Abstract:
:CD4+ cells from CsA-treated DA rats with long-surviving PVG heart allografts specifically suppress the capacity of naive CD4+ cells to restore allograft rejection in irradiated DA rats, but have normal donor-specific alloreactivity in MLC. CD4+ suppressor cells from CsA-treated DA rats cultured for 3 days against either PVG or DA spleen cells lost the capacity to transfer suppression into irradiated DA rats grafted with PVG hearts and regained the ability to mediate rejection. However, these cells retained suppressor function when stimulated with donor-specific alloantigen in media supplemented with 20% Con A supernatant. CD4+ cells from CsA-treated rats cultured against either third-party stimulator cells or syngeneic cells expressing anti-PVG idiotype in media supplemented with Con A supernatant failed to maintain suppressor cell function. CD4+ cells from CsA-treated rats cultured in media supplemented with Con A supernatant alone also failed to maintain suppressor function. Suppressor cell function in culture was not maintained by rIL-2. mAb to the IL-2 receptor alpha chain (CD25) prevented the maintenance of suppressor cell function in media supplemented with Con A supernatant. Con A supernatant is rich in IFN-gamma, but addition of an anti-IFN-gamma mAb to the culture did not affect the maintenance of suppressor cells. These studies demonstrate that the CD4+ suppressor cell from CsA-treated rats with long-surviving grafts is short-lived; its survival is dependent upon contact with specific alloantigens and cytokines, one of which is IL-2. In the absence of cytokines and/or specific alloantigen, the CD4+ cells regain the capacity to initiate graft rejection in irradiated rats, suggesting that within the CD4+ subpopulation there is a fragile balance between cells with the capacity to suppress and effect rejection.
journal_name
Transplantationjournal_title
Transplantationauthors
Pearce NW,Spinelli A,Gurley KE,Hall BMdoi
10.1097/00007890-199302000-00027subject
Has Abstractpub_date
1993-02-01 00:00:00pages
374-80issue
2eissn
0041-1337issn
1534-6080journal_volume
55pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Monocytes play a crucial role in the response of lymphocytes to phytomitogens. This role is evident during the very early events after exposure to the mitogen. Thus, significant lymphocyte transformation does occur when monocytes are removed from the culture within a few hours after exposure to mitogen, and the presen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197901000-00015
更新日期:1979-01-01 00:00:00
abstract::Interferon gamma and tumor necrosis factor alpha play a significant role in the upregulation of host immunity and inflammation, for example by induction and enhancement of the expression of major histocompatibility complex class I and II antigens on a wide variety of cell types, both in vitro and in vivo. In this stud...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199011000-00022
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181860a74
更新日期:2008-09-27 00:00:00
abstract::Acute rejection is a frequent cause of early graft dysfunction in renal transplantation, and serum creatinine is the most important measure of clinical response. However, there is little information on serum creatinine during rejection episodes. In this study, the determinants that might influence the clinical respons...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199507150-00006
更新日期:1995-07-15 00:00:00
abstract:BACKGROUND:Increasing use of kidney grafts for simultaneous liver and kidney (SLK) transplants is causing concern about the most effective utilization of scarce kidney graft resources. This study evaluated the impact of implementing the proposed United Network for Organ Sharing SLK transplant policy on outcomes for end...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000270
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:We previously described a reduced-intensity hematopoietic cell transplantation (HCT) regimen in dog leukocyte antigen (DLA)-haploidentical littermate recipients consisting of 450 cGy total body irradiation (TBI) and anti-CD44 monoclonal antibody (mAb) S5 before and mycophenolate mofetil (MMF)/cyclosporine (C...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000228908.10775.b0
更新日期:2006-08-15 00:00:00
abstract::Second-set rejection is generally considered to be mediated by cytotoxic humoral antibodies. A few discordant data have been reported, however. To address this question, we have taken advantage of a model in which specific cytotoxic alloantibodies are not produced although transplantation cellular immunity develops. F...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00003
更新日期:1993-09-01 00:00:00
abstract::Multiple pretransplant sera obtained from alloimmunized renal transplant recipients were tested for the presence of antiidiotypic-like antibodies (AB2) that inhibit donor-specific HLA antibodies in the microlymphocytotoxicity assay. Fourteen patients received repetitive single-donor blood transfusions (SDT). In this p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00013
更新日期:1989-07-01 00:00:00
abstract::In a randomized trial conducted in 9 Ontario transplant centers, 107 cadaver kidney donors were randomized so that both kidneys were preserved either by simple cold storage (CS) or by pulsatile perfusion (PP). After exclusions and losses to follow-up, there were 90 patients in the CS group and 91 in the PP group. Tota...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-06-01 00:00:00
abstract::T cells play an important role in protective immunity against tuberculosis. As patients are not reimmunized with BCG after BMT, the question arises as to whether PPD-specific memory T cells are transferred from the marrow donor to the recipient and persist in the long-term. We studied long-term survivors of non-T cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199301000-00014
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Prognostic models, which estimate survival probabilities, enable the survival benefit from a procedure to be assessed and allow the comparison of outcomes between centers. We therefore compared three models that estimate survival in the absence of transplantation for patients with alcoholic liver disease (AL...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/01.TP.0000089236.78772.57
更新日期:2003-11-27 00:00:00
abstract:BACKGROUND:Increased use of pediatric deceased donor kidneys could enlarge the deceased donor kidney pool. Kidney transplant outcomes from small pediatric donors were compared with those from ideal kidney (IK) and expanded criteria kidney (ECK) donors to understand the optimal use of pediatric donor kidneys. METHODS:K...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000002706
