Abstract:
:FK506, an immunosuppresant, was isolated from Streptomyces tsukubaensis. Intramuscular administration of FK506 (0.32 mg/kg or more) 5 days a week for two weeks after grafting prolonged the acceptance time of F344 skin allograft to WKA rats. Similar results were obtained with cyclosporine at 32 mg/kg or more, but other immunosuppressives (i.e., prednisolone, azathioprine, and bredinin) gave only a marginal prolongation. The prolonging effect of FK506 was obtained in various donor-recipient combinations across a major or minor histocompatibility barrier. The agent also prolonged the acceptance time of mouse skin xenografts to rats. Furthermore, maintenance doses of 3.2 or 0.32 mg/kg twice a week after an initial 14-day treatment with the agent at 3.2 mg/kg gave graft survival as long as the treatment was continued for more than 120 days. Our findings show that FK506 has a potent immunosuppressive effect in rats and suggest that the agent merits further investigation.
journal_name
Transplantationjournal_title
Transplantationauthors
Inamura N,Nakahara K,Kino T,Goto T,Aoki H,Yamaguchi I,Kohsaka M,Ochiai Tdoi
10.1097/00007890-198801000-00042subject
Has Abstractpub_date
1988-01-01 00:00:00pages
206-9issue
1eissn
0041-1337issn
1534-6080journal_volume
45pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::During anesthesia 5 mg of muromonab CD3 (OKT3), an anti-CD3 monoclonal antibody, was administered prophylactically to twelve patients undergoing cadaveric renal transplantation. Preoperatively, all patients were at or near their dry body weights. Methylprednisolone 500 mg on call to or in the operating room, azathiopr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199308000-00020
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies, especially those that fix complement, are associated with antibody-mediated rejection and graft failure. The C1q assay on single antigen beads detects a subset of HLA antibodies that can fix complement and precede C4d deposition. The aim of this study was to determin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318203fd26
更新日期:2011-02-15 00:00:00
abstract:BACKGROUND:In this report, we compare the long-term outcome of pediatric liver transplantation (LTx) patients maintained with tacrolimus-based and with cyclosporine (CsA)-based immunosuppressive therapy. We examine long-term patient and graft survival, the incidence of rejection, and immunosuppression-related complicat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200008270-00015
更新日期:2000-08-27 00:00:00
abstract::Gastrointestinal infection due to cytomegalovirus occurs frequently in liver transplant recipients. Upper gastrointestinal cytomegalovirus infection is associated with subjective complaints of nausea, a sense of abdominal fullness, and occasionally emesis and/or dysphagia. In order to determine whether these symptoms ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199207000-00012
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Transplantation enhances the risk of malignancies, due to the chronic use of antirejection medication. In the case of Kaposi's sarcoma (KS) the permissive effect of immunosuppression has been extensively studied, and cyclosporine (CsA) appears to play a key role. Here we have compared the incidence of KS in ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173803.97398.31
更新日期:2005-09-27 00:00:00
abstract::The purpose of this study was to investigate the effect of prostaglandin E1 on rabbit heart preservation. The hearts were arrested with cardioplegia (CP) solution, followed by intracoronary infusion of Euro-Collins (E-C) solution. They were immersed in E-C solution at 4 degrees C for 9 hr, flushed with terminal warm C...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199209000-00006
更新日期:1992-09-01 00:00:00
abstract::Serologic evidence of resolved hepatitis B virus (HBV) infection (HBV surface antigen negative, anti-HBV core antibody [HBc] positive) in a liver donor can be regarded as an occult infection with episomal HBV in the liver. The purpose of this study was to evaluate the safety of anti-HBc-positive living donors. Between...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000047030.38665.0D
更新日期:2003-02-15 00:00:00
abstract:BACKGROUND:Prediabetic glucose homeostasis alterations are important cardiovascular risk factors but their role in renal transplant recipients (RTR) has not been established. METHODS:In 172 RTRs without pretransplant or de novo diabetes, we measured carotid intima media thickness (c-IMT) and performed an oral glucose ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000284462.70064.ae
更新日期:2007-10-15 00:00:00
abstract:BACKGROUND:Survival after lung transplantation is mainly limited by the development of chronic lung allograft dysfunction (CLAD). The aim of this study was to investigate if platelet inhibition by clopidogrel has a functionally relevant influence on the microvascular integrity of orthotopic tracheal allografts as an an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002571
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:To optimize the methods used for human islet isolation for transplantation, it is important to improve our understanding of the structure of the islet-exocrine interface. In this study, the composition of collagen subtypes in the interface have been characterized and quantified in human pancreas. METHODS:Hu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000197482.91227.df
更新日期:2006-02-15 00:00:00
abstract::This study investigates the possibility that the active enhancing properties of bone marrow (BM) cells may be related to Ia-like determinants on their surface membranes. Less chromium was released on a cell per cell basis from nucleated baboon BM cells used as targets in complement-dependent cytotoxicity than from lab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197808000-00001
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Obliterative bronchiolitis (OB), chronic allograft rejection of the lung, is a major cause of morbidity and mortality after lung transplantation. Previous studies using the heterotopic mouse trachea model of chronic airway rejection have shown a T cell infiltrate composed of CD4+ and CD8+ T cells. The goal o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002150-00016
更新日期:2000-02-15 00:00:00
abstract:BACKGROUND:Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood. METHODS:Here, we assessed the impact of rapamycin o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001902
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Hypoalbuminemia is associated with poorer outcomes in renal transplantation. Diabetes can compound hypoalbuminemia's detrimental effects. Kidney-pancreas transplantation alters the diabetic milieu; yet, some patients continue to be hypoalbuminemic. METHODS:We retrospectively analyzed 232 patients who underw...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199907150-00014
