Expression of RT1.A and RT1.B/D antigens on endothelium of rat kidneys.

abstract：BACKGROUND:Donor hepatectomy and liver implantation time reduce long-term graft and patient survival after liver transplantation. It is not known whether these surgical times influence early outcomes after liver transplantation. METHODS:This single-center study evaluated the effect of donor hepatectomy and implantatio...

journal_title：Transplantation

authors： Gilbo N,Fieuws S,Meurisse N,Nevens F,van der Merwe S,Laleman W,Verslype C,Cassiman D,van Malenstein H,Roskams T,Sainz-Barriga M,Pirenne J,Jochmans I,Monbaliu D

更新日期：2020-05-28 00:00:00

abstract：:Donor graft major histocompatibility complex class I antigens are targets for both allogeneic and xenogeneic rejection. Mice homozygous for beta 2-microglobulin gene disruption express reduced amounts of surface MHC class I antigens. Liver cells from such mutant mice were transplanted into isogeneic, allogeneic, and x...

journal_title：Transplantation

authors： Li X,Faustman D

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:In kidney transplant recipients with alemtuzumab induction maintained on mycophenolate mofetil (MMF) immunosuppression, sirolimus (SRL) promotes significant expansion of circulating CD4+CD25high regulatory T cells (Treg). This might translate into more effective protection against chronic graft injury compar...

journal_title：Transplantation

authors： Ruggenenti P,Perico N,Gotti E,Cravedi P,D'Agati V,Gagliardini E,Abbate M,Gaspari F,Cattaneo D,Noris M,Casiraghi F,Todeschini M,Cugini D,Conti S,Remuzzi G

更新日期：2007-10-27 00:00:00

abstract：BACKGROUND:Acute rejection of allografts remains a significant problem in clinical transplantation, and the fundamental mechanism underlying this rejection are as yet only poorly elucidated. Recently, DNA microarrays have come into use for the study of gene expression profiles, and we have taken advantage of this new t...

journal_title：Transplantation

authors： Saiura A,Mataki C,Murakami T,Umetani M,Wada Y,Kohro T,Aburatani H,Harihara Y,Hamakubo T,Yamaguchi T,Hasegawa G,Naito M,Makuuchi M,Kodama T

更新日期：2001-07-27 00:00:00

abstract：BACKGROUND:Many reports of successful early withdrawal of regular maintenance steroids in transplant recipients have appeared in recent years. The question now arises whether, in the current age of powerful nonsteroidal immunosuppressants such as Neoral and Tacrolimus, routine administration of steroids posttransplant ...

journal_title：Transplantation

authors： Rolles K,Davidson BR,Burroughs AK

更新日期：1999-10-27 00:00:00

abstract：BACKGROUND:Although inactivated vaccines are recommended for immunocompromized patients, efficacy and safety of diphtheria and tetanus immunization in renal transplant recipients have received little attention so far. The aim of the study was to investigate the response to a standard diphtheria and tetanus booster vacc...

journal_title：Transplantation

authors： Enke BU,Bökenkamp A,Offner G,Bartmann P,Brodehl J

更新日期：1997-07-27 00:00:00

abstract：:Possible explanations for the immune deficiency usually associated with graft-versus-host disease include defective lymphocyte differentiation and active suppressor cell mechanisms. The present observations in a patient with chronic graft-versus-host disease delineate yet another possible mechanism: a failure of succe...

journal_title：Transplantation

authors： Dosch HM,Gelfand EW

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Remote ischemic preconditioning (RIPC) protects against liver ischemia reperfusion (IR) injury. An essential circulating mediator of this protection is nitric oxide (NO) induced by lower limb RIPC. One of the mechanisms through which NO generally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pat...

journal_title：Transplantation

authors： Abu-Amara M,Yang SY,Quaglia A,Rowley P,Tapuria N,Fuller B,Davidson B,Seifalian A

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:The prevalence of renal posttransplantation amputation and its impact on allograft and patient survival have not been widely reported. METHODS:We used an incident cohort of patients who underwent renal transplantation between June 2004 and September 2009. Amputation data were obtained using Medicare institu...

journal_title：Transplantation

authors： Brar A,Jindal RM,Sumrani N,John D,Mondal Z,Tedla F,Salifu MO

更新日期：2013-05-27 00:00:00

abstract：BACKGROUND:Induction immunosuppressive therapy with the anti-T-cell antibody Thymoglobulin decreases the incidence of acute rejection in adult kidney transplant (KTx) recipients, but limited data are available for pediatric KTx recipients. METHODS:We conducted a historical cohort study to compare rates of survival, re...