更新日期:2019-12-01 00:00:00
abstract::Intestinal transplantation has become the treatment of choice for patients who are experiencing life-threatening complications of intestinal failure. Early attempts with intestinal transplantation were unsuccessful as a consequence of both technical and immunologic failures. The introduction of tacrolimus provided the...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000126931.23349.15
更新日期:2004-05-15 00:00:00
abstract:BACKGROUND:Spontaneous tolerance to liver allograft has been reported previously in outbred pig models, but the lack of genetic background did not allow to analyze the impact of the major histocompatibility complex (MHC) on tolerance induction. A model of semi-identical liver allograft was therefore developed in inbred...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200006150-00014
更新日期:2000-06-15 00:00:00
abstract:BACKGROUND:Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model. METHODS:Purified porcine islets were transplanted in autoimmune (non-obese diabetic) ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199812150-00022
更新日期:1998-12-15 00:00:00
abstract:BACKGROUND:Co-stimulatory blockade has been shown to prolong allograft survival in different transplant models. We investigated the effect of combining humanized anti-CD80 and anti-CD86 monoclonal antibodies (mAb) with sirolimus in cynomolgus monkey renal transplant recipients. METHODS:After renal transplantation, gro...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000066806.10029.7A
更新日期:2003-06-27 00:00:00
abstract:BACKGROUND:A new vascularized concordant xenotransplant model using the Chinese hamster as donor and mouse as recipient species is reported. This model takes advantage of the wealth of informative immune reagents and knockout and transgenic backgrounds available for the mouse. METHODS:Heterotopic auxillary cardiac tra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199906150-00016
更新日期:1999-06-15 00:00:00
abstract:BACKGROUND:Renal transplant recipients have an increased incidence of cardiovascular disease, but less data exist about cerebrovascular atherosclerosis. In this study, we assessed the prevalence of carotid lesions as evaluated by B-mode ultrasonography in a group of renal transplant recipients, and we evaluated univari...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199902150-00005
更新日期:1999-02-15 00:00:00
abstract:BACKGROUND:Sensitization to human leukocyte antigens (HLA) is a significant barrier to transplantation. Currently, no proven therapy exists to improve access to transplantation for highly sensitized patients. Here, we report a novel approach using intravenous immune globulin to modulate anti-HLA antibody and improve th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000080685.31697.FC
更新日期:2003-08-27 00:00:00
abstract:BACKGROUND:In an effort to improve outcomes associated with living kidney donation, the Kidney Diseases Improving Global Outcomes (KDIGO) assembled a Work Group to develop comprehensive guidelines addressing the evaluation and care of living kidney donors. We conducted this systematic review to inform guideline develop...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001252
更新日期:2016-06-01 00:00:00
abstract::In a canine model of acute ischemic lung injury, a hypertonic citrate solution (HTC) widely used for renal preservation in the United Kingdom, was compared with modified Euro-Collins' solution (ECS) currently the most widely clinically used pulmonary perfusate. Ten beagle dogs underwent left thoracotomy and exclusion ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199105000-00022
更新日期:1991-05-01 00:00:00
abstract::Interferon is a potent stimulator of natural killer (NK) and killer (K) cell activity in human beings, both these cytotoxic functions representing host defense mechanisms against viral infections and lymphoid malignancy. Both NK and K cell functions are markedly impaired in conventionally immunosuppressed allograft re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198408000-00008
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Tacrolimus (Tac) and mycophenolate mofetil (MMF) are newly approved immunosuppressive agents. However, the safety and efficacy of the combination of MMF and Tac in primary liver transplantation has not been determined. METHODS:An Institutional Review Board-approved, open-label prospective randomized protoco...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199811270-00024
更新日期:1998-11-27 00:00:00
abstract::The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198311000-00001
更新日期:1983-11-01 00:00:00
abstract::Using C1q binding, Kg binding, and Raji cell radioimmunoassays, the relationship between renal allograft rejection and the circulating immune complexes was examined in 90 patients with renal transplants. The data showed that there was a significant quantitative correlation between C1q-binding and Raji-cell-binding act...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198308000-00009
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND:Abrupt temperature shift from hypothermia to normothermia incurred on reperfusion of organ grafts has been delineated as a genuine factor contributing to reperfusion injury and graft dysfunction after transplantation. METHODS:In a first clinical series of 6 patients, cold-stored livers, all allocated by the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000915
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000002890
更新日期:2019-11-01 00:00:00
abstract::Experimental studies of vein homografts in rats have shown prolonged patency resulting from an attenuated immune response. This study examined the response to Golden Syrian hamster vein xenografts. While one group of Sprague-Dawley rats served as a control, a second group was sensitized with 5 X 10(6) viable hamster s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198511000-00011
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Although inactivated vaccines are recommended for immunocompromized patients, efficacy and safety of diphtheria and tetanus immunization in renal transplant recipients have received little attention so far. The aim of the study was to investigate the response to a standard diphtheria and tetanus booster vacc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199707270-00010
更新日期:1997-07-27 00:00:00
abstract::Whole-body irradiation has been extensively used to ablate immune responsiveness in rodent recipients in adoptive allograft assays. This study was undertaken to determine the relative radioresistance and the tempo of regeneration, following whole-body irradiation, of cells involved in the allograft response. Six disti...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198809000-00018
更新日期:1988-09-01 00:00:00