradiol (E2) treatment on the lungs of female brain dead rats. METH...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003467

    authors: Ricardo-da-Silva FY,Armstrong R Jr,Vidal-Dos-Santos M,Correia CJ,Coutinho E Silva RDS,da Anunciação LF,Moreira LFP,Leuvenink HGD,Breithaupt-Faloppa AC

    更新日期:2020-10-07 00:00:00

  • Preoperative factors associated with outcome and their impact on resource use in 1148 consecutive primary liver transplants.

    abstract:BACKGROUND:Hepatic transplantation is a highly effective but costly treatment for end-stage hepatic dysfunction. One approach to improve efficiency in the use of scarce organs for transplantation is to identify preoperative factors that are associated with poor outcome posttransplantation. This may assist both in selec...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200109270-00023

    authors: Markmann JF,Markmann JW,Markmann DA,Bacquerizo A,Singer J,Holt CD,Gornbein J,Yersiz H,Morrissey M,Lerner SM,McDiarmid SV,Busuttil RW

    更新日期:2001-09-27 00:00:00

  • Signaling through CD31 protects endothelial cells from apoptosis.

    abstract::Endothelial damage has been implicated in the pathogenesis of chronic rejection. Conversely, expression of protective genes [including A20, A1, bcl-xl, and hemoxygenase-1 (HO-1)] in the endothelium has been associated with long-term graft survival. Overexpression of protective genes in cultured endothelial cells confe...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200102150-00020

    authors: Evans PC,Taylor ER,Kilshaw PJ

    更新日期:2001-02-15 00:00:00

  • Increased incidence of acute myeloid leukemia after liver transplantation? Description of three new cases and review of the literature.

    abstract:BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR)...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.TP.0000102549.40531.13

    authors: Camós M,Esteve J,Rimola A,Grande L,Rozman M,Colomer D,Villamor N,Costa D,Montserrat E

    更新日期:2004-01-27 00:00:00

  • Analysis of histoincompatibility in a natural population of the bisexual whiptail lizard Cnemidophorus tigris.

    abstract::Histoincompatibility was analyzed to describe as precisely as possible the sequence of gross morphological events taking place during allograft rejection among closely related conspecifics from a natural population of the bisexual lizard Cnemidophorus tigris. Two types of rejection were noted, depending on whether the...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197708000-00006

    authors: Cuellar O,Smart C

    更新日期:1977-08-01 00:00:00

  • Characterization of B cell antibodies in kidney transplant recipients.

    abstract::Antibodies against B lymphocytes were found in the serum of the majority of 59 kidney transplant recipients and of 22 eluates obtained from kidney allografts undergoing rejection. To characterize these B cell lymphocytotoxins we have used a mouse monoclonal anti-DR antibody (L227) that inhibits cytotoxicity of antibod...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198305000-00011

    authors: Nunez G,McPhaul JJ Jr,Stastny P

    更新日期:1983-05-01 00:00:00

  • Rhesus monkey immature monocyte-derived dendritic cells generate alloantigen-specific regulatory T cells from circulating CD4+CD127-/lo T cells.

    abstract:BACKGROUND:Generation of non-human primate regulatory T cells (Treg) with alloantigen (alloAg) specificity would allow their testing in preclinical transplant models. Low recovery of Treg from peripheral blood limits their potential utility. In small animals and humans, conventional myeloid dendritic cells (DC) have be...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181ba6b1f

    authors: Zahorchak AF,Raimondi G,Thomson AW

    更新日期:2009-11-15 00:00:00

  • A pilot study of immunosuppressive monotherapy in liver transplantation: tacrolimus versus microemulsified cyclosporin.

    abstract:BACKGROUND:Many reports of successful early withdrawal of regular maintenance steroids in transplant recipients have appeared in recent years. The question now arises whether, in the current age of powerful nonsteroidal immunosuppressants such as Neoral and Tacrolimus, routine administration of steroids posttransplant ...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007890-199910270-00021

    authors: Rolles K,Davidson BR,Burroughs AK

    更新日期:1999-10-27 00:00:00

  • Five-year follow-up of two siblings with aspartylglucosaminuria undergoing allogeneic stem-cell transplantation from unrelated donors.

    abstract:BACKGROUND:Aspartylglucosaminuria is a rare, inherited lysosomal disease characterized by a slowly progressive mental retardation and coarse facial and body features. With the intent to provide the deficient enzyme aspartylglucosaminidase, allogeneic stem-cell transplantation (ASCT) has been attempted. Only a few cases...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200408150-00015

    authors: Malm G,Månsson JE,Winiarski J,Mosskin M,Ringdén O

    更新日期:2004-08-15 00:00:00

  • Enhanced type 2 and diminished type 1 cytokines in neonatal tolerance.

    abstract::We examined the cytokine profiles associated with tolerance and rejection using the mouse model of neonatal tolerance. BALB/c mice primed with CAF1 splenocytes during the neonatal stage showed increased A/J skin graft survival of > 60 days and failed to develop anti-A/J cytotoxic responses, but rejected third-party C5...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199504150-00002

    authors: Chen N,Field EH

    更新日期:1995-04-15 00:00:00

  • Induction of allograft nonresponsiveness after intrathymic inoculation with donor class I allopeptides. II. Evidence for persistent chronic rejection despite high levels of donor microchimerism.

    abstract::We have recently demonstrated that three synthetic peptides corresponding to the donor class I RT1.Aa molecule induce long-term survival of cardiac allografts in the PVG.R8-to-PVG.1U rat strain combination (disparate for one isolated class I, RT1.A, molecule) when presented to the recipient immune system in the thymus...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199712270-00007

    authors: Shirwan H,Wu GD,Barwari L,Liu A,Cramer DV

    更新日期:1997-12-27 00:00:00

  • Influence of age in renal transplant infections: cases and controls study.

