Abstract:
:Preexisting diabetes mellitus (DM) has been regarded as a contraindication to heart transplantation (HT). This prejudice has been based upon concern over increased infection rates and worsening DM with the initiation of prednisone immunosuppression. To better evaluate these suppositions, we reviewed our experience with diabetic patients who underwent HT. Between 6/80 and 1/88, 367 nondiabetics (NDs) and 19 diabetics underwent HT at our institution. Of the 19 diabetic recipients (DRs), two were black and four were female. Six DRs were on insulin (average daily dose: 46 U) prior to HT, and the remainder required oral hypoglycemic agents. Following HT, five DRs had insulin substituted for oral hypoglycemics. The 11 insulin-dependent DRs now require an average daily dose of 48 U. The average duration of follow-up for the 19 DRs was 17 months (range 1-67 months). During this time, 5 hospitalizations were required for complications of diabetes. The rejection rate was not higher for the DRs than the NDs (0.37 events/100 pt. days vs. 0.51 events/100 pt. days). The DRs who have undergone coronary angiography up to 4 years following HT have had no evidence of coronary atherosclerosis. Three-year survival for DRs and NDs is similar. DRs have a slightly higher incidence of lethal infections than NDs, which is not statistically significant (16% at 17 months vs. 10% (p greater than 0.4). We conclude that carefully selected diabetics can undergo HT with minimal consequent worsening of their DM. Diabetic HT recipients do not suffer a higher incidence of graft atherosclerosis, rejection, or lethal infection.
journal_name
Transplantationjournal_title
Transplantationauthors
Ladowski JS,Kormos RL,Uretsky BF,Griffith BP,Armitage JM,Hardesty RLdoi
10.1097/00007890-199002000-00015subject
Has Abstractpub_date
1990-02-01 00:00:00pages
303-5issue
2eissn
0041-1337issn
1534-6080journal_volume
49pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::This study extends the finding that intrathymic (IT) injection of 3M KC1 extracts of T cells induces transplant tolerance to the use of well defined polymorphic MHC class I allopeptides derived from the hypervariable domain of RT1.Au (WF MHC class I). While three of the six synthetic RT1.Au peptides were immunogenic, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00034
更新日期:1996-12-27 00:00:00
abstract:BACKGROUND:CTLA4 immunoglobulin (Ig)G that binds to B7 effectively inhibits the signaling of CD28/CTLA4-B7 pathway and induces antigen specific T cell unresponsiveness in vitro and in vivo. Using CTLA4IgG, we examined induction of long-term graft survival and the mechanism of maintenance of tolerance in rat allogeneic ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199902270-00005
更新日期:1999-02-27 00:00:00
abstract:BACKGROUND:Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. METHODS:To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822c6e89
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:Cytotoxic IgG against class I antigens can contribute to renal dysfunction or failure after transplantation. However, the clinical relevance of IgG measured by flow cytometric cross-matching is controversial. This study correlated pre- and postoperative flow reactivity with clinical outcome among renal trans...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802150-00029
更新日期:1998-02-15 00:00:00
abstract::Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000202846.17619.a4
更新日期:2006-04-27 00:00:00
abstract:BACKGROUND:HLAMatchmaker is a computer algorithm that determines human leukocyte antigen (HLA) compatibility at the level of polymorphic amino acid triplets in antibody-accessible sequence positions. Recent studies have shown that HLA-DR-matched kidney transplant recipients with zero to two triplet mismatches had almos...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000055097.58209.83
更新日期:2003-03-27 00:00:00
abstract:BACKGROUND:We developed a nonviral gene transfer method using rapid injection of naked DNA targeting the liver and applied it in a rat model of liver transplantation. METHODS:Inbred Dark Agouti and Lewis rats were used. To test the efficacy and adverse effects of systemic or local (catheter-based) injection, different...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000118404.66106.e8
更新日期:2004-04-15 00:00:00
abstract::Fox kidney and skin grafts were transplanted into dog recipients. Fox kidneys, transplanted en bloc into untreated dogs, survived 6.2 +/- 0.4 days. The skin transplants survived 5.9 +/- 1.4 days. The grafted kidneys showed almost normal function before rejection. Both skin and kidney rejection were mediated through a ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197508000-00009
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:De novo donor HLA-specific (dnDSA) and non-HLA antibodies including antiangiotensin type 1 receptor antibodies (AT1R-abs) have been associated with antibody-mediated rejection (AMR) and decreased graft survival as well as cellular-mediated rejection (CMR) and early onset of microvasculopathy in heart transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000436927.08026.a8
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:The development of kidney dysfunction is one of the most important after liver transplantation (LT). Genetic variants of pathogenetically relevant cytokines may influence the development and course of the disease. The aim of our study was to evaluate the role of transforming growth factor-β1 (TGF-β1) polymor...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318242be0b
更新日期:2012-03-15 00:00:00
abstract::The frequency of donor-reactive and of third party-reactive cytotoxic T lymphocyte precursors (CTLp) was determined by limiting dilution analysis in the peripheral blood of 13 liver allograft recipients before (pre-tpx) and at various intervals (4 to 22 months) after (post-tpx) transplantation. In 6 of 13 patients wit...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-06-27 00:00:00
abstract::The aim of our study was to sensitize cells in vitro, follow their proliferative and cytotoxic responses, and determine their ability to cause lethal graft-versus-host disease (GVHD). C57BL/6 (H2b) spleen cells were incubated with irradiated BALB/C (H2d) Moloney lymphoma cells (LSTRA) in mixed leukocyte culture condit...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197612000-00008
更新日期:1976-12-01 00:00:00
abstract::A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes in vitro is described. Responding lymphocytes are cultured with mitomycin-C treated allogeneic stimulating cells in wells of replicate microtrays for both one-way mixed leukocyte culture (MLC) and cell-mediated lymph...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197606000-00005
