Abstract:
:The stability of HLA alloantibodies was studied in 128 antibody-positive, potential kidney transplant recipients over an average period of 3 years. Antibody detection was performed using an anti-human globulin-complement-dependent cytotoxicity technique. In this study, the specificity of antibodies was categorized as against either private epitopes or cross-reactive group (CREG) epitope clusters. Definable antibodies were found in 94% of patients, and 89.5% of the definable antibodies had specificity for CREG clusters. Patterns of antibody reactivity were stable in most of the patients evaluated, even though the percentage of panel-reactive antibody (PRA) often demonstrated considerable fluctuations. Of the 220 definable private-specific or CREG cluster-specific antibodies identified in the patients, nearly 80% persisted throughout the observation period. The fluctuations in % PRA were common, but usually were not due to the acquisition of new HLA antibodies. Most fluctuations were attributable to variable detection of specificities within the same CREG cluster, possibly due to technique variation or changes in antibody avidity or titer or in cell panel composition. This study demonstrates that patterns of antibody specificity are remarkably stable in this patient population, even though PRA values fluctuated. This study further suggests that HLA antibody specificity analysis is a more useful clinical parameter of lymphocytotoxicity testing than simple reporting of % PRA when identifying potential donors for individual patients.
journal_name
Transplantationjournal_title
Transplantationauthors
Rodey GE,Revels K,Fuller TCdoi
10.1097/00007890-199703270-00015subject
Has Abstractpub_date
1997-03-27 00:00:00pages
885-93issue
6eissn
0041-1337issn
1534-6080journal_volume
63pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::We reviewed the results of all percutaneous fine needle aspirations (FNA) and open lung biopsies (OLB) after bone marrow transplantation at our center (1984-1987) for the evaluation of focal lung lesions that developed or persisted despite antibiotic administration. We sought to determine the prevalence and types of i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198908000-00017
更新日期:1989-08-01 00:00:00
abstract::Unstimulated whole saliva and serum samples were collected from ten allogeneic bone marrow transplant recipients before and after bone marrow transplantation, seven donors, and from twenty healthy individuals. Two patterns with regard to salivary IgA were found after transplantation. In five patients, a short-lasting ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198811000-00016
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Successful islet transplantation can result in insulin independence in many patients with type 1 diabetes mellitus, but it often requires more than one islet infusion. The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited org...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c478fd
更新日期:2010-02-27 00:00:00
abstract::The results presented in this report demonstrate that T cells, isolated from AGUS rats bearing long-term (WAG X AGUS)F1 spleen allografts adoptively transferred to irradiated AGUS recipients could not mediate the rejection of WAG hearts but rejected PVG. A hearts in acute fashion. Further, unresponsive T cells were ab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198709000-00024
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Graft failure related to acute and chronic rejection remains an important problem in transplantation. An association has been reported between microchimerism and the development of tolerance. Since it has been established that cells of fetal origin can be found in maternal tissues long after parturition, and...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181705a0f
更新日期:2008-05-27 00:00:00
abstract:BACKGROUND:Thymoglobulin given before allo-hematopoietic stem-cell transplantation (HSCT) from unrelated donors reduces acute graft-versus-host disease (GvHD), but the optimal dose is unknown. METHOD:Four different doses of Thymoglobulin were given to 162 patients with hematologic malignancies undergoing unrelated don...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2004-07-15 00:00:00
abstract::A new case of anti-factor V inhibitor is described in a 46-year-old man, who received a liver transplantation for hepatocellular carcinoma, without exposure to bovine thrombin or fibrin glue during the operative course. The inhibition occurred on the 14th postoperative day, while the patient was being treated with oxa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199910150-00026
更新日期:1999-10-15 00:00:00
abstract:BACKGROUND:Hyperacute rejection (HAR) of pig-to-primate discordant xenografts is caused by the deposition of preexisting natural antibodies that recognize Galalpha1-3Gal (alphaGal)-terminating oligosaccharides on glycoproteins and glycolipids, followed by complement-mediated lysis of the graft's endothelium. In vitro, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802150-00009
更新日期:1998-02-15 00:00:00
abstract:BACKGROUND:Early enteral nutrition with solutions containing prebiotics (fiber) and probiotics (Lactobacillus) is suggested to reduce bacterial translocation and minimize the incidence of infections after liver transplantation. METHODS:In a prospective, randomized placebo-controlled trial consisting of 95 patients, we...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-200207150-00021
更新日期:2002-07-15 00:00:00
abstract::The development of allospecific cellular immunity during acute rat renal allograft rejection parallels alterations occurring in arachidonic acid metabolism, including increased production of the vasoconstrictor eicosanoid thromboxane A2 (TxA2). We have previously demonstrated that chronic inhibition of thromboxane syn...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:A pancreas transplant alone (PTA) in a nonuremic patient with brittle diabetes mellitus remains a rare procedure because the tradeoff for insulin independence is lifelong immunosuppression. METHODS:Herein we report our results at the University of Minnesota of 513 PTAs from December 17, 1966, through Decemb...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000296820.46978.3f
更新日期:2008-01-15 00:00:00
abstract::The humanization of animals is a powerful tool for the exploration of human disease pathogenesis in biomedical research, as well as for the development of therapeutic interventions with enhanced translational potential. Humanized models enable us to overcome biologic differences that exist between humans and other spe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003177
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Xenogeneic corneal fragments (guinea pig) are highly resistant to immune rejection in the anterior chamber of mouse eyes. Because guinea pigs and mice are discordant (i.e., mouse serum normally contains guinea pig reactive xenoantibodies), we wished to determine the extent to which xenogeneic corneal fragmen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002270-00025
