Abstract:
BACKGROUND:Longest bipolar length of the kidney graft is routinely measured for ultrasonographic assessment of graft size (GS), although the value of the graft length remains unclear. METHODS:In a single-center, observational study involving 319 deceased-donor kidney transplant recipients, we assessed variations in absolute and adjusted GS (corrected for body surface area) between 1 and 12 months after transplantation ([INCREMENT]GS1m→12m). We tested whether variations in GS during the first year were predictive of the composite outcome of a reduction of 50% or more in the estimated glomerular filtration rate or end-stage graft failure. RESULTS:At 1 year after transplantation, 121 patients (38%) had a decrease in GS ([INCREMENT]GS1m→12m <0), and 198 patients (62%) had an increase in GS ([INCREMENT]GS1m→12m ≥0). After a median follow-up of 53 months, 41 patients with a decrease in GS reached the composite outcome as compared with 12 patients with an increase in GS (34% and 6%, respectively; P < 0.001). Areas under the receiver operating characteristics curves of absolute and adjusted [INCREMENT]GS1m→12m for composite outcome were 0.81 (95% confidence interval [95% CI], 0.74-0.88) and 0.78 (95% CI, 0.70-0.86), respectively. In multivariate analysis, the risk of the composite outcome was significantly higher among patients with a decrease in GS during the first year after transplantation (hazard ratio, 4.55; 95% CI, 2.35-8.81; P < 0.001). CONCLUSIONS:A decrease in kidney GS during the first year after transplantation, as compared with an increase in GS, is a powerful predictor of subsequent graft dysfunction or end-stage graft failure.
journal_name
Transplantationjournal_title
Transplantationauthors
Černe S,Arnol M,Kandus A,Buturović-Ponikvar Jdoi
10.1097/TP.0000000000000977subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1759-66issue
8eissn
0041-1337issn
1534-6080journal_volume
100pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Portal vein thrombosis is the most common cause of portal hypertension in noncirrhotic patients. Variceal bleeding is difficult to treat in these patients, especially those with prehepatic diffuse portal mesenteric thrombosis. In a patient with refractory esophagogastroduodenal variceal bleeding as a result of diffuse...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000168344.16547.da
更新日期:2005-08-27 00:00:00
abstract:BACKGROUND:Composite tissue allotransplantation (CTA) is a recently introduced option for limb replacement and reconstruction of other nonreconstructible tissue defects. As with recipients of other allotransplants, CTA recipients can experience rejection episodes that are presumed to be mediated by immune mechanisms si...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2005-12-27 00:00:00
abstract:BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000054619.13962.30
更新日期:2003-03-15 00:00:00
abstract:BACKGROUND:Bone marrow transplantation (BMT) for class 3 patients with thalassemia is challenging due to high rates of graft rejection and transplant-related mortality. Since the first studies of BMT in the late 1980s, a number of conditioning regimens have been designed to improve outcomes, but with suboptimal results...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000928
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. METHODS:We have related polymorphisms that influence cytokine production in the tumor n...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199709150-00021
更新日期:1997-09-15 00:00:00
abstract:BACKGROUND:Overexposure to cyclosporine is a risk factor for chronic allograft nephropathy (CAN) and dose reduction has been advocated. The purpose of this study was to determine the impact of adding the non-nephrotoxic immunosuppressant, rapamycin, after cyclosporine dose reduction in renal-allograft recipients with C...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-200303270-00008
更新日期:2003-03-27 00:00:00
abstract:BACKGROUND:Early outcomes after human immunodeficiency virus (HIV) + liver transplantation (LT) are encouraging, but data are lacking regarding long-term outcomes and comparisons with matched HIV- patients. METHODS:We examined outcomes among 180 HIV+ LT, and compared outcomes to matched HIV- counterfactuals (Scientifi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000829
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Hypoalbuminemia is associated with poorer outcomes in renal transplantation. Diabetes can compound hypoalbuminemia's detrimental effects. Kidney-pancreas transplantation alters the diabetic milieu; yet, some patients continue to be hypoalbuminemic. METHODS:We retrospectively analyzed 232 patients who underw...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199907150-00014
更新日期:1999-07-15 00:00:00
abstract::We reviewed coded autopsy material from 71 dogs, 46 receiving allogeneic and 25 receiving autologous bone marrow transplants, to evaluate the hypothesis that lymphocytic bronchitis is associated with severe acute graft-versus-host disease (GVHD). We found no significant correlation between the presence of lymphocytic ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198403000-00003
更新日期:1984-03-01 00:00:00
abstract::A retrospective study of the 99 surviving heart and lung transplant (HLT) recipients at one center showed that 31% had significant anemia (hemoglobin less than 100g/L) six months after transplantation. Chronic anemia persisted in 18% of HLT recipients two years posttransplantation. A similar study of 100 heart transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199206000-00016
更新日期:1992-06-01 00:00:00
abstract::Tolerance induction by CD45RB monoclonal antibody (mAb) in murine allograft models is associated with an alteration in the CD45RBlo/CD45RBhi T-cell ratio in favor of CD45RBlo T cells, which can function as regulatory cells and promote tolerance. It has been proposed that inversion of the CD45RBhi/CD45RBlo normal T-cel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000072373.77323.D4
更新日期:2003-07-27 00:00:00
abstract:BACKGROUND:Anti-thymocyte globulin (ATG) is used frequently as induction therapy in renal transplant recipients. It has been standard practice that the various polyclonal anti-lymphocyte preparations be administered via central line, vascular shunt, or arteriovenous fistula to avoid thrombophlebitis. METHODS:We have s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005150-00038
更新日期:2000-05-15 00:00:00
abstract::To gain insight into the contribution of immunologic and hemodynamic factors in the progressive demise of structure and function in chronic renal allograft dysfunction, we studied the histological changes, the immunostainable glomerular anionic sites, and glomerular capillary hydrostatic pressures of rat renal allogra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612150-00018
