Abstract:
:Since the earliest days of transplantation, immunobiologists have sought means to prevent recognition and rejection of foreign tissue. The goal of these strategies is the retention of recipient immune function while selectively avoiding graft injury. Although considerable theoretical and technical problems remain, an analogous problem and solution already exists in nature. Here, we discuss the mechanisms by which organisms preclude or control autotoxicity, and for each, consider the corollaries between prevention of autotoxicity and graft rejection. Further study of these controls, including structural and conditional tolerance and accommodation, will offer insight into new therapies for allo- and xenotransplantation.
journal_name
Transplantationjournal_title
Transplantationauthors
Lynch RJ,Platt JLdoi
10.1097/TP.0b013e3181bcc93asubject
Has Abstractpub_date
2009-12-15 00:00:00pages
1233-6issue
11eissn
0041-1337issn
1534-6080pii
00007890-200912150-00001journal_volume
88pub_type
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