更新日期:1999-07-15 00:00:00
abstract:BACKGROUND:A striped pattern of fibrosis has been described in the kidneys of patients undergoing long-term cyclosporine or tacrolimus therapy. This lesion is frequently misconstrued as being specific for drug toxicity. METHODS:We performed clinicopathologic correlation on 18 patients with striped fibrosis identified ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199902150-00025
更新日期:1999-02-15 00:00:00
abstract::In order to understand in more detail the role of endogenous interleukin 1 receptor antagonist (IL-1ra) during bone marrow transplantation, IL-1ra serum levels of 28 patients undergoing allogeneic (n=25) or autologous (n=3) bone marrow transplantation were measured with a commercially available ELISA. In addition, the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199701150-00010
更新日期:1997-01-15 00:00:00
abstract:BACKGROUND:Renal dysfunction early after kidney transplantation has multiple causes including ischemia-reperfusion (I/R) injury and drug-induced nephrotoxicity. This study assesses the acute nephrotoxicity of tacrolimus (Tac) and sirolimus (Sir) in a rat renal isograft model. METHODS:Lewis renal isografts and uninephr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000128837.07640.ae
更新日期:2004-08-15 00:00:00
abstract:BACKGROUND:Brain death (BD) affects the viability of lungs for transplantation. A correlation exists between high lung inflammation after BD and the decrease in female sex hormones, especially estradiol. Therefore, we investigated the effects of 17β-estradiol (E2) treatment on the lungs of female brain dead rats. METH...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003467
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:Renal warm ischemic injury and immunosuppression with cyclosporin A (CsA) may contribute to chronic allograft nephropathy after cadaveric transplantation. This study establishes whether CsA can sensitize the kidney to injury and fibrosis induced by renal warm ischemia (RWI). METHODS:The left kidney of Sprag...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000113850.34945.dc
更新日期:2004-03-15 00:00:00
abstract::The purpose of this study was to investigate two promising immunosuppressive agents, didemnin B (DB) and FK506 (FK), during pregnancy to assess potential adverse maternal or fetal effects. Pregnant C3H mice were randomized into control and high- and low-dose treatment groups for each drug. Animals received daily injec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199107000-00022
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Infectious complications occur in approximately 50% of cadaveric liver transplant (CDLT) recipients. Living-donor liver transplantation (LDLT) is an established alternative to shorten the waiting time. Currently, the incidence of pulmonary infections after LDLT and the microbiologic causes are unknown. In th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816f61a6
更新日期:2008-06-15 00:00:00
abstract:BACKGROUND:Transjugular intrahepatic portosystemic shunt (TIPS) is used in the management of refractory ascites (RA) and variceal bleeds. Little data exist on TIPS safety, efficacy, and survival after liver transplantation (LT). METHODS:We conducted a retrospective analysis of patients who underwent TIPS placement aft...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31820e014e
更新日期:2011-04-15 00:00:00
abstract::The combination of pharmacokinetic and pharmacodynamic (measurement of the biological effect) monitoring of immunosuppressive drugs provides a method for the optimization of drug dosing. We chose to investigate this using mycophenolic acid (MPA), an immunosuppressive drug that mediates its effect by the inhibition of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601150-00018
更新日期:1996-01-15 00:00:00
abstract::The immunosuppressive effects of cyclosporin A were tested in a DA (RT-1a) to Lewis (RT-1(1) rat renal allograft model, which represents a very strong histocompatibility barrier. Dose-response studies established that oral doses of 5 mg/kg/day or higher gave complete suppression of rejection, while oral doses of 2 mg/...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198005000-00003
更新日期:1980-05-01 00:00:00
abstract::We describe four patients who suffered asystole, myocardial infarction (in two cases) and supraventricular tachycardia at the time of high-dose methylprednisolone infusion. One patient died during infusion. We measured the effects of methylprednisolone and placebo infusion on heart rate, blood pressure, and cardiac ou...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-198304000-00017
更新日期:1983-04-01 00:00:00
abstract::Islets were isolated from the pancreata of Sprague-Dawley rats and transplanted into streptozotocin-induced diabetic outbred Wistar rats. The effect of transplantation of islets into the cisterna magna on the diabetic state of the recipients was compared with that of the conventional transplantation of islets into liv...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199203000-00003
更新日期:1992-03-01 00:00:00
abstract::Survival times of allogeneic fetal pancreases were determined across various immunogenetic barriers using several inbred rat strains. Pancreases from 17-day-old embryos transplanted beneath the kidney capsule of normal, nonimmunosuppressed recipients were richly vascularized within a short period regardless of histoin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198001000-00008
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Allogeneic bone marrow transplantation is under investigation for a range of nonmalignant indications, including tolerance induction through mixed chimerism. This strategy has so far been tested experimentally only in young recipients. Due to immunosenescence, older patients have an increase in memory T cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182954618
更新日期:2013-06-27 00:00:00
abstract::We investigated the preventive effect of the immunosuppressive agent FK506 on autoimmune insulitis in nonobese diabetic mice. The mice were given FK506 in a dose of 1.0 mg/kg, every other day, from age 2 to 12, 2 to 6, and 4 to 12 weeks, respectively; after which, the incidence of insulitis and overt diabetes was moni...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199304000-00045
更新日期:1993-04-01 00:00:00
abstract::The mortality rates for CVDs in transplant recipients are greater than those in the general population (13). CVDs are a major cause of both patient and graft loss in renal transplant recipients, and improving cardiovascular health may help to extend both patient and graft survival. A complication of chronic renal fail...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-15 00:00:00