更新日期:2000-02-27 00:00:00
abstract:BACKGROUND:A striped pattern of fibrosis has been described in the kidneys of patients undergoing long-term cyclosporine or tacrolimus therapy. This lesion is frequently misconstrued as being specific for drug toxicity. METHODS:We performed clinicopathologic correlation on 18 patients with striped fibrosis identified ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199902150-00025
更新日期:1999-02-15 00:00:00
abstract::We describe four patients who suffered asystole, myocardial infarction (in two cases) and supraventricular tachycardia at the time of high-dose methylprednisolone infusion. One patient died during infusion. We measured the effects of methylprednisolone and placebo infusion on heart rate, blood pressure, and cardiac ou...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-198304000-00017
更新日期:1983-04-01 00:00:00
abstract::A rapid microcytotoxicity assay for the detection of HL-A antigens on tissue culture cells derived from human solid tumors is described. Tumor cells were prelabeled with 125Iododeoxyuridine. Isotopically labeled tumor cells were reacted with up to 37 highly selected HL-A antisera and diluted rabbit complement. Results...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197509000-00005
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:The efficiency of islet graft survival after intraportal implantation is compromised by host innate immune responses and the production of proinflammatory cytokines that cause acute cellular injury. This reaction activates intraislet nuclear factor-κB (NF-κB), causing production of gene products that have de...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a4190e
更新日期:2013-11-27 00:00:00
abstract:BACKGROUND:Urothelial carcinoma (UC) is a common complication after renal replacement therapy (RRT) among Chinese end-stage renal disease (ESRD) patients. It is unclear whether there are any differences in the clinicopathologic characteristics of UC between renal transplantation (RT) and dialysis patients; such differe...
journal_title:Transplantation
pub_type: 杂志文章,收录出版
doi:10.1097/TP.0000000000000112
更新日期:2014-09-15 00:00:00
abstract::Nonmajor histocompatibility complex (non-MHC) antigens are important targets of graft rejection and graft-versus-host disease in clinical transplantation. Little is known regarding immunity to non-MHC antigens. To study this problem we evaluated the effect of antihuman thymocyte globulin (ATG) on reactivity in autolog...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198102000-00001
更新日期:1981-02-01 00:00:00
abstract::We have proposed that the mechanisms of alloengraftment and variable acquired tolerance can be facilitated by minimum posttransplant immunosuppression. It was further suggested that the efficacy of minimalistic treatment could be enhanced by preoperative recipient conditioning with an antilymphoid antibody preparation...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000142674.78268.01
更新日期:2004-10-15 00:00:00
abstract::Anti-CD3 mAbs are potent inhibitors of T cell function; however, administration of mitogenic mAb can cause significant morbidity secondary to T cell activation and cytokine release. Nonmitogenic anti-CD3 mAb is immunosuppressive in mice without inducing detectable morbidity, and may thus be preferable for in vivo T ce...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-12-15 00:00:00
abstract:BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000071846.35825.B1
更新日期:2003-07-15 00:00:00
abstract::Vascularized xenografts are rejected acutely and hyperacutely in concordant or discordant combinations, respectively. We investigated the impact of the donor-recipient combination on the rejection of arterial xenografts, analyzing the cellular and extracellular matricial compartments. Aortic xenografts were performed ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199609270-00017
更新日期:1996-09-27 00:00:00
abstract:BACKGROUND:Infectious complications occur in approximately 50% of cadaveric liver transplant (CDLT) recipients. Living-donor liver transplantation (LDLT) is an established alternative to shorten the waiting time. Currently, the incidence of pulmonary infections after LDLT and the microbiologic causes are unknown. In th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816f61a6
更新日期:2008-06-15 00:00:00
abstract::Rapid and precise cyclosporine measurements are necessary to maximize immunosuppression and minimize toxicity. The new cyclosporine and metabolites TDx fluorescent polarization immunoassay was studied to determine its precision, sensitivity, and stability. Further, it was compared with the existing radioimmunoassay an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198902000-00013
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Systemic inflammation markers, such as neutrophil-to-lymphocyte ratio (NLR), have recently emerged as the prognostic factors for recurrence of liver tumors. METHODS:We assessed the ability of NLR and of other variables to predict the outcomes of orthotopic liver transplantation (OLT) for hepatocellular carc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182187cf0
更新日期:2011-06-15 00:00:00
abstract::During "hyperacute rejection" of rabbit heart perfused with transplantation alloantibodies, platelet activating factor (PAF) was released into the coronary effluent, which appeared to have physicochemical and functional properties similar to the 1-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (synthetic PAF) and ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198707000-00023
更新日期:1987-07-01 00:00:00
abstract:INTRODUCTION:Celsior (CEL) was formulated specifically for heart preservation. Recently some preliminary reports have suggested that CEL is also effective for liver preservation. In this study liver preservation with CEL was compared to colloid-free University of Wisconsin solution (MUW). METHODS:Arterialized rat live...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200010270-00002
更新日期:2000-10-27 00:00:00
abstract:BACKGROUND:In the United States, 1 in 10 infants and 1 in 20 older children die on the liver transplant waiting list. Increasing split liver transplantation could increase organ availability for these children, without decreasing transplants in adults. METHODS:Using United Network for Organ Sharing Standard Transplant...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002249
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:After pancreas transplantation, endocrine function is determined by the insulin secretory capacity of the transplanted pancreas. The authors evaluated the predictive value of postoperative oral glucose tolerance test (OGTT) and stimulated insulin secretion on long-term endocrine function. METHODS:Forty-one ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000098821.26466.DE
更新日期:2003-11-27 00:00:00