Natural killer cell interaction with murine allogeneic MHC class I molecules.


:Class I molecules of the MHC affect target cell sensitivity to NK cell repertoire. In the mouse, absence of MHC class I molecules on target cells is associated with an increased susceptibility to NK cell-mediated lysis, while syngeneic class I molecules confer protection. In contrast to the protective role of syngeneic class I molecules, less is known about the interaction between murine NK cells and allogenic class I MHC molecules. In theory, such could either be triggering, inert, or inhibitory. To directly address the role of allogeneic class I in interaction with NK cells of the mouse, a panel of polyclonal allogeneic murine NK cells were exposed to H-2b class I positive or negative target cells, and susceptibility to lysis was assessed. For all effectors studied, regardless of H-2 haplotype or genetic background, a preferential killing of class I-deficient targets was observed. This pattern was observed in vitro with tumor as well as lymphoblast targets, and in vivo in rapid elimination studies of radiolabeled tumor cells. The results demonstrate that protection from murine NK cell-mediated lysis can be conferred by the expression of allogeneic class I molecules. No evidence for a triggering effect caused by the expression of allogeneic class I molecules was observed. The data are discussed in relation to current models on NK cell/MHC class I interactions, alloreactivity mediated by NK cells, and the role of NK cells in allogeneic graft rejection responses.






Salcedo M,Höglund P,Ljunggren HG




Has Abstract


1995-08-15 00:00:00












  • Donor age affects fibrosis progression and graft survival after liver transplantation for hepatitis C.

    abstract:BACKGROUND:The use of liver allografts from an older donor (OD) (age>50 years) is a widespread strategy to manage the disparity between supply and demand of organs for liver transplantation. This study determines the effect of OD allografts on fibrosis progression and graft survival after liver transplantation in patie...


    pub_type: 杂志文章


    authors: Machicao VI,Bonatti H,Krishna M,Aqel BA,Lukens FJ,Nguyen JH,Rosser BG,Satyanarayana R,Grewal HP,Hewitt WR,Harnois DM,Crook JE,Steers JL,Dickson RC

    更新日期:2004-01-15 00:00:00

  • Effect of cyclosporine, cyclosporine metabolite 17, and other cyclosporine-related compounds on T lymphocyte clones derived from rejected human kidney grafts. I. Inhibition of proliferation.

    abstract::The effect of cyclosporine and metabolite 17 (M17) as well as other CsA-related compounds (CsG, dihydro-CsC, dihydro-CsD, CsH, B5.49, and H7.94) was tested on T lymphocyte clone proliferation. In these experiments, antigen and interleukin 2 (IL-2) dependent long-term T lymphocyte clones derived from a rejected human k...


    pub_type: 杂志文章


    authors: Chabannes D,Moreau JF,Soulillou JP

    更新日期:1987-12-01 00:00:00

  • Higher frequency of high-grade rejections in cardiac allograft patients after Quilty B lesions or grade 2/4 rejections.

    abstract:BACKGROUND:To better understand how different histologic patterns of allograft inflammation found on biopsies of human cardiac allografts progress to high-grade rejection, we undertook a statistical analysis of our institutional database to detect statistical patterns among different types of myocardial allograft infla...


    pub_type: 杂志文章


    authors: Smith RN,Chang Y,Houser S,Dec GW,Grazette L

    更新日期:2002-06-27 00:00:00

  • Alloimmunization-activated suppressor cells. II. In vitro activity of suppressor cells implicated in the abrogation of lethal graft-versus-host reaction.

    abstract::Incompatibility for DBA/2 (D2) minor histocompatibility antigens (MiHA) alone leads to a severe lethal graft-versus-host reaction (GVHR) in irradiated (D2 X B10.D2)F1 mice receiving a bone-marrow-plus-spleen-cell graft from B10.D2 donors. This mortality is abrogated when the donors are preimmunized simultaneously agai...