更新日期:1996-12-15 00:00:00
abstract::Athymic PVG-rnu/rnu (RT1c) rats were grafted with skin bearing isolated MHC disparities 7-14 days in advance of cell transfer. The ability of naive CD4+ or CD8+ thoracic duct lymphocytes to induce rejection was assessed by adoptive transfer of one or both T cell subsets into nude recipients bearing congenic PVG.r1 (MH...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Preexisting diabetes mellitus (DM) has been regarded as a contraindication to heart transplantation (HT). This prejudice has been based upon concern over increased infection rates and worsening DM with the initiation of prednisone immunosuppression. To better evaluate these suppositions, we reviewed our experience wit...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199002000-00015
更新日期:1990-02-01 00:00:00
abstract::Despite great improvements in renal allograft survival over the last 3 decades, long-term graft loss, particularly through antibody-mediated rejection, remains the bane of kidney transplantation. Interindividual patient variation means that a given immunosuppressive regimen may be inadequate in certain patients and ex...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e3181a2e295
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:Delayed graft function and acute rejections adversely affect the long-term survival of kidney transplantation. To decrease the incidences of these phenomena, we changed the initial immunosuppressive protocol in pediatric kidney transplantation in The Netherlands. METHODS:We compared a cohort (n=123) treated...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0b013e318187c3ad
更新日期:2008-11-15 00:00:00
abstract:BACKGROUND:The use of anti-B-cell and T-cell immunosuppressive agents leads to only a few weeks' survival of mouse-to-rat cardiac xenografts. METHODS:BALB/c cardiac xenografts were transplanted to Lewis rats treated with cyclosporine (CsA) and/or cobra venom factor (CVF). RESULTS:CsA alone did not prolong xenograft s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199805150-00012
更新日期:1998-05-15 00:00:00
abstract::In the USA approximately 10% of candidates for renal transplantation have serum antibodies to hepatitis C (HCV). To assess the possible impact of HCV infection on early posttransplant events we assessed allograft complications during the first 6 months following renal transplantation in three groups of adult renal all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199610270-00004
更新日期:1996-10-27 00:00:00
abstract::Advances in immunosuppression have reduced the incidence of acute graft loss after transplantation, but long-term allograft survival is still hindered by the development of chronic allograft injury, a multifactorial process that involves both immunologic and nonimmunologic components. Because these components become d...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e3181efcfbc
更新日期:2010-11-15 00:00:00
abstract::The safety of the use of kidneys procured from a hepatitis C virus (HCV)-positive cadaver donors in transplantation has recently been the subject of controversy. One factor that is important in determining the transmission of the virus and/or viral liver disease is the total viral inoculum to which the renal allograft...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199403270-00011
更新日期:1994-03-27 00:00:00
abstract:BACKGROUND:Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. METHODS:To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822c6e89
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:Steroid-resistant acute rejection is a risk factor for inferior renal allograft outcome. METHODS:From 873 kidney transplant recipients (1995-2005), 108 patients with a first rejection episode were selected for study using strict inclusion criteria and clinical endpoint definition. We aimed to predict respon...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825db651
更新日期:2012-09-27 00:00:00
abstract:BACKGROUND:There are limited data on the outcome of transplant recipients with familial Mediterranean fever (FMF)-associated AA amyloidosis. The aim of the present study is to evaluate demographic, clinical, laboratory, and prognostic characteristics and outcome measures of these patients. METHODS:Eighty-one renal tra...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000003043
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies produced after transplantation are frequently measured in transplant recipients, because they are strongly associated with humoral rejection and graft loss. However, antibodies can be induced by posttransplant blood transfusions rather than by the graft, casting doubt...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a24b96
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:The depletion of differential B cell and xenoreactive natural antibodies (XNA) by anti-delta and anti-mu injections was analyzed in adult mice. Sequential treatment with anti-delta and then anti-mu induces a complete depletion of B cells and XNA and represents a potential approach to induce xenograft toleran...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199912150-00017
更新日期:1999-12-15 00:00:00
abstract::Four skin graft models are created which vary in the rates of lymphatic and vascular reconstitution. Rat allografts (Brown Norway or (L times BN)F1 hybrid) transplanted to Lewis recipients by conventional (immediate lymphatic, delayed vascular), surgical anastomosis (immediate lymphatic, immediate vascular) or isolate...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197502000-00008
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND:Status 1A patients are prioritized over liver disease patients regardless of Model for End-stage Liver Disease (MELD) score. We aimed to identify groups with high waitlist mortality in Status 1A and MELD ≥40 patients to determine who would most benefit from transplantation. METHODS:Data on patients listed a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002651
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Treatment of chronic hepatitis C virus (HCV) infection after renal allograft transplantation has been an obstacle because of contraindications associated with IFN-based therapies. Direct-acting antiviral agents are highly efficient treatment options that do not require IFN and may not require ribavirin. Ther...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001414
更新日期:2017-05-01 00:00:00
abstract::A group of 170 patients having functional renal allografts were evaluated at least six months after renal transplantation. They were assessed for symptoms and signs of tendinitis in the Achilles and Supraspinatus tendons. Of the 170 patients, 34 had tendinitis. Four patients (11.8%) had spontaneous rupture of the Achi...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00