Abstract:
:A retrospective study of the 99 surviving heart and lung transplant (HLT) recipients at one center showed that 31% had significant anemia (hemoglobin less than 100g/L) six months after transplantation. Chronic anemia persisted in 18% of HLT recipients two years posttransplantation. A similar study of 100 heart transplant recipients showed no unexplained anemic patients. The prevalence of anemia after HLT was unrelated to the original diagnosis, immunosuppression, or acute rejection. All HLT recipients appeared to be unduly sensitive to the myelosuppressive effects of azathioprine. Detailed studies in 16 representative patients showed a normochromic, anisocytotic anemia with normal reticulocyte counts, B12 and folate levels, and haptoglobin levels and appropriate erythropoietin levels--but increased ESRs, low/normal iron levels and low/normal total iron binding capacity, normal or raised ferritin levels, and autoantibodies in 4 (25%). Bone marrow aspirates in 10 patients showed dyshemopoiesis out of proportion to the degree of anemia and colonies of activated lymphoid cells. The cause for this anemia appears to be a combination of anemia of chronic disease and dyshemopoiesis, both of uncertain etiology.
journal_name
Transplantationjournal_title
Transplantationauthors
Hunt BJ,Amin S,Halil O,Yacoub Mdoi
10.1097/00007890-199206000-00016subject
Has Abstractpub_date
1992-06-01 00:00:00pages
1251-6issue
6eissn
0041-1337issn
1534-6080journal_volume
53pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::We report the successful application of a hybrid artificial pancreas device for the treatment of severe diabetes mellitus induced by total pancreatectomy in two dogs. Control of the blood sugar was achieved for more than 1 year in these two animals without any immunosuppressive therapy. Although exogenous insulin was ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199304000-00005
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS. METHODS:We conducted a retrospective stu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829eda4f
更新日期:2013-10-15 00:00:00
abstract::Class I molecules of the MHC affect target cell sensitivity to NK cell repertoire. In the mouse, absence of MHC class I molecules on target cells is associated with an increased susceptibility to NK cell-mediated lysis, while syngeneic class I molecules confer protection. In contrast to the protective role of syngenei...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199508000-00013
更新日期:1995-08-15 00:00:00
abstract:BACKGROUND:We previously reported the novel activity of alloprimed CD8 T cells that suppress posttransplant alloantibody production. The purpose of the study is to investigate the expression and role of CXCR5 on antibody-suppressor CD8 T-cell function. METHODS:C57BL/6 mice were transplanted with FVB/N hepatocytes. All...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002683
更新日期:2019-09-01 00:00:00
abstract:INTRODUCTION:The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice. METHODS:Allogeneic hepatocytes (FVB/N, H-2q) were transplanted into C57BL/6....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200012270-00017
更新日期:2000-12-27 00:00:00
abstract:BACKGROUND:Delayed graft function (DGF) is associated with acute tubular necrosis. In this setting, surviving tubular cells may proliferate and replace injured cells. CD133Pax-2cells may play a role in the regeneration of tubular damage. The aim of this study was to demonstrate the presence of these cells in human kidn...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816a8891
更新日期:2008-04-27 00:00:00
abstract::Using C1q binding, Kg binding, and Raji cell radioimmunoassays, the relationship between renal allograft rejection and the circulating immune complexes was examined in 90 patients with renal transplants. The data showed that there was a significant quantitative correlation between C1q-binding and Raji-cell-binding act...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198308000-00009
更新日期:1983-08-01 00:00:00
abstract::Four skin graft models are created which vary in the rates of lymphatic and vascular reconstitution. Rat allografts (Brown Norway or (L times BN)F1 hybrid) transplanted to Lewis recipients by conventional (immediate lymphatic, delayed vascular), surgical anastomosis (immediate lymphatic, immediate vascular) or isolate...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197502000-00008
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND:Epitopes are the sites to which antibodies bind. Both alpha and beta peptide chains of the human leukocyte antigen-DQ heterodimers (DQA1 and DQB1, respectively) contain polymorphic regions. We can identify DQA1 and DQB1 epitopes by DQ single antigen beads assay of the antibodies, correlating the beads' react...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181804cd2
更新日期:2008-08-15 00:00:00
abstract::Pulmonary endothelium is considered the compartment most susceptible to preservation damage. This investigation was designed to analyze the efficacy of an original, University of Parma low-potassium-albumin solution (SPAL UP) on cultured human pulmonary artery endothelial cells (HPAEC) and to compare its effects with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611150-00036
更新日期:1996-11-15 00:00:00
abstract:BACKGROUND:Clinical studies suggest that the immunosuppressant mycophenolate mofetil is associated with anemia. However, the mechanism for this is not known. Here, we studied the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropoiesis in vitro. METHODS:Both UT-7 cells and p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318238da98
更新日期:2011-12-27 00:00:00
abstract:BACKGROUND:There are few prospective studies of prednisone-free immunosuppression (IS) in pediatric kidney transplant (KTx) recipients. We studied the outcomes of a protocol using rapid discontinuation of prednisone (RDP, <1 week) and thymoglobulin induction. METHODS:Twenty-one RDP recipients (mean age 14+/-3 years) r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ac6833
更新日期:2009-07-27 00:00:00
abstract:BACKGROUND:To define whether immunosuppressive agents that block the interleukin (IL)-2 pathway could prevent activation-induced cell death of activated T cells in the graft, we measured expression of IL-2, IL-2 receptor alpha chain (CD25), IL-15, Fas, and Fas ligand by real time reverse transcription-polymerase chain ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.TP.0000063937.53702.97
更新日期:2003-05-27 00:00:00
abstract::The humoral theory states that antibodies cause the rejection of allografts. From 1917 to 1929, extensive efforts were made to produce antibodies against tumors. It was finally realized that the antibodies were produced against the transplant antigens present on transplantable tumors, not against the tumor-specific an...