    pub_type: 杂志文章


    authors: Pritchard LL,Halle-Pannenko O

    更新日期:1983-09-01 00:00:00

  • Murine xenogeneic immune responses to the human testis: a presumed immune-privileged tissue.

    abstract:INTRODUCTION:Immune privilege provides a natural paradigm for potentially down-regulating allogeneic and xenogeneic inflammatory immune responses. Fas ligand has been suggested as a general underlying mechanism of immune privilege; the human Fas ligand has been shown to ligate murine Fas in vitro. METHODS:In this stud...


    pub_type: 杂志文章


    authors: Kimmel SG,Ohbatake M,Kushida M,Merguerian P,Clarke ID,Kim PC

    更新日期:2000-03-27 00:00:00

  • Increased negative impact of donor HLA-specific together with non-HLA-specific antibodies on graft outcome.

    abstract:BACKGROUND:De novo donor HLA-specific (dnDSA) and non-HLA antibodies including antiangiotensin type 1 receptor antibodies (AT1R-abs) have been associated with antibody-mediated rejection (AMR) and decreased graft survival as well as cellular-mediated rejection (CMR) and early onset of microvasculopathy in heart transpl...


    pub_type: 杂志文章


    authors: Reinsmoen NL,Lai CH,Mirocha J,Cao K,Ong G,Naim M,Wang Q,Haas M,Rafiei M,Czer L,Patel J,Kobashigawa J

    更新日期:2014-03-15 00:00:00

  • Description of B lymphocytes and plasma cells, complement, and chemokines/receptors in acute liver allograft rejection.

    abstract:BACKGROUND:Although antibody mechanisms play a pathogenetic role in liver allograft rejection, no data exist on B lymphocytes, plasma cells, complement, and chemokines in rejected liver tissue. METHODS:Liver biopsy specimens from 25 patients with acute allograft rejection (AR) (rejection activity index, RAI score: 1-9...


    pub_type: 杂志文章


    authors: Krukemeyer MG,Moeller J,Morawietz L,Rudolph B,Neumann U,Theruvath T,Neuhaus P,Krenn V

    更新日期:2004-07-15 00:00:00

  • Terminal sialic acid residues on human glycophorin A are recognized by porcine kupffer cells.

    abstract:BACKGROUND:We have previously shown that recognition of human erythrocytes by porcine Kupffer cells is mediated by a carbohydrate-dependent mechanism. The present study explores the possible ligands existing on human glycophorin A and tests their ability to inhibit erythrocyte rosette formation. METHODS:Human erythroc...


    pub_type: 杂志文章


    authors: Burlak C,Twining LM,Rees MA

    更新日期:2005-08-15 00:00:00

  • Enhancement of rat kidney allografts using haptenated alloantigens and antihapten antibody.

    abstract::The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--...


    pub_type: 杂志文章


    authors: Barber WH,Hutchinson IV,Morris PJ

    更新日期:1983-11-01 00:00:00

  • Direct induction of MHC class I, but not class II, expression on endothelial cells by cytomegalovirus infection.

    abstract::MHC expression on endothelial cells after cytomegalovirus infection was investigated using double antibody radioimmunoassays and immunofluorescence flow cytometry. After CMV infection there was an increase in class I and beta 2 microglobulin expression. This increase corresponds to the percentage of cells that are inf...


    pub_type: 杂志文章


    authors: van Dorp WT,Jonges E,Bruggeman CA,Daha MR,van Es LA,van Der Woude FJ

    更新日期:1989-09-01 00:00:00

  • Preemptive living donor kidney transplantation: do the benefits extend to all recipients?

    abstract:BACKGROUND:Preemptive kidney transplantation (prior to the institution of dialysis) avoids the morbidity and mortality of dialysis; however, detailed studies of high-risk patients are lacking. The aim of the current study was to compare recent outcomes of preemptive (P) versus nonpreemptive (NP) living donor kidney tra...


