Use of donor beta 2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts.

abstract：BACKGROUND:C-reactive protein (CRP) is a strong predictor of cardiovascular disease, all-cause mortality, and renal allograft loss. Little is known about the effects of immunosuppressive and cardiovascular risk-modifying drugs on CRP in renal transplant recipients. METHODS:We retrospectively identified stable patients...

journal_title：Transplantation

authors： Wong BM,Huang M,Zaltzman JS,Prasad GV

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Arterial hypertension (HT) is common in renal transplant recipients (RTRs). Control of HT is not optimal in this high-risk population despite recommendations for target blood pressure levels under 130/80 mm Hg. METHODS:We performed a cross-sectional analysis of the prevalence of uncontrolled HT, and using a...

journal_title：Transplantation

authors： Vetromile F,Pernin V,Szwarc I,Garrigue V,Delmas S,Mourad G,Fesler P

更新日期：2015-05-01 00:00:00

abstract：:Rapamycin prolongs allograft survival and induces donor-specific tolerance in some small animal transplant models. Large animal studies, however, are limited. We studied rapamycin in a porcine renal allograft model. Donor-recipient combinations were chosen based on high response in pretransplant MLCs. Allografts were ...

journal_title：Transplantation

authors： Almond PS,Moss A,Nakhleh RE,Melin M,Chen S,Salazar A,Shirabe K,Matas AJ

更新日期：1993-08-01 00:00:00

abstract：:The ability of concanavalin-A (Con-A) to activate lymphocytes to secrete human lymphotoxin (LT) was tested in the presence of agents known to modify the intracellular levels of cyclic nucleotides (cAMP and cGMP). Lymphocytes were treated with these agents at different stages of activation: (1) during the first encount...

journal_title：Transplantation

authors： Prieur AM,Granger GA

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND AND METHODS:To investigate the frequency of apoptosis and the expression of Fas/Fas ligand (FasL) in liver allografts, we examined 97 biopsy specimens from 62 patients after orthotopic liver transplantation. The results of the biopsies were as follows: acute allograft rejection (n=32); hepatitis C virus (HCV...

journal_title：Transplantation

authors： Tannapfel A,Kohlhaw K,Ebelt J,Hauss J,Liebert U,Berr F,Wittekind C

更新日期：1999-04-15 00:00:00

abstract：BACKGROUND:Mixed allogeneic hematopoietic chimerism has previously been reliably achieved and shown to induce tolerance to fully MHC-mismatched allografts in mice and monkeys. However, the establishment of hematopoietic chimerism has been difficult to achieve in the discordant pig-to-primate xenogeneic model. METHODS:...

journal_title：Transplantation

authors： Sablinski T,Emery DW,Monroy R,Hawley RJ,Xu Y,Gianello P,Lorf T,Kozlowski T,Bailin M,Cooper DK,Cosimi AB,Sachs DH

更新日期：1999-04-15 00:00:00

abstract：:We have used a polymerase chain reaction-based assay measuring polymorphic (CA)n repeats, a class of simple sequence repeats, to assess the success of allogeneic canine marrow transplants. Results were compared with those obtained with karyotype analysis of dividing cells in recipients that were sex mismatched with th...

journal_title：Transplantation

authors： Yu C,Ostrander E,Bryant E,Burnett R,Storb R

更新日期：1994-09-27 00:00:00

abstract：BACKGROUND:This study aimed at investigating the efficacy of the novel immunosuppressant FK778 to prevent the development and progression of chronic allograft vasculopathy (CAV). METHODS:Orthotopic aortic transplantations were performed in the PVG-to-ACI rat model and followed over the course of 120 days. Immunosuppre...

journal_title：Transplantation

authors： Deuse T,Hoyt G,Koyanagi T,Robbins RC,Schrepfer S

更新日期：2008-03-27 00:00:00

abstract：:Since calcium channel blocking agents and CsA exert an antiproliferative effect upon T cell mitogenesis, we have compared and characterized their immunosuppressive properties at the level of gene activation. Verapamil (greater than or equal to 30 microM), which blocks T cell mitogenesis and a rise in cytosolic calcium...

journal_title：Transplantation

authors： Walz G,Zanker B,Wieder K,Hadro E,Moscovitch-Lopatin M,Smith BR,Strom TB

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:In recent years, transplantation of islets and pancreas has become a viable option for patients debilitated with type I diabetes. The success of islet transplantation has been attributed to the ability to isolate high quality islets for transplantation and capacity to maintain the recipient's immunosuppressi...

