Abstract:
:The effect of cyclosporine and metabolite 17 (M17) as well as other CsA-related compounds (CsG, dihydro-CsC, dihydro-CsD, CsH, B5.49, and H7.94) was tested on T lymphocyte clone proliferation. In these experiments, antigen and interleukin 2 (IL-2) dependent long-term T lymphocyte clones derived from a rejected human kidney graft infiltrate were used. They were specifically committed (proliferation and cytotoxicity) for the donor Epstein-Barr virus (EBV)-transformed cells. CsA strongly inhibited clone T cell proliferation induced by the antigen. Inhibition of antigen-driven proliferation was reversed by pure recombinant IL-2 (rec-IL-2) only when low amounts of CsA (less than 25 ng/ml) were used, whereas this lymphokine was ineffective at higher but still pharmacological CsA concentrations (50-500 ng/ml). Increasing rec-IL-2 concentrations did not modify this finding. In addition, CsA, did not inhibit the growth signal(s) induced by rec-IL-2/IL-2 receptor interactions when R-IL-2 is pre-expressed on clone cells. M17 was far less effective in inhibiting antigen-induced clone cell proliferation (50% inhibition at 16 ng/ml versus 500 ng/ml with, respectively, CsA and M17) but was nevertheless inhibitory. This observation, if extended to other metabolites, could be important for interpretation of the relevance of "CsA" concentration through radio-immunoassay monitoring of recipients' blood. Although CsA appeared to display the major inhibitory effect, dihydro-CsC and CsG, as well as B5.49 and H7.94 CsA-related compounds, also exhibited strong activity. Dihydro-CsD was less inhibitory, and CsH had no effect.
journal_name
Transplantationjournal_title
Transplantationauthors
Chabannes D,Moreau JF,Soulillou JPdoi
10.1097/00007890-198712000-00019subject
Has Abstractpub_date
1987-12-01 00:00:00pages
813-7issue
6eissn
0041-1337issn
1534-6080journal_volume
44pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Unstimulated whole saliva and serum samples were collected from ten allogeneic bone marrow transplant recipients before and after bone marrow transplantation, seven donors, and from twenty healthy individuals. Two patterns with regard to salivary IgA were found after transplantation. In five patients, a short-lasting ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198811000-00016
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Angiogenesis contributes to the repair process after renal ischemia/reperfusion (I/R) injury. In the present study, we tested the role of miR-21 in the angiogenesis induced by hypoxia inducible factor (HIF)-1α through inhibiting a predicted target gene thrombospondin 1 (TSP-1). METHODS:To stabilize HIF-1α, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001501
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:We have previously demonstrated that in a concordant hamster-to-nude rat cardiac transplant model, T-independent specific B-lymphocyte and natural killer (NK)-cell tolerance could be induced, leading to long-term xenograft (Xg) survival. Here, we investigated whether the same could be achieved in a clinicall...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199907150-00024
更新日期:1999-07-15 00:00:00
abstract:BACKGROUND:Solid-organ transplant recipients with pretransplant malignancies (PTM) have worse overall survival (OS) compared to recipients without history of malignancy. However, it is unknown whether the increased risk of mortality is due to recurrent cancer-related deaths. METHODS:All solid-organ transplant recipien...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002178
更新日期:2018-07-01 00:00:00
abstract::Graft and patient survival rates were analyzed in 239 consecutive first cadaver renal transplants as a function of time of administration of blood transfusion and the number of units given. There was no statistically significant difference in patient survival in comparing patients who were never transfused, patients n...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198012000-00008
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:In kidney transplantation, dynamic prediction of patient and kidney graft survival (DynPG) may help to promote therapeutic alliance by delivering personalized evidence-based information about long-term graft survival for kidney transplant recipients. The objective of the current study is to externally valida...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003209
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:CD4+ T cells play an essential role in allograft rejection. The monoclonal anti-rat CD4 antibody, RIB 5/2, has been shown to modulate the CD4 glycoprotein without eliminating the recipient T cells. We have successfully induced tolerance to rat heart allografts by recipient pretreatment with a single dose of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001270-00015
更新日期:2000-01-27 00:00:00
abstract::Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the pr...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-11-15 00:00:00
abstract::In a canine model of dog leukocyte antigen (DLA)-identical nonmyeloablative marrow transplantation including postgrafting immunosuppression with cyclosporine (CSP) and mycophenolate mofetil (MMF), engraftment was only transient with 100 cGy total body irradiation (TBI) conditioning, indicating suboptimal pretransplant...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000181168.42461.0b
更新日期:2005-11-27 00:00:00
abstract::Endothelial cells serve an important role in augmenting immune responses through enhanced expression of MHC class II antigens. Immune-mediated vascular injury associated with rejection requires reendothelialization to restore vascular integrity. The origin of the reparative endothelial cells can be determined when ABO...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199102000-00033
更新日期:1991-02-01 00:00:00
abstract::Three hundred thirty-two marrow graft recipients and 241 healthy marrow donors were studied by skin testing with recall and neoantigens. Two hundred thirty patients with leukemia and seventy-eight patients with aplastic anemia received allogeneic HLA-identical sibling marrow. Twenty-four patients with leukemia receive...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198402000-00006
更新日期:1984-02-01 00:00:00
abstract::Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199509000-00016
更新日期:1995-09-15 00:00:00
abstract:BACKGROUND:Systemic inflammation markers, such as neutrophil-to-lymphocyte ratio (NLR), have recently emerged as the prognostic factors for recurrence of liver tumors. METHODS:We assessed the ability of NLR and of other variables to predict the outcomes of orthotopic liver transplantation (OLT) for hepatocellular carc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182187cf0