    pub_type: 杂志文章


    authors: Innocenti GR,Wadei HM,Prieto M,Dean PG,Ramos EJ,Textor S,Khamash H,Larson TS,Cosio F,Kosberg K,Fix L,Bauer C,Stegall MD

    更新日期:2007-01-27 00:00:00

  • A simplified model for heterotopic rat heart transplantation.

    abstract::A technique for simplified heterotopic rat heart transplantation having only aorto-aortic anastomosis is presented. The heterotopic rt heart survives and functions well when one lung lobe is attached t the transplantation and functions as a reservoir. Iso- and allotransplants are compared by electrocardiogram (ECG) de...


    pub_type: 杂志文章


    authors: Lee S,Macedo AR,Curtis GP,Lee D,Orloff MJ

    更新日期:1982-04-01 00:00:00

  • Sequential antilymphoblast globulin and cyclosporine for renal transplantation.

    abstract::The nephrotoxic effects of cyclosporine (CsA) seem to be augmented by co-existing renal injury. A high rate of prolonged delayed function (acute tubular necrosis [ATN]) and non-function (NF) has been associated with the use of CsA prior to and following renal transplantation. Cyclosporine has also been associated with...


    pub_type: 杂志文章


    authors: Sommer BG,Henry M,Ferguson RM

    更新日期:1987-01-01 00:00:00

  • Science of composite tissue allotransplantation.

    abstract::The science of composite tissue allotransplantation (CTA) is rooted in progressive thinking by surgeons, fueled by innovative solutions, and aided by understanding the immunology of tolerance and rejection. These three factors have allowed CTA to progress from science fiction to science fact. Research using preclinica...


    pub_type: 杂志文章,评审


    authors: Swearingen B,Ravindra K,Xu H,Wu S,Breidenbach WC,Ildstad ST

    更新日期:2008-09-15 00:00:00

  • Donor-specific skin transplants activate allodestructive T cells in mice resistant to neonatal H-2 tolerance induction.

    abstract::Mice of the B10 background that are class II I-E nonexpressing demonstrate a relative resistance to neonatal induction of tolerance of class I alloantigens from I-E-expressing B10 strains. The majority of these injected mice delete donor-responsive and "I-E-reactive" (V beta 11+) cells in the immediate postinoculation...


    pub_type: 杂志文章


    authors: Nassiri M,Viciana A,Streilein JW,Ruiz P

    更新日期:1993-12-01 00:00:00

  • Long-term culture of islets abrogates cytokine-induced or lymphocyte-induced increase of antigen expression on beta cells.

    abstract:BACKGROUND:Immunogenicity of a graft depends on its expression of major histocompatability complex (MHC) antigens and adhesion molecules and on the amount of intragraft leukocytes, the so-called passenger leukocytes. Although long-term culture reduces passenger leukocytes, permanent acceptance is not necessarily observ...


    pub_type: 杂志文章


    authors: Kuttler B,Hartmann A,Wanka H

    更新日期:2002-08-27 00:00:00

  • Ontogeny of suppressor cells. II. Suppression of graft-versus-host and mixed leukocyte culture responses by embryonic cells.

    abstract::Ontogenic development of suppressor cells was studied in mouse embryos. It was found that liver cells of embryos at various stages of gestation were capable of interfering with the mixed leukocyte culture (MLC) reaction. The MLC reaction was also inhibited by embryonic spleen and thymus cells. However, the latter were...


    pub_type: 杂志文章


    authors: Globerson A,Umiel T

    更新日期:1978-12-01 00:00:00

  • Adherence to Lamivudine after an early withdrawal of hepatitis B immune globulin plays an important role in the long-term prevention of hepatitis B virus recurrence.