journal_title：Transplantation

authors： Mohanakumar T,Narayanan K,Desai N,Ramachandran S,Shenoy S,Jendrisak M,Susskind BM,Olack B,Benshoff N,Phelan DL,Brennan DC,Fernandez LA,Odorico JS,Polonsky KS

更新日期：2006-07-27 00:00:00

abstract：BACKGROUND:Renal warm ischemic injury and immunosuppression with cyclosporin A (CsA) may contribute to chronic allograft nephropathy after cadaveric transplantation. This study establishes whether CsA can sensitize the kidney to injury and fibrosis induced by renal warm ischemia (RWI). METHODS:The left kidney of Sprag...

journal_title：Transplantation

authors： Ahmed A,Huang L,Raftery AT,Ahmed AK,Fahmy H,El Nahas AM,Haylor JL

更新日期：2004-03-15 00:00:00

abstract：:Data of 32,000 donors were utilized for a computer simulation to analyze the effect of selection parameters on the outcome of kidney transplants. If the HLA match grade is considered for organ allocation, the overall 1-year graft survival rate is up to 7% higher for first cadaver transplants and up to 12% higher for s...

journal_title：Transplantation

authors： Wujciak T,Opelz G

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Chronic renal allograft failure remains a major challenge to overcome. Factors such as donor quality, delayed graft function (DGF), acute rejection, and immunosuppression are known to affect long-term outcome, but their relationship to histological damage to graft outcome is unclear. METHODS:Protocol kidney...

journal_title：Transplantation

authors： Nankivell BJ,Fenton-Lee CA,Kuypers DR,Cheung E,Allen RD,O'Connell PJ,Chapman JR

更新日期：2001-02-27 00:00:00

abstract：:Heterologous anti-immunoglobulin is a potent immunosuppressive agent that prolongs H-2- and H-3-incompatible skin graft survival. In conjunction with antithymocyte serum, anti-immunoglobulin promotes greater graft life than either antiserum used alone, without evidence of toxicity to recipient animals. Combination tre...

journal_title：Transplantation

authors： Constantian MB,Couser WG,Mannick JA

更新日期：1977-11-01 00:00:00

abstract：:Rat liver transplantation was utilized to study the effect of hepatic iron on the control of iron absorption. Six iron-loaded and six normal livers were transplanted into normal or iron-loaded animals. Iron absorption was measured pretransplant and 10 days posttransplant by total-body counting (59Fe). The animals were...

journal_title：Transplantation

authors： Adams PC,Reece AS,Powell LW,Halliday JW

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Chronic lung disease and pulmonary failure are complications that can occur after bone marrow transplantation (BMT) and are associated with severe morbidity and mortality. METHODS:We report on four patients who developed chronic, progressive, and irreversible lung disease 1 to 3 years after allogeneic BMT i...

journal_title：Transplantation

authors： Heath JA,Kurland G,Spray TL,Kernan NA,Small TN,Brochstein JA,Gillio AP,Boklan J,O'Reilly RJ,Boulad F

更新日期：2001-12-27 00:00:00

abstract：:P-31 nuclear magnetic resonance (NMR) spectroscopy was used to evaluate heterotropic cardiac allograft rejection in the rat. To enable optimal application of NMR spectroscopy for the in vivo study of myocardial metabolism in the transplanted organ, an accessory heart transplantation to groin in the rat was used. The a...

journal_title：Transplantation

authors： Haug CE,Shapiro JI,Chan L,Weil R 3rd

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Obesity is a common problem following renal transplantation. Rimonabant, a cannabinoid-1 receptor blocker, offers a new approach for reducing obesity. METHODS:The potential pharmacokinetic interaction between rimonabant and cyclosporine A (CsA, n=10) and tacrolimus (Tac, n=8) was assessed in stable renal tr...

journal_title：Transplantation

authors： Amundsen R,Asberg A,Robertsen I,Vethe NT,Bergan S,Hartmann A,Midtvedt K

更新日期：2009-04-27 00:00:00

abstract：:Renal function was observed retrospectively in a population of 228 adults who underwent a cardiac allograft at the University of Pittsburgh from June 1980 through June 1987, survived a minimum of one year, and received cyclosporine. Renal function was determined by serial measurement of serum creatinine concentration....

journal_title：Transplantation

authors： Greenberg A,Thompson ME,Griffith BJ,Hardesty RL,Kormos RL,el-Shahawy MA,Janosky JE,Puschett JB

