Abstract:
BACKGROUND:Chronic lung disease and pulmonary failure are complications that can occur after bone marrow transplantation (BMT) and are associated with severe morbidity and mortality. METHODS:We report on four patients who developed chronic, progressive, and irreversible lung disease 1 to 3 years after allogeneic BMT in childhood. These patients had chronic graft-versus-host disease (n=3) or radiation-related pulmonary fibrosis (n=1). Three patients underwent double lung transplants and one patient underwent a single lung transplant 2 to 14 years after BMT. RESULTS:All four patients tolerated the lung transplantation procedure well and showed significant clinical improvement with normalization of pulmonary function tests by 1 year posttransplant. One patient died from infectious complications 3 years after lung transplantation, and one patient died after chronic rejection of the transplanted lungs 6 years posttransplant. Two patients remain alive without significant respiratory impairment 2 and 7 years after lung transplantation. CONCLUSION:We conclude that lung transplantation offers a viable therapeutic option for patients who develop respiratory failure secondary to BMT.
journal_name
Transplantationjournal_title
Transplantationauthors
Heath JA,Kurland G,Spray TL,Kernan NA,Small TN,Brochstein JA,Gillio AP,Boklan J,O'Reilly RJ,Boulad Fdoi
10.1097/00007890-200112270-00020subject
Has Abstractpub_date
2001-12-27 00:00:00pages
1986-90issue
12eissn
0041-1337issn
1534-6080journal_volume
72pub_type
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