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:Our goal was to test the intragraft mRNA expression and production of two chemokines that are potent chemoattractants for antigen-primed T cells, interferon-gamma inducible protein 10 (IP-10) and monokine-induced by IFN-gamma, (Mig), in allogeneic heart grafts. METHODS:Syngeneic or allogeneic A/J (H-2a) hea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003270-00020
更新日期:2000-03-27 00:00:00
abstract::Advances in immunosuppression have reduced the incidence of acute graft loss after transplantation, but long-term allograft survival is still hindered by the development of chronic allograft injury, a multifactorial process that involves both immunologic and nonimmunologic components. Because these components become d...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e3181efcfbc
更新日期:2010-11-15 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion syndrome has been recognized as an important pathogenic factor in renal transplantation, not only in the development of delayed graft function but also in the development of acute and chronic rejection. Hypoxia-inducible factor (HIF)-1 activates transcription of several genes implicated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000063128.86981.B2
更新日期:2003-05-27 00:00:00
abstract:BACKGROUND:In hamster-to-rat cardiac xenografts, long-term survival (LTS) is obtained in 60% of recipients if vascular rejection is overcome by cobra venom factor and cyclosporine (CsA). It has been suggested that this accommodation state could be due to the Th2 response. METHODS:We examined the infiltrate by using im...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199806270-00004
更新日期:1998-06-27 00:00:00
abstract:BACKGROUND:It has been proposed that hyperacute rejection (HAR) of pig-to-primate vascularized xenografts is due in large part to ineffective regulation of recipient complement by pig complement regulatory proteins (CRPs), and indeed transgenic expression of human CRPs in pigs can prevent hyperacute rejection. However,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200009270-00014
更新日期:2000-09-27 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the population pharmacokinetics of tacrolimus in pediatric liver transplant recipients and to identify factors that may explain pharmacokinetic variability. METHODS:Data were collected retrospectively from 35 children who received oral immunosuppressant therapy with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200109270-00013
更新日期:2001-09-27 00:00:00
abstract::Although extrinsic denervation is inevitable after intestinal transplantation and leads to poor intestinal function, little is known about the occurrence of extrinsic reinnervation. In this study, extrinsic sympathetic reinnervation was investigated morphologically following syngeneic intestinal transplantation perfor...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-02-15 00:00:00
abstract:BACKGROUND:Both laboratory and clinical studies have shown that dietary lipids may affect immunologic responses. This study was conducted to compare different classes of long-chain unsaturated fatty acids for their effect on allograft survival in animals receiving a donor-specific transfusion and a short course of low-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199805270-00004
更新日期:1998-05-27 00:00:00
abstract::Infection remains one of the major complications of nonspecific immunosuppression in renal transplant patients and accounts for significant morbidity and mortality. The incidence of infectious complications has been shown to be related to the degree of immunosuppression and correlated with the total steroid dosage, us...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199701150-00030
更新日期:1997-01-15 00:00:00
abstract::Despite previous attempts there is currently no suitable animal model available for xenogeneic graft versus host disease (XGVHD) mediated via human immunocompetent cells. Recently, we have developed an efficient protocol to engraft SCID mice with human peripheral blood lymphocytes (Hu-PBLs). The engraftment efficiency...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-07-27 00:00:00
abstract:BACKGROUND:Murine umbilical cord blood cells (UCBCs) were studied for their ability to reconstitute the hematopoietic system. METHODS:On average, 150 microL of cord blood per fetus containing 1.2 to 2 x 10(4) nucleated cells were collected from day 18.5 fetal umbilical cord, and 3 to 6 x 10(3) cells per fetus were obt...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000065295.99190.03
更新日期:2003-06-15 00:00:00
abstract:BACKGROUND:The piggyback technique of orthotopic liver transplantation is an attractive alternative that preserves the recipient inferior vena cava and allows uninterrupted venous blood return during the anhepatic phase. As with other transplantation techniques, the vascular anastomoses required by the piggyback techni...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199908150-00018
更新日期:1999-08-15 00:00:00
abstract:BACKGROUND:It has been suggested that T cells primed by processed donor major histocompatibility complex antigen (the "indirect" pathway of allorecognition) may be responsible for mediating chronic allograft rejection. The purpose of this study was to develop a clinically useful assay to study the occurrence of indirec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199709270-00001
更新日期:1997-09-27 00:00:00
abstract::To determine the nature and sequence of the histologic changes in the early rejection of pancreaticoduodenal allografts and to assess the correlation between pancreaticoduodenal biopsy findings and the pathologic changes in the graft, we performed serial cystoscopically directed needle biopsies of pancreaticoduodenal ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198911000-00008
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e31822805d7
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:The significance of late urinary tract infections (UTIs) after renal transplantation and their association with scarring and graft dysfunction remains controversial. We sought to define the prevalence of renal scarring in allograft recipients with a history of late recurrent UTIs, to determine whether the pr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000275377.09660.fa
更新日期:2007-08-15 00:00:00
abstract:BACKGROUND:Treatment of fetal pancreas (FP) isografts with insulin-like growth factor-I greatly improves the rate of conversion to euglycemia in diabetic rats. Complete knowledge of other factors that may facilitate the engraftment and function of FP in vivo is still embryonic. Augmenter of liver regeneration (ALR) is ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199801150-00007
更新日期:1998-01-15 00:00:00