更新日期：1990-10-01 00:00:00

abstract：:Flow cytometry (FC) is increasingly being used as a crossmatch procedure in addition to the standard complement-dependent cytotoxicity (CDC) test. In fact, FC offers a number of advantages over CDC and has the potential to become the primary crossmatch technique for cadaveric donor renal transplantation. We evaluated ...

journal_title：Transplantation

authors： Scornik JC,Brunson ME,Schaub B,Howard RJ,Pfaff WW

更新日期：1994-02-27 00:00:00

abstract：BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...

journal_title：Transplantation

authors： Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez D

更新日期：2010-03-27 00:00:00

abstract：:Renal allografts were performed in miniature swine that were identical at their major histocompatibility locus and were presensitized by skin grafts from their prospective renal donors. All of these renal grafts were rejected in a hyperacute or markedly accelerated manner compared to the survival of comparable grafts ...

journal_title：Transplantation

authors： Kirkman RL,Colvin RB,Flye MW,Williams GM,Sachs DH

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Donation after cardiac death (DCD) increases the number of donor kidneys but is associated with more primary nonfunction (PNF) and delayed graft function (DGF). It has been suggested that biomarkers in the preservation solution of machine perfused kidneys may predict PNF, although evidence is lacking. METHO...

journal_title：Transplantation

authors： Hoogland ER,de Vries EE,Christiaans MH,Winkens B,Snoeijs MG,van Heurn LW

更新日期：2013-02-27 00:00:00

abstract：:The stability of HLA alloantibodies was studied in 128 antibody-positive, potential kidney transplant recipients over an average period of 3 years. Antibody detection was performed using an anti-human globulin-complement-dependent cytotoxicity technique. In this study, the specificity of antibodies was categorized as ...

journal_title：Transplantation

authors： Rodey GE,Revels K,Fuller TC

更新日期：1997-03-27 00:00:00

abstract：:The monoclonal antibodies (MoAb) CR11-351 and KS1 are secreted by hybridomas generated with splenocytes from BALB/c mice immunized with the cultured human B lymphoid cells LG-2 (HLA-A2,A2,B27,B27). The 2 monoclonal antibodies immunoprecipitated components with a superimposable 2-dimensional gel electrophoretic profile...

journal_title：Transplantation

authors： Tsujisaki M,Sakaguchi K,Igarashi M,Richiardi P,Perosa F,Ferrone S

更新日期：1988-03-01 00:00:00

abstract：:We performed a multicenter study to investigate the problem of cadaver kidney transplants that never achieve function, or that recover after a period of delayed function, and we used multivariate techniques to model the results. Sixty-nine patients who received cadaver kidney transplants that never functioned (NF) wer...

journal_title：Transplantation

authors： Halloran P,Aprile M

更新日期：1988-01-01 00:00:00

abstract：:Hepatocyte transplantation is an investigational alternative to orthotopic liver transplantation to treat liver based inborn errors of metabolism. We report successful hepatocyte transplantation in a 4-year-old girl with infantile Refsum disease. Hepatocytes were isolated from the left liver segment of two male donors...

journal_title：Transplantation

authors： Sokal EM,Smets F,Bourgois A,Van Maldergem L,Buts JP,Reding R,Bernard Otte J,Evrard V,Latinne D,Vincent MF,Moser A,Soriano HE

更新日期：2003-08-27 00:00:00

abstract：:Since the earliest days of transplantation, immunobiologists have sought means to prevent recognition and rejection of foreign tissue. The goal of these strategies is the retention of recipient immune function while selectively avoiding graft injury. Although considerable theoretical and technical problems remain, an ...

journal_title：Transplantation

authors： Lynch RJ,Platt JL

更新日期：2009-12-15 00:00:00

abstract：:Renal vasoconstriction has been implicated as a major contributing factor for the nephrotoxic effects of cyclosporine. In an attempt to assess the relative contribution of thromboxane (Tx), the effects of coadministering CsA with the selective Tx synthetase inhibitor, Dazmegrel (DAZ) (Pfizer, Inc.), were determined. R...

journal_title：Transplantation

authors： Gladue RP,Newborg MF

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CO releasing molecules (CORM)-401 has recently...

journal_title：Transplantation

authors： Bhattacharjee RN,Richard-Mohamed M,Sun Q,Haig A,Aboalsamh G,Barrett P,Mayer R,Alhasan I,Pineda-Solis K,Jiang L,Alharbi H,Saha M,Patterson E,Sener A,Cepinskas G,Jevnikar AM,Luke PPW

更新日期：2018-07-01 00:00:00