更新日期:1976-06-01 00:00:00
abstract:INTRODUCTION:The importance of HLA matching for renal transplantation outcomes has been appreciated for several decades. It has been hypothesized that as pharmacologic immunosuppression becomes stronger and more specific, the impact of HLA matching may be vanishing. Mycophenolate Mofetil (MMF) has been demonstrated to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200102150-00010
更新日期:2001-02-15 00:00:00
abstract:BACKGROUND:The shortage of livers for transplantation has prompted transplant centers to seek alternatives to conventional cadaveric liver transplantation. Left lateral segmentectomy from living donors has proven to be a safe operation for the donor with excellent results in the pediatric population. Left lobectomy, co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199909270-00012
更新日期:1999-09-27 00:00:00
abstract::Twenty eight consecutive combined renal and pancreatic transplantations with enteric exocrine diversion were performed between June 1984 and May 1986. The one-year actuarial patient survival and renal and pancreatic graft survival were 90%, 67%, and 69%, respectively. Nineteen pancreatic grafts and eighteen renal graf...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198705000-00014
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:We sought to compare the immunoreactive potential of human cord blood (CB) versus normal adult bone marrow (BM) versus mobilized blood (peripheral blood stem cells; PBSC) from cancer patients. METHODS:Forty mice were randomized to receive a range of doses of T cell-replete cell preparations from one of the ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199909150-00006
更新日期:1999-09-15 00:00:00
abstract::The benefits of cytomegalovirus (CMV) prophylaxis in preventing the direct effects of CMV infection and disease are well established; however, the impact of exposure to antiviral agents on preventing the indirect effects of CMV infection are poorly defined. This article reviews the results of current studies demonstra...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000230459.22968.26
更新日期:2006-07-27 00:00:00
abstract:BACKGROUND:Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CO releasing molecules (CORM)-401 has recently...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002201
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The long-term outcome of lung transplantation is impeded by the development of obliterative bronchiolitis (OB). We sought to investigate the relationship between the apoptosis of tracheal epithelial cells and bone marrow-derived myofibroblasts in the process of OB. METHODS:The mouse orthotopic tracheal tran...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001230
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Focal segmental glomerulosclerosis (FSGS), the second leading cause of end stage renal disease in children, appears to be increasing. Moreover, posttransplantation FSGS recurrence is a major problem, and there is concern that children receiving kidneys from living donors (LD) have increased recurrence risk. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829c2431
更新日期:2013-09-01 00:00:00
abstract::Natural suppressor (NS) activity is detected in tissues undergoing intense hematopoietic regeneration. This includes the spleens of mice recovering from total lymphoid irradiation or cyclophosphamide treatment, or after induction of chronic graft-versus-host disease against minor histocompatibility antigens. NS cells ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00038
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Uterus transplantation is a treatment for absolute uterine infertility and can be performed with living and deceased donors. Given the safety and increased utilization of robotic assistance with other gynecologic and transplant donor operations, we adopted a robot-assisted approach to donor hysterectomy. Thi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003211
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Donor T cells are primarily responsible for graft-versus-host disease (GVHD). Three effector pathways have been described for T-cell cytotoxicity: granzyme B/perforin, Fas/Fas ligand (FasL), and secreted molecules such as tumor necrosis factor (TNF)-alpha. Therefore, this study evaluates the gene expression ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000100465.83529.42
更新日期:2004-01-27 00:00:00
abstract::To characterize further lymphomas which arise in chronically immunosuppressed allotransplant patients, we studied the clinical and histological features of seven cases of nonHodgkin's lymphoma and determined the immunological phenotype in four cases, which developed in a series of 182 patients who underwent cardiac tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198204000-00002
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:Subclinical T cell-mediated rejection (subTCMR) is commonly found after liver transplantation and has a good short-term prognosis, even when it is left untreated. Donor-specific antibodies (DSA) are putatively associated with a worse prognosis for recipient and graft after liver transplantation. METHODS:To ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003034
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Recently, TT virus (TTV) was discovered as a potential causative agent for non-A-E hepatitis. Little is known about the prevalence of TTV infection in renal transplant recipients. METHODS:One hundred and seventeen Brazilian renal transplant recipients and 100 normal subjects were examined to determine the p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200010270-00012
更新日期:2000-10-27 00:00:00
abstract:INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182370db1
更新日期:2011-12-27 00:00:00
abstract::Although liver transplantation (LT) is the best treatment for patients with localized hepatocellular carcinoma (HCC), recurrence occurs in 6%-18% of patients. Several factors, particularly morphological criteria combined with dynamic parameters, known before LT modify this risk and combined in prediction models may be...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000003196
更新日期:2020-06-01 00:00:00
abstract::Acute rejection episodes still occur after kidney transplantation in spite of modern immunosuppressive protocols including combined tacrolimus, mycophenolate mofetil, and prednisolone. The authors present seven cases of biopsy-proven acute rejection after kidney transplantation refractory to conventional rejection the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000147197.24050.61
更新日期:2005-01-15 00:00:00