    abstract::Lamivudine combined with hepatitis B immune globulin (HBIg) is the standard of care for preventing the recurrence hepatitis B virus after liver transplant. To determine the risk of hepatitis B virus (HBV) recurrence after early withdrawal of HBIg in patients receiving lamivudine maintenance therapy, 20 patients receiv...


    pub_type: 杂志文章,随机对照试验


    authors: Buti M,Mas A,Prieto M,Casafont F,González A,Miras M,Herrero JI,Jardi R,Esteban R

    更新日期:2007-09-15 00:00:00

  • The large center variation in half-lives of kidney transplants.

    abstract::Based on a log-linear model for analyzing multiple effects, center variation in the UCLA Transplant Registry is the most influential factor in early renal graft survival. Among 68 active centers accounting for 70% of all transplants between 1985 and 1989, the 1-year graft survival (adjusted for 15 covariates) varied f...


    pub_type: 杂志文章


    authors: Gjertson DW,Terasaki PI

    更新日期:1992-02-01 00:00:00

  • Long-term metabolic control of autoimmune diabetes in spontaneously diabetic nonobese diabetic mice by nonvascularized microencapsulated adult porcine islets.

    abstract:BACKGROUND:The long-term metabolic function of microencapsulated xenogeneic adult porcine islets (API) was assessed in a murine model of type 1 diabetes mellitus. METHODS:API were encapsulated in barium-gelled alginate and transplanted intraperitoneally in diabetic nonobese diabetic (NOD) mice given no immunosuppressi...


    pub_type: 杂志文章


    authors: Cui H,Tucker-Burden C,Cauffiel SM,Barry AK,Iwakoshi NN,Weber CJ,Safley SA

    更新日期:2009-07-27 00:00:00

  • The impact of donor and recipient hepatitis B surface antigen status on liver disease and survival in renal transplant recipients.

    abstract::Ninety-eight renal transplant recipients who had been followed for 1-6.5 years (median 3.2 years) were reviewed to determine the effect of donor and recipient hepatitis B surface antigen status on the incidence of hepatitis and on patient survival. The cumulative risk of developing hepatitis posttransplant was signifi...


    pub_type: 杂志文章


    authors: Chan PC,Lok AS,Cheng IK,Chan MK

    更新日期:1992-01-01 00:00:00

  • Effect of preprocurement ventilation on lungs donated after cardiac death in a canine lung transplantation model.

    abstract:BACKGROUND:One method of countering chronic lung donor shortages is the practice of donation after cardiac death (DCD). However, this technique inevitably leads to pulmonary dysfunction related to warm ischemia. One promising method of alleviating this problem is ventilation. However, it can rarely be initiated from th...


    pub_type: 杂志文章


    authors: Sakamoto J,Chen F,Yamada T,Nakajima D,Ohsumi A,Kikuchi R,Zhao X,Fujinaga T,Shoji T,Sakai H,Bando T,Date H

    更新日期:2011-10-27 00:00:00

  • Associations between cyclosporine therapy and interstitial fibrosis in renal allograft biopsies.

    abstract::A retrospective masked study of 120 consecutive renal transplant biopsies was performed to evaluate the potential associations of cyclosporine (CsA) therapy and other factors on the degree and progression of interstitial fibrosis (IF). Allograft biopsies were obtained from patients receiving CsA (CsA+; n = 59) and not...


    pub_type: 杂志文章


    authors: Ruiz P,Kolbeck PC,Scroggs MW,Sanfilippo F

    更新日期:1988-01-01 00:00:00

  • Cyclosporine nephrotoxicity in cardiac allograft patients--a seven-year follow-up.

    abstract::Renal function was observed retrospectively in a population of 228 adults who underwent a cardiac allograft at the University of Pittsburgh from June 1980 through June 1987, survived a minimum of one year, and received cyclosporine. Renal function was determined by serial measurement of serum creatinine concentration....


    pub_type: 杂志文章


    authors: Greenberg A,Thompson ME,Griffith BJ,Hardesty RL,Kormos RL,el-Shahawy MA,Janosky JE,Puschett JB