journal_title：Transplantation

authors： Khositseth S,Matas A,Cook ME,Gillingham KJ,Chavers BM

更新日期：2005-04-27 00:00:00

abstract：BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...

journal_title：Transplantation

authors： Suzuki S,Bing H,Sugawara T,Matsuda Y,Tabata T,Hoshikawa Y,Saijo Y,Kondo T

更新日期：2004-08-27 00:00:00

abstract：BACKGROUND:The once-daily (QD), prolonged-release formulation of tacrolimus has been shown to improve adherence versus twice-daily (BD) tacrolimus. Treatment nonadherence in transplant recipients has been associated with poor graft outcomes. METHODS:This open-label, parallel-group study randomized adults with end-stag...

journal_title：Transplantation

authors： Albano L,Banas B,Klempnauer JL,Glyda M,Viklicky O,Kamar N,Optimising immunoSuppression After Kidney transplantation with ADVAGRAF Study Group.

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:In kidney transplantation, dynamic prediction of patient and kidney graft survival (DynPG) may help to promote therapeutic alliance by delivering personalized evidence-based information about long-term graft survival for kidney transplant recipients. The objective of the current study is to externally valida...

journal_title：Transplantation

authors： Lenain R,Dantan E,Giral M,Foucher Y,Asar Ö,Naesens M,Hazzan M,Fournier MC

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:New-onset diabetes is common after kidney transplantation, but the benefit of lifestyle intervention to improve glucose metabolism posttransplantation is unproven. METHODS:We conducted a single-center, randomized controlled trial involving 130 nondiabetic kidney transplant recipients with stable function be...

journal_title：Transplantation

authors： Kuningas K,Driscoll J,Mair R,Smith H,Dutton M,Day E,Sharif AA

更新日期：2020-07-01 00:00:00

abstract：:Two patients at our institution underwent single lung transplantation. The procedure and the patient's postoperative course were uncomplicated in each case. Pathological examination of each pneumonectomy specimen revealed a well-differentiated adenocarcinoma; both were less than 1 cm in size. The remainder of each lun...

journal_title：Transplantation

authors： Svendsen CA,Bengtson RB,Park SJ,Shumway SJ

更新日期：1998-10-27 00:00:00

abstract：BACKGROUND:We have previously shown that CD8 depletion or CD34 selection of peripheral blood stem cells (PBSC) reduced the incidence of acute graft-versus-host disease (GvHD) after nonmyeloablative stem-cell transplantation (NMSCT). In this study, we analyze the effect of CD8 depletion or CD34 selection of the graft on...

journal_title：Transplantation

authors： Baron F,Schaaf-Lafontaine N,Humblet-Baron S,Meuris N,Castermans E,Baudoux E,Frère P,Bours V,Fillet G,Beguin Y

更新日期：2003-12-27 00:00:00

abstract：BACKGROUND:Renal allografts were performed in rhesus monkeys using FN18-CRM9, a potent immunotoxin capable of depleting T cells to less than 1% of baseline levels in blood and lymph nodes, as a preparative agent. We have recently reported that animals pretreated with FN18-CRM9 1 week before transplantation without furt...

journal_title：Transplantation

authors： Fechner JH Jr,Vargo DJ,Geissler EK,Graeb C,Wang J,Hanaway MJ,Watkins DI,Piekarczyk M,Neville DM Jr,Knechtle SJ

更新日期：1997-05-15 00:00:00

abstract：:The production and release of cytokines and their receptors are of critical importance in mediating graft injury. In order to evaluate the expression of cytokines in renal allograft biopsies, we performed immunocytochemical studies to detect activated cells positive for TNF-alpha, IFN-gamma, and IL-2R, using an alkali...

journal_title：Transplantation

authors： Noronha IL,Eberlein-Gonska M,Hartley B,Stephens S,Cameron JS,Waldherr R

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Chronically elevated vasopressin (VP) plasma levels have been shown to induce accelerated renal function decline in rats with chronic renal failure. Whether endogenous VP is a renal risk factor in humans has not been investigated yet. We aimed to investigate whether, in renal transplant recipients, VP concen...

journal_title：Transplantation

authors： Meijer E,Bakker SJ,de Jong PE,Homan van der Heide JJ,van Son WJ,Struck J,Lems SP,Gansevoort RT

更新日期：2009-08-27 00:00:00

abstract：:Donor pancreas utilization rates for whole organ transplant have remained low and have decreased over time. To identify the reasons for nonuse of pancreas from donors who meet common baseline acceptance criteria, we examined Organ Procurement and Transplantation Network data from 2005 to 2007 and identified a subgroup...