    abstract::Kidney transplantation in elderly patients is a good therapeutic option, but the incidence of infections compared to younger patients must be studied. Case and control study was performed with 40 cases (patients older than 65) and 40 controls (younger than 65) receiving a kidney transplant between January 2000 and Aug...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000173822.05877.d7

    authors: Trouillhet I,Benito N,Cervera C,Rivas P,Cofán F,Almela M,Angeles Marcos M,Puig de la Bellacasa J,Pumarola T,Oppenheimer F,Moreno-Camacho A

    更新日期:2005-10-15 00:00:00

  • The high incidence of BK polyoma virus infection among renal transplant recipients in India.

    abstract::BK polyoma virus causes allograft dysfunction as a result of tubulo-interstitial nephritis in 2% to 5% of renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in India is unknown. We used routine histologic examination, immunohistochemistry, and electron microscopy to retr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000113163.02039.30

    authors: Sachdeva MS,Nada R,Jha V,Sakhuja V,Joshi K

    更新日期:2004-02-15 00:00:00

  • 31P nuclear magnetic resonance spectroscopic evaluation of liver preservation solutions.

    abstract::The individual effects of verapamil and 2 antioxidants on perfused rat liver nucleoside triphosphate (NTP) recovery following cold storage in University of Wisconsin (UW) solution was assessed using 31P nuclear magnetic resonance spectroscopy. The pharmacological agents were added to UW solution and were present only ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Bowers JL,Neymark E,Cook CU,Clouse ME

    更新日期:1994-06-15 00:00:00

  • CD4+ and B lymphocytes in transplantation immunity. II. Augmented rejection of tumor allografts by mice lacking B cells.

    abstract::To test the importance of B lymphocytes in immunity to major histocompatibility complex class I alloantigens, B cell-deficient mice were generated by reconstituting severe combined immunodeficiency mice, which lack functional B and T lymphocytes, with T cells or with both T and B cells. The reconstituted mice were cha...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Monach PA,Schreiber H,Rowley DA

    更新日期:1993-06-01 00:00:00

  • Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody.

    abstract::Monoclonal antibodies to CD3 have been shown to activate T cells in vivo and in vitro but have also been shown to render T cells anergic in vitro. In this study G4.18, a mouse IgG3 mAb, was produced that appeared to recognize CD3 by its binding to all peripheral T cells, including a population not recognized by mAb to...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199303000-00001

    authors: Nicolls MR,Aversa GG,Pearce NW,Spinelli A,Berger MF,Gurley KE,Hall BM

    更新日期:1993-03-01 00:00:00

  • Clinical utility of a quantitative polymerase chain reaction for diagnosis of cytomegalovirus disease in solid organ transplant patients.

    abstract:BACKGROUND:Accurate and rapid diagnosis of human cytomegalovirus (HCMV) disease in solid organ transplant patients remains a challenge. We evaluated the clinical utility of a quantitative polymerase chain reaction (QPCR) method to diagnose transplant patients with HCMV disease. METHODS:A total of 429 plasma samples fr...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199910150-00016

    authors: Ferreira-Gonzalez A,Fisher RA,Weymouth LA,Langley MR,Wolfe L,Wilkinson DS,Garrett CT

    更新日期:1999-10-15 00:00:00

  • Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.

    abstract::The mission of the recently established Immune Tolerance Network includes the development of protocols for the induction of transplant tolerance in organ allograft recipients and the development of assays that correlate with and may be predictive of the tolerant state. The state of clinical organ transplant tolerance ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Thomson AW,Mazariegos GV,Reyes J,Donnenberg VS,Donnenberg AD,Bentlejewski C,Zahorchak AF,O'Connell PJ,Fung JJ,Jankowska-Gan E,Burlingham WJ,Heeger PS,Zeevi A

    更新日期:2001-10-27 00:00:00

  • Significance of true-positive and false-positive pretransplantation lymphocytotoxic crossmatch in primary liver allograft outcomes.

    abstract:BACKGROUND:At the time of transplantation, a recipient's serum is tested against the prospective donor's lymphocytes to identify specific reactivity and to look for a donor-specific crossmatch (CXM). Here, we investigated the relationship between the pretransplantation lymphocytotoxic CXM results and the long-term outc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31828d155a

    authors: Shin M,Moon HH,Kim JM,Park JB,Kwon CH,Kim SJ,Lee SK,Joh JW

    更新日期:2013-06-15 00:00:00

  • Hepatitis C virus and nonliver solid organ transplantation.

    abstract::: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0b013e318273fec4

    authors: Carbone M,Mutimer D,Neuberger J

    更新日期:2013-03-27 00:00:00

  • Characterization of antiidiotypic antibodies to donor HLA that develop after liver transplantation.

    abstract::Several studies have reported the development of antiidiotypic antibodies to anti-HLA alloantibodies in renal allograft transplant recipients, postulating their potential beneficial role in allograft survival. In order to evaluate the role of anti-HLA antiidiotypic antibodies in human liver transplant recipients and t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199308000-00037

    authors: Chauhan B,Phelan DL,Marsh JW,Mohanakumar T

    更新日期:1993-08-01 00:00:00

  • Control of cyclosporine A-induced tumor progression using 15-deoxyspergualin for rat cardiac transplantation.

    abstract::Immunosuppressive therapy increases the risk of recurrence of initial cancers in organ transplant patients, and compelling therapeutic protocols are needed to suppress the malignancy and protect the allograft. We examined the potential use of 15-deoxyspergualin (DSG) in relation to organ transplantation and cancer. Th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000271496.75233.f6

    authors: Ohsawa I,Uemoto S,Kobayashi E,Murakami T

    更新日期:2007-08-15 00:00:00