    更新日期:1990-10-01 00:00:00

  • Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up.

    abstract::Hepatocyte transplantation is an investigational alternative to orthotopic liver transplantation to treat liver based inborn errors of metabolism. We report successful hepatocyte transplantation in a 4-year-old girl with infantile Refsum disease. Hepatocytes were isolated from the left liver segment of two male donors...


    pub_type: 杂志文章


    authors: Sokal EM,Smets F,Bourgois A,Van Maldergem L,Buts JP,Reding R,Bernard Otte J,Evrard V,Latinne D,Vincent MF,Moser A,Soriano HE

    更新日期:2003-08-27 00:00:00

  • Establishment of canine pulmonary hypertension with dehydromonocrotaline. Importance of larger animal model for lung transplantation.

    abstract::Single lung isografting in rats with pulmonary hypertension has been reported. However, it is hard to evaluate cardiopulmonary hemodynamics accurately or to use circulatory assists during procedures using rats. Therefore, we tried to establish a model of pulmonary hypertension in the beagle. Twenty young beagles were ...


    pub_type: 杂志文章


    authors: Okada M,Yamashita C,Okada M,Okada K

    更新日期:1995-07-15 00:00:00

  • Functional abnormalities of sinusoidal endothelial cells in rats with acute liver rejection.

    abstract::The purpose of this study was to determine the changes of hepatic sinusoidal endothelial cell (SEC) function in acute liver rejection with respect to receptor-mediated endocytosis. Orthotopic rat liver transplantation was performed in Lewis rats grafted with DA livers and in Lewis rats grafted with Lewis livers as rej...


    pub_type: 杂志文章


    authors: Yokoi Y,Nakamura S,Muro H,Baba S

    更新日期:1994-01-01 00:00:00

  • Evaluation of Low- Versus High-dose Valganciclovir for Prevention of Cytomegalovirus Disease in High-risk Renal Transplant Recipients.

    abstract:BACKGROUND:Despite proven efficacy of prolonged cytomegalovirus (CMV) prophylaxis using valganciclovir 900 mg/day, some centers use 450 mg/day due to reported success and cost savings. This multicenter, retrospective study compared the efficacy and safety of 6 months of low-dose versus high-dose valganciclovir prophyla...


    pub_type: 杂志文章,多中心研究


    authors: Gabardi S,Asipenko N,Fleming J,Lor K,McDevitt-Potter L,Mohammed A,Rogers C,Tichy EM,Weng R,Lee RA

    更新日期:2015-07-01 00:00:00

  • Multivariate analysis of donor risk factors for graft survival in kidney transplantation.

    abstract:BACKGROUND:The results of the transplantation of marginal donor kidneys remain controversial. This study aimed to investigate the impact of donor risk factors as predictors of kidney-graft outcome. METHODS:Allograft failure risk factors were studied in 7,209 cadaveric kidney-transplant recipients reporting to the Etab...


    pub_type: 杂志文章


    authors: Pessione F,Cohen S,Durand D,Hourmant M,Kessler M,Legendre C,Mourad G,Noël C,Peraldi MN,Pouteil-Noble C,Tuppin P,Hiesse C

    更新日期:2003-02-15 00:00:00

  • Bladder augmentation using tissue-engineered autologous oral mucosal epithelial cell sheets grafted on demucosalized gastric flaps.

    abstract:BACKGROUND:At present, autologous intestinal segments are often used for bladder reconstruction. However, the gastrointestinal mucosa often causes various complications. METHODS:Oral mucosal tissues were obtained from the buccal cavity of beagle dogs. Primary oral mucosal epithelial cells were cultured on temperature-...


    pub_type: 杂志文章


    authors: Watanabe E,Yamato M,Shiroyanagi Y,Tanabe K,Okano T

    更新日期:2011-04-15 00:00:00