journal_title:Transplantation
pub_type: 历史文章,杂志文章
doi:10.1097/TP.0b013e3182483713
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:Solitary pancreas transplants, both pancreas transplant alone (PTA) and pancreas after kidney (PAK), have higher rejection rates and lower graft survivals than simultaneous pancreas-kidney transplants (SPK). The aim of this study is to compare three different antibody induction regimens in solitary pancreas ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200111270-00017
更新日期:2001-11-27 00:00:00
abstract:BACKGROUND:A pancreas transplant alone (PTA) in a nonuremic patient with brittle diabetes mellitus remains a rare procedure because the tradeoff for insulin independence is lifelong immunosuppression. METHODS:Herein we report our results at the University of Minnesota of 513 PTAs from December 17, 1966, through Decemb...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000296820.46978.3f
更新日期:2008-01-15 00:00:00
abstract:BACKGROUND:Genetic variants of the renin-angiotensin system (RAS) have been implicated in the progression of native kidney diseases. A decreased long-term renal allograft function has also been associated with increased activity of RAS, which may be genetically determined. METHODS:The effect of the angiotensinogen (AG...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200203270-00023
更新日期:2002-03-27 00:00:00
abstract::The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a pivotal role in cellular metabolism and in a wide range of eukaryotic biological/cellular functions and signaling networks. Additionally, as ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001806
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Successful islet transplantation can result in insulin independence in many patients with type 1 diabetes mellitus, but it often requires more than one islet infusion. The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited org...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c478fd
更新日期:2010-02-27 00:00:00
abstract::In a prospective randomized double-blind placebo-controlled trial, the effect of rh-SOD, given in a dose of 200 mg intravenously during surgery to cyclosporine-treated recipients of cadaveric renal allografts, on both acute and chronic rejection events as well as patient and graft survival was investigated by analyzin...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199401001-00010
更新日期:1994-01-01 00:00:00
abstract::We have previously shown that trophic factor supplementation (TFS) of University of Wisconsin (UW) solution enhanced kidney viability after cold storage. Here, we use an in vitro model to study the effect of TFS on early apoptotic changes after cold ischemic storage. Mitochondrial membrane potential was determined by ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000242524.35562.4b
更新日期:2007-01-15 00:00:00
abstract::The results of kidney retransplantation in the cyclosporine era remain to be determined. Over a 42-month period, 76 nonprimary renal transplants (66 second, 7 third, 3 fourth allografts) were performed in 73 recipients under cyclosporine immunosuppression. The patient population was predominantly white (90.4%) with a ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Bone marrow cells (BMCs) are believed to have the ability to generate functional hepatocytes and have some merits as a therapeutic modality for metabolic liver diseases. However, the appearance of BMC-derived hepatocytes (BMDHs) is low. We hypothesized that early BMC injection would be feasible for creating ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31819e0528
更新日期:2009-04-27 00:00:00
abstract::Rapamycin prolongs allograft survival and induces donor-specific tolerance in some small animal transplant models. Large animal studies, however, are limited. We studied rapamycin in a porcine renal allograft model. Donor-recipient combinations were chosen based on high response in pretransplant MLCs. Allografts were ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised. METHODS:Forty-three hepatitis B virus car...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199906150-00006
更新日期:1999-06-15 00:00:00
abstract:BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000178378.53616.ca
更新日期:2005-11-15 00:00:00
abstract:BACKGROUND:A precise understanding of immunological mechanisms is needed to prevent transplant vasculopathy. METHODS:The developing process of transplant vasculopathy was investigated by retransplanting rat cardiac allografts and measuring the expressions of 21 different genes inside the retransplanted allografts unde...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200009150-00005
更新日期:2000-09-15 00:00:00
abstract:BACKGROUND:We herein investigate critical ischemia times and the effect of novel preservation solutions such as new histidine-tryptophan-ketoglutarate (HTK-N) and TiProtec on the individual tissues of a rat limb isograft. METHODS:Orthotopic hind-limb transplantations were performed in male Lewis rats after 2 hours, 6 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001845
更新日期:2017-09-01 00:00:00
abstract::BALB/cxDBA/2Wf F1 (CD2F1) mice were lethally irradiated and reconstituted with syngeneic bone marrow cells untreated or treated with 75 micrograms/ml of mafosfamide. One day after bone marrow transplantation some groups of mice were injected with syngeneic splenocytes, peripheral blood leukocytes, or thymocytes. Seven...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199104000-00020
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Organ transplantation has been successfully practiced for decades, but the outcome of cell transplantation remains disappointing. This is the case in animal models; liver allografts in mice are spontaneously accepted without requirement of immunosuppression, whereas hepatocyte transplants in the same combina...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818bfd13
更新日期:2008-12-15 00:00:00