journal_title：Transplantation

authors： Wiseman AC,Wainright JL,Sleeman E,McBride MA,Baker T,Samana C,Stock P

更新日期：2010-09-15 00:00:00

abstract：:This study extends the finding that intrathymic (IT) injection of 3M KC1 extracts of T cells induces transplant tolerance to the use of well defined polymorphic MHC class I allopeptides derived from the hypervariable domain of RT1.Au (WF MHC class I). While three of the six synthetic RT1.Au peptides were immunogenic, ...

journal_title：Transplantation

authors： Chowdhury NC,Murphy B,Sayegh MH,Jin MX,Roy DK,Hardy MA,Oluwole SF

更新日期：1996-12-27 00:00:00

abstract：:Cyclosporine CsA nephrotoxicity was examined in male Sprague-Dawley rats with or without prior uninephrectomy, injected daily with 12.5 mg/kg CsA, and fed a salt-depleted or normal diet for 3-10 weeks. Control rats received the CsA vehicle. CsA induced a fall in creatinine clearance in salt-depleted rats, from 1.3 +/-...

journal_title：Transplantation

authors： Rosen S,Greenfeld Z,Brezis M

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:This study aimed at investigating the efficacy of the novel immunosuppressant FK778 to prevent the development and progression of chronic allograft vasculopathy (CAV). METHODS:Orthotopic aortic transplantations were performed in the PVG-to-ACI rat model and followed over the course of 120 days. Immunosuppre...

journal_title：Transplantation

authors： Deuse T,Hoyt G,Koyanagi T,Robbins RC,Schrepfer S

更新日期：2008-03-27 00:00:00

abstract：:The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a pivotal role in cellular metabolism and in a wide range of eukaryotic biological/cellular functions and signaling networks. Additionally, as ...

journal_title：Transplantation

authors： Zaza G,Granata S,Caletti C,Signorini L,Stallone G,Lupo A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The aim of this single-center study was to investigate whether trough level adjusted mycophenolate mofetil (MMF) is more efficacious in combination with tacrolimus (TAC) or cyclosporine (CsA) and to evaluate the impact of either drug on MMF dosage. METHODS:Sixty patients (TAC, n = 30; CsA, n = 30) undergoin...

journal_title：Transplantation

authors： Meiser BM,Groetzner J,Kaczmarek I,Landwehr P,Müller M,Jung S,Uberfuhr P,Fraunberger P,Stempfle HU,Weis M,Reichart B

更新日期：2004-08-27 00:00:00

abstract：BACKGROUND:In previous studies of cynomolgus monkey lung allograft recipients, we demonstrated significant immunosuppressive efficacy but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin). The current study was designed to com...

journal_title：Transplantation

authors： Hausen B,Gummert J,Berry GJ,Christians U,Serkova N,Ikonen T,Hook L,Legay F,Schuler W,Schreier MH,Morris RE

更新日期：2000-02-27 00:00:00

abstract：BACKGROUND:Patients with high tacrolimus clearance eliminate more drug within a dose interval compared with those with low clearance. Delays in dosing time will result in transient periods of lower concentrations in high versus low clearance patients. Transient subtherapeutic tacrolimus concentrations may induce acute ...

journal_title：Transplantation

authors： Egeland EJ,Robertsen I,Hermann M,Midtvedt K,Størset E,Gustavsen MT,Reisæter AV,Klaasen R,Bergan S,Holdaas H,Hartmann A,Åsberg A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Previous studies have identified more morbidity in simultaneous pancreas-kidney (SPK) transplant recipients compared with kidney alone (KA) recipients. With the development of novel immunosuppressive drugs, studies are needed to determine optimal treatment regimens in specific patient populations. METHODS:W...

journal_title：Transplantation

authors： Lee CM,Scandling JD,Krieger NR,Dafoe DC,Alfrey EJ

更新日期：1997-11-15 00:00:00

abstract：:The immune response to cytomegalovirus (CMV) infection is highly complex, including humoral, cellular, innate, and adaptive immune responses. Detection of CMV by the innate immune system triggers production of type I IFNs and inflammatory cytokines which initiate cellular and humoral responses that are critical during...

journal_title：Transplantation

authors： Carbone J

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Although it is generally considered that livers with moderate steatosis can be safely used in the setting of living-donor liver transplantation, the effect of the regenerative process of such a graft on postoperative liver function is incompletely understood. We assessed the morphologic and functional altera...

journal_title：Transplantation

authors： Ninomiya M,Shimada M,Terashi T,Ijichi H,Yonemura Y,Harada N,Soejima Y,Suehiro T,Maehara Y

更新日期：2004-02-15 00:00:00